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PubMed:2205477 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-32 protein denotes glucocorticoid binding sites
T2 40-69 protein denotes human glucocorticoid receptor
T3 123-137 cell_type denotes leukemic cells
T4 164-187 protein denotes glucocorticoid receptor
T5 189-191 protein denotes GR
T6 253-255 protein denotes GR
T7 493-505 cell_line denotes CEM C7 cells
T8 509-546 cell_line denotes human acute lymphoblastic T-cell line
T9 831-845 cell_type denotes leukemic cells
T10 996-1008 cell_line denotes CEM C7 cells
T11 1070-1102 protein denotes higher affinity CVZ binding site
T12 1186-1197 cell_line denotes B-cell line
T13 1199-1203 cell_line denotes IM-9
T14 1311-1330 protein denotes CVZ's binding sites
T15 1397-1399 protein denotes GR
T16 1540-1568 protein denotes glucocorticoid binding sites
T17 1582-1584 protein denotes GR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-70 Sentence denotes Two glucocorticoid binding sites on the human glucocorticoid receptor.
S2 71-193 Sentence denotes Glucocorticoids are known to have a lytic effect in leukemic cells via interactions with the glucocorticoid receptor (GR).
S3 194-279 Sentence denotes Cortisol and various synthetic glucocorticoids bind to the GR with one-site kinetics.
S4 280-548 Sentence denotes Cortivazol (CVZ) is a unique, high potency synthetic glucocorticoid, which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from CEM C7 cells (a human acute lymphoblastic T-cell line).
S5 549-696 Sentence denotes It has previously been shown that the lower affinity class of sites are similar in affinity and site molarity to those recognized by dexamethasone.
S6 697-820 Sentence denotes The higher affinity sites bind CVZ with 20- to 50-fold greater affinity, consistent with CVZ's enhanced biological effects.
S7 821-1009 Sentence denotes In mutant leukemic cells resistant to the lytic effects of dexamethasone, CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in CEM C7 cells.
S8 1010-1103 Sentence denotes We have carried out experiments to define the nature of the higher affinity CVZ binding site.
S9 1104-1491 Sentence denotes We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line, IM-9; 2) the antiglucocorticoid RU 38486 is able to block both CVZ's higher and lower affinity sites; 3) all of CVZ's binding sites are on a protein immunologically indistinguishable from the human GR; and 4) freshly isolated clones of CVZ-resistant cells have lost all binding sites for CVZ.
S10 1492-1617 Sentence denotes These data indicate that CVZ is recognizing two glucocorticoid binding sites on the human GR or a protein very similar to it.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-32 NP denotes Two glucocorticoid binding sites
C2 36-69 NP denotes the human glucocorticoid receptor
C3 160-192 NP denotes the glucocorticoid receptor (GR)
C4 249-255 NP denotes the GR
C5 280-296 NP denotes Cortivazol (CVZ)
C6 300-347 NP denotes a unique, high potency synthetic glucocorticoid
C7 349-354 NP denotes which
C8 493-547 NP denotes CEM C7 cells (a human acute lymphoblastic T-cell line)
C9 602-616 NP denotes class of sites
C10 662-667 NP denotes those
C11 682-695 NP denotes dexamethasone
C12 697-722 NP denotes The higher affinity sites
C13 728-731 NP denotes CVZ
C14 786-789 NP denotes CVZ
C16 880-893 NP denotes dexamethasone
C15 824-893 NP denotes mutant leukemic cells resistant to the lytic effects of dexamethasone
C17 895-898 NP denotes CVZ
C18 910-919 NP denotes the cells
C19 996-1008 NP denotes CEM C7 cells
C20 1066-1102 NP denotes the higher affinity CVZ binding site
C21 1125-1128 NP denotes CVZ
C22 1163-1197 NP denotes a second, independent, B-cell line
C23 1199-1203 NP denotes IM-9
C24 1262-1265 NP denotes CVZ
C26 1311-1314 NP denotes CVZ
C25 1304-1330 NP denotes all of CVZ's binding sites
C28 1487-1490 NP denotes CVZ
C27 1465-1490 NP denotes all binding sites for CVZ
C29 1517-1520 NP denotes CVZ
C30 1536-1568 NP denotes two glucocorticoid binding sites
C31 1572-1584 NP denotes the human GR
R1 C4 C3 coref-ident the GR,the glucocorticoid receptor (GR)
R2 C7 C6 coref-relat which,"a unique, high potency synthetic glucocorticoid"
R3 C10 C9 coref-pron those,class of sites
R4 C13 C5 coref-ident CVZ,Cortivazol (CVZ)
R5 C14 C13 coref-ident CVZ,CVZ
R6 C16 C11 coref-ident dexamethasone,dexamethasone
R7 C17 C14 coref-ident CVZ,CVZ
R8 C18 C15 coref-ident the cells,mutant leukemic cells resistant to the lytic effects of dexamethasone
R9 C19 C8 coref-ident CEM C7 cells,CEM C7 cells (a human acute lymphoblastic T-cell line)
R10 C20 C12 coref-ident the higher affinity CVZ binding site,The higher affinity sites
R11 C21 C17 coref-ident CVZ,CVZ
R12 C23 C22 coref-appos IM-9,"a second, independent, B-cell line"
R13 C24 C21 coref-ident CVZ,CVZ
R14 C26 C24 coref-ident CVZ,CVZ
R15 C28 C26 coref-ident CVZ,CVZ
R16 C27 C25 coref-ident all binding sites for CVZ,all of CVZ's binding sites
R17 C29 C28 coref-ident CVZ,CVZ
R18 C30 C1 coref-ident two glucocorticoid binding sites,Two glucocorticoid binding sites
R19 C31 C2 coref-ident the human GR,the human glucocorticoid receptor

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-32 protein_domain_or_region denotes glucocorticoid binding sites
T2 40-69 protein_family_or_group denotes human glucocorticoid receptor
T3 71-86 lipid denotes Glucocorticoids
T4 123-137 cell_type denotes leukemic cells
T5 164-187 protein_family_or_group denotes glucocorticoid receptor
T6 189-191 protein_family_or_group denotes GR
T7 194-202 lipid denotes Cortisol
T8 215-240 lipid denotes synthetic glucocorticoids
T9 253-255 protein_family_or_group denotes GR
T10 261-278 other_name denotes one-site kinetics
T11 280-290 other_organic_compound denotes Cortivazol
T12 292-295 other_organic_compound denotes CVZ
T13 323-347 other_organic_compound denotes synthetic glucocorticoid
T14 361-374 other_organic_compound denotes phenylpyrazol
T15 388-394 other_organic_compound denotes A-ring
T16 402-417 lipid denotes steroid nucleus
T17 493-505 cell_line denotes CEM C7 cells
T18 509-546 cell_line denotes human acute lymphoblastic T-cell line
T19 632-640 other_name denotes affinity
T20 645-658 other_name denotes site molarity
T21 682-695 lipid denotes dexamethasone
T22 701-707 other_name denotes higher
T23 708-716 other_name denotes affinity
T24 728-731 other_organic_compound denotes CVZ
T25 760-768 other_name denotes affinity
T26 786-789 other_organic_compound denotes CVZ
T27 801-819 other_name denotes biological effects
T28 831-845 cell_type denotes leukemic cells
T29 880-893 lipid denotes dexamethasone
T30 895-898 other_organic_compound denotes CVZ
T31 979-987 other_name denotes affinity
T32 996-1008 cell_line denotes CEM C7 cells
T33 1070-1076 protein_domain_or_region denotes higher
T34 1077-1085 other_name denotes affinity
T35 1086-1089 other_organic_compound denotes CVZ
T36 1125-1128 other_organic_compound denotes CVZ
T37 1186-1197 cell_line denotes B-cell line
T38 1199-1203 cell_line denotes IM-9
T39 1212-1230 other_name denotes antiglucocorticoid
T40 1231-1239 other_organic_compound denotes RU 38486
T41 1262-1265 other_organic_compound denotes CVZ
T42 1285-1293 other_name denotes affinity
T43 1311-1314 other_organic_compound denotes CVZ
T44 1397-1399 protein_family_or_group denotes GR
T45 1435-1438 other_organic_compound denotes CVZ
T46 1487-1490 other_organic_compound denotes CVZ
T47 1517-1520 other_organic_compound denotes CVZ
T48 1540-1568 protein_domain_or_region denotes glucocorticoid binding sites
T49 1582-1584 protein_family_or_group denotes GR