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PubMed:22166430 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 10090 denotes Mouse
T2 0-5 D051379 denotes Mouse
T3 17-22 PR:Q5S006 denotes LRRK2
T4 17-22 PR:000003033 denotes LRRK2
T5 17-22 PR:Q5S007 denotes LRRK2
T10 23-42 D010300 denotes Parkinson's disease
T11 23-42 D010300 denotes Parkinson's disease
T14 56-63 D004194 denotes disease
T15 56-63 D004194 denotes disease
T18 95-120 D019636 denotes neurodegenerative disease
T19 95-120 D019636 denotes neurodegenerative disease
T23 135-142 6308 denotes Leucine
T24 135-142 SO:0001437 denotes Leucine
T22 135-142 CHEBI:15603 denotes Leucine
T25 135-142 D007930 denotes Leucine
T26 135-142 CHEBI:25017 denotes Leucine
T27 135-142 D007930 denotes Leucine
T28 148-154 SO:0001068 denotes repeat
T29 165-170 PR:Q5S006 denotes LRRK2
T30 165-170 PR:000003033 denotes LRRK2
T31 165-170 PR:Q5S007 denotes LRRK2
T32 187-191 SO:0000704 denotes gene
T35 196-201 PR:000003033 denotes PARK8
T36 196-201 PR:Q5S007 denotes PARK8
T34 196-201 607060 denotes PARK8
T37 215-233 C566739 denotes autosomal dominant
T38 319-325 D000818 denotes Animal
T39 399-404 PR:Q5S006 denotes LRRK2
T40 399-404 PR:000003033 denotes LRRK2
T41 399-404 PR:Q5S007 denotes LRRK2
T42 414-426 GO:0009405 denotes pathogenesis
T43 446-451 D006801 denotes human
T44 452-483 SO:0000153 denotes Bacterial Artificial Chromosome
T45 473-483 GO:0005694 denotes Chromosome
T47 485-488 SO:0000153 denotes BAC
T48 499-509 SO:0000781 denotes transgenic
T49 499-515 D008822 denotes transgenic mouse
T52 541-546 PR:Q5S006 denotes LRRK2
T53 541-546 PR:000003033 denotes LRRK2
T54 541-546 PR:Q5S007 denotes LRRK2
T55 643-647 PR:000005054 denotes mice
T57 643-647 O89094 denotes mice
T56 643-647 D051379 denotes mice
T58 643-647 10095 denotes mice
T59 685-699 GO:0003774 denotes motor activity
T61 751-759 6375 denotes levodopa
T60 751-759 D007980 denotes levodopa
T62 751-759 CHEBI:15765 denotes levodopa
T63 751-759 D007980 denotes levodopa
T64 898-901 PR:P16525 denotes tau
T65 898-901 PR:000024142 denotes tau
T66 898-901 PR:P10636 denotes tau
T67 898-901 PR:000010173 denotes tau
T68 898-901 PR:P19332 denotes tau
T70 898-901 PR:P10637 denotes tau
T69 898-901 CHEBI:36355 denotes tau
T71 907-911 PR:000005054 denotes mice
T73 907-911 O89094 denotes mice
T72 907-911 D051379 denotes mice
T74 907-911 10095 denotes mice
T75 938-946 CHEBI:59905 denotes dopamine
T76 938-946 CHEBI:18243 denotes dopamine
T77 938-946 D004298 denotes dopamine
T78 938-946 D004298 denotes dopamine
T79 938-946 3628 denotes dopamine
T80 982-987 UBERON:6110636 denotes brain
T81 982-987 UBERON:0000955 denotes brain
T85 1048-1059 MGI:1913975 denotes LRRK2 mouse
T86 1054-1059 10090 denotes mouse
T87 1054-1059 D051379 denotes mouse

Allie

Id Subject Object Predicate Lexical cue
SS1_22166430_1_0 44-63 expanded denotes Parkinson's disease
SS2_22166430_1_0 65-67 abbr denotes PD
SS1_22166430_2_0 135-163 expanded denotes Leucine-rich-repeat-kinase 2
SS2_22166430_2_0 165-170 abbr denotes LRRK2
SS1_22166430_4_0 452-483 expanded denotes Bacterial Artificial Chromosome
SS2_22166430_4_0 485-488 abbr denotes BAC
AE1_22166430_1_0 SS1_22166430_1_0 SS2_22166430_1_0 abbreviatedTo Parkinson's disease,PD
AE1_22166430_2_0 SS1_22166430_2_0 SS2_22166430_2_0 abbreviatedTo Leucine-rich-repeat-kinase 2,LRRK2
AE1_22166430_4_0 SS1_22166430_4_0 SS2_22166430_4_0 abbreviatedTo Bacterial Artificial Chromosome,BAC

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 44-121 DRI_Background denotes Parkinson's disease (PD) is the second most common neurodegenerative disease.
T2 122-318 DRI_Outcome denotes Mutations in Leucine-rich-repeat-kinase 2 (LRRK2), the causative gene for PARK8 type PD with autosomal dominant inheritance, are the most prevalent genetic causes of both familial and sporadic PD.
T3 319-427 DRI_Background denotes Animal models are critical tools in the attempt to understand the mechanisms of LRRK2-mediated pathogenesis.
T4 428-636 DRI_Outcome denotes We have generated human Bacterial Artificial Chromosome (BAC) mediated transgenic mouse models expressing mutant LRRK2 that robustly recapitulate the behavioral, neurochemical and pathological features of PD.
T5 637-760 DRI_Background denotes These mice develop an age-dependent decrease in motor activity that is progressive and responds to treatment with levodopa.
T6 761-902 DRI_Background denotes Pathologically, the most salient phenotype is early axonopathy of nigrostriatal dopaminergic neurons, accompanied by hyperphosphorylated tau.
T7 903-1026 DRI_Outcome denotes The mice also exhibit a consistent dopamine transmission deficit in both acute brain slices and live freely moving animals.
T8 1027-1186 DRI_Outcome denotes Here we will discuss LRRK2 mouse models from several laboratories, their commonalities and differences, and offer scientific insights drawn from these studies.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 44-53 HP_0001300 denotes Parkinson
T2 215-245 HP_0000006 denotes autosomal dominant inheritance
T3 215-233 HP_0000006 denotes autosomal dominant

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22166430-0#17#22#gene120892 17-22 gene120892 denotes LRRK2
22166430-0#23#42#diseaseC0030567 23-42 diseaseC0030567 denotes Parkinson's disease
17#22#gene12089223#42#diseaseC0030567 22166430-0#17#22#gene120892 22166430-0#23#42#diseaseC0030567 associated_with LRRK2,Parkinson's disease