PubMed:22264780 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":133,"end":139},"obj":"gene:3767"},{"id":"T1","span":{"begin":197,"end":212},"obj":"disease:C0011860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"Allie","denotations":[{"id":"SS1_22264780_2_0","span":{"begin":266,"end":306},"obj":"expanded"},{"id":"SS2_22264780_2_0","span":{"begin":308,"end":313},"obj":"abbr"},{"id":"SS1_22264780_2_1","span":{"begin":343,"end":353},"obj":"expanded"},{"id":"SS2_22264780_2_1","span":{"begin":355,"end":358},"obj":"abbr"}],"relations":[{"id":"AE1_22264780_2_0","pred":"abbreviatedTo","subj":"SS1_22264780_2_0","obj":"SS2_22264780_2_0"},{"id":"AE1_22264780_2_1","pred":"abbreviatedTo","subj":"SS1_22264780_2_1","obj":"SS2_22264780_2_1"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"22264780-0#50#56#geners5219","span":{"begin":50,"end":56},"obj":"geners5219"},{"id":"22264780-0#87#95#diseaseC0011847","span":{"begin":87,"end":95},"obj":"diseaseC0011847"},{"id":"22264780-0#87#95#diseaseC0011849","span":{"begin":87,"end":95},"obj":"diseaseC0011849"}],"relations":[{"id":"50#56#geners521987#95#diseaseC0011847","pred":"associated_with","subj":"22264780-0#50#56#geners5219","obj":"22264780-0#87#95#diseaseC0011847"},{"id":"50#56#geners521987#95#diseaseC0011849","pred":"associated_with","subj":"22264780-0#50#56#geners5219","obj":"22264780-0#87#95#diseaseC0011849"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22264780-0#29#35#gene3767","span":{"begin":29,"end":35},"obj":"gene3767"},{"id":"22264780-0#87#95#diseaseC0011847","span":{"begin":87,"end":95},"obj":"diseaseC0011847"},{"id":"22264780-0#87#95#diseaseC0011849","span":{"begin":87,"end":95},"obj":"diseaseC0011849"},{"id":"22264780-1#0#6#gene3767","span":{"begin":133,"end":139},"obj":"gene3767"},{"id":"22264780-1#64#79#diseaseC0011860","span":{"begin":197,"end":212},"obj":"diseaseC0011860"}],"relations":[{"id":"29#35#gene376787#95#diseaseC0011847","pred":"associated_with","subj":"22264780-0#29#35#gene3767","obj":"22264780-0#87#95#diseaseC0011847"},{"id":"29#35#gene376787#95#diseaseC0011849","pred":"associated_with","subj":"22264780-0#29#35#gene3767","obj":"22264780-0#87#95#diseaseC0011849"},{"id":"0#6#gene376764#79#diseaseC0011860","pred":"associated_with","subj":"22264780-1#0#6#gene3767","obj":"22264780-1#64#79#diseaseC0011860"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":133,"end":213},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":214,"end":360},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":361,"end":435},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":436,"end":517},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":518,"end":630},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T2","span":{"begin":133,"end":213},"obj":"Sentence"},{"id":"T3","span":{"begin":214,"end":360},"obj":"Sentence"},{"id":"T4","span":{"begin":361,"end":435},"obj":"Sentence"},{"id":"T5","span":{"begin":436,"end":517},"obj":"Sentence"},{"id":"T6","span":{"begin":518,"end":630},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T522","span":{"begin":29,"end":35},"obj":"gene:3767"},{"id":"T523","span":{"begin":87,"end":95},"obj":"disease:C0011847"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T522","obj":"T523"},{"id":"R2","pred":"associated_with","subj":"T522","obj":"T523"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"PubTator4TogoVar","denotations":[{"id":"28","span":{"begin":419,"end":425},"obj":"SNP"},{"id":"6","span":{"begin":50,"end":56},"obj":"SNP"}],"attributes":[{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"},{"id":"A6","pred":"resolved_to","subj":"6","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"6","span":{"begin":50,"end":56},"obj":"SNP"},{"id":"28","span":{"begin":419,"end":425},"obj":"SNP"},{"id":"T1","span":{"begin":50,"end":56},"obj":"SNP"},{"id":"T1","span":{"begin":419,"end":425},"obj":"SNP"}],"attributes":[{"id":"A6","pred":"resolved_to","subj":"6","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"},{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs5219;VariantGroup:0;CorrespondingGene:3767;RS#:5219;CorrespondingSpecies:9606"}],"text":"Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.\nKCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association."}