> top > docs > PubMed:22033923 > annotations

PubMed:22033923 JSONTXT

Annnotations TAB JSON ListView MergeView

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 704-713 http://purl.obolibrary.org/obo/MAT_0000279 denotes placentas

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
TextSentencer_T2 147-392 Sentence denotes Several recently published studies have suggested that decreasing VEGF levels result in placental oxidative stress in preeclampsia, although the question as to how decreased VEGF concentrations increase oxidative stress still remains unanswered.
TextSentencer_T3 393-530 Sentence denotes Here, we show that VEGF activated Nrf2, the main regulating factor of the intracellular redox balance, in the cytotrophic cell line BeWo.
TextSentencer_T4 531-736 Sentence denotes In turn, this activated the production of antioxidative enzymes thioredoxin, thioredoxin reductase, and heme oxygenase-1, which showed a decrease in their expression in the placentas of preeclamptic women.
TextSentencer_T5 737-810 Sentence denotes Nevertheless, this activation occurred without oxidative stress stimulus.
TextSentencer_T6 811-922 Sentence denotes As a consequence, the activation of Nrf2 protected BeWo cells against H(2)O(2)/Fe(2+)-induced oxidative damage.
TextSentencer_T7 923-987 Sentence denotes We further show that VEGF up-regulated the expression of itself.
TextSentencer_T8 988-1220 Sentence denotes A positive feedback loop was described in which VEGF activated Nrf2 in an ERK1/2-dependent manner; the up-regulation of HO-1 expression by Nrf2 augmented the production of carbon monoxide, which in turn up-regulated VEGF expression.
TextSentencer_T9 1221-1364 Sentence denotes In conclusion, VEGF induces the Nrf2 pathway to protect against oxidative stress and, via a positive feedback loop, to elevate VEGF expression.
TextSentencer_T10 1365-1595 Sentence denotes Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia.
T1 0-146 Sentence denotes Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.
T2 147-392 Sentence denotes Several recently published studies have suggested that decreasing VEGF levels result in placental oxidative stress in preeclampsia, although the question as to how decreased VEGF concentrations increase oxidative stress still remains unanswered.
T3 393-530 Sentence denotes Here, we show that VEGF activated Nrf2, the main regulating factor of the intracellular redox balance, in the cytotrophic cell line BeWo.
T4 531-736 Sentence denotes In turn, this activated the production of antioxidative enzymes thioredoxin, thioredoxin reductase, and heme oxygenase-1, which showed a decrease in their expression in the placentas of preeclamptic women.
T5 737-810 Sentence denotes Nevertheless, this activation occurred without oxidative stress stimulus.
T6 811-922 Sentence denotes As a consequence, the activation of Nrf2 protected BeWo cells against H(2)O(2)/Fe(2+)-induced oxidative damage.
T7 923-987 Sentence denotes We further show that VEGF up-regulated the expression of itself.
T8 988-1220 Sentence denotes A positive feedback loop was described in which VEGF activated Nrf2 in an ERK1/2-dependent manner; the up-regulation of HO-1 expression by Nrf2 augmented the production of carbon monoxide, which in turn up-regulated VEGF expression.
T9 1221-1364 Sentence denotes In conclusion, VEGF induces the Nrf2 pathway to protect against oxidative stress and, via a positive feedback loop, to elevate VEGF expression.
T10 1365-1595 Sentence denotes Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1253-1257 gene:4780 denotes Nrf2
T1 1295-1301 disease:C3825627 denotes stress
R1 T0 T1 associated_with Nrf2,stress

Allie

Id Subject Object Predicate Lexical cue
SS1_22033923_0_0 18-52 expanded denotes vascular endothelial growth factor
SS2_22033923_0_0 54-58 abbr denotes VEGF
SS1_22033923_0_1 64-107 expanded denotes nuclear factor erythroid 2-related factor-2
SS2_22033923_0_1 109-113 abbr denotes Nrf2
AE1_22033923_0_0 SS1_22033923_0_0 SS2_22033923_0_0 abbreviatedTo vascular endothelial growth factor,VEGF
AE1_22033923_0_1 SS1_22033923_0_1 SS2_22033923_0_1 abbreviatedTo nuclear factor erythroid 2-related factor-2,Nrf2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 265-277 HP_0100602 denotes preeclampsia
T2 1414-1426 HP_0100602 denotes preeclampsia
T3 1582-1594 HP_0100602 denotes preeclampsia

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 133-145 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 265-277 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 1414-1426 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1582-1594 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 133-145 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 265-277 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 717-729 ORPHA:275555 denotes preeclamptic
PD-Preeclampsia-B_T4 1414-1426 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 1582-1594 ORPHA:275555 denotes preeclampsia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 704-713 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T1 18-52 HGNC:VEGFA denotes vascular endothelial growth factor
PD-PreeclampsiaGenes-B_T2 18-52 HGNC:VEGFB denotes vascular endothelial growth factor
PD-PreeclampsiaGenes-B_T3 18-52 HGNC:VEGFC denotes vascular endothelial growth factor
PD-PreeclampsiaGenes-B_T4 64-90 HGNC:NFE2 denotes nuclear factor erythroid 2
PD-PreeclampsiaGenes-B_T5 635-651 HGNC:HMOX1 denotes heme oxygenase-1
PD-PreeclampsiaGenes-B_T6 635-649 HGNC:HMOX2 denotes heme oxygenase
PD-PreeclampsiaGenes-B_T7 595-606 HGNC:TXN denotes thioredoxin
PD-PreeclampsiaGenes-B_T8 608-619 HGNC:TXN denotes thioredoxin
PD-PreeclampsiaGenes-B_T9 608-629 HGNC:TXNRD3 denotes thioredoxin reductase
PD-PreeclampsiaGenes-B_T10 608-629 HGNC:TXNRD2 denotes thioredoxin reductase
PD-PreeclampsiaGenes-B_T11 608-629 HGNC:TXNRD1 denotes thioredoxin reductase

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 235-244 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental
PD-UBERON-AE-B_T2 704-713 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T3 1465-1474 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 704-713 Body_part denotes placentas http://purl.obolibrary.org/obo/MAT_0000279

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 133-145 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T2 265-277 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T3 1414-1426 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T4 1582-1594 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 467-480 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T2 704-713 Body_part denotes placentas http://purl.obolibrary.org/obo/UBERON_0001987

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 245-261 Phenotype denotes oxidative stress HP:0025464
T2 350-366 Phenotype denotes oxidative stress HP:0025464
T3 784-800 Phenotype denotes oxidative stress HP:0025464
T4 1285-1301 Phenotype denotes oxidative stress HP:0025464