PubMed:2244708 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2244708","sourcedb":"PubMed","sourceid":"2244708","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2244708","text":"Silk-induced asthma in children: a report of 64 cases.\nA total of 64 children less than 15 years of age with asthma caused by silk were studied. The diagnosis was based on a history of wheezing, positive skin tests to silk, positive conjunctival or nasal provocation tests, or serum IgE-Sw (silk waste). The average age of onset was 4 years 2 months. Sex ratio (M:F) was 3.6:1. A positive skin test is essential for the diagnosis. Conjunctival provocation tests were performed in 80% of cases because of reliability, safety, and convenience. The first symptom appeared an average of 10 months after initial exposure to silk. In 61% of patients, asthma was accompanied by allergic rhinitis but in only 14% of cases by conjunctivitis. In most cases, asthma occurred in winter, due to seasonal use of bed quilts or clothes filled with silk. Silk is a highly potent allergen. The average mean wheal diameter elicited by silk in prick testing was larger than two histamine equivalent prick tests. A cross reactivity exists among mulberry silk, and silkworm cocoons, batryticated silkworms, and silkworm chrysalis.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":109,"end":115},"obj":"HP_0002099"},{"id":"T2","span":{"begin":645,"end":651},"obj":"HP_0002099"},{"id":"T3","span":{"begin":671,"end":688},"obj":"HP_0003193"},{"id":"T4","span":{"begin":680,"end":688},"obj":"HP_0012384"},{"id":"T5","span":{"begin":748,"end":754},"obj":"HP_0002099"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"}]},{"project":"silkworm","denotations":[{"id":"T1","span":{"begin":13,"end":19},"obj":"Disease:MESH:D001249"},{"id":"T2","span":{"begin":23,"end":31},"obj":"Species:9606"},{"id":"T3","span":{"begin":69,"end":77},"obj":"Species:9606"},{"id":"T4","span":{"begin":109,"end":115},"obj":"Disease:MESH:D001249"},{"id":"T5","span":{"begin":185,"end":193},"obj":"Disease:MESH:D012135"},{"id":"T6","span":{"begin":635,"end":643},"obj":"Species:9606"},{"id":"T7","span":{"begin":645,"end":651},"obj":"Disease:MESH:D001249"},{"id":"T8","span":{"begin":671,"end":688},"obj":"Disease:MESH:D065631"},{"id":"T9","span":{"begin":717,"end":731},"obj":"Disease:MESH:D003231"},{"id":"T10","span":{"begin":748,"end":754},"obj":"Disease:MESH:D001249"},{"id":"T11","span":{"begin":958,"end":967},"obj":"Chemical:MESH:D006632"},{"id":"T12","span":{"begin":1043,"end":1051},"obj":"Species:7091"},{"id":"T13","span":{"begin":1074,"end":1083},"obj":"Species:7091"},{"id":"T14","span":{"begin":1089,"end":1097},"obj":"Species:7091"}],"attributes":[{"subj":"T1","pred":"source","obj":"silkworm"},{"subj":"T2","pred":"source","obj":"silkworm"},{"subj":"T3","pred":"source","obj":"silkworm"},{"subj":"T4","pred":"source","obj":"silkworm"},{"subj":"T5","pred":"source","obj":"silkworm"},{"subj":"T6","pred":"source","obj":"silkworm"},{"subj":"T7","pred":"source","obj":"silkworm"},{"subj":"T8","pred":"source","obj":"silkworm"},{"subj":"T9","pred":"source","obj":"silkworm"},{"subj":"T10","pred":"source","obj":"silkworm"},{"subj":"T11","pred":"source","obj":"silkworm"},{"subj":"T12","pred":"source","obj":"silkworm"},{"subj":"T13","pred":"source","obj":"silkworm"},{"subj":"T14","pred":"source","obj":"silkworm"}]},{"project":"silkwormbase","denotations":[{"id":"T1","span":{"begin":13,"end":19},"obj":"Disease:MESH:D001249"},{"id":"T10","span":{"begin":748,"end":754},"obj":"Disease:MESH:D001249"},{"id":"T11","span":{"begin":958,"end":967},"obj":"Chemical:MESH:D006632"},{"id":"T12","span":{"begin":1043,"end":1051},"obj":"Species:7091"},{"id":"T13","span":{"begin":1074,"end":1083},"obj":"Species:7091"},{"id":"T14","span":{"begin":1089,"end":1097},"obj":"Species:7091"},{"id":"T2","span":{"begin":23,"end":31},"obj":"Species:9606"},{"id":"T3","span":{"begin":69,"end":77},"obj":"Species:9606"},{"id":"T4","span":{"begin":109,"end":115},"obj":"Disease:MESH:D001249"},{"id":"T5","span":{"begin":185,"end":193},"obj":"Disease:MESH:D012135"},{"id":"T6","span":{"begin":635,"end":643},"obj":"Species:9606"},{"id":"T7","span":{"begin":645,"end":651},"obj":"Disease:MESH:D001249"},{"id":"T8","span":{"begin":671,"end":688},"obj":"Disease:MESH:D065631"},{"id":"T9","span":{"begin":717,"end":731},"obj":"Disease:MESH:D003231"}],"attributes":[{"subj":"T1","pred":"source","obj":"silkwormbase"},{"subj":"T10","pred":"source","obj":"silkwormbase"},{"subj":"T11","pred":"source","obj":"silkwormbase"},{"subj":"T12","pred":"source","obj":"silkwormbase"},{"subj":"T13","pred":"source","obj":"silkwormbase"},{"subj":"T14","pred":"source","obj":"silkwormbase"},{"subj":"T2","pred":"source","obj":"silkwormbase"},{"subj":"T3","pred":"source","obj":"silkwormbase"},{"subj":"T4","pred":"source","obj":"silkwormbase"},{"subj":"T5","pred":"source","obj":"silkwormbase"},{"subj":"T6","pred":"source","obj":"silkwormbase"},{"subj":"T7","pred":"source","obj":"silkwormbase"},{"subj":"T8","pred":"source","obj":"silkwormbase"},{"subj":"T9","pred":"source","obj":"silkwormbase"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ec93e9","default":true},{"id":"silkworm","color":"#93ecd5"},{"id":"silkwormbase","color":"#ecbb93"}]}]}}