PubMed:22190250
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22190250","sourcedb":"PubMed","sourceid":"22190250","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22190250","text":"Intravenous ketamine for treatment-resistant major depressive disorder.\nOBJECTIVE: To evaluate the literature regarding the efficacy and safety of intravenous ketamine for treatment-resistant major depressive disorder (MDD).\nDATA SOURCES: A MEDLINE search (1966-September 2011) was performed using the terms treatment-resistant depression and ketamine. The search was restricted to articles published in English and reporting on use of ketamine in humans.\nSTUDY SELECTION AND DATA EXTRACTION: All English-language articles identified from the data search were evaluated. Data were eligible for inclusion if they were primary literature and evaluated the efficacy of ketamine for depressive symptoms in treatment-resistant MDD. One case report, 3 case series, 3 open-label trials, and 1 randomized crossover trial were included.\nDATA SYNTHESIS: Several medications are available for treatment-resistant MDD; however, they are often limited by a slow onset of therapeutic effect and tolerability. It has been suggested that ketamine, a rapid-acting, N-methyl-D-aspartate glutamate receptor antagonist, may have antidepressant effects. Case reports, case series, and select trials evaluating ketamine use for depressive symptoms in treatment-resistant MDD have demonstrated a rapid effect for reductions of scores on a number of depression scales; however, its sustainability effect remains unknown. Several studies reported a large or moderate to large effect size for ketamine. Additionally, these studies showed that ketamine use in this patient population is associated with relatively well-tolerated adverse effects.\nCONCLUSIONS: Ketamine for treatment-resistant MDD requires further evaluation before it can be considered a viable treatment option.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_22190250_2_0","span":{"begin":192,"end":217},"obj":"expanded"},{"id":"SS2_22190250_2_0","span":{"begin":219,"end":222},"obj":"abbr"}],"relations":[{"id":"AE1_22190250_2_0","pred":"abbreviatedTo","subj":"SS1_22190250_2_0","obj":"SS2_22190250_2_0"}],"attributes":[{"subj":"SS1_22190250_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_22190250_2_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":198,"end":208},"obj":"HP_0000716"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec93de","default":true},{"id":"PubmedHPO","color":"#93ece0"}]}]}}