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PubMed:22419161 JSONTXT

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Allie

Id Subject Object Predicate Lexical cue
SS1_22419161_2_0 270-294 expanded denotes non-structural protein 1
SS2_22419161_2_0 296-299 abbr denotes NS1
SS1_22419161_3_0 482-525 expanded denotes human PAF1 transcription elongation complex
SS2_22419161_3_0 527-533 abbr denotes hPAF1C
AE1_22419161_2_0 SS1_22419161_2_0 SS2_22419161_2_0 abbreviatedTo non-structural protein 1,NS1
AE1_22419161_3_0 SS1_22419161_3_0 SS2_22419161_3_0 abbreviatedTo human PAF1 transcription elongation complex,hPAF1C

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22419161-3#17#20#gene10625 352-355 gene10625 denotes NS1
22419161-3#17#20#gene5781 352-355 gene5781 denotes NS1
22419161-3#32#41#diseaseC0021400 367-376 diseaseC0021400 denotes influenza
17#20#gene1062532#41#diseaseC0021400 22419161-3#17#20#gene10625 22419161-3#32#41#diseaseC0021400 associated_with NS1,influenza
17#20#gene578132#41#diseaseC0021400 22419161-3#17#20#gene5781 22419161-3#32#41#diseaseC0021400 associated_with NS1,influenza

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2700 352-355 gene:10625 denotes NS1
T2701 367-376 disease:C0021400 denotes influenza
R1 T2700 T2701 associated_with NS1,influenza
R2 T2700 T2701 associated_with NS1,influenza

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-68 Sentence denotes Suppression of the antiviral response by an influenza histone mimic.
TextSentencer_T2 69-153 Sentence denotes Viral infection is commonly associated with virus-driven hijacking of host proteins.
TextSentencer_T3 154-334 Sentence denotes Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-structural protein 1 (NS1) with the infected cell epigenome.
TextSentencer_T4 335-535 Sentence denotes We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
TextSentencer_T5 536-687 Sentence denotes We demonstrate that binding of NS1 to hPAF1C depends on the NS1 histone mimic and results in suppression of hPAF1C-mediated transcriptional elongation.
TextSentencer_T6 688-757 Sentence denotes Furthermore, human PAF1 has a crucial role in the antiviral response.
TextSentencer_T7 758-926 Sentence denotes Loss of hPAF1C binding by NS1 attenuates influenza infection, whereas hPAF1C deficiency reduces antiviral gene expression and renders cells more susceptible to viruses.
TextSentencer_T8 927-1104 Sentence denotes We propose that the histone mimic in NS1 enables the influenza virus to affect inducible gene expression selectively, thus contributing to suppression of the antiviral response.
T1 0-68 Sentence denotes Suppression of the antiviral response by an influenza histone mimic.
T2 69-153 Sentence denotes Viral infection is commonly associated with virus-driven hijacking of host proteins.
T3 154-334 Sentence denotes Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-structural protein 1 (NS1) with the infected cell epigenome.
T4 335-535 Sentence denotes We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
T5 536-687 Sentence denotes We demonstrate that binding of NS1 to hPAF1C depends on the NS1 histone mimic and results in suppression of hPAF1C-mediated transcriptional elongation.
T6 688-757 Sentence denotes Furthermore, human PAF1 has a crucial role in the antiviral response.
T7 758-926 Sentence denotes Loss of hPAF1C binding by NS1 attenuates influenza infection, whereas hPAF1C deficiency reduces antiviral gene expression and renders cells more susceptible to viruses.
T8 927-1104 Sentence denotes We propose that the histone mimic in NS1 enables the influenza virus to affect inducible gene expression selectively, thus contributing to suppression of the antiviral response.