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c_corpus

Id Subject Object Predicate Lexical cue
T4 0-11 3640 denotes Doxycycline
T1 0-11 CHEBI:60648 denotes Doxycycline
T2 0-11 D004318 denotes Doxycycline
T3 0-11 CHEBI:50845 denotes Doxycycline
T5 0-11 D004318 denotes Doxycycline
T6 53-70 D002545 denotes cerebral ischemia
T7 53-70 D002545 denotes cerebral ischemia
T10 62-89 D015427 denotes ischemia-reperfusion injury
T11 62-89 D015427 denotes ischemia-reperfusion injury
T14 136-139 P34722 denotes PKC
T15 136-139 P13678 denotes PKC
T16 136-139 P05130 denotes PKC
T18 136-139 PR:000045382 denotes PKC
T17 136-139 GO:0004697 denotes PKC
T19 136-139 C537180 denotes PKC
T20 141-150 GO:0023052 denotes signaling
T21 154-158 10118 denotes rats
T22 154-158 10116 denotes rats
T23 154-158 D051381 denotes rats
T24 215-237 CHEBI:63726 denotes neuroprotective agents
T25 215-237 D018696 denotes neuroprotective agents
T26 215-237 D018696 denotes neuroprotective agents
T27 268-285 D002545 denotes cerebral ischemia
T28 268-285 D002545 denotes cerebral ischemia
T31 277-304 D015427 denotes ischemia-reperfusion injury
T32 277-304 D015427 denotes ischemia-reperfusion injury
T38 370-381 3640 denotes doxycycline
T35 370-381 CHEBI:60648 denotes doxycycline
T36 370-381 D004318 denotes doxycycline
T37 370-381 CHEBI:50845 denotes doxycycline
T39 370-381 D004318 denotes doxycycline
T40 383-397 CHEBI:144644 denotes a tetracycline
T43 385-397 10395 denotes tetracycline
T46 398-408 D000900 denotes antibiotic
T47 398-408 D000900 denotes antibiotic
T48 398-408 CHEBI:33281 denotes antibiotic
T49 463-472 MOP:0000569 denotes reduction
T52 489-518 D015427 denotes ischemia-reperfusion injuries
T53 489-518 D015427 denotes ischemia-reperfusion injuries
T56 539-544 UBERON:6110636 denotes brain
T57 539-544 UBERON:0000955 denotes brain
T59 565-568 PR:P63003-1 denotes rat
T60 565-568 PR:Q2G0B1 denotes rat
T61 565-568 PR:Q8VHJ4 denotes rat
T58 565-568 10116 denotes rat
T62 565-568 D051381 denotes rat
T63 579-601 UBERON:0001627 denotes middle cerebral artery
T64 579-611 D020244 denotes middle cerebral artery occlusion
T65 579-611 D020244 denotes middle cerebral artery occlusion
T73 681-692 3640 denotes doxycycline
T70 681-692 CHEBI:60648 denotes doxycycline
T71 681-692 D004318 denotes doxycycline
T72 681-692 CHEBI:50845 denotes doxycycline
T74 681-692 D004318 denotes doxycycline
T75 705-724 UBERON:0000120 denotes blood-brain barrier
T78 726-729 UBERON:0000120 denotes BBB
T92 784-803 D017207 denotes Sprague-Dawley rats
T102 904-915 3640 denotes doxycycline
T99 904-915 CHEBI:60648 denotes doxycycline
T100 904-915 D004318 denotes doxycycline
T101 904-915 CHEBI:50845 denotes doxycycline
T103 904-915 D004318 denotes doxycycline
T107 979-990 3640 denotes doxycycline
T104 979-990 CHEBI:60648 denotes doxycycline
T105 979-990 D004318 denotes doxycycline
T106 979-990 CHEBI:50845 denotes doxycycline
T108 979-990 D004318 denotes doxycycline
T109 1017-1020 UBERON:0000120 denotes BBB
T110 1033-1049 D002544 denotes cerebral infarct
T111 1033-1049 D002544 denotes cerebral infarct
T114 1079-1089 D005070 denotes Evans blue
T115 1079-1089 D005070 denotes Evans blue
T116 1079-1089 CHEBI:82467 denotes Evans blue
T117 1124-1127 Q41249 denotes PCR
T118 1124-1127 O66148 denotes PCR
T119 1124-1127 Q59987 denotes PCR
T120 1124-1127 Q01289 denotes PCR
T121 1124-1127 O80333 denotes PCR
T122 1124-1127 P15904 denotes PCR
T123 1124-1127 Q9SDT1 denotes PCR
T124 1124-1127 Q39617 denotes PCR
T128 1210-1221 3640 denotes doxycycline
T125 1210-1221 CHEBI:60648 denotes doxycycline
T126 1210-1221 D004318 denotes doxycycline
T127 1210-1221 CHEBI:50845 denotes doxycycline
T129 1210-1221 D004318 denotes doxycycline
T130 1239-1248 SO:0000119 denotes regulated
T131 1267-1281 GO:0070160 denotes tight junction
T133 1273-1281 SO:0000699 denotes junction
T132 1273-1281 UBERON:0007651 denotes junction
T134 1282-1291 Q9JKD6 denotes claudin-5
T135 1282-1291 O00501 denotes claudin-5
T136 1282-1291 PR:000005553 denotes claudin-5
T137 1282-1291 Q2HJ22 denotes claudin-5
T139 1282-1291 O54942 denotes claudin-5
T138 1282-1291 D062507 denotes claudin-5
T141 1293-1301 Q91049 denotes occludin
T142 1293-1301 Q6P6T5 denotes occludin
T143 1293-1301 Q9PUN1 denotes occludin
T144 1293-1301 Q16625 denotes occludin
T145 1293-1301 PR:000002207 denotes occludin
T146 1293-1301 Q61146 denotes occludin
T147 1293-1301 Q28269 denotes occludin
T148 1293-1301 Q28793 denotes occludin
T149 1293-1301 Q5RFS5 denotes occludin
T140 1293-1301 D062793 denotes occludin
T150 1307-1311 PR:P39447 denotes ZO-1
T151 1307-1311 PR:Q07157 denotes ZO-1
T152 1307-1311 PR:000016364 denotes ZO-1
T153 1372-1375 Q41249 denotes PCR
T154 1372-1375 O66148 denotes PCR
T155 1372-1375 Q59987 denotes PCR
T156 1372-1375 Q01289 denotes PCR
T157 1372-1375 O80333 denotes PCR
T158 1372-1375 P15904 denotes PCR
T159 1372-1375 Q9SDT1 denotes PCR
T160 1372-1375 Q39617 denotes PCR
T161 1395-1402 4716 denotes gelatin
T162 1395-1402 D005780 denotes gelatin
T163 1395-1402 CHEBI:5291 denotes gelatin
T164 1441-1445 SO:0000704 denotes gene
T169 1450-1457 SO:0000104 denotes protein
T168 1450-1457 PR:000000001 denotes protein
T166 1450-1457 CHEBI:36080 denotes protein
T167 1450-1457 CHEBI:11122 denotes protein
T165 1450-1457 GO:0003675 denotes protein
T170 1487-1493 UBERON:0027368 denotes matrix
T171 1487-1512 D020782 denotes matrix metalloproteinases
T173 1514-1518 D020782 denotes MMPs
T174 1520-1523 CHEBI:340824 denotes MMP
T177 1520-1523 CHEBI:59761 denotes MMP
T178 1520-1525 PR:P08253 denotes MMP-2
T179 1520-1525 Q9GLE5 denotes MMP-2
T180 1520-1525 P08253 denotes MMP-2
T181 1520-1525 Q90611 denotes MMP-2
T183 1520-1525 PR:Q8MPP3 denotes MMP-2
T184 1520-1525 P33436 denotes MMP-2
T185 1520-1525 PR:Q90611 denotes MMP-2
T186 1520-1525 PR:P33436 denotes MMP-2
T187 1520-1525 PR:000010479 denotes MMP-2
T188 1520-1525 PR:P33434 denotes MMP-2
T189 1520-1525 P33434 denotes MMP-2
T190 1520-1525 P50757 denotes MMP-2
T182 1520-1525 GO:0004228 denotes MMP-2
T191 1530-1533 CHEBI:340824 denotes MMP
T194 1530-1533 CHEBI:59761 denotes MMP
T195 1530-1535 PR:P50282 denotes MMP-9
T196 1530-1535 PR:P14780 denotes MMP-9
T197 1530-1535 P14780 denotes MMP-9
T198 1530-1535 PR:P41245 denotes MMP-9
T199 1530-1535 P41246 denotes MMP-9
T200 1530-1535 P41245 denotes MMP-9
T201 1530-1535 PR:P52176 denotes MMP-9
T202 1530-1535 P50282 denotes MMP-9
T204 1530-1535 PR:000010491 denotes MMP-9
T205 1530-1535 P52176 denotes MMP-9
T206 1530-1535 O18733 denotes MMP-9
T203 1530-1535 GO:0004229 denotes MMP-9
T207 1607-1615 D007511 denotes ischemia
T208 1607-1615 D007511 denotes ischemia
T212 1659-1670 3640 denotes doxycycline
T209 1659-1670 CHEBI:60648 denotes doxycycline
T210 1659-1670 D004318 denotes doxycycline
T211 1659-1670 CHEBI:50845 denotes doxycycline
T213 1659-1670 D004318 denotes doxycycline
T217 1692-1703 3640 denotes doxycycline
T214 1692-1703 CHEBI:60648 denotes doxycycline
T215 1692-1703 D004318 denotes doxycycline
T216 1692-1703 CHEBI:50845 denotes doxycycline
T218 1692-1703 D004318 denotes doxycycline
T219 1761-1764 P34722 denotes PKC
T220 1761-1764 P13678 denotes PKC
T221 1761-1764 P05130 denotes PKC
T223 1761-1764 PR:000045382 denotes PKC
T222 1761-1764 GO:0004697 denotes PKC
T224 1761-1764 C537180 denotes PKC
T227 1766-1770 SO:0000234 denotes mRNA
T225 1766-1770 D012333 denotes mRNA
T226 1766-1770 CHEBI:33699 denotes mRNA
T232 1775-1782 SO:0000104 denotes protein
T231 1775-1782 PR:000000001 denotes protein
T228 1775-1782 GO:0003675 denotes protein
T229 1775-1782 CHEBI:36080 denotes protein
T230 1775-1782 CHEBI:11122 denotes protein
T233 1789-1797 D007511 denotes ischemia
T234 1789-1797 D007511 denotes ischemia
T238 1866-1877 3640 denotes doxycycline
T235 1866-1877 CHEBI:60648 denotes doxycycline
T236 1866-1877 D004318 denotes doxycycline
T237 1866-1877 CHEBI:50845 denotes doxycycline
T239 1866-1877 D004318 denotes doxycycline
T240 1886-1889 UBERON:0000120 denotes BBB
T241 1947-1957 GO:0065007 denotes regulation
T242 1961-1975 GO:0070160 denotes tight junction
T243 1961-1984 D062725 denotes tight junction proteins
T245 1967-1975 SO:0000699 denotes junction
T244 1967-1975 UBERON:0007651 denotes junction
T247 2003-2006 CHEBI:340824 denotes MMP
T250 2003-2006 CHEBI:59761 denotes MMP
T251 2003-2008 PR:P08253 denotes MMP-2
T252 2003-2008 Q9GLE5 denotes MMP-2
T253 2003-2008 P08253 denotes MMP-2
T254 2003-2008 Q90611 denotes MMP-2
T256 2003-2008 PR:Q8MPP3 denotes MMP-2
T257 2003-2008 P33436 denotes MMP-2
T258 2003-2008 PR:Q90611 denotes MMP-2
T259 2003-2008 PR:P33436 denotes MMP-2
T260 2003-2008 PR:000010479 denotes MMP-2
T261 2003-2008 PR:P33434 denotes MMP-2
T262 2003-2008 P33434 denotes MMP-2
T263 2003-2008 P50757 denotes MMP-2
T255 2003-2008 GO:0004228 denotes MMP-2
T264 2007-2013 PR:O04529 denotes 2, MMP
T265 2010-2013 CHEBI:340824 denotes MMP
T268 2010-2013 CHEBI:59761 denotes MMP
T269 2010-2015 PR:P50282 denotes MMP-9
T270 2010-2015 PR:P14780 denotes MMP-9
T271 2010-2015 P14780 denotes MMP-9
T272 2010-2015 PR:P41245 denotes MMP-9
T273 2010-2015 P41246 denotes MMP-9
T274 2010-2015 P41245 denotes MMP-9
T275 2010-2015 PR:P52176 denotes MMP-9
T276 2010-2015 P50282 denotes MMP-9
T278 2010-2015 PR:000010491 denotes MMP-9
T279 2010-2015 P52176 denotes MMP-9
T280 2010-2015 O18733 denotes MMP-9
T277 2010-2015 GO:0004229 denotes MMP-9
T281 2021-2024 P34722 denotes PKC
T282 2021-2024 P13678 denotes PKC
T283 2021-2024 P05130 denotes PKC
T285 2021-2024 PR:000045382 denotes PKC
T284 2021-2024 GO:0004697 denotes PKC
T286 2021-2024 C537180 denotes PKC

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 160-359 DRI_Challenge denotes The strategy for the development of effective and safe neuroprotective agents has great potential to reduce cerebral ischemia-reperfusion injury and improve the functional outcome in stroke patients.
T2 360-552 DRI_Challenge denotes Recently, doxycycline, a tetracycline antibiotic, has been shown to have neuroprotective efficiency in reduction of a variety of ischemia-reperfusion injuries as well as ischemic brain damage.
T3 553-778 DRI_Approach denotes We used the rat models of middle cerebral artery occlusion (MCAO) and reperfusion to investigate the effects of treatments with doxycycline against the blood-brain barrier (BBB) leakage at 3, 12, 72, and 120 h of reperfusion.
T4 779-937 DRI_Background denotes Male Sprague-Dawley rats were subjected to MCAO for 2 h followed by reperfusion for 3, 12, 72, and 120 h and received either doxycycline (45 mg/kg) or saline.
T5 938-1113 DRI_Outcome denotes The results showed that the treatment of doxycycline significantly reduced the BBB leakage and cerebral infarct volume, which were proved by Evans blue assay and TTC staining.
T6 1114-1346 DRI_Background denotes Real-time PCR, immunohistochemistry, and western blot assay verified that the administration of doxycycline significantly up-regulated the expression of tight junction claudin-5, occludin, and ZO-1 from 3 to 120 h after reperfusion.
T7 1347-1681 DRI_Outcome denotes The results of real-time PCR, western blot, and gelatin zymography analyses revealed that the gene and protein expression and activities of matrix metalloproteinases (MMPs) MMP-2 and MMP-9 were significantly elevated in a different time-dependent manner after ischemia-reperfusion but significantly inhibited by doxycycline treatment.
T8 1682-1810 DRI_Outcome denotes Moreover, doxycycline could also significantly down-regulate the expression of PKCδ mRNA and protein after ischemia-reperfusion.
T9 1811-2026 DRI_Background denotes These results suggested that the protective effects of doxycycline against BBB damage induced by reperfusion might be related to the up-regulation of tight junction proteins and inhibition of MMP-2, MMP-9, and PKCδ.

Allie

Id Subject Object Predicate Lexical cue
SS1_22173873_3_0 579-611 expanded denotes middle cerebral artery occlusion
SS2_22173873_3_0 613-617 abbr denotes MCAO
SS1_22173873_3_1 705-724 expanded denotes blood-brain barrier
SS2_22173873_3_1 726-729 abbr denotes BBB
SS1_22173873_7_0 1487-1512 expanded denotes matrix metalloproteinases
SS2_22173873_7_0 1514-1518 abbr denotes MMPs
AE1_22173873_3_0 SS1_22173873_3_0 SS2_22173873_3_0 abbreviatedTo middle cerebral artery occlusion,MCAO
AE1_22173873_3_1 SS1_22173873_3_1 SS2_22173873_3_1 abbreviatedTo blood-brain barrier,BBB
AE1_22173873_7_0 SS1_22173873_7_0 SS2_22173873_7_0 abbreviatedTo matrix metalloproteinases,MMPs

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 268-285 HP_0002637 denotes cerebral ischemia
T2 343-349 HP_0001297 denotes stroke