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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 128-298 OBJECTIVE denotes To research the effects of moschus, borneol, styrax and benzoinum on the structure and function of blood brain barrier in cerebral ischemia-reperfusion injury model rats.
T2 307-767 METHODS denotes Focal middle cerebral artery occlusion (MCAO) was introduced as an in vivo ischemic model in rats. After 2 h MCAO, nylon suture was pulled up 1 cm to give blood reperfusion. After 22 h reperfusion, all animals were decapitated. The ultramicrostructure of blood brain barrier of ischemia hemisphere side in fronto-parietal cortex region by transmission electron microscope, and the content of VEGF and MMP-9 in ischemia side brain tissue were measured by ELISA.
T3 776-2489 RESULTS denotes In model and solvent group rats, the capillary endothelium cells, astro-glial cells and nerve cells in ischemia hemisphere side in fronto-parietal region were emerged in different degree compared with sham-operated groups, which exhibited tight junction between endothelial cells being opened, basal lamina being dissolved, and permeability increasing, and cellularedema. In borneol (0.2 g x kg(-1)) group rats, the structure of three kinds of cells were nearly normal, which tight junction structure was clear, rough endoplasmic reticulum and polyribosome could be found in cytoplasm. In moschus (66.6 mg x kg(-1)) group rats, the structure of capillary endothelium cells and astrocytes were nearly normal as well as the basal lamina, but the electrons in neurons was maldistribution. In styrax (1.332 g x kg(-1)) group rats, astrocytes were nearly normal, while capillary endothelial cells and neurons exhibited oedema in different degrees. And the basal lamina was discontinuous, augmentation of cell spaces in endothelial cells increased the permeability, some endoplasmic reticulum broadened and ribosome ablated. In benzoinum (1.0 g x kg(-1)) group rats, oedema of capillary endothelial cells and astrocytes was significant, basal lamina broke. Meanwhile endoplasmic reticulum broadened as vacuole, the number of ribosome in rough endoplasmic reticulum decreased, crista mitochondriales in some neurons disappeared as vacuole which hint oedema happened. Results also showed that borneol decrease the level of VEGF in ischemia side brain tissue significantly, while has little influence on the level of MMP-9. Moschus showed the tendency to decrease the level of VEGF and MMP-9 in ischemia side brain tissue.
T4 2502-2816 CONCLUSIONS denotes Aromatic resuscitation drugs showed the protection effect on blood brain barrier in cerebral ischemia-reperfusion injury rats, which the protection effect of moschus and borneol were better than that of styrax and benzoinum. The mechanism of protection effect maybe related to decrease the level of VEGF and MMP-9.

c_corpus

Id Subject Object Predicate Lexical cue
T1 35-40 CHEBI:23888 denotes drugs
T113 1070-1082 UBERON:0000482 denotes basal lamina
T120 1151-1158 1368202 denotes borneol
T2 44-63 UBERON:0000120 denotes blood brain barrier
T5 67-84 D002545 denotes cerebral ischemia
T6 67-84 D002545 denotes cerebral ischemia
T9 76-103 D015427 denotes ischemia-reperfusion injury
T10 76-103 D015427 denotes ischemia-reperfusion injury
T13 110-114 10118 denotes rats
T14 110-114 10116 denotes rats
T15 110-114 D051381 denotes rats
T19 164-171 1368202 denotes borneol
T16 164-171 C022871 denotes borneol
T17 164-171 CHEBI:15394 denotes borneol
T18 164-171 CHEBI:15393 denotes borneol
T20 164-171 CHEBI:28093 denotes borneol
T21 164-171 C022871 denotes borneol
T22 173-179 D032362 denotes styrax
T23 227-246 UBERON:0000120 denotes blood brain barrier
T26 250-267 D002545 denotes cerebral ischemia
T27 250-267 D002545 denotes cerebral ischemia
T30 259-286 D015427 denotes ischemia-reperfusion injury
T31 259-286 D015427 denotes ischemia-reperfusion injury
T34 293-297 10118 denotes rats
T35 293-297 10116 denotes rats
T36 293-297 D051381 denotes rats
T37 313-335 UBERON:0001627 denotes middle cerebral artery
T38 313-345 D020244 denotes middle cerebral artery occlusion
T39 313-345 D020244 denotes middle cerebral artery occlusion
T44 400-404 10118 denotes rats
T45 400-404 10116 denotes rats
T46 400-404 D051381 denotes rats
T47 422-427 D009757 denotes nylon
T48 428-434 UBERON:0003685 denotes suture
T49 428-434 UBERON:4200215 denotes suture
T50 446-450 P81827 denotes up 1
T51 446-450 P11684 denotes up 1
T52 446-450 P09867 denotes up 1
T53 446-450 PR:000014505 denotes up 1
T54 562-581 UBERON:0000120 denotes blood brain barrier
T57 585-593 D007511 denotes ischemia
T58 585-593 D007511 denotes ischemia
T59 594-604 UBERON:0001869 denotes hemisphere
T61 620-635 UBERON:0016530 denotes parietal cortex
T63 659-667 CHEBI:10545 denotes electron
T65 699-703 PR:P15692 denotes VEGF
T66 699-703 PR:Q00731 denotes VEGF
T68 699-703 PR:O73682 denotes VEGF
T69 699-703 PR:P16612 denotes VEGF
T70 699-703 PR:000017284 denotes VEGF
T71 699-703 PR:P67964 denotes VEGF
T64 699-703 D042461 denotes VEGF
T67 699-703 D042461 denotes VEGF
T72 708-711 CHEBI:340824 denotes MMP
T75 708-711 CHEBI:59761 denotes MMP
T76 708-713 PR:P50282 denotes MMP-9
T77 708-713 PR:P14780 denotes MMP-9
T78 708-713 P14780 denotes MMP-9
T79 708-713 PR:P41245 denotes MMP-9
T80 708-713 P41246 denotes MMP-9
T81 708-713 P41245 denotes MMP-9
T82 708-713 PR:P52176 denotes MMP-9
T83 708-713 P50282 denotes MMP-9
T85 708-713 PR:000010491 denotes MMP-9
T86 708-713 P52176 denotes MMP-9
T87 708-713 O18733 denotes MMP-9
T84 708-713 GO:0004229 denotes MMP-9
T88 717-725 D007511 denotes ischemia
T89 717-725 D007511 denotes ischemia
T90 731-736 UBERON:6110636 denotes brain
T91 731-736 UBERON:0000955 denotes brain
T92 737-743 UBERON:0000479 denotes tissue
T93 789-796 CHEBI:46787 denotes solvent
T94 803-807 10118 denotes rats
T95 803-807 10116 denotes rats
T96 803-807 D051381 denotes rats
T98 813-834 UBERON:0001915 denotes capillary endothelium
T100 864-869 UBERON:0001021 denotes nerve
T101 879-887 D007511 denotes ischemia
T102 879-887 D007511 denotes ischemia
T103 888-898 UBERON:0001869 denotes hemisphere
T105 914-929 UBERON:0001872 denotes parietal region
T106 977-981 C005703 denotes sham
T107 977-981 C005703 denotes sham
T108 977-981 CHEBI:45615 denotes sham
T109 1015-1029 GO:0070160 denotes tight junction
T111 1021-1029 SO:0000699 denotes junction
T110 1021-1029 UBERON:0007651 denotes junction
T112 1070-1082 GO:0005604 denotes basal lamina
T117 1151-1158 C022871 denotes borneol
T118 1151-1158 CHEBI:15394 denotes borneol
T119 1151-1158 CHEBI:15393 denotes borneol
T121 1151-1158 CHEBI:28093 denotes borneol
T122 1151-1158 C022871 denotes borneol
T127 1182-1186 10118 denotes rats
T128 1182-1186 10116 denotes rats
T129 1182-1186 D051381 denotes rats
T130 1252-1266 GO:0070160 denotes tight junction
T132 1258-1266 SO:0000699 denotes junction
T131 1258-1266 UBERON:0007651 denotes junction
T133 1288-1315 GO:0005791 denotes rough endoplasmic reticulum
T135 1306-1315 UBERON:0007361 denotes reticulum
T136 1320-1332 GO:0005844 denotes polyribosome
T137 1351-1360 GO:0005737 denotes cytoplasm
T142 1398-1402 10118 denotes rats
T143 1398-1402 10116 denotes rats
T144 1398-1402 D051381 denotes rats
T146 1421-1442 UBERON:0001915 denotes capillary endothelium
T149 1498-1510 UBERON:0000482 denotes basal lamina
T148 1498-1510 GO:0005604 denotes basal lamina
T153 1565-1571 D032362 denotes styrax
T158 1597-1601 10118 denotes rats
T159 1597-1601 10116 denotes rats
T160 1597-1601 D051381 denotes rats
T161 1640-1649 UBERON:0001982 denotes capillary
T163 1727-1739 UBERON:0000482 denotes basal lamina
T162 1727-1739 GO:0005604 denotes basal lamina
T167 1841-1862 GO:0005783 denotes endoplasmic reticulum
T168 1853-1862 UBERON:0007361 denotes reticulum
T169 1877-1885 GO:0005840 denotes ribosome
T174 1931-1935 10118 denotes rats
T175 1931-1935 10116 denotes rats
T176 1931-1935 D051381 denotes rats
T177 1947-1956 UBERON:0001982 denotes capillary
T179 2007-2019 UBERON:0000482 denotes basal lamina
T178 2007-2019 GO:0005604 denotes basal lamina
T183 2037-2058 GO:0005783 denotes endoplasmic reticulum
T184 2049-2058 UBERON:0007361 denotes reticulum
T185 2072-2079 GO:0005773 denotes vacuole
T186 2095-2103 GO:0005840 denotes ribosome
T187 2107-2134 GO:0005791 denotes rough endoplasmic reticulum
T189 2125-2134 UBERON:0007361 denotes reticulum
T190 2200-2207 GO:0005773 denotes vacuole
T194 2261-2268 1368202 denotes borneol
T191 2261-2268 C022871 denotes borneol
T192 2261-2268 CHEBI:15394 denotes borneol
T193 2261-2268 CHEBI:15393 denotes borneol
T195 2261-2268 CHEBI:28093 denotes borneol
T196 2261-2268 C022871 denotes borneol
T198 2291-2295 PR:P15692 denotes VEGF
T199 2291-2295 PR:Q00731 denotes VEGF
T201 2291-2295 PR:O73682 denotes VEGF
T202 2291-2295 PR:P16612 denotes VEGF
T203 2291-2295 PR:000017284 denotes VEGF
T204 2291-2295 PR:P67964 denotes VEGF
T197 2291-2295 D042461 denotes VEGF
T200 2291-2295 D042461 denotes VEGF
T205 2299-2307 D007511 denotes ischemia
T206 2299-2307 D007511 denotes ischemia
T207 2313-2318 UBERON:6110636 denotes brain
T208 2313-2318 UBERON:0000955 denotes brain
T209 2319-2325 UBERON:0000479 denotes tissue
T210 2384-2387 CHEBI:340824 denotes MMP
T213 2384-2387 CHEBI:59761 denotes MMP
T214 2384-2389 PR:P50282 denotes MMP-9
T215 2384-2389 PR:P14780 denotes MMP-9
T216 2384-2389 P14780 denotes MMP-9
T217 2384-2389 PR:P41245 denotes MMP-9
T218 2384-2389 P41246 denotes MMP-9
T219 2384-2389 P41245 denotes MMP-9
T220 2384-2389 PR:P52176 denotes MMP-9
T221 2384-2389 P50282 denotes MMP-9
T223 2384-2389 PR:000010491 denotes MMP-9
T224 2384-2389 P52176 denotes MMP-9
T225 2384-2389 O18733 denotes MMP-9
T222 2384-2389 GO:0004229 denotes MMP-9
T227 2444-2448 PR:P15692 denotes VEGF
T228 2444-2448 PR:Q00731 denotes VEGF
T230 2444-2448 PR:O73682 denotes VEGF
T231 2444-2448 PR:P16612 denotes VEGF
T232 2444-2448 PR:000017284 denotes VEGF
T233 2444-2448 PR:P67964 denotes VEGF
T226 2444-2448 D042461 denotes VEGF
T229 2444-2448 D042461 denotes VEGF
T234 2453-2456 CHEBI:340824 denotes MMP
T237 2453-2456 CHEBI:59761 denotes MMP
T238 2453-2458 PR:P50282 denotes MMP-9
T239 2453-2458 PR:P14780 denotes MMP-9
T240 2453-2458 P14780 denotes MMP-9
T241 2453-2458 PR:P41245 denotes MMP-9
T242 2453-2458 P41246 denotes MMP-9
T243 2453-2458 P41245 denotes MMP-9
T244 2453-2458 PR:P52176 denotes MMP-9
T245 2453-2458 P50282 denotes MMP-9
T247 2453-2458 PR:000010491 denotes MMP-9
T248 2453-2458 P52176 denotes MMP-9
T249 2453-2458 O18733 denotes MMP-9
T246 2453-2458 GO:0004229 denotes MMP-9
T250 2462-2470 D007511 denotes ischemia
T251 2462-2470 D007511 denotes ischemia
T252 2476-2481 UBERON:6110636 denotes brain
T253 2476-2481 UBERON:0000955 denotes brain
T254 2482-2488 UBERON:0000479 denotes tissue
T255 2525-2530 CHEBI:23888 denotes drugs
T256 2563-2582 UBERON:0000120 denotes blood brain barrier
T259 2586-2603 D002545 denotes cerebral ischemia
T260 2586-2603 D002545 denotes cerebral ischemia
T263 2595-2622 D015427 denotes ischemia-reperfusion injury
T264 2595-2622 D015427 denotes ischemia-reperfusion injury
T267 2623-2627 10118 denotes rats
T268 2623-2627 10116 denotes rats
T269 2623-2627 D051381 denotes rats
T273 2672-2679 1368202 denotes borneol
T270 2672-2679 C022871 denotes borneol
T271 2672-2679 CHEBI:15394 denotes borneol
T272 2672-2679 CHEBI:15393 denotes borneol
T274 2672-2679 CHEBI:28093 denotes borneol
T275 2672-2679 C022871 denotes borneol
T276 2705-2711 D032362 denotes styrax
T278 2801-2805 PR:P15692 denotes VEGF
T279 2801-2805 PR:Q00731 denotes VEGF
T281 2801-2805 PR:O73682 denotes VEGF
T282 2801-2805 PR:P16612 denotes VEGF
T283 2801-2805 PR:000017284 denotes VEGF
T284 2801-2805 PR:P67964 denotes VEGF
T277 2801-2805 D042461 denotes VEGF
T280 2801-2805 D042461 denotes VEGF
T285 2810-2813 CHEBI:340824 denotes MMP
T288 2810-2813 CHEBI:59761 denotes MMP
T289 2810-2815 PR:P50282 denotes MMP-9
T290 2810-2815 PR:P14780 denotes MMP-9
T291 2810-2815 P14780 denotes MMP-9
T292 2810-2815 PR:P41245 denotes MMP-9
T293 2810-2815 P41246 denotes MMP-9
T294 2810-2815 P41245 denotes MMP-9
T295 2810-2815 PR:P52176 denotes MMP-9
T296 2810-2815 P50282 denotes MMP-9
T298 2810-2815 PR:000010491 denotes MMP-9
T299 2810-2815 P52176 denotes MMP-9
T300 2810-2815 O18733 denotes MMP-9
T297 2810-2815 GO:0004229 denotes MMP-9

Allie

Id Subject Object Predicate Lexical cue
SS1_22256767_4_0 313-345 expanded denotes middle cerebral artery occlusion
SS2_22256767_4_0 347-351 abbr denotes MCAO
AE1_22256767_4_0 SS1_22256767_4_0 SS2_22256767_4_0 abbreviatedTo middle cerebral artery occlusion,MCAO

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-116 DRI_Background denotes [Effects of aromatic resuscitation drugs on blood brain barrier in cerebral ischemia-reperfusion injury model rats].
T2 122-298 DRI_Background denotes TIVE: To research the effects of moschus, borneol, styrax and benzoinum on the structure and function of blood brain barrier in cerebral ischemia-reperfusion injury model rats.
T3 307-405 DRI_Background denotes Focal middle cerebral artery occlusion (MCAO) was introduced as an in vivo ischemic model in rats.
T4 406-480 DRI_Unspecified denotes After 2 h MCAO, nylon suture was pulled up 1 cm to give blood reperfusion.
T5 481-534 DRI_Background denotes After 22 h reperfusion, all animals were decapitated.
T6 535-767 DRI_Background denotes The ultramicrostructure of blood brain barrier of ischemia hemisphere side in fronto-parietal cortex region by transmission electron microscope, and the content of VEGF and MMP-9 in ischemia side brain tissue were measured by ELISA.
T7 776-1147 DRI_Background denotes In model and solvent group rats, the capillary endothelium cells, astro-glial cells and nerve cells in ischemia hemisphere side in fronto-parietal region were emerged in different degree compared with sham-operated groups, which exhibited tight junction between endothelial cells being opened, basal lamina being dissolved, and permeability increasing, and cellularedema.
T8 1148-1361 DRI_Approach denotes In borneol (0.2 g x kg(-1)) group rats, the structure of three kinds of cells were nearly normal, which tight junction structure was clear, rough endoplasmic reticulum and polyribosome could be found in cytoplasm.
T9 1362-1561 DRI_Approach denotes In moschus (66.6 mg x kg(-1)) group rats, the structure of capillary endothelium cells and astrocytes were nearly normal as well as the basal lamina, but the electrons in neurons was maldistribution.
T10 1562-1718 DRI_Background denotes In styrax (1.332 g x kg(-1)) group rats, astrocytes were nearly normal, while capillary endothelial cells and neurons exhibited oedema in different degrees.
T11 1719-1894 DRI_Background denotes And the basal lamina was discontinuous, augmentation of cell spaces in endothelial cells increased the permeability, some endoplasmic reticulum broadened and ribosome ablated.
T12 1895-2026 DRI_Background denotes In benzoinum (1.0 g x kg(-1)) group rats, oedema of capillary endothelial cells and astrocytes was significant, basal lamina broke.
T13 2027-2235 DRI_Outcome denotes Meanwhile endoplasmic reticulum broadened as vacuole, the number of ribosome in rough endoplasmic reticulum decreased, crista mitochondriales in some neurons disappeared as vacuole which hint oedema happened.
T14 2236-2390 DRI_Background denotes Results also showed that borneol decrease the level of VEGF in ischemia side brain tissue significantly, while has little influence on the level of MMP-9.
T15 2391-2489 DRI_Challenge denotes Moschus showed the tendency to decrease the level of VEGF and MMP-9 in ischemia side brain tissue.
T16 2502-2726 DRI_Background denotes Aromatic resuscitation drugs showed the protection effect on blood brain barrier in cerebral ischemia-reperfusion injury rats, which the protection effect of moschus and borneol were better than that of styrax and benzoinum.
T17 2727-2816 DRI_Background denotes The mechanism of protection effect maybe related to decrease the level of VEGF and MMP-9.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 2586-2603 HP_0002637 denotes cerebral ischemia