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PubMed:22375000 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 236-258 http://purl.obolibrary.org/obo/MAT_0000457 denotes central nervous system
T2 244-258 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system

DisGeNET

Id Subject Object Predicate Lexical cue
T0 334-338 gene:8620 denotes NPFF
T1 287-300 disease:C0700095 denotes neuroblastoma
T2 334-338 gene:8620 denotes NPFF
T3 287-300 disease:C0027819 denotes neuroblastoma
T4 334-338 gene:8620 denotes NPFF
T5 308-315 disease:C0700095 denotes SH-SY5Y
T6 334-338 gene:8620 denotes NPFF
T7 308-315 disease:C0027819 denotes SH-SY5Y
T8 400-403 gene:4988 denotes MOP
T9 287-300 disease:C0700095 denotes neuroblastoma
T10 400-403 gene:4988 denotes MOP
T11 287-300 disease:C0027819 denotes neuroblastoma
T12 400-403 gene:94233 denotes MOP
T13 287-300 disease:C0700095 denotes neuroblastoma
T14 400-403 gene:94233 denotes MOP
T15 287-300 disease:C0027819 denotes neuroblastoma
T16 400-403 gene:57486 denotes MOP
T17 287-300 disease:C0700095 denotes neuroblastoma
T18 400-403 gene:57486 denotes MOP
T19 308-315 disease:C0027819 denotes SH-SY5Y
T20 400-403 gene:4988 denotes MOP
T21 308-315 disease:C0700095 denotes SH-SY5Y
T22 400-403 gene:4988 denotes MOP
T23 308-315 disease:C0027819 denotes SH-SY5Y
T24 400-403 gene:94233 denotes MOP
T25 308-315 disease:C0700095 denotes SH-SY5Y
T26 400-403 gene:94233 denotes MOP
T27 308-315 disease:C0027819 denotes SH-SY5Y
T28 400-403 gene:57486 denotes MOP
T29 308-315 disease:C0700095 denotes SH-SY5Y
T30 400-403 gene:57486 denotes MOP
T31 287-300 disease:C0027819 denotes neuroblastoma
T32 514-520 gene:10886 denotes NPFF(2
T33 491-498 disease:C0700095 denotes SH-SY5Y
T34 514-520 gene:10886 denotes NPFF(2
T35 491-498 disease:C0027819 denotes SH-SY5Y
R1 T0 T1 associated_with NPFF,neuroblastoma
R2 T2 T3 associated_with NPFF,neuroblastoma
R3 T4 T5 associated_with NPFF,SH-SY5Y
R4 T6 T7 associated_with NPFF,SH-SY5Y
R5 T8 T9 associated_with MOP,neuroblastoma
R6 T10 T11 associated_with MOP,neuroblastoma
R7 T12 T13 associated_with MOP,neuroblastoma
R8 T14 T15 associated_with MOP,neuroblastoma
R9 T16 T17 associated_with MOP,neuroblastoma
R10 T18 T19 associated_with MOP,SH-SY5Y
R11 T20 T21 associated_with MOP,SH-SY5Y
R12 T22 T23 associated_with MOP,SH-SY5Y
R13 T24 T25 associated_with MOP,SH-SY5Y
R14 T26 T27 associated_with MOP,SH-SY5Y
R15 T28 T29 associated_with MOP,SH-SY5Y
R16 T30 T31 associated_with MOP,neuroblastoma
R17 T32 T33 associated_with NPFF(2,SH-SY5Y
R18 T34 T35 associated_with NPFF(2,SH-SY5Y

Allie

Id Subject Object Predicate Lexical cue
SS1_22375000_1_0 143-158 expanded denotes Neuropeptide FF
SS2_22375000_1_0 160-164 abbr denotes NPFF
SS1_22375000_2_0 390-398 expanded denotes μ-opioid
SS2_22375000_2_0 400-403 abbr denotes MOP
AE1_22375000_1_0 SS1_22375000_1_0 SS2_22375000_1_0 abbreviatedTo Neuropeptide FF,NPFF
AE1_22375000_2_0 SS1_22375000_2_0 SS2_22375000_2_0 abbreviatedTo μ-opioid,MOP

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 287-300 HP_0003006 denotes neuroblastoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22375000-2#74#78#gene8620 334-338 gene8620 denotes NPFF
22375000-2#140#143#gene57486 400-403 gene57486 denotes MOP
22375000-2#140#143#gene94233 400-403 gene94233 denotes MOP
22375000-2#140#143#gene4988 400-403 gene4988 denotes MOP
22375000-2#140#143#gene57486 400-403 gene57486 denotes MOP
22375000-2#140#143#gene94233 400-403 gene94233 denotes MOP
22375000-2#140#143#gene4988 400-403 gene4988 denotes MOP
22375000-2#27#40#diseaseC0700095 287-300 diseaseC0700095 denotes neuroblastoma
22375000-2#27#40#diseaseC0027819 287-300 diseaseC0027819 denotes neuroblastoma
22375000-2#48#55#diseaseC0700095 308-315 diseaseC0700095 denotes SH-SY5Y
22375000-2#48#55#diseaseC0027819 308-315 diseaseC0027819 denotes SH-SY5Y
22375000-2#27#40#diseaseC0700095 287-300 diseaseC0700095 denotes neuroblastoma
22375000-2#27#40#diseaseC0027819 287-300 diseaseC0027819 denotes neuroblastoma
22375000-2#27#40#diseaseC0700095 287-300 diseaseC0700095 denotes neuroblastoma
22375000-2#27#40#diseaseC0027819 287-300 diseaseC0027819 denotes neuroblastoma
22375000-2#27#40#diseaseC0700095 287-300 diseaseC0700095 denotes neuroblastoma
22375000-2#27#40#diseaseC0027819 287-300 diseaseC0027819 denotes neuroblastoma
22375000-2#48#55#diseaseC0700095 308-315 diseaseC0700095 denotes SH-SY5Y
22375000-2#48#55#diseaseC0027819 308-315 diseaseC0027819 denotes SH-SY5Y
22375000-2#48#55#diseaseC0700095 308-315 diseaseC0700095 denotes SH-SY5Y
22375000-2#48#55#diseaseC0027819 308-315 diseaseC0027819 denotes SH-SY5Y
22375000-2#48#55#diseaseC0700095 308-315 diseaseC0700095 denotes SH-SY5Y
22375000-2#48#55#diseaseC0027819 308-315 diseaseC0027819 denotes SH-SY5Y
22375000-3#30#36#gene10886 514-520 gene10886 denotes NPFF(2
22375000-3#7#14#diseaseC0700095 491-498 diseaseC0700095 denotes SH-SY5Y
22375000-3#7#14#diseaseC0027819 491-498 diseaseC0027819 denotes SH-SY5Y
74#78#gene862027#40#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0700095 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0027819 associated_with NPFF,neuroblastoma
74#78#gene862048#55#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0700095 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0027819 associated_with NPFF,SH-SY5Y
74#78#gene862027#40#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0700095 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0027819 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0700095 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0027819 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0700095 associated_with NPFF,neuroblastoma
74#78#gene862027#40#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#27#40#diseaseC0027819 associated_with NPFF,neuroblastoma
74#78#gene862048#55#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0700095 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0027819 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0700095 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0027819 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0700095 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0700095 associated_with NPFF,SH-SY5Y
74#78#gene862048#55#diseaseC0027819 22375000-2#74#78#gene8620 22375000-2#48#55#diseaseC0027819 associated_with NPFF,SH-SY5Y
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene5748627#40#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0700095 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene5748648#55#diseaseC0027819 22375000-2#140#143#gene57486 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene9423327#40#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0700095 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene9423348#55#diseaseC0027819 22375000-2#140#143#gene94233 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0700095 associated_with MOP,neuroblastoma
140#143#gene498827#40#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#27#40#diseaseC0027819 associated_with MOP,neuroblastoma
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0700095 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0700095 associated_with MOP,SH-SY5Y
140#143#gene498848#55#diseaseC0027819 22375000-2#140#143#gene4988 22375000-2#48#55#diseaseC0027819 associated_with MOP,SH-SY5Y
30#36#gene108867#14#diseaseC0700095 22375000-3#30#36#gene10886 22375000-3#7#14#diseaseC0700095 associated_with NPFF(2,SH-SY5Y
30#36#gene108867#14#diseaseC0027819 22375000-3#30#36#gene10886 22375000-3#7#14#diseaseC0027819 associated_with NPFF(2,SH-SY5Y

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T890 334-338 gene:8620 denotes NPFF
T891 287-300 disease:C0700095 denotes neuroblastoma
T892 308-315 disease:C0700095 denotes SH-SY5Y
T893 400-403 gene:57486 denotes MOP
T894 514-520 gene:10886 denotes NPFF(2
T895 491-498 disease:C0700095 denotes SH-SY5Y
R1 T890 T891 associated_with NPFF,neuroblastoma
R2 T890 T891 associated_with NPFF,neuroblastoma
R3 T890 T892 associated_with NPFF,SH-SY5Y
R4 T890 T892 associated_with NPFF,SH-SY5Y
R5 T893 T891 associated_with MOP,neuroblastoma
R6 T893 T891 associated_with MOP,neuroblastoma
R7 T893 T891 associated_with MOP,neuroblastoma
R8 T893 T891 associated_with MOP,neuroblastoma
R9 T893 T891 associated_with MOP,neuroblastoma
R10 T893 T891 associated_with MOP,neuroblastoma
R11 T893 T892 associated_with MOP,SH-SY5Y
R12 T893 T892 associated_with MOP,SH-SY5Y
R13 T893 T892 associated_with MOP,SH-SY5Y
R14 T893 T892 associated_with MOP,SH-SY5Y
R15 T893 T892 associated_with MOP,SH-SY5Y
R16 T893 T892 associated_with MOP,SH-SY5Y
R17 T894 T895 associated_with NPFF(2,SH-SY5Y
R18 T894 T895 associated_with NPFF(2,SH-SY5Y

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.
TextSentencer_T2 143-259 Sentence denotes Neuropeptide FF (NPFF) interacts with specific receptors to modulate opioid functions in the central nervous system.
TextSentencer_T3 260-483 Sentence denotes On dissociated neurons and neuroblastoma cells (SH-SY5Y) transfected with NPFF receptors, NPFF acts as a functional antagonist of μ-opioid (MOP) receptors by attenuating the opioid-induced inhibition of calcium conductance.
TextSentencer_T4 484-564 Sentence denotes In the SH-SY5Y model, MOP and NPFF(2) receptors have been shown to heteromerize.
TextSentencer_T5 565-771 Sentence denotes To understand the molecular mechanism involved in the anti-opioid activity of NPFF, we have investigated the phosphorylation status of the MOP receptor using phospho-specific antibody and mass spectrometry.
TextSentencer_T6 772-976 Sentence denotes Similarly to direct opioid receptor stimulation, activation of the NPFF(2) receptor by [D-Tyr-1-(NMe)Phe-3]NPFF (1DMe), an analog of NPFF, induced the phosphorylation of Ser-377 of the human MOP receptor.
TextSentencer_T7 977-1193 Sentence denotes This heterologous phosphorylation was unaffected by inhibition of second messenger-dependent kinases and, contrarily to homologous phosphorylation, was prevented by inactivation of G(i/o) proteins by pertussis toxin.
TextSentencer_T8 1194-1371 Sentence denotes Using siRNA knockdown we could demonstrate that 1DMe-induced Ser-377 cross-phosphorylation and MOP receptor loss of function were mediated by the G protein receptor kinase GRK2.
TextSentencer_T9 1372-1692 Sentence denotes In addition, mass spectrometric analysis revealed that the phosphorylation pattern of MOP receptors was qualitatively similar after treatment with the MOP agonist Tyr-D-Ala-Gly (NMe)-Phe-Gly-ol (DAMGO) or after treatment with the NPFF agonist 1DMe, but the level of multiple phosphorylation was more intense after DAMGO.
TextSentencer_T10 1693-1826 Sentence denotes Finally, NPFF(2) receptor activation was sufficient to recruit β-arrestin2 to the MOP receptor but not to induce its internalization.
TextSentencer_T11 1827-2015 Sentence denotes These data show that NPFF-induced heterologous desensitization of MOP receptor signaling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor complex.
T1 0-142 Sentence denotes GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.
T2 143-259 Sentence denotes Neuropeptide FF (NPFF) interacts with specific receptors to modulate opioid functions in the central nervous system.
T3 260-483 Sentence denotes On dissociated neurons and neuroblastoma cells (SH-SY5Y) transfected with NPFF receptors, NPFF acts as a functional antagonist of μ-opioid (MOP) receptors by attenuating the opioid-induced inhibition of calcium conductance.
T4 484-564 Sentence denotes In the SH-SY5Y model, MOP and NPFF(2) receptors have been shown to heteromerize.
T5 565-771 Sentence denotes To understand the molecular mechanism involved in the anti-opioid activity of NPFF, we have investigated the phosphorylation status of the MOP receptor using phospho-specific antibody and mass spectrometry.
T6 772-976 Sentence denotes Similarly to direct opioid receptor stimulation, activation of the NPFF(2) receptor by [D-Tyr-1-(NMe)Phe-3]NPFF (1DMe), an analog of NPFF, induced the phosphorylation of Ser-377 of the human MOP receptor.
T7 977-1193 Sentence denotes This heterologous phosphorylation was unaffected by inhibition of second messenger-dependent kinases and, contrarily to homologous phosphorylation, was prevented by inactivation of G(i/o) proteins by pertussis toxin.
T8 1194-1371 Sentence denotes Using siRNA knockdown we could demonstrate that 1DMe-induced Ser-377 cross-phosphorylation and MOP receptor loss of function were mediated by the G protein receptor kinase GRK2.
T9 1372-1692 Sentence denotes In addition, mass spectrometric analysis revealed that the phosphorylation pattern of MOP receptors was qualitatively similar after treatment with the MOP agonist Tyr-D-Ala-Gly (NMe)-Phe-Gly-ol (DAMGO) or after treatment with the NPFF agonist 1DMe, but the level of multiple phosphorylation was more intense after DAMGO.
T10 1693-1826 Sentence denotes Finally, NPFF(2) receptor activation was sufficient to recruit β-arrestin2 to the MOP receptor but not to induce its internalization.
T11 1827-2015 Sentence denotes These data show that NPFF-induced heterologous desensitization of MOP receptor signaling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor complex.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 236-243 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 236-258 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
PD-UBERON-AE-B_T3 244-258 http://purl.obolibrary.org/obo/UBERON_0001016 denotes nervous system

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 236-243 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 236-258 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
PD-UBERON-AE-B_T3 244-258 http://purl.obolibrary.org/obo/UBERON_0001016 denotes nervous system
PD-UBERON-AE-B_T4 275-282 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 236-258 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 287-300 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 287-300 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 1177-1186 Disease denotes pertussis http://purl.obolibrary.org/obo/MONDO_0005077

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 957-962 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 236-258 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 275-282 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540