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PubMed:22296330 JSONTXT

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Allie

Id Subject Object Predicate Lexical cue
SS1_22296330_1_0 395-417 expanded denotes kinetic isotope effect
SS2_22296330_1_0 419-422 abbr denotes KIE
AE1_22296330_1_0 SS1_22296330_1_0 SS2_22296330_1_0 abbreviatedTo kinetic isotope effect,KIE

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 29-44 Disease denotes Vibrio cholerae http://purl.obolibrary.org/obo/MONDO_0015766
T2 478-493 Disease denotes Vibrio cholerae http://purl.obolibrary.org/obo/MONDO_0015766

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 264-270 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 274-277 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 557-563 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 567-570 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T5 804-810 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6 987-993 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7 997-1000 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T8 1009-1015 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T9 1019-1022 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 1400-1406 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 29-44 Disease denotes Vibrio cholerae http://purl.obolibrary.org/obo/MONDO_0015766
T2 478-493 Disease denotes Vibrio cholerae http://purl.obolibrary.org/obo/MONDO_0015766

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 29-44 OrganismTaxon denotes Vibrio cholerae 666
T2 478-493 OrganismTaxon denotes Vibrio cholerae 666

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues.
T2 108-535 Sentence denotes A series of isotopically labeled natural substrate analogues (phenyl 5-N-acetyl-α-d-neuraminyl-(2→3)-β-d-galactopyranosyl-(1→4)-1-thio-β-d-glucopyranoside; Neu5Acα2,3LacβSPh, and the corresponding 2→6 isomer) were prepared chemoenzymatically in order to characterize, by use of multiple kinetic isotope effect (KIE) measurements, the glycosylation transition states for Vibrio cholerae sialidase-catalyzed hydrolysis reactions.
T3 536-777 Sentence denotes The derived KIEs for Neu5Acα2,3LacβSPh for the ring oxygen ((18)V/K), leaving group oxygen ((18)V/K), C3-S deuterium ((D)V/K(S)) and C3-R deuterium ((D)V/K(R)) are 1.029 ± 0.002, 0.983 ± 0.001, 1.034 ± 0.002, and 1.043 ± 0.002, respectively.
T4 778-931 Sentence denotes In addition, the KIEs for Neu5Acα2,6βSPh for C3-S deuterium ((D)V/K(S)) and C3-R deuterium ((D)V/K(R)) are 1.021 ± 0.001 and 1.049 ± 0.001, respectively.
T5 932-1118 Sentence denotes The glycosylation transition state structures for both Neu5Acα2,3LacβSPh and Neu5Acα2,6LacβSPh were modeled computationally using the experimental KIE values as goodness of fit criteria.
T6 1119-1337 Sentence denotes Both transition states are late with largely cleaved glycosidic bonds coupled to pyranosyl ring flattening ((4)H(5) half-chair conformation) with little or no nucleophilic involvement of the enzymatic tyrosine residue.
T7 1338-1508 Sentence denotes Notably, the transition state for the catalyzed hydrolysis of Neu5Acα2,6βSPh appears to incorporate a lesser degree of general-acid catalysis, relative to the 2,3-isomer.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 264-270 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 274-277 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 557-563 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 567-570 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T5 804-810 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6 987-993 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7 997-1000 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T8 1009-1015 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T9 1019-1022 Glycan denotes Lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 1400-1406 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 29-44 OrganismTaxon denotes Vibrio cholerae 666
T2 478-493 OrganismTaxon denotes Vibrio cholerae 666