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PubMed:22427674 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 120-127 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T2 455-474 Cell denotes hippocampal neurons http://purl.obolibrary.org/obo/CL:0002608
T3 916-924 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540

sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon.
T2 129-289 Sentence denotes Synaptic loss is the earliest pathological change in Alzheimer disease (AD) and is the pathological change most directly correlated with the degree of dementia.
T3 290-395 Sentence denotes ApoE4 is the major genetic risk factor for the age-dependent form of AD, which accounts for 95% of cases.
T4 396-597 Sentence denotes Here we show that in synaptic networks formed from primary hippocampal neurons in culture, apoE3, but not apoE4, prevents the loss of synaptic networks produced by amyloid β oligomers (amylospheroids).
T5 598-876 Sentence denotes Specific activators of PKCε, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid methyl ester and bryostatin 1, protected against synaptic loss by amylospheroids, whereas PKCε inhibitors blocked this synaptic protection and also blocked the protection by apoE3.
T6 877-971 Sentence denotes Blocking LRP1, an apoE receptor on the neuronal membrane, also blocked the protection by apoE.
T7 972-1064 Sentence denotes ApoE3, but not apoE4, induced the synthesis of PKCε mRNA and expression of the PKCε protein.
T8 1065-1155 Sentence denotes Amyloid β specifically blocked the expression of PKCε but had no effect on other isoforms.
T9 1156-1274 Sentence denotes These results suggest that protection against synaptic loss by apoE is mediated by a novel intracellular PKCε pathway.
T10 1275-1397 Sentence denotes This apoE pathway may account for much of the protective effect of apoE and reduced risk for the age-dependent form of AD.
T11 1398-1482 Sentence denotes This finding supports the potential efficacy of newly developed therapeutics for AD.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 182-199 HP_0002511 denotes Alzheimer disease
T2 280-288 HP_0000726 denotes dementia
T3 560-567 HP_0011034 denotes amyloid
T4 1065-1072 HP_0011034 denotes Amyloid

Allie

Id Subject Object Predicate Lexical cue
SS1_22427674_0_0 0-17 expanded denotes Apolipoprotein E3
SS2_22427674_0_0 19-24 abbr denotes ApoE3
SS1_22427674_1_0 182-199 expanded denotes Alzheimer disease
SS2_22427674_1_0 201-203 abbr denotes AD
AE1_22427674_0_0 SS1_22427674_0_0 SS2_22427674_0_0 abbreviatedTo Apolipoprotein E3,ApoE3
AE1_22427674_1_0 SS1_22427674_1_0 SS2_22427674_1_0 abbreviatedTo Alzheimer disease,AD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22427674-2#0#5#gene348 290-295 gene348 denotes ApoE4
22427674-2#69#71#diseaseC0002395 359-361 diseaseC0002395 denotes AD
0#5#gene34869#71#diseaseC0002395 22427674-2#0#5#gene348 22427674-2#69#71#diseaseC0002395 associated_with ApoE4,AD

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 182-199 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T2 201-203 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T3 280-288 Disease denotes dementia http://purl.obolibrary.org/obo/MONDO_0001627
T4 359-361 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T5 560-567 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T6 1065-1072 Disease denotes Amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T7 1394-1396 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T8 1479-1481 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 182-199 Phenotype denotes Alzheimer disease HP:0002511
T2 201-203 Phenotype denotes AD HP:0002511
T3 280-288 Phenotype denotes dementia HP:0000726
T4 359-361 Phenotype denotes AD HP:0002511
T5 1394-1396 Phenotype denotes AD HP:0002511
T6 1479-1481 Phenotype denotes AD HP:0002511

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 455-474 Body_part denotes hippocampal neurons http://purl.obolibrary.org/obo/CL_0002608
T2 925-933 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 1247-1260 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622