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PubMed:2237444 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 145-180 protein denotes transcriptional regulatory proteins
T2 386-424 protein denotes sequence-specific DNA-binding proteins
T3 513-551 DNA denotes octamer or kappa B consensus sequences
T4 617-645 protein denotes octamer transcription factor
T5 649-676 protein denotes nuclear factor (NF)-kappa B
T6 866-882 DNA denotes reporter plasmid
T7 886-896 protein denotes NF-kappa B
T8 925-968 DNA denotes human immunodeficiency virus (HIV) enhancer
T9 1052-1087 cell_line denotes transiently transfected B cell line
T10 1154-1171 DNA denotes octamer consensus
T11 1175-1198 cell_line denotes Jurkat T leukemia cells
T12 1209-1222 protein denotes interleukin-2
T13 1224-1228 protein denotes IL-2
T14 1284-1304 DNA denotes mutated octamer site
T15 1312-1325 DNA denotes IL-2 enhancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 931-947 HP_0002721 denotes immunodeficiency
T2 1184-1192 HP_0001909 denotes leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-85 Sentence denotes Regulation of gene expression with double-stranded phosphorothioate oligonucleotides.
S2 86-268 Sentence denotes Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how these factors participate in cellular differentiation.
S3 269-371 Sentence denotes The functions of these proteins can be antagonized by several methods, each with specific limitations.
S4 372-552 Sentence denotes Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences.
S5 553-677 Sentence denotes The phosphorothioate oligonucleotides specifically bound either octamer transcription factor or nuclear factor (NF)-kappa B.
S6 678-831 Sentence denotes The modified oligonucleotides accumulated in cells more effectively than standard ds oligonucleotides and modulated gene expression in a specific manner.
S7 832-1088 Sentence denotes Octamer-dependent activation of a reporter plasmid or NF-kappa B-dependent activation of the human immunodeficiency virus (HIV) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line.
S8 1089-1326 Sentence denotes Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 (IL-2) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer.
S9 1327-1507 Sentence denotes The ds phosphorothioate oligonucleotides probably compete for binding of specific transcription factors and may provide anti-viral, immunosuppressive, or other therapeutic effects.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 35-84 NP denotes double-stranded phosphorothioate oligonucleotides
C3 136-180 NP denotes specific transcriptional regulatory proteins
C2 86-180 NP denotes Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins
C4 214-227 NP denotes these factors
C5 286-300 NP denotes these proteins
C7 443-497 NP denotes double-stranded (ds) phosphorothioate oligonucleotides
C8 498-502 NP denotes that
C6 443-551 NP denotes double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences
C9 553-590 NP denotes The phosphorothioate oligonucleotides
C10 751-779 NP denotes standard ds oligonucleotides
C12 1101-1134 NP denotes phosphorothioate oligonucleotides
C13 1135-1139 NP denotes that
C11 1101-1171 NP denotes phosphorothioate oligonucleotides that contained the octamer consensus
C14 1243-1251 NP denotes a degree
C15 1263-1267 NP denotes that
C16 1327-1367 NP denotes The ds phosphorothioate oligonucleotides
R1 C4 C2 coref-ident these factors,Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins
R2 C5 C3 coref-ident these proteins,specific transcriptional regulatory proteins
R3 C8 C7 coref-relat that,double-stranded (ds) phosphorothioate oligonucleotides
R4 C6 C1 coref-ident double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences,double-stranded phosphorothioate oligonucleotides
R5 C13 C12 coref-relat that,phosphorothioate oligonucleotides
R6 C11 C9 coref-ident phosphorothioate oligonucleotides that contained the octamer consensus,The phosphorothioate oligonucleotides
R7 C15 C14 coref-pron that,a degree
R8 C16 C10 coref-ident The ds phosphorothioate oligonucleotides,standard ds oligonucleotides

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-29 other_name denotes gene expression
T2 35-84 polynucleotide denotes double-stranded phosphorothioate oligonucleotides
T3 100-118 other_name denotes gene transcription
T4 145-180 protein_family_or_group denotes transcriptional regulatory proteins
T5 243-267 other_name denotes cellular differentiation
T6 386-424 protein_family_or_group denotes sequence-specific DNA-binding proteins
T7 443-497 polynucleotide denotes double-stranded (ds) phosphorothioate oligonucleotides
T8 557-590 polynucleotide denotes phosphorothioate oligonucleotides
T9 617-645 protein_family_or_group denotes octamer transcription factor
T10 649-676 protein_molecule denotes nuclear factor (NF)-kappa B
T11 682-707 polynucleotide denotes modified oligonucleotides
T12 751-779 polynucleotide denotes standard ds oligonucleotides
T13 794-809 other_name denotes gene expression
T14 832-860 other_name denotes Octamer-dependent activation
T15 866-882 DNA_molecule denotes reporter plasmid
T16 886-896 protein_molecule denotes NF-kappa B
T17 925-953 virus denotes human immunodeficiency virus
T18 955-958 virus denotes HIV
T19 1004-1036 polynucleotide denotes phosphorothioate oligonucleotide
T20 1052-1087 cell_line denotes transiently transfected B cell line
T21 1101-1134 polynucleotide denotes phosphorothioate oligonucleotides
T22 1154-1171 DNA_domain_or_region denotes octamer consensus
T23 1175-1198 cell_line denotes Jurkat T leukemia cells
T24 1209-1222 protein_molecule denotes interleukin-2
T25 1224-1228 protein_molecule denotes IL-2
T26 1284-1304 DNA_domain_or_region denotes mutated octamer site
T27 1312-1325 DNA_domain_or_region denotes IL-2 enhancer
T28 1334-1367 polynucleotide denotes phosphorothioate oligonucleotides
T29 1447-1457 other_name denotes anti-viral
T30 1459-1476 other_name denotes immunosuppressive
T31 1487-1506 other_name denotes therapeutic effects