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PubMed:22286761 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-114 Sentence denotes YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.
TextSentencer_T2 115-232 Sentence denotes Malignant mesothelioma (MM) shows frequent inactivation of the neurofibromatosis type 2 (NF2) -tumor-suppressor gene.
TextSentencer_T3 233-452 Sentence denotes Recent studies have documented that the Hippo signaling pathway, a downstream cascade of Merlin (a product of NF2), has a key role in organ size control and carcinogenesis by regulating cell proliferation and apoptosis.
TextSentencer_T4 453-799 Sentence denotes We previously reported that MMs show overexpression of Yes-associated protein (YAP) transcriptional coactivator, the main downstream effector of the Hippo signaling pathway, which results from the inactivation of NF2, LATS2 and/or SAV1 genes (the latter two encoding core components of the mammalian Hippo pathway) or amplification of YAP itself.
TextSentencer_T5 800-927 Sentence denotes However, the detailed roles of YAP remain unclear, especially the target genes of YAP that enhance MM cell growth and survival.
TextSentencer_T6 928-1087 Sentence denotes Here, we demonstrated that YAP-knockdown inhibited cell motility, invasion and anchorage-independent growth as well as cell proliferation of MM cells in vitro.
TextSentencer_T7 1088-1277 Sentence denotes We analyzed genes commonly regulated by YAP in three MM cell lines with constitutive YAP-activation, and found that the major subsets of YAP-upregulating genes encode cell cycle regulators.
TextSentencer_T8 1278-1395 Sentence denotes Among them, YAP directly induced the transcription of CCND1 and FOXM1, in cooperation with TEAD transcription factor.
TextSentencer_T9 1396-1556 Sentence denotes We also found that knockdown of CCND1 and FOXM1 suppressed MM cell proliferation, although the inhibitory effects were less evident than those of YAP knockdown.
TextSentencer_T10 1557-1703 Sentence denotes These results indicate that constitutive YAP activation in MM cells promotes cell cycle progression giving more aggressive phenotypes to MM cells.
T1 0-114 Sentence denotes YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.
T2 115-232 Sentence denotes Malignant mesothelioma (MM) shows frequent inactivation of the neurofibromatosis type 2 (NF2) -tumor-suppressor gene.
T3 233-452 Sentence denotes Recent studies have documented that the Hippo signaling pathway, a downstream cascade of Merlin (a product of NF2), has a key role in organ size control and carcinogenesis by regulating cell proliferation and apoptosis.
T4 453-799 Sentence denotes We previously reported that MMs show overexpression of Yes-associated protein (YAP) transcriptional coactivator, the main downstream effector of the Hippo signaling pathway, which results from the inactivation of NF2, LATS2 and/or SAV1 genes (the latter two encoding core components of the mammalian Hippo pathway) or amplification of YAP itself.
T5 800-927 Sentence denotes However, the detailed roles of YAP remain unclear, especially the target genes of YAP that enhance MM cell growth and survival.
T6 928-1087 Sentence denotes Here, we demonstrated that YAP-knockdown inhibited cell motility, invasion and anchorage-independent growth as well as cell proliferation of MM cells in vitro.
T7 1088-1277 Sentence denotes We analyzed genes commonly regulated by YAP in three MM cell lines with constitutive YAP-activation, and found that the major subsets of YAP-upregulating genes encode cell cycle regulators.
T8 1278-1395 Sentence denotes Among them, YAP directly induced the transcription of CCND1 and FOXM1, in cooperation with TEAD transcription factor.
T9 1396-1556 Sentence denotes We also found that knockdown of CCND1 and FOXM1 suppressed MM cell proliferation, although the inhibitory effects were less evident than those of YAP knockdown.
T10 1557-1703 Sentence denotes These results indicate that constitutive YAP activation in MM cells promotes cell cycle progression giving more aggressive phenotypes to MM cells.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1428-1433 gene:595 denotes CCND1
T1 1455-1457 disease:C0345967 denotes MM
T2 1438-1443 gene:2305 denotes FOXM1
T3 1455-1457 disease:C0345967 denotes MM
R1 T0 T1 associated_with CCND1,MM
R2 T2 T3 associated_with FOXM1,MM

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 115-137 HP_0100001 denotes Malignant mesothelioma
T2 178-195 HP_0001067 denotes neurofibromatosis
T3 210-215 HP_0002664 denotes tumor
T4 1669-1679 HP_0000718 denotes aggressive

Allie

Id Subject Object Predicate Lexical cue
SS1_22286761_1_0 115-137 expanded denotes Malignant mesothelioma
SS2_22286761_1_0 139-141 abbr denotes MM
SS1_22286761_1_1 178-202 expanded denotes neurofibromatosis type 2
SS2_22286761_1_1 204-207 abbr denotes NF2
SS1_22286761_3_0 508-530 expanded denotes Yes-associated protein
SS2_22286761_3_0 532-535 abbr denotes YAP
AE1_22286761_1_0 SS1_22286761_1_0 SS2_22286761_1_0 abbreviatedTo Malignant mesothelioma,MM
AE1_22286761_1_1 SS1_22286761_1_1 SS2_22286761_1_1 abbreviatedTo neurofibromatosis type 2,NF2
AE1_22286761_3_0 SS1_22286761_3_0 SS2_22286761_3_0 abbreviatedTo Yes-associated protein,YAP

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22286761-3#218#223#gene26524 671-676 gene26524 denotes LATS2
22286761-3#231#235#gene60485 684-688 gene60485 denotes SAV1
22286761-3#28#30#diseaseC1290375 481-483 diseaseC1290375 denotes MM
22286761-3#28#30#diseaseC0345967 481-483 diseaseC0345967 denotes MM
22286761-3#28#30#diseaseC1290375 481-483 diseaseC1290375 denotes MM
22286761-3#28#30#diseaseC0345967 481-483 diseaseC0345967 denotes MM
22286761-8#32#37#gene595 1428-1433 gene595 denotes CCND1
22286761-8#42#47#gene2305 1438-1443 gene2305 denotes FOXM1
22286761-8#59#61#diseaseC1290375 1455-1457 diseaseC1290375 denotes MM
22286761-8#59#61#diseaseC0345967 1455-1457 diseaseC0345967 denotes MM
22286761-8#59#61#diseaseC1290375 1455-1457 diseaseC1290375 denotes MM
22286761-8#59#61#diseaseC0345967 1455-1457 diseaseC0345967 denotes MM
218#223#gene2652428#30#diseaseC1290375 22286761-3#218#223#gene26524 22286761-3#28#30#diseaseC1290375 associated_with LATS2,MM
218#223#gene2652428#30#diseaseC0345967 22286761-3#218#223#gene26524 22286761-3#28#30#diseaseC0345967 associated_with LATS2,MM
218#223#gene2652428#30#diseaseC1290375 22286761-3#218#223#gene26524 22286761-3#28#30#diseaseC1290375 associated_with LATS2,MM
218#223#gene2652428#30#diseaseC0345967 22286761-3#218#223#gene26524 22286761-3#28#30#diseaseC0345967 associated_with LATS2,MM
231#235#gene6048528#30#diseaseC1290375 22286761-3#231#235#gene60485 22286761-3#28#30#diseaseC1290375 associated_with SAV1,MM
231#235#gene6048528#30#diseaseC0345967 22286761-3#231#235#gene60485 22286761-3#28#30#diseaseC0345967 associated_with SAV1,MM
231#235#gene6048528#30#diseaseC1290375 22286761-3#231#235#gene60485 22286761-3#28#30#diseaseC1290375 associated_with SAV1,MM
231#235#gene6048528#30#diseaseC0345967 22286761-3#231#235#gene60485 22286761-3#28#30#diseaseC0345967 associated_with SAV1,MM
32#37#gene59559#61#diseaseC1290375 22286761-8#32#37#gene595 22286761-8#59#61#diseaseC1290375 associated_with CCND1,MM
32#37#gene59559#61#diseaseC0345967 22286761-8#32#37#gene595 22286761-8#59#61#diseaseC0345967 associated_with CCND1,MM
32#37#gene59559#61#diseaseC1290375 22286761-8#32#37#gene595 22286761-8#59#61#diseaseC1290375 associated_with CCND1,MM
32#37#gene59559#61#diseaseC0345967 22286761-8#32#37#gene595 22286761-8#59#61#diseaseC0345967 associated_with CCND1,MM
42#47#gene230559#61#diseaseC1290375 22286761-8#42#47#gene2305 22286761-8#59#61#diseaseC1290375 associated_with FOXM1,MM
42#47#gene230559#61#diseaseC0345967 22286761-8#42#47#gene2305 22286761-8#59#61#diseaseC0345967 associated_with FOXM1,MM
42#47#gene230559#61#diseaseC1290375 22286761-8#42#47#gene2305 22286761-8#59#61#diseaseC1290375 associated_with FOXM1,MM
42#47#gene230559#61#diseaseC0345967 22286761-8#42#47#gene2305 22286761-8#59#61#diseaseC0345967 associated_with FOXM1,MM

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1101 671-676 gene:26524 denotes LATS2
T1102 481-483 disease:C1290375 denotes MM
T1103 684-688 gene:60485 denotes SAV1
R1 T1101 T1102 associated_with LATS2,MM
R2 T1101 T1102 associated_with LATS2,MM
R3 T1103 T1102 associated_with SAV1,MM
R4 T1103 T1102 associated_with SAV1,MM

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 367-372 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 367-372 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ