PubMed:22465138 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":196,"end":205},"obj":"HP_0001300"}],"text":"Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.\nRecently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P=0.97 and P=0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China."}

{"project":"Allie","denotations":[{"id":"SS1_22465138_1_0","span":{"begin":196,"end":215},"obj":"expanded"},{"id":"SS2_22465138_1_0","span":{"begin":217,"end":219},"obj":"abbr"}],"relations":[{"id":"AE1_22465138_1_0","pred":"abbreviatedTo","subj":"SS1_22465138_1_0","obj":"SS2_22465138_1_0"}],"text":"Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.\nRecently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P=0.97 and P=0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"22465138-0#28#37#geners6812193","span":{"begin":28,"end":37},"obj":"geners6812193"},{"id":"22465138-0#56#75#diseaseC0030567","span":{"begin":56,"end":75},"obj":"diseaseC0030567"}],"relations":[{"id":"28#37#geners681219356#75#diseaseC0030567","pred":"associated_with","subj":"22465138-0#28#37#geners6812193","obj":"22465138-0#56#75#diseaseC0030567"}],"text":"Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.\nRecently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P=0.97 and P=0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China."}

{"project":"PubTator4TogoVar","denotations":[{"id":"4","span":{"begin":28,"end":37},"obj":"SNP"},{"id":"18","span":{"begin":128,"end":137},"obj":"SNP"},{"id":"22","span":{"begin":361,"end":370},"obj":"SNP"},{"id":"24","span":{"begin":423,"end":432},"obj":"SNP"},{"id":"27","span":{"begin":684,"end":693},"obj":"SNP"},{"id":"28","span":{"begin":832,"end":841},"obj":"SNP"}],"attributes":[{"id":"A4","pred":"resolved_to","subj":"4","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A18","pred":"resolved_to","subj":"18","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A22","pred":"resolved_to","subj":"22","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A24","pred":"resolved_to","subj":"24","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A27","pred":"resolved_to","subj":"27","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"}],"text":"Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.\nRecently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P=0.97 and P=0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"4","span":{"begin":28,"end":37},"obj":"SNP"},{"id":"18","span":{"begin":128,"end":137},"obj":"SNP"},{"id":"22","span":{"begin":361,"end":370},"obj":"SNP"},{"id":"24","span":{"begin":423,"end":432},"obj":"SNP"},{"id":"27","span":{"begin":684,"end":693},"obj":"SNP"},{"id":"28","span":{"begin":832,"end":841},"obj":"SNP"},{"id":"T1","span":{"begin":28,"end":37},"obj":"SNP"},{"id":"T1","span":{"begin":128,"end":137},"obj":"SNP"},{"id":"T2","span":{"begin":361,"end":370},"obj":"SNP"},{"id":"T3","span":{"begin":423,"end":432},"obj":"SNP"},{"id":"T4","span":{"begin":684,"end":693},"obj":"SNP"},{"id":"T5","span":{"begin":832,"end":841},"obj":"SNP"}],"attributes":[{"id":"A4","pred":"resolved_to","subj":"4","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A18","pred":"resolved_to","subj":"18","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A22","pred":"resolved_to","subj":"22","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A24","pred":"resolved_to","subj":"24","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A27","pred":"resolved_to","subj":"27","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A5","pred":"resolved_to","subj":"T4","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"},{"id":"A6","pred":"resolved_to","subj":"T5","obj":"tmVar:rs6812193;VariantGroup:0;CorrespondingGene:100129583;RS#:6812193;CorrespondingSpecies:9606"}],"text":"Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.\nRecently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P=0.97 and P=0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China."}