PubMed:22220678 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":68},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":69,"end":82},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":83,"end":137},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":138,"end":273},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":274,"end":284},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":285,"end":386},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":387,"end":395},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":396,"end":488},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":489,"end":497},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":498,"end":562},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":563,"end":690},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":691,"end":821},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":822,"end":1004},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1005,"end":1285},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1286,"end":1298},"obj":"Sentence"},{"id":"TextSentencer_T16","span":{"begin":1299,"end":1555},"obj":"Sentence"},{"id":"TextSentencer_T17","span":{"begin":1556,"end":1726},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":68},"obj":"Sentence"},{"id":"T2","span":{"begin":69,"end":82},"obj":"Sentence"},{"id":"T3","span":{"begin":83,"end":137},"obj":"Sentence"},{"id":"T4","span":{"begin":138,"end":273},"obj":"Sentence"},{"id":"T5","span":{"begin":274,"end":284},"obj":"Sentence"},{"id":"T6","span":{"begin":285,"end":386},"obj":"Sentence"},{"id":"T7","span":{"begin":387,"end":395},"obj":"Sentence"},{"id":"T8","span":{"begin":396,"end":488},"obj":"Sentence"},{"id":"T9","span":{"begin":489,"end":497},"obj":"Sentence"},{"id":"T10","span":{"begin":498,"end":562},"obj":"Sentence"},{"id":"T11","span":{"begin":563,"end":690},"obj":"Sentence"},{"id":"T12","span":{"begin":691,"end":821},"obj":"Sentence"},{"id":"T13","span":{"begin":822,"end":1004},"obj":"Sentence"},{"id":"T14","span":{"begin":1005,"end":1285},"obj":"Sentence"},{"id":"T15","span":{"begin":1286,"end":1298},"obj":"Sentence"},{"id":"T16","span":{"begin":1299,"end":1555},"obj":"Sentence"},{"id":"T17","span":{"begin":1556,"end":1726},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Perinatal outcome for pregnancies complicated with thrombocytopenia.\nINTRODUCTION: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns.\nOBJECTIVE: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia.\nMETHODS: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period.\nRESULTS: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery - highest risk for severe thrombocytopenia (RR=8.69, p\u003c0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR=7.97, p=0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia - 2047.50 ± 938.98 g (p=0.02) versus 3224.86 ± 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR=11.94, p=0.00), with medium weight of 2462.05 ± 794.54 g versus 2932.37 ± 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 ± 496.00 g (p=0.00) in normal pregnancies.\nCONCLUSIONS: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome - for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetus/newborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":83,"end":99},"obj":"HP_0001873"},{"id":"T2","span":{"begin":138,"end":150},"obj":"HP_0100602"},{"id":"T3","span":{"begin":174,"end":190},"obj":"HP_0001873"},{"id":"T4","span":{"begin":226,"end":242},"obj":"HP_0001622"},{"id":"T5","span":{"begin":247,"end":263},"obj":"HP_0001518"}],"text":"Perinatal outcome for pregnancies complicated with thrombocytopenia.\nINTRODUCTION: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns.\nOBJECTIVE: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia.\nMETHODS: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period.\nRESULTS: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery - highest risk for severe thrombocytopenia (RR=8.69, p\u003c0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR=7.97, p=0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia - 2047.50 ± 938.98 g (p=0.02) versus 3224.86 ± 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR=11.94, p=0.00), with medium weight of 2462.05 ± 794.54 g versus 2932.37 ± 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 ± 496.00 g (p=0.00) in normal pregnancies.\nCONCLUSIONS: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome - for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetus/newborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention."}

{"project":"Preeclampsia","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":138,"end":150},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":151,"end":165},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":708,"end":720},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T4","span":{"begin":724,"end":738},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T5","span":{"begin":1029,"end":1041},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T6","span":{"begin":1405,"end":1417},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T7","span":{"begin":1422,"end":1436},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Perinatal outcome for pregnancies complicated with thrombocytopenia.\nINTRODUCTION: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns.\nOBJECTIVE: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia.\nMETHODS: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period.\nRESULTS: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery - highest risk for severe thrombocytopenia (RR=8.69, p\u003c0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR=7.97, p=0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia - 2047.50 ± 938.98 g (p=0.02) versus 3224.86 ± 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR=11.94, p=0.00), with medium weight of 2462.05 ± 794.54 g versus 2932.37 ± 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 ± 496.00 g (p=0.00) in normal pregnancies.\nCONCLUSIONS: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome - for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetus/newborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention."}

{"project":"Preeclampsia-compare","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":138,"end":150},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":151,"end":165},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":708,"end":720},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T4","span":{"begin":724,"end":738},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T5","span":{"begin":1029,"end":1041},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T6","span":{"begin":1405,"end":1417},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T7","span":{"begin":1422,"end":1436},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Perinatal outcome for pregnancies complicated with thrombocytopenia.\nINTRODUCTION: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns.\nOBJECTIVE: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia.\nMETHODS: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period.\nRESULTS: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery - highest risk for severe thrombocytopenia (RR=8.69, p\u003c0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR=7.97, p=0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia - 2047.50 ± 938.98 g (p=0.02) versus 3224.86 ± 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR=11.94, p=0.00), with medium weight of 2462.05 ± 794.54 g versus 2932.37 ± 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 ± 496.00 g (p=0.00) in normal pregnancies.\nCONCLUSIONS: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome - for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetus/newborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention."}