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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 133-265 DRI_Background denotes Numerous studies have aimed to elucidate markers for the onset of decompensatory hypertrophy and heart failure in vivo and in vitro.
T2 266-438 DRI_Background denotes Alterations in the force-frequency relationship are commonly used as markers for heart failure with a negative staircase being a hallmark of decompensated cardiac function.
T3 439-750 DRI_Challenge denotes Here we aim to determine the functional and molecular alterations in the very early stages of compensatory hypertrophy through analysis of the force-frequency relationship, using a novel isolated muscle culture system that allows assessment of force-frequency relationship during the development of hypertrophy.
T4 751-871 DRI_Outcome denotes New Zealand white male rabbit trabeculae excised from the right ventricular free wall were utilized for all experiments.
T5 872-1205 DRI_Approach denotes Briefly, muscles held at constant preload and contracting isometrically were stimulated to contract in culture for 24 h, and in a subset up to 48 h. We found that, upon an increase in the preload and maintaining the muscles in culture for up to 24 h, there was an increase in baseline force produced by isolated trabeculae over time.
T6 1206-1287 DRI_Approach denotes This suggests a gradual compensatory response to the impact of increased preload.
T7 1288-1484 DRI_Approach denotes Temporal analysis of the force-frequency response during this progression revealed a significant blunting (at 12 h) and then reversal of the positive staircase as culture time increased (at 24 h).
T8 1485-1614 DRI_Background denotes Phosphorylation analysis revealed a significant decrease in desmin and troponin (Tn)I phosphorylation from 12 to 24 h in culture.
T9 1615-1750 DRI_Challenge denotes These results show that even very early on in the compensatory hypertrophy state, the force-frequency relationship is already affected.
T10 1751-1925 DRI_Background denotes This effect on force-frequency relationship may, in addition to protein expression changes, be partially attributed to the alterations in myofilament protein phosphorylation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 366-367 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 393-394 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 444-446 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 618-619 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 987-991 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T6 1000-1001 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 1015-1019 CVCL_J272|Hybridoma|Mus musculus denotes 48 h
T8 1015-1017 CVCL_J728|Hybridoma|Mus musculus denotes 48
T9 1021-1023 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T10 1041-1043 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T11 1041-1043 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T12 1117-1121 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T13 1133-1135 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T14 1133-1135 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T15 1200-1204 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T16 1220-1221 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1371-1372 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T18 1459-1463 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T19 1478-1482 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T20 1519-1520 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T21 1598-1602 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T22 1795-1798 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T23 1834-1841 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes

GoldHamster

Id Subject Object Predicate Lexical cue
T1 105-119 UBERON:0002349 denotes cardiac muscle
T2 105-119 UBERON:0001133 denotes cardiac muscle
T3 105-131 GO:0003300 denotes cardiac muscle hypertrophy
T7 113-131 614160 denotes muscle hypertrophy
T10 214-225 D006984 denotes hypertrophy
T11 214-225 D006984 denotes hypertrophy
T12 230-243 D006333 denotes heart failure
T13 230-243 D006333 denotes heart failure
T14 347-360 D006333 denotes heart failure
T15 347-360 D006333 denotes heart failure
T16 546-557 D006984 denotes hypertrophy
T17 546-557 D006984 denotes hypertrophy
T18 635-641 UBERON:0001630 denotes muscle
T19 635-641 UBERON:0005090 denotes muscle
T20 738-749 D006984 denotes hypertrophy
T21 738-749 D006984 denotes hypertrophy
T22 769-773 UBERON:0003101 denotes male
T23 769-773 CHEBI:30780 denotes male
T25 774-780 813859 denotes rabbit
T24 774-780 D011817 denotes rabbit
T26 774-780 9986 denotes rabbit
T27 781-791 UBERON:0004124 denotes trabeculae
T28 832-836 UBERON:0000060 denotes wall
T29 881-888 UBERON:0001015 denotes muscles
T30 987-991 CVCL_8262 denotes 24 h
T31 1088-1095 UBERON:0001015 denotes muscles
T32 1117-1121 CVCL_8262 denotes 24 h
T33 1184-1194 UBERON:0004124 denotes trabeculae
T34 1259-1265 PR:Q54JW9 denotes impact
T35 1259-1265 PR:Q642J4 denotes impact
T37 1478-1482 CVCL_8262 denotes 24 h
T38 1485-1500 GO:0016310 denotes Phosphorylation
T40 1545-1551 P02541 denotes desmin
T41 1545-1551 P48675 denotes desmin
T42 1545-1551 P17661 denotes desmin
T43 1545-1551 Q5XFN2 denotes desmin
T44 1545-1551 O62654 denotes desmin
T45 1545-1551 P02542 denotes desmin
T46 1545-1551 P02540 denotes desmin
T49 1545-1551 PR:000006427 denotes desmin
T50 1545-1551 P23239 denotes desmin
T51 1545-1551 P31001 denotes desmin
T47 1545-1551 D003893 denotes desmin
T39 1545-1551 GO:0045098 denotes desmin
T48 1545-1551 GO:0045100 denotes desmin
T52 1556-1564 D014336 denotes troponin
T53 1566-1570 P36188 denotes Tn)I
T54 1571-1586 GO:0016310 denotes phosphorylation
T55 1598-1602 CVCL_8262 denotes 24 h
T56 1601-1605 CHEBI:13359 denotes h in
T57 1678-1689 D006984 denotes hypertrophy
T58 1678-1689 D006984 denotes hypertrophy
T62 1815-1822 PR:000000001 denotes protein
T60 1815-1822 CHEBI:36080 denotes protein
T61 1815-1822 CHEBI:11122 denotes protein
T63 1815-1822 SO:0000104 denotes protein
T59 1815-1822 GO:0003675 denotes protein
T64 1889-1900 GO:0036379 denotes myofilament
T68 1901-1908 PR:000000001 denotes protein
T66 1901-1908 CHEBI:36080 denotes protein
T67 1901-1908 CHEBI:11122 denotes protein
T69 1901-1908 SO:0000104 denotes protein
T65 1901-1908 GO:0003675 denotes protein
T70 1901-1924 GO:0006468 denotes protein phosphorylation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 230-243 HP_0001635 denotes heart failure
T2 347-360 HP_0001635 denotes heart failure
T3 918-929 HP_0001371 denotes contracting
T4 963-971 HP_0001371 denotes contract

Allie

Id Subject Object Predicate Lexical cue
SS1_22467304_9_0 1556-1564 expanded denotes troponin
SS2_22467304_9_0 1566-1568 abbr denotes Tn
AE1_22467304_9_0 SS1_22467304_9_0 SS2_22467304_9_0 abbreviatedTo troponin,Tn