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PubMed:22498306 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 2009-2013 gene:960 denotes CD44
T1 1927-1940 disease:C0596263 denotes tumorigenesis
T2 2009-2013 gene:960 denotes CD44
T3 1950-1964 disease:C0029925 denotes ovarian cancer
T4 2009-2013 gene:960 denotes CD44
T5 1950-1964 disease:C1140680 denotes ovarian cancer
R1 T0 T1 associated_with CD44,tumorigenesis
R2 T2 T3 associated_with CD44,ovarian cancer
R3 T4 T5 associated_with CD44,ovarian cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22498306_1_0 182-205 expanded denotes cancer-initiating cells
SS2_22498306_1_0 207-211 abbr denotes CICs
SS1_22498306_3_0 479-492 expanded denotes microRNA-199a
SS2_22498306_3_0 494-502 abbr denotes miR-199a
AE1_22498306_1_0 SS1_22498306_1_0 SS2_22498306_1_0 abbreviatedTo cancer-initiating cells,CICs
AE1_22498306_3_0 SS1_22498306_3_0 SS2_22498306_3_0 abbreviatedTo microRNA-199a,miR-199a

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 122-136 HP_0100615 denotes ovarian cancer
T2 130-136 HP_0002664 denotes cancer
T3 182-188 HP_0002664 denotes cancer
T4 507-521 HP_0100615 denotes ovarian cancer
T5 515-521 HP_0002664 denotes cancer
T6 711-724 HP_0100615 denotes ovarian tumor
T7 719-724 HP_0002664 denotes tumor
T8 1829-1835 HP_0002664 denotes tumors
T9 1950-1964 HP_0100615 denotes ovarian cancer
T10 1958-1964 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22498306-0#22#26#gene960 22-26 gene960 denotes CD44
22498306-0#86#100#diseaseC0029925 86-100 diseaseC0029925 denotes ovarian cancer
22498306-0#86#100#diseaseC1140680 86-100 diseaseC1140680 denotes ovarian cancer
22498306-10#141#145#gene960 2009-2013 gene960 denotes CD44
22498306-10#59#72#diseaseC0596263 1927-1940 diseaseC0596263 denotes tumorigenesis
22498306-5#9#14#gene3815 656-661 gene3815 denotes CD117
22498306-5#64#77#diseaseC0919267 711-724 diseaseC0919267 denotes ovarian tumor
22#26#gene96086#100#diseaseC0029925 22498306-0#22#26#gene960 22498306-0#86#100#diseaseC0029925 associated_with CD44,ovarian cancer
22#26#gene96086#100#diseaseC1140680 22498306-0#22#26#gene960 22498306-0#86#100#diseaseC1140680 associated_with CD44,ovarian cancer
141#145#gene96059#72#diseaseC0596263 22498306-10#141#145#gene960 22498306-10#59#72#diseaseC0596263 associated_with CD44,tumorigenesis
9#14#gene381564#77#diseaseC0919267 22498306-5#9#14#gene3815 22498306-5#64#77#diseaseC0919267 associated_with CD117,ovarian tumor

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2899 22-26 gene:960 denotes CD44
T2900 86-100 disease:C0029925 denotes ovarian cancer
R1 T2899 T2900 associated_with CD44,ovarian cancer
R2 T2899 T2900 associated_with CD44,ovarian cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.
TextSentencer_T2 119-317 Sentence denotes In ovarian cancer, CD44(+) /CD117(+) stem cells, also known as cancer-initiating cells (CICs), are highly proliferative, have a low degree of differentiation, and are resistant to chemotherapeutics.
TextSentencer_T3 318-435 Sentence denotes Therefore, the CD44(+) /CD117(+) subpopulation is thought to be an important target for novel therapeutic strategies.
TextSentencer_T4 436-533 Sentence denotes In this study, we investigated the role of microRNA-199a (miR-199a) in ovarian cancer stem cells.
TextSentencer_T5 534-646 Sentence denotes Luciferase reporter gene assays confirmed that miR-199a targets CD44 via an miR-199a-binding site in the 3'-UTR.
TextSentencer_T6 647-829 Sentence denotes CD44(+) /CD117(+) ovarian CICs were enriched from human primary ovarian tumor tissues and confirmed by flow cytometric sorting. miR-199a was cloned and transfected into ovarian CICs.
TextSentencer_T7 830-997 Sentence denotes CD44 mRNA and protein expression was significantly decreased in miR-199a-transfected ovarian CICs as compared with miR-199a mutant-transfected and untransfected cells.
TextSentencer_T8 998-1561 Sentence denotes Cell cycle analysis, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide proliferation assays, the colony formation assay and the transwell migration assay indicated that miR-199a significantly affected cell cycle regulation and suppressed the proliferation and invasive capacity of ovarian CICs in vitro. miR-199a significantly increased the chemosensitivity of ovarian CICs to cisplatin, pacitaxel, and adriamycin, and reduced mRNA expression of the multidrug resistance gene ABCG2 as compared with miR-199a mutant-transfected and untransfected cells.
TextSentencer_T9 1562-1734 Sentence denotes The expression of stemness markers was also significantly reduced in miR-199a-transfected CICs as compared with miR-199a mutant-transfected and untransfected ovarian cells.
TextSentencer_T10 1735-1867 Sentence denotes Furthermore, xenograft experiments confirmed that miR-199a suppressed the growth of xenograft tumors formed by ovarian CICs in vivo.
TextSentencer_T11 1868-2014 Sentence denotes Thus, expression of endogenous mature miR-199a may prevent tumorigenesis in human ovarian cancer by regulating expression of its target gene CD44.
T1 0-118 Sentence denotes MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.
T2 119-317 Sentence denotes In ovarian cancer, CD44(+) /CD117(+) stem cells, also known as cancer-initiating cells (CICs), are highly proliferative, have a low degree of differentiation, and are resistant to chemotherapeutics.
T3 318-435 Sentence denotes Therefore, the CD44(+) /CD117(+) subpopulation is thought to be an important target for novel therapeutic strategies.
T4 436-533 Sentence denotes In this study, we investigated the role of microRNA-199a (miR-199a) in ovarian cancer stem cells.
T5 534-646 Sentence denotes Luciferase reporter gene assays confirmed that miR-199a targets CD44 via an miR-199a-binding site in the 3'-UTR.
T6 647-829 Sentence denotes CD44(+) /CD117(+) ovarian CICs were enriched from human primary ovarian tumor tissues and confirmed by flow cytometric sorting. miR-199a was cloned and transfected into ovarian CICs.
T7 830-997 Sentence denotes CD44 mRNA and protein expression was significantly decreased in miR-199a-transfected ovarian CICs as compared with miR-199a mutant-transfected and untransfected cells.
T8 998-1561 Sentence denotes Cell cycle analysis, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide proliferation assays, the colony formation assay and the transwell migration assay indicated that miR-199a significantly affected cell cycle regulation and suppressed the proliferation and invasive capacity of ovarian CICs in vitro. miR-199a significantly increased the chemosensitivity of ovarian CICs to cisplatin, pacitaxel, and adriamycin, and reduced mRNA expression of the multidrug resistance gene ABCG2 as compared with miR-199a mutant-transfected and untransfected cells.
T9 1562-1734 Sentence denotes The expression of stemness markers was also significantly reduced in miR-199a-transfected CICs as compared with miR-199a mutant-transfected and untransfected ovarian cells.
T10 1735-1867 Sentence denotes Furthermore, xenograft experiments confirmed that miR-199a suppressed the growth of xenograft tumors formed by ovarian CICs in vivo.
T11 1868-2014 Sentence denotes Thus, expression of endogenous mature miR-199a may prevent tumorigenesis in human ovarian cancer by regulating expression of its target gene CD44.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 725-732 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 725-732 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues