PubMed:22131818
Annnotations
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-97 | Sentence | denotes | Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. |
| T2 | 98-251 | Sentence | denotes | Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients. |
| T3 | 252-346 | Sentence | denotes | It is not known whether these alleles are associated with specific clinical phenotypes in SLE. |
| T4 | 347-503 | Sentence | denotes | We studied 252 well-characterized SLE patients from a multiethnic cohort, genotyping the rs11730582, rs28357094, rs6532040, and rs9138 SNPs in the OPN gene. |
| T5 | 504-575 | Sentence | denotes | Ancestry informative markers were used to control for genetic ancestry. |
| T6 | 576-772 | Sentence | denotes | The SLE-risk allele rs9138C in the 3' UTR region was associated with photosensitivity in lupus patients across all ancestral backgrounds (meta-analysis OR = 3.2, 95% CI = 1.6-6.5, P = 1.0 × 10⁻³). |
| T7 | 773-980 | Sentence | denotes | Additionally, the promoter variant rs11730582C demonstrated suggestive evidence for association with two hematologic traits: thrombocytopenia (OR = 2.1, P = 0.023) and hemolytic anemia (OR = 2.6, P = 0.036). |
| T8 | 981-1224 | Sentence | denotes | These clinical associations with SNPs in the promoter and 3' UTR regions align with previously reported SLE-susceptibility SNPs in OPN and suggest potential roles for these variants in antibody-mediated cytopenias and skin inflammation in SLE. |
| T1 | 0-97 | Sentence | denotes | Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. |
| T2 | 98-251 | Sentence | denotes | Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients. |
| T3 | 252-346 | Sentence | denotes | It is not known whether these alleles are associated with specific clinical phenotypes in SLE. |
| T4 | 347-503 | Sentence | denotes | We studied 252 well-characterized SLE patients from a multiethnic cohort, genotyping the rs11730582, rs28357094, rs6532040, and rs9138 SNPs in the OPN gene. |
| T5 | 504-575 | Sentence | denotes | Ancestry informative markers were used to control for genetic ancestry. |
| T6 | 576-772 | Sentence | denotes | The SLE-risk allele rs9138C in the 3' UTR region was associated with photosensitivity in lupus patients across all ancestral backgrounds (meta-analysis OR = 3.2, 95% CI = 1.6-6.5, P = 1.0 × 10⁻³). |
| T7 | 773-980 | Sentence | denotes | Additionally, the promoter variant rs11730582C demonstrated suggestive evidence for association with two hematologic traits: thrombocytopenia (OR = 2.1, P = 0.023) and hemolytic anemia (OR = 2.6, P = 0.036). |
| T8 | 981-1224 | Sentence | denotes | These clinical associations with SNPs in the promoter and 3' UTR regions align with previously reported SLE-susceptibility SNPs in OPN and suggest potential roles for these variants in antibody-mediated cytopenias and skin inflammation in SLE. |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-97 | Sentence | denotes | Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. |
| TextSentencer_T2 | 98-251 | Sentence | denotes | Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients. |
| TextSentencer_T3 | 252-346 | Sentence | denotes | It is not known whether these alleles are associated with specific clinical phenotypes in SLE. |
| TextSentencer_T4 | 347-503 | Sentence | denotes | We studied 252 well-characterized SLE patients from a multiethnic cohort, genotyping the rs11730582, rs28357094, rs6532040, and rs9138 SNPs in the OPN gene. |
| TextSentencer_T5 | 504-575 | Sentence | denotes | Ancestry informative markers were used to control for genetic ancestry. |
| TextSentencer_T6 | 576-772 | Sentence | denotes | The SLE-risk allele rs9138C in the 3' UTR region was associated with photosensitivity in lupus patients across all ancestral backgrounds (meta-analysis OR = 3.2, 95% CI = 1.6-6.5, P = 1.0 × 10⁻³). |
| TextSentencer_T7 | 773-980 | Sentence | denotes | Additionally, the promoter variant rs11730582C demonstrated suggestive evidence for association with two hematologic traits: thrombocytopenia (OR = 2.1, P = 0.023) and hemolytic anemia (OR = 2.6, P = 0.036). |
| TextSentencer_T8 | 981-1224 | Sentence | denotes | These clinical associations with SNPs in the promoter and 3' UTR regions align with previously reported SLE-susceptibility SNPs in OPN and suggest potential roles for these variants in antibody-mediated cytopenias and skin inflammation in SLE. |
| T1 | 0-97 | Sentence | denotes | Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. |
| T2 | 98-251 | Sentence | denotes | Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients. |
| T3 | 252-346 | Sentence | denotes | It is not known whether these alleles are associated with specific clinical phenotypes in SLE. |
| T4 | 347-503 | Sentence | denotes | We studied 252 well-characterized SLE patients from a multiethnic cohort, genotyping the rs11730582, rs28357094, rs6532040, and rs9138 SNPs in the OPN gene. |
| T5 | 504-575 | Sentence | denotes | Ancestry informative markers were used to control for genetic ancestry. |
| T6 | 576-772 | Sentence | denotes | The SLE-risk allele rs9138C in the 3' UTR region was associated with photosensitivity in lupus patients across all ancestral backgrounds (meta-analysis OR = 3.2, 95% CI = 1.6-6.5, P = 1.0 × 10⁻³). |
| T7 | 773-980 | Sentence | denotes | Additionally, the promoter variant rs11730582C demonstrated suggestive evidence for association with two hematologic traits: thrombocytopenia (OR = 2.1, P = 0.023) and hemolytic anemia (OR = 2.6, P = 0.036). |
| T8 | 981-1224 | Sentence | denotes | These clinical associations with SNPs in the promoter and 3' UTR regions align with previously reported SLE-susceptibility SNPs in OPN and suggest potential roles for these variants in antibody-mediated cytopenias and skin inflammation in SLE. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-11 | gene:6696 | denotes | Osteopontin |
| T1 | 68-96 | disease:C0024141 | denotes | systemic lupus erythematosus |
| R1 | T0 | T1 | associated_with | Osteopontin,systemic lupus erythematosus |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22131818_1_0 | 114-125 | expanded | denotes | osteopontin |
| SS2_22131818_1_0 | 127-130 | abbr | denotes | OPN |
| SS1_22131818_1_1 | 163-191 | expanded | denotes | systemic lupus erythematosus |
| SS2_22131818_1_1 | 193-196 | abbr | denotes | SLE |
| AE1_22131818_1_0 | SS1_22131818_1_0 | SS2_22131818_1_0 | abbreviatedTo | osteopontin,OPN |
| AE1_22131818_1_1 | SS1_22131818_1_1 | SS2_22131818_1_1 | abbreviatedTo | systemic lupus erythematosus,SLE |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 163-191 | HP_0002725 | denotes | systemic lupus erythematosus |
| T2 | 645-661 | HP_0000992 | denotes | photosensitivity |
| T3 | 898-914 | HP_0001873 | denotes | thrombocytopenia |
| T4 | 941-957 | HP_0001878 | denotes | hemolytic anemia |
| T5 | 951-957 | HP_0001903 | denotes | anemia |
| T6 | 1199-1216 | HP_0011123 | denotes | skin inflammation |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22131818-0#0#11#gene6696 | 0-11 | gene6696 | denotes | Osteopontin |
| 22131818-0#68#96#diseaseC0024141 | 68-96 | diseaseC0024141 | denotes | systemic lupus erythematosus |
| 22131818-7#131#134#gene6696 | 1112-1115 | gene6696 | denotes | OPN |
| 22131818-7#218#235#diseaseC0011603 | 1199-1216 | diseaseC0011603 | denotes | skin inflammation |
| 22131818-7#218#235#diseaseC3875321 | 1199-1216 | diseaseC3875321 | denotes | skin inflammation |
| 0#11#gene669668#96#diseaseC0024141 | 22131818-0#0#11#gene6696 | 22131818-0#68#96#diseaseC0024141 | associated_with | Osteopontin,systemic lupus erythematosus |
| 131#134#gene6696218#235#diseaseC0011603 | 22131818-7#131#134#gene6696 | 22131818-7#218#235#diseaseC0011603 | associated_with | OPN,skin inflammation |
| 131#134#gene6696218#235#diseaseC3875321 | 22131818-7#131#134#gene6696 | 22131818-7#218#235#diseaseC3875321 | associated_with | OPN,skin inflammation |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2216 | 1112-1115 | gene:6696 | denotes | OPN |
| T2217 | 1199-1216 | disease:C0011603 | denotes | skin inflammation |
| R1 | T2216 | T2217 | associated_with | OPN,skin inflammation |
| R2 | T2216 | T2217 | associated_with | OPN,skin inflammation |