PubMed:22450157
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 87-97 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 190-200 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 228-238 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 375-385 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 410-420 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 769-784 | Cell | denotes | (M2) macrophage | http://purl.obolibrary.org/obo/CL:0000890 |
| T12 | 774-784 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T14 | 809-819 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T16 | 837-848 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T17 | 916-926 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T19 | 1680-1694 | Cell | denotes | M1 macrophages | http://purl.obolibrary.org/obo/CL:0000863 |
| T20 | 1742-1756 | Cell | denotes | M2 macrophages | http://purl.obolibrary.org/obo/CL:0000890 |
| T21 | 1765-1775 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T23 | 1848-1858 | Cell | denotes | phagocytic | http://purl.obolibrary.org/obo/CL:0000234 |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 600-610 | gene:3958 | denotes | galectin-3 |
| T1 | 669-678 | disease:C0023418 | denotes | leukaemia |
| T2 | 831-836 | gene:3078 | denotes | HFL-1 |
| T3 | 669-678 | disease:C0023418 | denotes | leukaemia |
| T4 | 831-836 | gene:3078 | denotes | HFL-1 |
| T5 | 859-875 | disease:C0006142 | denotes | breast carcinoma |
| T6 | 831-836 | gene:3078 | denotes | HFL-1 |
| T7 | 859-875 | disease:C0678222 | denotes | breast carcinoma |
| R1 | T0 | T1 | associated_with | galectin-3,leukaemia |
| R2 | T2 | T3 | associated_with | HFL-1,leukaemia |
| R3 | T4 | T5 | associated_with | HFL-1,breast carcinoma |
| R4 | T6 | T7 | associated_with | HFL-1,breast carcinoma |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22450157_8_0 | 1059-1090 | expanded | denotes | carbohydrate recognition domain |
| SS2_22450157_8_0 | 1092-1095 | abbr | denotes | CRD |
| AE1_22450157_8_0 | SS1_22450157_8_0 | SS2_22450157_8_0 | abbreviatedTo | carbohydrate recognition domain,CRD |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22450157-4#65#75#gene3958 | 600-610 | gene3958 | denotes | galectin-3 |
| 22450157-4#296#301#gene3078 | 831-836 | gene3078 | denotes | HFL-1 |
| 22450157-4#134#143#diseaseC0023418 | 669-678 | diseaseC0023418 | denotes | leukaemia |
| 22450157-4#324#340#diseaseC0678222 | 859-875 | diseaseC0678222 | denotes | breast carcinoma |
| 22450157-4#134#143#diseaseC0023418 | 669-678 | diseaseC0023418 | denotes | leukaemia |
| 22450157-4#324#340#diseaseC0678222 | 859-875 | diseaseC0678222 | denotes | breast carcinoma |
| 65#75#gene3958134#143#diseaseC0023418 | 22450157-4#65#75#gene3958 | 22450157-4#134#143#diseaseC0023418 | associated_with | galectin-3,leukaemia |
| 65#75#gene3958324#340#diseaseC0678222 | 22450157-4#65#75#gene3958 | 22450157-4#324#340#diseaseC0678222 | associated_with | galectin-3,breast carcinoma |
| 65#75#gene3958134#143#diseaseC0023418 | 22450157-4#65#75#gene3958 | 22450157-4#134#143#diseaseC0023418 | associated_with | galectin-3,leukaemia |
| 65#75#gene3958324#340#diseaseC0678222 | 22450157-4#65#75#gene3958 | 22450157-4#324#340#diseaseC0678222 | associated_with | galectin-3,breast carcinoma |
| 296#301#gene3078134#143#diseaseC0023418 | 22450157-4#296#301#gene3078 | 22450157-4#134#143#diseaseC0023418 | associated_with | HFL-1,leukaemia |
| 296#301#gene3078324#340#diseaseC0678222 | 22450157-4#296#301#gene3078 | 22450157-4#324#340#diseaseC0678222 | associated_with | HFL-1,breast carcinoma |
| 296#301#gene3078134#143#diseaseC0023418 | 22450157-4#296#301#gene3078 | 22450157-4#134#143#diseaseC0023418 | associated_with | HFL-1,leukaemia |
| 296#301#gene3078324#340#diseaseC0678222 | 22450157-4#296#301#gene3078 | 22450157-4#324#340#diseaseC0678222 | associated_with | HFL-1,breast carcinoma |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 859-875 | Disease | denotes | breast carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 669-678 | Phenotype | denotes | leukaemia | HP:0001909 |
| T2 | 859-875 | Phenotype | denotes | breast carcinoma | HP:0003002 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 961-968 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 669-678 | Phenotype | denotes | leukaemia | HP:0001909 |
| T2 | 859-875 | Phenotype | denotes | breast carcinoma | HP:0003002 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 859-875 | Disease | denotes | breast carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 663-668 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 87-97 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 190-200 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 228-238 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 375-385 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 410-420 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 769-784 | Cell | denotes | (M2) macrophage | http://purl.obolibrary.org/obo/CL:0000890 |
| T12 | 774-784 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T14 | 809-819 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T16 | 837-848 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T17 | 916-926 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T19 | 1680-1694 | Cell | denotes | M1 macrophages | http://purl.obolibrary.org/obo/CL:0000863 |
| T20 | 1742-1756 | Cell | denotes | M2 macrophages | http://purl.obolibrary.org/obo/CL:0000890 |
| T21 | 1765-1775 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T23 | 1848-1858 | Cell | denotes | phagocytic | http://purl.obolibrary.org/obo/CL:0000234 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 87-97 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 190-200 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T3 | 228-238 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 375-385 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 410-420 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 774-784 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T7 | 809-819 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 837-848 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T9 | 859-865 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T10 | 916-926 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 1683-1694 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 1745-1756 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T13 | 1765-1775 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-114 | Sentence | denotes | Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types. |
| T2 | 115-126 | Sentence | denotes | BACKGROUND: |
| T3 | 127-245 | Sentence | denotes | Galectin-3 (the Mac-2 antigen) is abundantly expressed in both macrophage like cells and certain non-macrophage cells. |
| T4 | 246-427 | Sentence | denotes | We have studied endocytosis of galectin-3 as one important step relevant for its function, and compared it between variants of a macrophage like cell line, and non-macrophage cells. |
| T5 | 428-436 | Sentence | denotes | METHODS: |
| T6 | 437-534 | Sentence | denotes | Endocytosis of galectin-3 was observed by fluorescence microscopy and measured by flow cytometry. |
| T7 | 535-876 | Sentence | denotes | The endocytosis mechanism was analysed using galectin-3 mutants, galectin-3 inhibitors and endocytic pathways inhibitors in the human leukaemia THP-1 cell line differentiated into naïve (M0), classical (M1) or alternatively activated (M2) macrophage like cells, and the non-macrophage cell lines HFL-1 fibroblasts and SKBR3 breast carcinoma. |
| T8 | 877-885 | Sentence | denotes | RESULTS: |
| T9 | 886-1097 | Sentence | denotes | Galectin-3 endocytosis in non-macrophage cells and M2 cells was blocked by lactose and a potent galectin-3 inhibitor TD139, and also by the R186S mutation in the galectin-3 carbohydrate recognition domain (CRD). |
| T10 | 1098-1242 | Sentence | denotes | In M1 cells galectin-3 endocytosis could be inhibited only by chlorpromazine and by interference with the non-CRD N-terminal part of galectin-3. |
| T11 | 1243-1415 | Sentence | denotes | In all the cell types galectin-3 entered early endosomes within 5-10 min, to be subsequently targeted mainly to non-degradative vesicles, where it remained even after 24 h. |
| T12 | 1416-1428 | Sentence | denotes | CONCLUSIONS: |
| T13 | 1429-1609 | Sentence | denotes | Galectin-3 endocytosis in M1 cells is receptor mediated and carbohydrate independent, while in M2 cells it is CRD mediated, although the non-CRD galectin-3 domain is also involved. |
| T14 | 1610-1893 | Sentence | denotes | General significance The demonstration that galectin-3 endocytosis in M1 macrophages is carbohydrate independent and different from M2 macrophages and non-macrophage cells, suggests novel, immunologically significant interactions between phagocytic cells, galectin-3 and its ligands. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 961-968 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 663-668 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 87-97 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 190-200 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T3 | 228-238 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 375-385 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 410-420 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 774-784 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T7 | 809-819 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 837-848 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T9 | 859-865 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T10 | 916-926 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 1683-1694 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 1745-1756 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T13 | 1765-1775 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |