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PubMed:22337883 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
T2 120-244 Sentence denotes The interaction of transcription factors with specific DNA sequences is critical for activation of gene expression programs.
T3 245-436 Sentence denotes In endothelial cells (EC), the transcription factor NF-κB is important in the switch from quiescence to activation, and is tightly controlled to avoid excessive inflammation and organ damage.
T4 437-516 Sentence denotes Here we describe a novel mechanism that controls the activation of NF-κB in EC.
T5 517-665 Sentence denotes The transcription factor Erg, the most highly expressed ETS member in resting EC, controls quiescence by repressing proinflammatory gene expression.
T6 666-850 Sentence denotes Focusing on intercellular adhesion molecule 1(ICAM)-1 as a model, we identify two ETS binding sites (EBS -118 and -181) within the ICAM-1 promoter required for Erg-mediated repression.
T7 851-954 Sentence denotes We show that Erg binds to both EBS -118 and EBS -181, the latter located within the NF-κB binding site.
T8 955-1122 Sentence denotes Interestingly, inhibition of Erg expression in quiescent EC results in increased NF-κB-dependent ICAM-1 expression, indicating that Erg represses basal NF-κB activity.
T9 1123-1229 Sentence denotes Erg prevents NF-κB p65 from binding to the ICAM-1 promoter, suggesting a direct mechanism of interference.
T10 1230-1475 Sentence denotes Gene set enrichment analysis of transcriptome profiles of Erg and NF-κB-dependent genes, together with chromatin immunoprecipitation (ChIP) studies, reveals that this mechanism is common to other proinflammatory genes, including cIAP-2 and IL-8.
T11 1476-1657 Sentence denotes These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus providing an important barrier to protect against inappropriate endothelial activation.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
T2 120-244 Sentence denotes The interaction of transcription factors with specific DNA sequences is critical for activation of gene expression programs.
T3 245-436 Sentence denotes In endothelial cells (EC), the transcription factor NF-κB is important in the switch from quiescence to activation, and is tightly controlled to avoid excessive inflammation and organ damage.
T4 437-516 Sentence denotes Here we describe a novel mechanism that controls the activation of NF-κB in EC.
T5 517-665 Sentence denotes The transcription factor Erg, the most highly expressed ETS member in resting EC, controls quiescence by repressing proinflammatory gene expression.
T6 666-850 Sentence denotes Focusing on intercellular adhesion molecule 1(ICAM)-1 as a model, we identify two ETS binding sites (EBS -118 and -181) within the ICAM-1 promoter required for Erg-mediated repression.
T7 851-954 Sentence denotes We show that Erg binds to both EBS -118 and EBS -181, the latter located within the NF-κB binding site.
T8 955-1122 Sentence denotes Interestingly, inhibition of Erg expression in quiescent EC results in increased NF-κB-dependent ICAM-1 expression, indicating that Erg represses basal NF-κB activity.
T9 1123-1229 Sentence denotes Erg prevents NF-κB p65 from binding to the ICAM-1 promoter, suggesting a direct mechanism of interference.
T10 1230-1475 Sentence denotes Gene set enrichment analysis of transcriptome profiles of Erg and NF-κB-dependent genes, together with chromatin immunoprecipitation (ChIP) studies, reveals that this mechanism is common to other proinflammatory genes, including cIAP-2 and IL-8.
T11 1476-1657 Sentence denotes These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus providing an important barrier to protect against inappropriate endothelial activation.
T1 0-119 Sentence denotes The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
T2 120-244 Sentence denotes The interaction of transcription factors with specific DNA sequences is critical for activation of gene expression programs.
T3 245-436 Sentence denotes In endothelial cells (EC), the transcription factor NF-κB is important in the switch from quiescence to activation, and is tightly controlled to avoid excessive inflammation and organ damage.
T4 437-516 Sentence denotes Here we describe a novel mechanism that controls the activation of NF-κB in EC.
T5 517-665 Sentence denotes The transcription factor Erg, the most highly expressed ETS member in resting EC, controls quiescence by repressing proinflammatory gene expression.
T6 666-850 Sentence denotes Focusing on intercellular adhesion molecule 1(ICAM)-1 as a model, we identify two ETS binding sites (EBS -118 and -181) within the ICAM-1 promoter required for Erg-mediated repression.
T7 851-954 Sentence denotes We show that Erg binds to both EBS -118 and EBS -181, the latter located within the NF-κB binding site.
T8 955-1122 Sentence denotes Interestingly, inhibition of Erg expression in quiescent EC results in increased NF-κB-dependent ICAM-1 expression, indicating that Erg represses basal NF-κB activity.
T9 1123-1229 Sentence denotes Erg prevents NF-κB p65 from binding to the ICAM-1 promoter, suggesting a direct mechanism of interference.
T10 1230-1475 Sentence denotes Gene set enrichment analysis of transcriptome profiles of Erg and NF-κB-dependent genes, together with chromatin immunoprecipitation (ChIP) studies, reveals that this mechanism is common to other proinflammatory genes, including cIAP-2 and IL-8.
T11 1476-1657 Sentence denotes These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus providing an important barrier to protect against inappropriate endothelial activation.

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 25-28 Gene_or_gene_product denotes Erg
T2 92-114 Complex denotes nuclear factor (NF)-κB
T3 115-118 Gene_or_gene_product denotes p65
T4 297-302 Complex denotes NF-κB
T5 504-509 Complex denotes NF-κB
T6 542-545 Gene_or_gene_product denotes Erg
T7 573-576 Gene_or_gene_product denotes ETS
T8 678-719 Gene_or_gene_product denotes intercellular adhesion molecule 1(ICAM)-1
T9 748-751 Gene_or_gene_product denotes ETS
T10 797-803 Gene_or_gene_product denotes ICAM-1
T11 826-829 Gene_or_gene_product denotes Erg
T12 864-867 Gene_or_gene_product denotes Erg
T13 935-940 Complex denotes NF-κB
T14 984-987 Gene_or_gene_product denotes Erg
T15 1036-1041 Complex denotes NF-κB
T16 1052-1058 Gene_or_gene_product denotes ICAM-1
T17 1087-1090 Gene_or_gene_product denotes Erg
T18 1107-1112 Complex denotes NF-κB
T19 1123-1126 Gene_or_gene_product denotes Erg
T20 1136-1141 Complex denotes NF-κB
T21 1142-1145 Gene_or_gene_product denotes p65
T22 1166-1172 Gene_or_gene_product denotes ICAM-1
T23 1288-1291 Gene_or_gene_product denotes Erg
T24 1296-1301 Complex denotes NF-κB
T25 1333-1342 Cellular_component denotes chromatin
T26 1459-1465 Gene_or_gene_product denotes cIAP-2
T27 1470-1474 Gene_or_gene_product denotes IL-8
T28 1510-1513 Gene_or_gene_product denotes Erg

Allie

Id Subject Object Predicate Lexical cue
SS1_22337883_0_0 92-106 expanded denotes nuclear factor
SS2_22337883_0_0 108-110 abbr denotes NF
SS1_22337883_2_0 248-265 expanded denotes endothelial cells
SS2_22337883_2_0 267-269 abbr denotes EC
SS1_22337883_9_0 1333-1362 expanded denotes chromatin immunoprecipitation
SS2_22337883_9_0 1364-1368 abbr denotes ChIP
AE1_22337883_0_0 SS1_22337883_0_0 SS2_22337883_0_0 abbreviatedTo nuclear factor,NF
AE1_22337883_2_0 SS1_22337883_2_0 SS2_22337883_2_0 abbreviatedTo endothelial cells,EC
AE1_22337883_9_0 SS1_22337883_9_0 SS2_22337883_9_0 abbreviatedTo chromatin immunoprecipitation,ChIP

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 406-418 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 767-770 Disease denotes EBS http://purl.obolibrary.org/obo/MONDO_0017610
T3 882-885 Disease denotes EBS http://purl.obolibrary.org/obo/MONDO_0017610
T4 895-898 Disease denotes EBS http://purl.obolibrary.org/obo/MONDO_0017610
T5 1551-1563 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1519-1529 OrganismTaxon denotes gatekeeper 2795565

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 38-54 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 248-265 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T3 267-269 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T4 423-428 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T6 513-515 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T7 595-597 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T8 1012-1014 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 38-54 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 248-265 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T3 267-269 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T4 513-515 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T5 595-597 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T6 1012-1014 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T7 1101-1106 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324