PubMed:22027827
Annnotations
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 97-116 | Glycan_Motif | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48059CD|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45827GY |
T3 | 467-486 | Glycan_Motif | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48059CD|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45827GY |
T5 | 823-832 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
T7 | 834-837 | Glycan_Motif | denotes | Gal | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT |
T8 | 913-916 | Glycan_Motif | denotes | Gal | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT |
T9 | 1046-1049 | Glycan_Motif | denotes | Gal | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT |
T10 | 1236-1249 | Glycan_Motif | denotes | antigens by a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G58507AZ |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-127 | Sentence | denotes | Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. |
T2 | 128-294 | Sentence | denotes | Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. |
T3 | 295-444 | Sentence | denotes | Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement. |
T4 | 445-506 | Sentence | denotes | These strains share a lacto-N-neotetraose (nLc4) LOS α chain. |
T5 | 507-674 | Sentence | denotes | We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG. |
T6 | 675-748 | Sentence | denotes | We found that the nLc4 α chain conforms at least four different antigens. |
T7 | 749-925 | Sentence | denotes | We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue. |
T8 | 926-1110 | Sentence | denotes | IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains. |
T9 | 1111-1311 | Sentence | denotes | These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms. |
T10 | 1312-1549 | Sentence | denotes | Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 97-116 | https://glytoucan.org/Structures/Glycans/G45827GY | denotes | lacto-N-neotetraose |
T2 | 97-116 | https://glytoucan.org/Structures/Glycans/G48059CD | denotes | lacto-N-neotetraose |
T3 | 467-486 | https://glytoucan.org/Structures/Glycans/G45827GY | denotes | lacto-N-neotetraose |
T4 | 467-486 | https://glytoucan.org/Structures/Glycans/G48059CD | denotes | lacto-N-neotetraose |
T5 | 823-832 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
T6 | 823-832 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
T7 | 1236-1249 | https://glytoucan.org/Structures/Glycans/G58507AZ | denotes | antigens by a |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T1 | 97-116 | GlycoEpitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
T2 | 467-486 | GlycoEpitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 246-256 | http://purl.obolibrary.org/obo/MAT_0000446 | denotes | oropharynx |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_22027827_2_0 | 334-353 | expanded | denotes | lipooligosaccharide |
SS2_22027827_2_0 | 355-358 | abbr | denotes | LOS |
SS1_22027827_6_0 | 823-832 | expanded | denotes | galactose |
SS2_22027827_6_0 | 834-837 | abbr | denotes | Gal |
AE1_22027827_2_0 | SS1_22027827_2_0 | SS2_22027827_2_0 | abbreviatedTo | lipooligosaccharide,LOS |
AE1_22027827_6_0 | SS1_22027827_6_0 | SS2_22027827_6_0 | abbreviatedTo | galactose,Gal |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 246-256 | Body_part | denotes | oropharynx | http://purl.obolibrary.org/obo/MAT_0000446 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 52-73 | Disease | denotes | meningococcal disease | http://purl.obolibrary.org/obo/MONDO_0005373 |
T2 | 1438-1459 | Disease | denotes | meningococcal disease | http://purl.obolibrary.org/obo/MONDO_0005373 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 97-116 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
T2 | 467-486 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
T3 | 488-492 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T4 | 583-587 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T5 | 661-665 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T6 | 693-697 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T7 | 794-798 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T8 | 1032-1036 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T9 | 1359-1363 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 97-116 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
T2 | 467-486 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 52-73 | Disease | denotes | meningococcal disease | http://purl.obolibrary.org/obo/MONDO_0005373 |
T2 | 1438-1459 | Disease | denotes | meningococcal disease | http://purl.obolibrary.org/obo/MONDO_0005373 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 0-5 | OrganismTaxon | denotes | Human | 9606 |
T2 | 184-206 | OrganismTaxon | denotes | Neisseria meningitidis | 487 |
T3 | 295-300 | OrganismTaxon | denotes | Human | 9606 |
T4 | 427-432 | OrganismTaxon | denotes | human | 9606 |
T5 | 1170-1175 | OrganismTaxon | denotes | human | 9606 |
T6 | 1353-1358 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 246-256 | Body_part | denotes | oropharynx | http://purl.obolibrary.org/obo/UBERON_0001729 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 246-256 | Body_part | denotes | oropharynx | http://purl.obolibrary.org/obo/MAT_0000446 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-127 | Sentence | denotes | Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. |
T2 | 128-294 | Sentence | denotes | Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. |
T3 | 295-444 | Sentence | denotes | Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement. |
T4 | 445-506 | Sentence | denotes | These strains share a lacto-N-neotetraose (nLc4) LOS α chain. |
T5 | 507-674 | Sentence | denotes | We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG. |
T6 | 675-748 | Sentence | denotes | We found that the nLc4 α chain conforms at least four different antigens. |
T7 | 749-925 | Sentence | denotes | We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue. |
T8 | 926-1110 | Sentence | denotes | IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains. |
T9 | 1111-1311 | Sentence | denotes | These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms. |
T10 | 1312-1549 | Sentence | denotes | Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-127 | Sentence | denotes | Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. |
T2 | 128-294 | Sentence | denotes | Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. |
T3 | 295-444 | Sentence | denotes | Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement. |
T4 | 445-506 | Sentence | denotes | These strains share a lacto-N-neotetraose (nLc4) LOS α chain. |
T5 | 507-674 | Sentence | denotes | We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG. |
T6 | 675-748 | Sentence | denotes | We found that the nLc4 α chain conforms at least four different antigens. |
T7 | 749-925 | Sentence | denotes | We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue. |
T8 | 926-1110 | Sentence | denotes | IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains. |
T9 | 1111-1311 | Sentence | denotes | These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms. |
T10 | 1312-1549 | Sentence | denotes | Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 97-116 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
T2 | 467-486 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
T3 | 488-492 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T4 | 583-587 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T5 | 661-665 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T6 | 693-697 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T7 | 794-798 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T8 | 1032-1036 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
T9 | 1359-1363 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 97-116 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
T2 | 467-486 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 0-5 | OrganismTaxon | denotes | Human | 9606 |
T2 | 184-206 | OrganismTaxon | denotes | Neisseria meningitidis | 487 |
T3 | 295-300 | OrganismTaxon | denotes | Human | 9606 |
T4 | 427-432 | OrganismTaxon | denotes | human | 9606 |
T5 | 1170-1175 | OrganismTaxon | denotes | human | 9606 |
T6 | 1353-1358 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 246-256 | Body_part | denotes | oropharynx | http://purl.obolibrary.org/obo/UBERON_0001729 |