Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-143 |
Sentence |
denotes |
Characterization of a new erythroid/megakaryocyte-specific nuclear factor that binds the promoter of the housekeeping human glycophorin C gene. |
T2 |
144-280 |
Sentence |
denotes |
Human glycophorin C (GPC) is an integral membrane protein found in many cell types but which exhibits increased expression in red cells. |
T3 |
281-476 |
Sentence |
denotes |
We have investigated the in vitro binding of nuclear protein factors to the GPC gene 5'-flanking region which was transcriptionally active when transfected into erythroid and non-erythroid cells. |
T4 |
477-650 |
Sentence |
denotes |
We found that in addition to known ubiquitous or erythroid trans-acting factors, a presently uncharacterized erythroid/megakaryocyte-specific protein binds the GPC promoter. |
T5 |
651-860 |
Sentence |
denotes |
This factor, that we called NFE-6, is present in embryonic, fetal, or adult-like human or mouse erythroleukemic cell lines, in a megakaryoblastic cell line, but not in lymphoid or non-hematopoietic cell lines. |
T6 |
861-1000 |
Sentence |
denotes |
These data suggest that NFE-6, like the well characterized NFE-1 factor, is tissue- but not stage-specific and is conserved across species. |
T7 |
1001-1155 |
Sentence |
denotes |
It is proposed that NFE-6 might be involved in the quantitative change in the expression of the house-keeping GPC gene related to red cell specialization. |
T1 |
0-143 |
Sentence |
denotes |
Characterization of a new erythroid/megakaryocyte-specific nuclear factor that binds the promoter of the housekeeping human glycophorin C gene. |
T2 |
144-280 |
Sentence |
denotes |
Human glycophorin C (GPC) is an integral membrane protein found in many cell types but which exhibits increased expression in red cells. |
T3 |
281-476 |
Sentence |
denotes |
We have investigated the in vitro binding of nuclear protein factors to the GPC gene 5'-flanking region which was transcriptionally active when transfected into erythroid and non-erythroid cells. |
T4 |
477-650 |
Sentence |
denotes |
We found that in addition to known ubiquitous or erythroid trans-acting factors, a presently uncharacterized erythroid/megakaryocyte-specific protein binds the GPC promoter. |
T5 |
651-860 |
Sentence |
denotes |
This factor, that we called NFE-6, is present in embryonic, fetal, or adult-like human or mouse erythroleukemic cell lines, in a megakaryoblastic cell line, but not in lymphoid or non-hematopoietic cell lines. |
T6 |
861-1000 |
Sentence |
denotes |
These data suggest that NFE-6, like the well characterized NFE-1 factor, is tissue- but not stage-specific and is conserved across species. |
T7 |
1001-1155 |
Sentence |
denotes |
It is proposed that NFE-6 might be involved in the quantitative change in the expression of the house-keeping GPC gene related to red cell specialization. |