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PubMed:22027827 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 97-116 Glycan_Motif denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48059CD|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45827GY
T3 467-486 Glycan_Motif denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48059CD|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45827GY
T5 823-832 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T7 834-837 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T8 913-916 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T9 1046-1049 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T10 1236-1249 Glycan_Motif denotes antigens by a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G58507AZ

sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
T2 128-294 Sentence denotes Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease.
T3 295-444 Sentence denotes Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement.
T4 445-506 Sentence denotes These strains share a lacto-N-neotetraose (nLc4) LOS α chain.
T5 507-674 Sentence denotes We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG.
T6 675-748 Sentence denotes We found that the nLc4 α chain conforms at least four different antigens.
T7 749-925 Sentence denotes We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue.
T8 926-1110 Sentence denotes IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains.
T9 1111-1311 Sentence denotes These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms.
T10 1312-1549 Sentence denotes Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 97-116 https://glytoucan.org/Structures/Glycans/G45827GY denotes lacto-N-neotetraose
T2 97-116 https://glytoucan.org/Structures/Glycans/G48059CD denotes lacto-N-neotetraose
T3 467-486 https://glytoucan.org/Structures/Glycans/G45827GY denotes lacto-N-neotetraose
T4 467-486 https://glytoucan.org/Structures/Glycans/G48059CD denotes lacto-N-neotetraose
T5 823-832 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T6 823-832 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T7 1236-1249 https://glytoucan.org/Structures/Glycans/G58507AZ denotes antigens by a

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 97-116 GlycoEpitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350
T2 467-486 GlycoEpitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 246-256 http://purl.obolibrary.org/obo/MAT_0000446 denotes oropharynx

Allie

Id Subject Object Predicate Lexical cue
SS1_22027827_2_0 334-353 expanded denotes lipooligosaccharide
SS2_22027827_2_0 355-358 abbr denotes LOS
SS1_22027827_6_0 823-832 expanded denotes galactose
SS2_22027827_6_0 834-837 abbr denotes Gal
AE1_22027827_2_0 SS1_22027827_2_0 SS2_22027827_2_0 abbreviatedTo lipooligosaccharide,LOS
AE1_22027827_6_0 SS1_22027827_6_0 SS2_22027827_6_0 abbreviatedTo galactose,Gal

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 246-256 Body_part denotes oropharynx http://purl.obolibrary.org/obo/MAT_0000446

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 52-73 Disease denotes meningococcal disease http://purl.obolibrary.org/obo/MONDO_0005373
T2 1438-1459 Disease denotes meningococcal disease http://purl.obolibrary.org/obo/MONDO_0005373

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 97-116 Glycan denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD
T2 467-486 Glycan denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD
T3 488-492 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T4 583-587 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T5 661-665 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T6 693-697 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T7 794-798 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T8 1032-1036 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T9 1359-1363 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 97-116 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350
T2 467-486 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 52-73 Disease denotes meningococcal disease http://purl.obolibrary.org/obo/MONDO_0005373
T2 1438-1459 Disease denotes meningococcal disease http://purl.obolibrary.org/obo/MONDO_0005373

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human 9606
T2 184-206 OrganismTaxon denotes Neisseria meningitidis 487
T3 295-300 OrganismTaxon denotes Human 9606
T4 427-432 OrganismTaxon denotes human 9606
T5 1170-1175 OrganismTaxon denotes human 9606
T6 1353-1358 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 246-256 Body_part denotes oropharynx http://purl.obolibrary.org/obo/UBERON_0001729

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 246-256 Body_part denotes oropharynx http://purl.obolibrary.org/obo/MAT_0000446

sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
T2 128-294 Sentence denotes Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease.
T3 295-444 Sentence denotes Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement.
T4 445-506 Sentence denotes These strains share a lacto-N-neotetraose (nLc4) LOS α chain.
T5 507-674 Sentence denotes We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG.
T6 675-748 Sentence denotes We found that the nLc4 α chain conforms at least four different antigens.
T7 749-925 Sentence denotes We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue.
T8 926-1110 Sentence denotes IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains.
T9 1111-1311 Sentence denotes These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms.
T10 1312-1549 Sentence denotes Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
T2 128-294 Sentence denotes Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease.
T3 295-444 Sentence denotes Human IgGs that bind the neisserial L7 lipooligosaccharide (LOS) are bactericidal for L3,7 and L2,4 meningococci in the presence of human complement.
T4 445-506 Sentence denotes These strains share a lacto-N-neotetraose (nLc4) LOS α chain.
T5 507-674 Sentence denotes We used a set of mutants that have successive saccharide deletions from the nLc4 α chain to characterize further the binding and bactericidal activity of nLc4 LOS IgG.
T6 675-748 Sentence denotes We found that the nLc4 α chain conforms at least four different antigens.
T7 749-925 Sentence denotes We separately purified IgG that required the nLc4 (non-reducing) terminal galactose (Gal) for binding and IgG that bound the truncated nLc3 α chain that lacks this Gal residue.
T8 926-1110 Sentence denotes IgG that bound the internal nLc3 α chain killed both L3,7 and L2,4 strains, whereas IgG that required the nLc4 terminal Gal residue for binding killed L2,4 stains but not L3,7 strains.
T9 1111-1311 Sentence denotes These results show that the diversity of LOS antibodies in human serum is as much a function of the conformation of multiple antigens by a single glycoform as of the production of multiple glycoforms.
T10 1312-1549 Sentence denotes Differences in sensitivity to killing by human nLc4 LOS IgG may account for the fact that fully two-thirds of endemic group B meningococcal disease in infants and children is caused by L3,7 strains, but only 20% is caused by L2,4 stains.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 97-116 Glycan denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD
T2 467-486 Glycan denotes lacto-N-neotetraose https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD
T3 488-492 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T4 583-587 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T5 661-665 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T6 693-697 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T7 794-798 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T8 1032-1036 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ
T9 1359-1363 Glycan denotes nLc4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 97-116 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350
T2 467-486 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lacto-N-neotetraose http://www.glycoepitope.jp/epitopes/EP0350

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human 9606
T2 184-206 OrganismTaxon denotes Neisseria meningitidis 487
T3 295-300 OrganismTaxon denotes Human 9606
T4 427-432 OrganismTaxon denotes human 9606
T5 1170-1175 OrganismTaxon denotes human 9606
T6 1353-1358 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 246-256 Body_part denotes oropharynx http://purl.obolibrary.org/obo/UBERON_0001729