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PubMed:22128166 JSON TXT

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GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	64-67	Glycan_Motif	denotes	Gm1	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T3	107-112	Glycan_Motif	denotes	G(M1)	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T5	438-443	Glycan_Motif	denotes	G(M1)	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T7	461-476	Glycan_Motif	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW
T8	556-565	Glycan_Motif	denotes	galactose	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T10	669-678	Glycan_Motif	denotes	galactose	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE

Glycosmos6-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glyco_epitope_db_id
T1	461-476	GlycoEpitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	64-67	https://glytoucan.org/Structures/Glycans/G46613JI	denotes	Gm1
T2	64-67	https://glytoucan.org/Structures/Glycans/G48558GR	denotes	Gm1
T3	107-112	https://glytoucan.org/Structures/Glycans/G46613JI	denotes	G(M1)
T4	107-112	https://glytoucan.org/Structures/Glycans/G48558GR	denotes	G(M1)
T5	438-443	https://glytoucan.org/Structures/Glycans/G46613JI	denotes	G(M1)
T6	438-443	https://glytoucan.org/Structures/Glycans/G48558GR	denotes	G(M1)
T7	461-476	https://glytoucan.org/Structures/Glycans/G82109MW	denotes	keratan sulfate
T8	556-565	https://glytoucan.org/Structures/Glycans/G65889KE	denotes	galactose
T9	556-565	https://glytoucan.org/Structures/Glycans/G68158BT	denotes	galactose
T10	669-678	https://glytoucan.org/Structures/Glycans/G65889KE	denotes	galactose
T11	669-678	https://glytoucan.org/Structures/Glycans/G68158BT	denotes	galactose

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-106	Sentence	denotes	Crystal structure of human β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases.
T2	107-291	Sentence	denotes	G(M1) gangliosidosis and Morquio B are autosomal recessive lysosomal storage diseases associated with a neurodegenerative disorder or dwarfism and skeletal abnormalities, respectively.
T3	292-575	Sentence	denotes	These diseases are caused by deficiencies in the lysosomal enzyme β-d-galactosidase (β-Gal), which lead to accumulations of the β-Gal substrates, G(M1) ganglioside, and keratan sulfate. β-Gal is an exoglycosidase that catalyzes the hydrolysis of terminal β-linked galactose residues.
T4	576-727	Sentence	denotes	This study shows the crystal structures of human β-Gal in complex with its catalytic product galactose or with its inhibitor 1-deoxygalactonojirimycin.
T5	728-823	Sentence	denotes	Human β-Gal is composed of a catalytic TIM barrel domain followed by β-domain 1 and β-domain 2.
T6	824-989	Sentence	denotes	To gain structural insight into the molecular defects of β-Gal in the above diseases, the disease-causing mutations were mapped onto the three-dimensional structure.
T7	990-1049	Sentence	denotes	Finally, the possible causes of the diseases are discussed.

DisGeNET

Id	Subject	Object	Predicate	Lexical cue
T0	27-42	gene:2720	denotes	β-galactosidase
T1	64-82	disease:C0085131	denotes	Gm1 gangliosidosis
R1	T0	T1	associated_with	β-galactosidase,Gm1 gangliosidosis

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	146-165	HP_0000007	denotes	autosomal recessive
T2	241-249	HP_0003510	denotes	dwarfism
T3	254-276	HP_0000924	denotes	skeletal abnormalities

Allie

Id	Subject	Object	Predicate	Lexical cue
SS1_22128166_2_0	358-375	expanded	denotes	β-d-galactosidase
SS2_22128166_2_0	377-382	abbr	denotes	β-Gal
AE1_22128166_2_0	SS1_22128166_2_0	SS2_22128166_2_0	abbreviatedTo	β-d-galactosidase,β-Gal

DisGeNET5_gene_disease

Id	Subject	Object	Predicate	Lexical cue
22128166-0#27#42#gene2720	27-42	gene2720	denotes	β-galactosidase
22128166-0#64#82#diseaseC0085131	64-82	diseaseC0085131	denotes	Gm1 gangliosidosis
27#42#gene272064#82#diseaseC0085131	22128166-0#27#42#gene2720	22128166-0#64#82#diseaseC0085131	associated_with	β-galactosidase,Gm1 gangliosidosis

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	64-67	Glycan	denotes	Gm1	https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2	107-112	Glycan	denotes	G(M1)	https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3	438-443	Glycan	denotes	G(M1)	https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4	461-476	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	241-249	Phenotype	denotes	dwarfism	HP:0003510
T2	254-276	Phenotype	denotes	skeletal abnormalities	HP:0000924

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	64-82	Disease	denotes	Gm1 gangliosidosis	http://purl.obolibrary.org/obo/MONDO_0018149
T2	107-127	Disease	denotes	G(M1) gangliosidosis	http://purl.obolibrary.org/obo/MONDO_0018149
T3	166-192	Disease	denotes	lysosomal storage diseases	http://purl.obolibrary.org/obo/MONDO_0002561

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	461-476	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW

GlyCosmos-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	461-476	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

GlyCosmos15-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	241-249	Phenotype	denotes	dwarfism	HP:0003510
T2	254-276	Phenotype	denotes	skeletal abnormalities	HP:0000924

GlyCosmos15-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	64-82	Disease	denotes	Gm1 gangliosidosis	MONDO:0018149
T2	107-127	Disease	denotes	G(M1) gangliosidosis	MONDO:0018149
T3	166-192	Disease	denotes	lysosomal storage diseases	MONDO:0002561

GlyCosmos15-Taxon

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	21-26	Organism	denotes	human	9606
T2	619-624	Organism	denotes	human	9606
T3	728-733	Organism	denotes	Human	9606

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-106	Sentence	denotes	Crystal structure of human β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases.
T2	107-291	Sentence	denotes	G(M1) gangliosidosis and Morquio B are autosomal recessive lysosomal storage diseases associated with a neurodegenerative disorder or dwarfism and skeletal abnormalities, respectively.
T3	292-575	Sentence	denotes	These diseases are caused by deficiencies in the lysosomal enzyme β-d-galactosidase (β-Gal), which lead to accumulations of the β-Gal substrates, G(M1) ganglioside, and keratan sulfate. β-Gal is an exoglycosidase that catalyzes the hydrolysis of terminal β-linked galactose residues.
T4	576-727	Sentence	denotes	This study shows the crystal structures of human β-Gal in complex with its catalytic product galactose or with its inhibitor 1-deoxygalactonojirimycin.
T5	728-823	Sentence	denotes	Human β-Gal is composed of a catalytic TIM barrel domain followed by β-domain 1 and β-domain 2.
T6	824-989	Sentence	denotes	To gain structural insight into the molecular defects of β-Gal in the above diseases, the disease-causing mutations were mapped onto the three-dimensional structure.
T7	990-1049	Sentence	denotes	Finally, the possible causes of the diseases are discussed.

GlyCosmos15-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	461-476	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

GlyCosmos15-FMA

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	146-155	Body_part	denotes	autosomal	FMA:74406
T2	166-175	Body_part	denotes	lysosomal	FMA:63836
T3	341-350	Body_part	denotes	lysosomal	FMA:63836

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	21-26	OrganismTaxon	denotes	human	9606
T2	619-624	OrganismTaxon	denotes	human	9606
T3	728-733	OrganismTaxon	denotes	Human	9606