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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-10 P41350 denotes Caveolin-1
T2 0-10 Q07E02 denotes Caveolin-1
T3 0-10 Q07DV9 denotes Caveolin-1
T4 0-10 Q2IBG8 denotes Caveolin-1
T5 0-10 Q2QL79 denotes Caveolin-1
T6 0-10 Q09YN6 denotes Caveolin-1
T7 0-10 Q2QLB0 denotes Caveolin-1
T8 0-10 P49817 denotes Caveolin-1
T9 0-10 Q2QLH7 denotes Caveolin-1
T10 0-10 Q03135 denotes Caveolin-1
T11 0-10 Q2QLF2 denotes Caveolin-1
T12 0-10 P35431 denotes Caveolin-1
T13 0-10 Q09YH8 denotes Caveolin-1
T15 0-10 A0M8S7 denotes Caveolin-1
T16 0-10 Q2IBF0 denotes Caveolin-1
T17 0-10 A1X149 denotes Caveolin-1
T18 0-10 Q2IBA5 denotes Caveolin-1
T19 0-10 Q07DZ2 denotes Caveolin-1
T20 0-10 Q00PJ9 denotes Caveolin-1
T21 0-10 Q07DX1 denotes Caveolin-1
T22 0-10 Q108U7 denotes Caveolin-1
T23 0-10 Q2IBC1 denotes Caveolin-1
T24 0-10 Q6RVA9 denotes Caveolin-1
T25 0-10 Q94051 denotes Caveolin-1
T26 0-10 Q09YK1 denotes Caveolin-1
T27 0-10 Q07DY2 denotes Caveolin-1
T28 0-10 Q9YGM8 denotes Caveolin-1
T29 0-10 Q6B3Y2 denotes Caveolin-1
T30 0-10 Q07E38 denotes Caveolin-1
T31 0-10 Q2QL90 denotes Caveolin-1
T32 0-10 P33724 denotes Caveolin-1
T33 0-10 PR:000003198 denotes Caveolin-1
T34 0-10 Q07E49 denotes Caveolin-1
T35 0-10 Q07E25 denotes Caveolin-1
T36 0-10 P79132 denotes Caveolin-1
T37 0-10 A0M8R6 denotes Caveolin-1
T38 0-10 Q2IBD7 denotes Caveolin-1
T39 0-10 Q2QLC1 denotes Caveolin-1
T40 0-10 Q2QLG6 denotes Caveolin-1
T14 0-10 D051242 denotes Caveolin-1
T44 21-33 7442 denotes nitric oxide
T41 21-33 CHEBI:16480 denotes nitric oxide
T42 21-33 D009569 denotes nitric oxide
T43 21-33 D009569 denotes nitric oxide
T47 43-49 UBERON:0027368 denotes matrix
T48 43-68 D020782 denotes matrix metalloproteinases
T50 82-101 UBERON:0000120 denotes blood-brain barrier
T53 124-141 D002545 denotes cerebral ischemia
T54 124-141 D002545 denotes cerebral ischemia
T57 146-164 D015427 denotes reperfusion injury
T58 146-164 D015427 denotes reperfusion injury
T59 179-189 P41350 denotes caveolin-1
T60 179-189 Q07E02 denotes caveolin-1
T61 179-189 Q07DV9 denotes caveolin-1
T62 179-189 Q2IBG8 denotes caveolin-1
T63 179-189 Q2QL79 denotes caveolin-1
T64 179-189 Q09YN6 denotes caveolin-1
T65 179-189 Q2QLB0 denotes caveolin-1
T66 179-189 P49817 denotes caveolin-1
T67 179-189 Q2QLH7 denotes caveolin-1
T68 179-189 Q03135 denotes caveolin-1
T69 179-189 Q2QLF2 denotes caveolin-1
T70 179-189 P35431 denotes caveolin-1
T71 179-189 Q09YH8 denotes caveolin-1
T73 179-189 A0M8S7 denotes caveolin-1
T74 179-189 Q2IBF0 denotes caveolin-1
T75 179-189 A1X149 denotes caveolin-1
T76 179-189 Q2IBA5 denotes caveolin-1
T77 179-189 Q07DZ2 denotes caveolin-1
T78 179-189 Q00PJ9 denotes caveolin-1
T79 179-189 Q07DX1 denotes caveolin-1
T80 179-189 Q108U7 denotes caveolin-1
T81 179-189 Q2IBC1 denotes caveolin-1
T82 179-189 Q6RVA9 denotes caveolin-1
T83 179-189 Q94051 denotes caveolin-1
T84 179-189 Q09YK1 denotes caveolin-1
T85 179-189 Q07DY2 denotes caveolin-1
T86 179-189 Q9YGM8 denotes caveolin-1
T87 179-189 Q6B3Y2 denotes caveolin-1
T88 179-189 Q07E38 denotes caveolin-1
T89 179-189 Q2QL90 denotes caveolin-1
T90 179-189 P33724 denotes caveolin-1
T91 179-189 PR:000003198 denotes caveolin-1
T92 179-189 Q07E49 denotes caveolin-1
T93 179-189 Q07E25 denotes caveolin-1
T94 179-189 P79132 denotes caveolin-1
T95 179-189 A0M8R6 denotes caveolin-1
T96 179-189 Q2IBD7 denotes caveolin-1
T97 179-189 Q2QLC1 denotes caveolin-1
T98 179-189 Q2QLG6 denotes caveolin-1
T72 179-189 D051242 denotes caveolin-1
T99 191-194 12618 denotes cav
T102 191-194 1051671 denotes cav
T111 191-196 CVCL_KR36 denotes cav-1
T107 191-196 PR:Q03135 denotes cav-1
T108 191-196 PR:P35431 denotes cav-1
T109 191-196 PR:P49817 denotes cav-1
T110 191-196 PR:P93025 denotes cav-1
T112 191-196 PR:Q94051 denotes cav-1
T113 191-196 PR:000003198 denotes cav-1
T114 191-196 PR:P41350 denotes cav-1
T115 212-231 UBERON:0000120 denotes blood-brain barrier
T118 233-236 UBERON:0000120 denotes BBB
T119 296-299 12618 denotes cav
T122 296-299 1051671 denotes cav
T131 296-301 CVCL_KR36 denotes cav-1
T127 296-301 PR:Q03135 denotes cav-1
T128 296-301 PR:P35431 denotes cav-1
T129 296-301 PR:P49817 denotes cav-1
T130 296-301 PR:P93025 denotes cav-1
T132 296-301 PR:Q94051 denotes cav-1
T133 296-301 PR:000003198 denotes cav-1
T134 296-301 PR:P41350 denotes cav-1
T135 311-320 SO:0000119 denotes regulated
T139 343-355 7442 denotes nitric oxide
T136 343-355 CHEBI:16480 denotes nitric oxide
T137 343-355 D009569 denotes nitric oxide
T138 343-355 D009569 denotes nitric oxide
T142 381-384 12618 denotes cav
T145 381-384 1051671 denotes cav
T154 381-386 CVCL_KR36 denotes cav-1
T150 381-386 PR:Q03135 denotes cav-1
T151 381-386 PR:P35431 denotes cav-1
T152 381-386 PR:P49817 denotes cav-1
T153 381-386 PR:P93025 denotes cav-1
T155 381-386 PR:Q94051 denotes cav-1
T156 381-386 PR:000003198 denotes cav-1
T157 381-386 PR:P41350 denotes cav-1
T158 396-413 D002545 denotes cerebral ischemia
T159 396-413 D002545 denotes cerebral ischemia
T162 418-436 D015427 denotes reperfusion injury
T163 418-436 D015427 denotes reperfusion injury
T164 492-495 12618 denotes cav
T167 492-495 1051671 denotes cav
T176 492-497 CVCL_KR36 denotes cav-1
T172 492-497 PR:Q03135 denotes cav-1
T173 492-497 PR:P35431 denotes cav-1
T174 492-497 PR:P49817 denotes cav-1
T175 492-497 PR:P93025 denotes cav-1
T177 492-497 PR:Q94051 denotes cav-1
T178 492-497 PR:000003198 denotes cav-1
T179 492-497 PR:P41350 denotes cav-1
T180 509-512 UBERON:0000120 denotes BBB
T181 530-536 UBERON:0027368 denotes matrix
T182 530-555 D020782 denotes matrix metalloproteinases
T184 557-561 D020782 denotes MMPs
T185 579-596 D002545 denotes cerebral ischemia
T186 579-596 D002545 denotes cerebral ischemia
T189 588-615 D015427 denotes ischemia-reperfusion injury
T190 588-615 D015427 denotes ischemia-reperfusion injury
T193 637-654 D002545 denotes cerebral ischemia
T194 637-654 D002545 denotes cerebral ischemia
T197 672-681 SO:0000119 denotes regulated
T198 700-703 12618 denotes cav
T201 700-703 1051671 denotes cav
T210 700-705 CVCL_KR36 denotes cav-1
T206 700-705 PR:Q03135 denotes cav-1
T207 700-705 PR:P35431 denotes cav-1
T208 700-705 PR:P49817 denotes cav-1
T209 700-705 PR:P93025 denotes cav-1
T211 700-705 PR:Q94051 denotes cav-1
T212 700-705 PR:000003198 denotes cav-1
T213 700-705 PR:P41350 denotes cav-1
T214 718-724 UBERON:0001851 denotes cortex
T215 739-750 UBERON:0002421 denotes hippocampus
T216 739-750 UBERON:0001954 denotes hippocampus
T217 739-750 UBERON:0002961 denotes hippocampus
T218 756-762 UBERON:0001851 denotes cortex
T219 775-780 UBERON:6110636 denotes brain
T220 775-780 UBERON:0000955 denotes brain
T221 791-801 GO:0065007 denotes regulation
T222 805-808 12618 denotes cav
T225 805-808 1051671 denotes cav
T234 805-810 CVCL_KR36 denotes cav-1
T230 805-810 PR:Q03135 denotes cav-1
T231 805-810 PR:P35431 denotes cav-1
T232 805-810 PR:P49817 denotes cav-1
T233 805-810 PR:P93025 denotes cav-1
T235 805-810 PR:Q94051 denotes cav-1
T236 805-810 PR:000003198 denotes cav-1
T237 805-810 PR:P41350 denotes cav-1
T238 845-848 CHEBI:340824 denotes MMP
T241 845-848 CHEBI:59761 denotes MMP
T242 845-850 PR:P08253 denotes MMP-2
T243 845-850 Q9GLE5 denotes MMP-2
T244 845-850 P08253 denotes MMP-2
T245 845-850 Q90611 denotes MMP-2
T247 845-850 PR:Q8MPP3 denotes MMP-2
T248 845-850 P33436 denotes MMP-2
T249 845-850 PR:Q90611 denotes MMP-2
T250 845-850 PR:P33436 denotes MMP-2
T251 845-850 PR:000010479 denotes MMP-2
T252 845-850 PR:P33434 denotes MMP-2
T253 845-850 P33434 denotes MMP-2
T254 845-850 P50757 denotes MMP-2
T246 845-850 GO:0004228 denotes MMP-2
T255 880-894 GO:0070160 denotes tight junction
T257 886-894 SO:0000699 denotes junction
T256 886-894 UBERON:0007651 denotes junction
T258 900-907 GO:0003675 denotes protein
T262 900-907 SO:0000104 denotes protein
T261 900-907 PR:000000001 denotes protein
T259 900-907 CHEBI:36080 denotes protein
T260 900-907 CHEBI:11122 denotes protein
T263 908-914 UBERON:0006762 denotes zonula
T264 908-924 GO:0005923 denotes zonula occludens
T265 926-931 PR:P39447 denotes ZO)-1
T266 926-931 PR:Q07157 denotes ZO)-1
T267 926-931 PR:000016364 denotes ZO)-1
T268 956-959 UBERON:0000120 denotes BBB
T269 987-1022 D019331 denotes N(G) -nitro-L-arginine methyl ester
T270 987-1022 D019331 denotes N(G) -nitro-L-arginine methyl ester
T271 987-1022 CHEBI:7549 denotes N(G) -nitro-L-arginine methyl ester
T282 1001-1009 1091 denotes arginine
T279 1001-1009 SO:0001451 denotes arginine
T292 1024-1030 D019331 denotes L-NAME
T293 1024-1030 D019331 denotes L-NAME
T294 1024-1030 CHEBI:7549 denotes L-NAME
T298 1048-1060 7442 denotes nitric oxide
T299 1048-1069 O61309 denotes nitric oxide synthase
T300 1048-1069 Q8T8C0 denotes nitric oxide synthase
T301 1048-1069 Q9I9M2 denotes nitric oxide synthase
T302 1048-1069 Q27571 denotes nitric oxide synthase
T304 1048-1069 O61608 denotes nitric oxide synthase
T303 1048-1069 D019001 denotes nitric oxide synthase
T307 1071-1074 PR:000010970 denotes NOS
T308 1071-1074 PR:Q80WY3 denotes NOS
T309 1071-1074 Q26240 denotes NOS
T310 1071-1074 Q9I9M2 denotes NOS
T311 1071-1074 PR:Q27571 denotes NOS
T312 1071-1074 O61608 denotes NOS
T313 1071-1074 PR:P25724 denotes NOS
T314 1071-1085 GO:0051001 denotes NOS) inhibitor
T315 1076-1085 CHEBI:35222 denotes inhibitor
T316 1114-1117 12618 denotes cav
T319 1114-1117 1051671 denotes cav
T328 1114-1119 CVCL_KR36 denotes cav-1
T324 1114-1119 PR:Q03135 denotes cav-1
T325 1114-1119 PR:P35431 denotes cav-1
T326 1114-1119 PR:P49817 denotes cav-1
T327 1114-1119 PR:P93025 denotes cav-1
T329 1114-1119 PR:Q94051 denotes cav-1
T330 1114-1119 PR:000003198 denotes cav-1
T331 1114-1119 PR:P41350 denotes cav-1
T332 1131-1135 D020782 denotes MMPs
T333 1158-1161 UBERON:0000120 denotes BBB
T334 1202-1205 12618 denotes cav
T337 1202-1205 1051671 denotes cav
T342 1202-1207 PR:Q03135 denotes cav-1
T343 1202-1207 PR:P35431 denotes cav-1
T344 1202-1207 PR:P49817 denotes cav-1
T345 1202-1207 PR:P93025 denotes cav-1
T347 1202-1207 PR:Q94051 denotes cav-1
T348 1202-1207 PR:000003198 denotes cav-1
T349 1202-1207 PR:P41350 denotes cav-1
T346 1202-1207 CVCL_KR36 denotes cav-1
T350 1222-1226 D020782 denotes MMPs
T351 1231-1234 UBERON:0000120 denotes BBB
T352 1282-1285 12618 denotes cav
T355 1282-1285 1051671 denotes cav
T360 1282-1287 PR:Q03135 denotes cav-1
T361 1282-1287 PR:P35431 denotes cav-1
T362 1282-1287 PR:P49817 denotes cav-1
T363 1282-1287 PR:P93025 denotes cav-1
T365 1282-1287 PR:Q94051 denotes cav-1
T366 1282-1287 PR:000003198 denotes cav-1
T367 1282-1287 PR:P41350 denotes cav-1
T364 1282-1287 CVCL_KR36 denotes cav-1
T368 1310-1315 UBERON:6110636 denotes brain
T369 1310-1315 UBERON:0000955 denotes brain
T370 1369-1372 12618 denotes cav
T373 1369-1372 1051671 denotes cav
T378 1369-1374 PR:Q03135 denotes cav-1
T379 1369-1374 PR:P35431 denotes cav-1
T380 1369-1374 PR:P49817 denotes cav-1
T381 1369-1374 PR:P93025 denotes cav-1
T383 1369-1374 PR:Q94051 denotes cav-1
T384 1369-1374 PR:000003198 denotes cav-1
T385 1369-1374 PR:P41350 denotes cav-1
T382 1369-1374 CVCL_KR36 denotes cav-1
T386 1389-1393 PR:000005054 denotes mice
T388 1389-1393 O89094 denotes mice
T387 1389-1393 D051379 denotes mice
T389 1389-1393 10095 denotes mice
T390 1403-1406 12618 denotes Cav
T393 1403-1406 1051671 denotes Cav
T398 1403-1408 PR:Q03135 denotes Cav-1
T399 1403-1408 PR:P35431 denotes Cav-1
T400 1403-1408 PR:P49817 denotes Cav-1
T401 1403-1408 PR:P93025 denotes Cav-1
T403 1403-1408 PR:Q94051 denotes Cav-1
T404 1403-1408 PR:000003198 denotes Cav-1
T405 1403-1408 PR:P41350 denotes Cav-1
T402 1403-1408 CVCL_KR36 denotes Cav-1
T406 1440-1444 D020782 denotes MMPs
T407 1486-1503 D002545 denotes cerebral ischemia
T408 1486-1503 D002545 denotes cerebral ischemia
T411 1517-1520 12618 denotes cav
T414 1517-1520 1051671 denotes cav
T423 1517-1522 CVCL_KR36 denotes cav-1
T419 1517-1522 PR:Q03135 denotes cav-1
T420 1517-1522 PR:P35431 denotes cav-1
T421 1517-1522 PR:P49817 denotes cav-1
T422 1517-1522 PR:P93025 denotes cav-1
T424 1517-1522 PR:Q94051 denotes cav-1
T425 1517-1522 PR:000003198 denotes cav-1
T426 1517-1522 PR:P41350 denotes cav-1
T427 1523-1533 SO:1000029 denotes deficiency
T428 1534-1538 PR:000005054 denotes mice
T430 1534-1538 O89094 denotes mice
T429 1534-1538 D051379 denotes mice
T431 1534-1538 10095 denotes mice
T432 1556-1560 D020782 denotes MMPs
T433 1576-1579 UBERON:0000120 denotes BBB
T434 1598-1607 SO:0000817 denotes wild-type
T435 1608-1612 PR:000005054 denotes mice
T437 1608-1612 O89094 denotes mice
T436 1608-1612 D051379 denotes mice
T438 1608-1612 10095 denotes mice
T439 1644-1650 D019331 denotes L-NAME
T440 1644-1650 D019331 denotes L-NAME
T441 1644-1650 CHEBI:7549 denotes L-NAME
T442 1654-1658 D020782 denotes MMPs
T443 1672-1675 UBERON:0000120 denotes BBB
T444 1712-1715 12618 denotes cav
T447 1712-1715 1051671 denotes cav
T456 1712-1717 CVCL_KR36 denotes cav-1
T452 1712-1717 PR:Q03135 denotes cav-1
T453 1712-1717 PR:P35431 denotes cav-1
T454 1712-1717 PR:P49817 denotes cav-1
T455 1712-1717 PR:P93025 denotes cav-1
T457 1712-1717 PR:Q94051 denotes cav-1
T458 1712-1717 PR:000003198 denotes cav-1
T459 1712-1717 PR:P41350 denotes cav-1
T460 1718-1728 SO:1000029 denotes deficiency
T461 1729-1733 PR:000005054 denotes mice
T463 1729-1733 O89094 denotes mice
T462 1729-1733 D051379 denotes mice
T464 1729-1733 10095 denotes mice
T465 1784-1787 12618 denotes cav
T468 1784-1787 1051671 denotes cav
T477 1784-1789 CVCL_KR36 denotes cav-1
T473 1784-1789 PR:Q03135 denotes cav-1
T474 1784-1789 PR:P35431 denotes cav-1
T475 1784-1789 PR:P49817 denotes cav-1
T476 1784-1789 PR:P93025 denotes cav-1
T478 1784-1789 PR:Q94051 denotes cav-1
T479 1784-1789 PR:000003198 denotes cav-1
T480 1784-1789 PR:P41350 denotes cav-1
T481 1826-1830 D020782 denotes MMPs
T482 1844-1847 UBERON:0000120 denotes BBB
T483 1870-1887 D002545 denotes cerebral ischemia
T484 1870-1887 D002545 denotes cerebral ischemia
T487 1892-1910 D015427 denotes reperfusion injury
T488 1892-1910 D015427 denotes reperfusion injury
T489 1927-1933 D019331 denotes L-NAME
T490 1927-1933 D019331 denotes L-NAME
T491 1927-1933 CHEBI:7549 denotes L-NAME
T492 1937-1941 D020782 denotes MMPs
T493 1955-1958 UBERON:0000120 denotes BBB
T494 2011-2014 12618 denotes cav
T497 2011-2014 1051671 denotes cav
T502 2011-2016 PR:Q03135 denotes cav-1
T503 2011-2016 PR:P35431 denotes cav-1
T504 2011-2016 PR:P49817 denotes cav-1
T505 2011-2016 PR:P93025 denotes cav-1
T507 2011-2016 PR:Q94051 denotes cav-1
T508 2011-2016 PR:000003198 denotes cav-1
T509 2011-2016 PR:P41350 denotes cav-1
T506 2011-2016 CVCL_KR36 denotes cav-1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 396-413 HP_0002637 denotes cerebral ischemia
T2 579-596 HP_0002637 denotes cerebral ischemia
T3 637-654 HP_0002637 denotes cerebral ischemia
T4 1486-1503 HP_0002637 denotes cerebral ischemia
T5 1870-1887 HP_0002637 denotes cerebral ischemia

Allie

Id Subject Object Predicate Lexical cue
SS1_22007835_1_0 179-189 expanded denotes caveolin-1
SS2_22007835_1_0 191-196 abbr denotes cav-1
SS1_22007835_1_1 212-231 expanded denotes blood-brain barrier
SS2_22007835_1_1 233-236 abbr denotes BBB
SS1_22007835_2_0 343-355 expanded denotes nitric oxide
SS2_22007835_2_0 357-359 abbr denotes NO
SS1_22007835_3_0 530-555 expanded denotes matrix metalloproteinases
SS2_22007835_3_0 557-561 abbr denotes MMPs
SS1_22007835_5_0 880-894 expanded denotes tight junction
SS2_22007835_5_0 896-898 abbr denotes TJ
SS1_22007835_5_1 908-924 expanded denotes zonula occludens
SS2_22007835_5_1 926-928 abbr denotes ZO
SS1_22007835_6_0 1048-1069 expanded denotes nitric oxide synthase
SS2_22007835_6_0 1071-1074 abbr denotes NOS
SS1_22007835_7_0 1310-1347 expanded denotes brain microvascular endothelial cells
SS2_22007835_7_0 1349-1354 abbr denotes BMECs
SS1_22007835_7_1 1375-1383 expanded denotes knockout
SS2_22007835_7_1 1385-1387 abbr denotes KO
AE1_22007835_1_0 SS1_22007835_1_0 SS2_22007835_1_0 abbreviatedTo caveolin-1,cav-1
AE1_22007835_1_1 SS1_22007835_1_1 SS2_22007835_1_1 abbreviatedTo blood-brain barrier,BBB
AE1_22007835_2_0 SS1_22007835_2_0 SS2_22007835_2_0 abbreviatedTo nitric oxide,NO
AE1_22007835_3_0 SS1_22007835_3_0 SS2_22007835_3_0 abbreviatedTo matrix metalloproteinases,MMPs
AE1_22007835_5_0 SS1_22007835_5_0 SS2_22007835_5_0 abbreviatedTo tight junction,TJ
AE1_22007835_5_1 SS1_22007835_5_1 SS2_22007835_5_1 abbreviatedTo zonula occludens,ZO
AE1_22007835_6_0 SS1_22007835_6_0 SS2_22007835_6_0 abbreviatedTo nitric oxide synthase,NOS
AE1_22007835_7_0 SS1_22007835_7_0 SS2_22007835_7_0 abbreviatedTo brain microvascular endothelial cells,BMECs
AE1_22007835_7_1 SS1_22007835_7_1 SS2_22007835_7_1 abbreviatedTo knockout,KO

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-165 DRI_Background denotes Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury.
T2 166-267 DRI_Background denotes The roles of caveolin-1 (cav-1) in regulating blood-brain barrier (BBB) permeability are unclear yet.
T3 268-437 DRI_Outcome denotes We previously reported that cav-1 was down-regulated and the production of nitric oxide (NO) induced the loss of cav-1 in focal cerebral ischemia and reperfusion injury.
T4 438-616 DRI_Challenge denotes The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix metalloproteinases (MMPs) activity during cerebral ischemia-reperfusion injury.
T5 617-781 DRI_Outcome denotes We found that focal cerebral ischemia-reperfusion down-regulated the expression of cav-1 in isolated cortex microvessels, hippocampus, and cortex of ischemic brain.
T6 782-907 DRI_Approach denotes The down-regulation of cav-1 was correlated with the increased MMP-2 and -9 activities, decreased tight junction (TJ) protein
T7 908-924 Token_Label.OUTSIDE denotes zonula occludens
T8 925-973 DRI_Approach denotes (ZO)-1 expression and enhanced BBB permeability.
T9 974-1175 DRI_Background denotes Treatment of N(G) -nitro-L-arginine methyl ester [L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor] reserved the expression of cav-1, inhibited MMPs activity, and reduced BBB permeability.
T10 1176-1402 DRI_Outcome denotes To elucidate the roles of cav-1 in regulating MMPs and BBB permeability, we used two approaches including cav-1 knockdown in cultured brain microvascular endothelial cells (BMECs) in vitro and cav-1 knockout (KO) mice in vivo.
T11 1403-1463 DRI_Outcome denotes Cav-1 knockdown remarkably increased MMPs activity in BMECs.
T12 1464-1613 DRI_Background denotes Meanwhile, with focal cerebral ischemia-reperfusion, cav-1 deficiency mice displayed higher MMPs activities and BBB permeability than wild-type mice.
T13 1614-1734 DRI_Outcome denotes Interestingly, the effects of L-NAME on MMPs activity and BBB permeability was partly reversed in cav-1 deficiency mice.
T14 1735-1911 DRI_Challenge denotes These results, when taken together, suggest that cav-1 plays important roles in regulating MMPs activity and BBB permeability in focal cerebral ischemia and reperfusion injury.
T15 1912-2017 DRI_Background denotes The effects of L-NAME on MMPs activity and BBB permeability are partly mediated by preservation of cav-1.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 166-267 DRI_Background denotes The roles of caveolin-1 (cav-1) in regulating blood-brain barrier (BBB) permeability are unclear yet.
T2 268-437 DRI_Outcome denotes We previously reported that cav-1 was down-regulated and the production of nitric oxide (NO) induced the loss of cav-1 in focal cerebral ischemia and reperfusion injury.
T3 438-616 DRI_Challenge denotes The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix metalloproteinases (MMPs) activity during cerebral ischemia-reperfusion injury.
T4 617-781 DRI_Outcome denotes We found that focal cerebral ischemia-reperfusion down-regulated the expression of cav-1 in isolated cortex microvessels, hippocampus, and cortex of ischemic brain.
T5 782-907 DRI_Approach denotes The down-regulation of cav-1 was correlated with the increased MMP-2 and -9 activities, decreased tight junction (TJ) protein
T6 925-973 DRI_Approach denotes (ZO)-1 expression and enhanced BBB permeability.
T7 974-1175 DRI_Background denotes Treatment of N(G) -nitro-L-arginine methyl ester [L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor] reserved the expression of cav-1, inhibited MMPs activity, and reduced BBB permeability.
T8 1176-1402 DRI_Outcome denotes To elucidate the roles of cav-1 in regulating MMPs and BBB permeability, we used two approaches including cav-1 knockdown in cultured brain microvascular endothelial cells (BMECs) in vitro and cav-1 knockout (KO) mice in vivo.
T9 1403-1463 DRI_Outcome denotes Cav-1 knockdown remarkably increased MMPs activity in BMECs.
T10 1464-1613 DRI_Background denotes Meanwhile, with focal cerebral ischemia-reperfusion, cav-1 deficiency mice displayed higher MMPs activities and BBB permeability than wild-type mice.
T11 1614-1734 DRI_Outcome denotes Interestingly, the effects of L-NAME on MMPs activity and BBB permeability was partly reversed in cav-1 deficiency mice.
T12 1735-1911 DRI_Challenge denotes These results, when taken together, suggest that cav-1 plays important roles in regulating MMPs activity and BBB permeability in focal cerebral ischemia and reperfusion injury.
T13 1912-2017 DRI_Background denotes The effects of L-NAME on MMPs activity and BBB permeability are partly mediated by preservation of cav-1.