> top > docs > PubMed:22315971 > annotations

PubMed:22315971 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 63-72 SO:0000817 denotes wild-type
T2 84-89 PR:Q5S006 denotes LRRK2
T3 84-89 PR:000003033 denotes LRRK2
T4 84-89 PR:Q5S007 denotes LRRK2
T5 94-97 PR:P16525 denotes Tau
T6 94-97 PR:000024142 denotes Tau
T7 94-97 PR:P10636 denotes Tau
T8 94-97 PR:000010173 denotes Tau
T9 94-97 PR:P19332 denotes Tau
T11 94-97 PR:P10637 denotes Tau
T10 94-97 CHEBI:36355 denotes Tau
T16 112-119 SO:0000104 denotes protein
T15 112-119 PR:000000001 denotes protein
T12 112-119 GO:0003675 denotes protein
T13 112-119 CHEBI:36080 denotes protein
T14 112-119 CHEBI:11122 denotes protein
T19 172-189 D010300 denotes Parkinson disease
T20 172-189 D010300 denotes Parkinson disease
T23 201-206 D006801 denotes human
T24 207-212 PR:Q5S006 denotes LRRK2
T25 207-212 PR:000003033 denotes LRRK2
T26 207-212 PR:Q5S007 denotes LRRK2
T27 213-217 SO:0000704 denotes gene
T28 267-271 SO:0000704 denotes gene
T31 310-338 D010300 denotes idiopathic Parkinson disease
T32 310-338 D010300 denotes idiopathic Parkinson disease
T39 354-368 MOP:0000795 denotes S substitution
T40 356-368 SO:1000002 denotes substitution
T41 388-396 SO:0000109 denotes mutation
T42 400-405 PR:Q5S006 denotes LRRK2
T43 400-405 PR:000003033 denotes LRRK2
T44 400-405 PR:Q5S007 denotes LRRK2
T45 418-426 SO:0000109 denotes mutation
T46 503-508 PR:Q5S006 denotes LRRK2
T47 503-508 PR:000003033 denotes LRRK2
T48 503-508 PR:Q5S007 denotes LRRK2
T49 526-529 PR:P16525 denotes Tau
T50 526-529 PR:000024142 denotes Tau
T51 526-529 PR:P10636 denotes Tau
T52 526-529 PR:000010173 denotes Tau
T53 526-529 PR:P19332 denotes Tau
T55 526-529 PR:P10637 denotes Tau
T54 526-529 CHEBI:36355 denotes Tau
T56 576-581 PR:Q5S006 denotes LRRK2
T57 576-581 PR:000003033 denotes LRRK2
T58 576-581 PR:Q5S007 denotes LRRK2
T59 621-624 PR:P16525 denotes Tau
T60 621-624 PR:000024142 denotes Tau
T61 621-624 PR:P10636 denotes Tau
T62 621-624 PR:000010173 denotes Tau
T63 621-624 PR:P19332 denotes Tau
T65 621-624 PR:P10637 denotes Tau
T64 621-624 CHEBI:36355 denotes Tau
T66 645-650 PR:Q5S006 denotes LRRK2
T67 645-650 PR:000003033 denotes LRRK2
T68 645-650 PR:Q5S007 denotes LRRK2
T69 664-667 PR:P16525 denotes Tau
T70 664-667 PR:000024142 denotes Tau
T71 664-667 PR:P10636 denotes Tau
T72 664-667 PR:000010173 denotes Tau
T73 664-667 PR:P19332 denotes Tau
T75 664-667 PR:P10637 denotes Tau
T74 664-667 CHEBI:36355 denotes Tau
T76 743-748 D006801 denotes human
T77 749-754 PR:Q5S006 denotes LRRK2
T78 749-754 PR:000003033 denotes LRRK2
T79 749-754 PR:Q5S007 denotes LRRK2
T80 756-765 SO:0000817 denotes wild-type
T81 825-828 PR:P16525 denotes Tau
T82 825-828 PR:000024142 denotes Tau
T83 825-828 PR:P10636 denotes Tau
T84 825-828 PR:000010173 denotes Tau
T85 825-828 PR:P19332 denotes Tau
T87 825-828 PR:P10637 denotes Tau
T86 825-828 CHEBI:36355 denotes Tau
T88 899-904 PR:Q5S006 denotes LRRK2
T89 899-904 PR:000003033 denotes LRRK2
T90 899-904 PR:Q5S007 denotes LRRK2
T94 924-931 PR:000000001 denotes protein
T92 924-931 CHEBI:36080 denotes protein
T93 924-931 CHEBI:11122 denotes protein
T95 924-931 SO:0000104 denotes protein
T91 924-931 GO:0003675 denotes protein
T96 1001-1006 PR:Q5S006 denotes LRRK2
T97 1001-1006 PR:000003033 denotes LRRK2
T98 1001-1006 PR:Q5S007 denotes LRRK2
T99 1011-1014 PR:P16525 denotes Tau
T100 1011-1014 PR:000024142 denotes Tau
T101 1011-1014 PR:P10636 denotes Tau
T102 1011-1014 PR:000010173 denotes Tau
T103 1011-1014 PR:P19332 denotes Tau
T105 1011-1014 PR:P10637 denotes Tau
T104 1011-1014 CHEBI:36355 denotes Tau
T106 1055-1063 CHEBI:36080 denotes proteins
T107 1087-1105 D012269 denotes ribosomal proteins
T109 1097-1120 D024101 denotes proteins, mitochondrial
T110 1107-1129 D024101 denotes mitochondrial proteins
T112 1146-1152 CHEBI:24636 denotes proton
T113 1146-1152 D011522 denotes proton
T114 1146-1152 D011522 denotes proton
T115 1153-1159 A3DIJ8 denotes ATPase
T117 1153-1159 Q9SIY3 denotes ATPase
T116 1153-1159 D000251 denotes ATPase
T118 1186-1195 GO:0016236 denotes autophagy
T119 1186-1195 GO:0006914 denotes autophagy
T120 1226-1231 PR:Q5S006 denotes LRRK2
T121 1226-1231 PR:000003033 denotes LRRK2
T122 1226-1231 PR:Q5S007 denotes LRRK2
T127 1282-1289 SO:0000104 denotes protein
T126 1282-1289 PR:000000001 denotes protein
T123 1282-1289 GO:0003675 denotes protein
T124 1282-1289 CHEBI:36080 denotes protein
T125 1282-1289 CHEBI:11122 denotes protein
T128 1282-1299 GO:0018158 denotes protein oxidation
T129 1290-1299 MOP:0000568 denotes oxidation
T130 1304-1309 CHEBI:18059 denotes lipid
T135 1356-1363 SO:0000104 denotes protein
T134 1356-1363 PR:000000001 denotes protein
T131 1356-1363 GO:0003675 denotes protein
T132 1356-1363 CHEBI:36080 denotes protein
T133 1356-1363 CHEBI:11122 denotes protein
T136 1370-1389 CHEBI:32585 denotes 4-hydroxy-2-nonenal
T137 1370-1389 C027576 denotes 4-hydroxy-2-nonenal
T138 1370-1389 C027576 denotes 4-hydroxy-2-nonenal
T143 1391-1394 CHEBI:32585 denotes HNE
T144 1391-1394 CHEBI:58968 denotes HNE
T145 1482-1487 PR:Q5S006 denotes LRRK2
T146 1482-1487 PR:000003033 denotes LRRK2
T147 1482-1487 PR:Q5S007 denotes LRRK2
T148 1509-1512 PR:P16525 denotes Tau
T149 1509-1512 PR:000024142 denotes Tau
T150 1509-1512 PR:P10636 denotes Tau
T151 1509-1512 PR:000010173 denotes Tau
T152 1509-1512 PR:P19332 denotes Tau
T154 1509-1512 PR:P10637 denotes Tau
T153 1509-1512 CHEBI:36355 denotes Tau
T155 1578-1581 PR:P16525 denotes Tau
T156 1578-1581 PR:000024142 denotes Tau
T157 1578-1581 PR:P10636 denotes Tau
T158 1578-1581 PR:000010173 denotes Tau
T159 1578-1581 PR:P19332 denotes Tau
T161 1578-1581 PR:P10637 denotes Tau
T160 1578-1581 CHEBI:36355 denotes Tau
T162 1592-1609 D019636 denotes neurodegenerative
T163 1592-1609 D019636 denotes neurodegenerative
T164 1610-1619 UBERON:0004529 denotes processes
T165 1671-1676 PR:Q5S006 denotes LRRK2
T166 1671-1676 PR:000003033 denotes LRRK2
T167 1671-1676 PR:Q5S007 denotes LRRK2
T168 1757-1766 GO:0016236 denotes autophagy
T169 1757-1766 GO:0006914 denotes autophagy
T174 1772-1779 SO:0000104 denotes protein
T173 1772-1779 PR:000000001 denotes protein
T170 1772-1779 GO:0003675 denotes protein
T171 1772-1779 CHEBI:36080 denotes protein
T172 1772-1779 CHEBI:11122 denotes protein
T175 1772-1791 GO:0006412 denotes protein translation

DisGeNET

Id Subject Object Predicate Lexical cue
T0 84-89 gene:120892 denotes LRRK2
T1 172-189 disease:C0030567 denotes Parkinson disease
T2 207-212 gene:120892 denotes LRRK2
T3 310-338 disease:C0030567 denotes idiopathic Parkinson disease
T4 207-212 gene:120892 denotes LRRK2
T5 340-342 disease:C0030567 denotes PD
T6 503-508 gene:120892 denotes LRRK2
T7 515-517 disease:C0030567 denotes PD
T8 645-650 gene:120892 denotes LRRK2
T9 695-697 disease:C0030567 denotes PD
R1 T0 T1 associated_with LRRK2,Parkinson disease
R2 T2 T3 associated_with LRRK2,idiopathic Parkinson disease
R3 T4 T5 associated_with LRRK2,PD
R4 T6 T7 associated_with LRRK2,PD
R5 T8 T9 associated_with LRRK2,PD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 275-295 HP_0000006 denotes autosomal-dominantly
T2 275-305 HP_0000006 denotes autosomal-dominantly inherited
T3 321-330 HP_0001300 denotes Parkinson

Allie

Id Subject Object Predicate Lexical cue
SS1_22315971_2_0 321-338 expanded denotes Parkinson disease
SS2_22315971_2_0 340-342 abbr denotes PD
SS1_22315971_6_0 756-765 expanded denotes wild-type
SS2_22315971_6_0 767-769 abbr denotes WT
SS1_22315971_10_0 1370-1389 expanded denotes 4-hydroxy-2-nonenal
SS2_22315971_10_0 1391-1394 abbr denotes HNE
AE1_22315971_2_0 SS1_22315971_2_0 SS2_22315971_2_0 abbreviatedTo Parkinson disease,PD
AE1_22315971_6_0 SS1_22315971_6_0 SS2_22315971_6_0 abbreviatedTo wild-type,WT
AE1_22315971_10_0 SS1_22315971_10_0 SS2_22315971_10_0 abbreviatedTo 4-hydroxy-2-nonenal,HNE

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-190 DRI_Background denotes Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease.
T2 197-344 DRI_Background denotes The human LRRK2 gene has been identified as the most common causative gene of autosomal-dominantly inherited and idiopathic Parkinson disease (PD).
T3 345-406 DRI_Approach denotes The G2019S substitution is the most common mutation in LRRK2.
T4 407-488 DRI_Background denotes The R1441C mutation also occurs in cases of familial PD, but is not as prevalent.
T5 489-625 DRI_Outcome denotes Some cases of LRRK2-based PD exhibit Tau pathology, which suggests that alterations on LRRK2 activity affect the pathophysiology of Tau.
T6 626-829 DRI_Outcome denotes To investigate how LRRK2 might affect Tau and the pathophysiology of PD, we generated lines of C. elegans expressing human LRRK2 [wild-type (WT) or mutated (G2019S or R1441C)] with and without V337M Tau.
T7 830-971 DRI_Background denotes Expression and redox proteomics were used to identify the effects of LRRK2 (WT and mutant) on protein expression and oxidative modifications.
T8 981-1196 DRI_Background denotes Co-expression of WT LRRK2 and Tau led to increased expression of numerous proteins, including several 60S ribosomal proteins, mitochondrial proteins, and the V-type proton ATPase, which is associated with autophagy.
T9 1197-1355 DRI_Background denotes C. elegans expressing mutant LRRK2 showed similar changes, but also showed increased protein oxidation and lipid peroxidation, the latter indexed as increased
T10 1356-1389 Token_Label.OUTSIDE denotes protein-bound 4-hydroxy-2-nonenal
T11 1390-1396 DRI_Background denotes (HNE).
T12 1409-1620 DRI_Challenge denotes Our study brings new knowledge about the possible alterations induced by LRRK2 (WT and mutated) and Tau interactions, suggesting the involvement of G2019S and R1441C in Tau-dependent neurodegenerative processes.
T13 1633-1792 DRI_Background denotes These results suggest that changes in LRRK2 expression or activity lead to corresponding changes in mitochondrial function, autophagy, and protein translation.
T14 1793-1866 DRI_Background denotes These findings are discussed with reference to the pathophysiology of PD.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 197-971 OBJECTIVE denotes The human LRRK2 gene has been identified as the most common causative gene of autosomal-dominantly inherited and idiopathic Parkinson disease (PD). The G2019S substitution is the most common mutation in LRRK2. The R1441C mutation also occurs in cases of familial PD, but is not as prevalent. Some cases of LRRK2-based PD exhibit Tau pathology, which suggests that alterations on LRRK2 activity affect the pathophysiology of Tau. To investigate how LRRK2 might affect Tau and the pathophysiology of PD, we generated lines of C. elegans expressing human LRRK2 [wild-type (WT) or mutated (G2019S or R1441C)] with and without V337M Tau. Expression and redox proteomics were used to identify the effects of LRRK2 (WT and mutant) on protein expression and oxidative modifications.
T2 981-1396 RESULTS denotes Co-expression of WT LRRK2 and Tau led to increased expression of numerous proteins, including several 60S ribosomal proteins, mitochondrial proteins, and the V-type proton ATPase, which is associated with autophagy. C. elegans expressing mutant LRRK2 showed similar changes, but also showed increased protein oxidation and lipid peroxidation, the latter indexed as increased protein-bound 4-hydroxy-2-nonenal (HNE).
T3 1409-1620 METHODS denotes Our study brings new knowledge about the possible alterations induced by LRRK2 (WT and mutated) and Tau interactions, suggesting the involvement of G2019S and R1441C in Tau-dependent neurodegenerative processes.
T4 1633-1866 CONCLUSIONS denotes These results suggest that changes in LRRK2 expression or activity lead to corresponding changes in mitochondrial function, autophagy, and protein translation. These findings are discussed with reference to the pathophysiology of PD.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
22315971-3#4#10#geners33939927 411-417 geners33939927 denotes R1441C
22315971-3#53#55#diseaseC0030567 460-462 diseaseC0030567 denotes PD
22315971-5#157#163#geners34637584 783-789 geners34637584 denotes G2019S
22315971-5#69#71#diseaseC0030567 695-697 diseaseC0030567 denotes PD
4#10#geners3393992753#55#diseaseC0030567 22315971-3#4#10#geners33939927 22315971-3#53#55#diseaseC0030567 associated_with R1441C,PD
157#163#geners3463758469#71#diseaseC0030567 22315971-5#157#163#geners34637584 22315971-5#69#71#diseaseC0030567 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22315971-0#84#89#gene120892 84-89 gene120892 denotes LRRK2
22315971-0#172#189#diseaseC0030567 172-189 diseaseC0030567 denotes Parkinson disease
84#89#gene120892172#189#diseaseC0030567 22315971-0#84#89#gene120892 22315971-0#172#189#diseaseC0030567 associated_with LRRK2,Parkinson disease