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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
T2 98-276 Sentence denotes Activation of transcription factor NF-κB and inflammasome-directed caspase-1 cleavage of IL-1β are key processes in the inflammatory response to pathogen or host-derived signals.
T3 277-495 Sentence denotes Pyrin-only proteins (POPs) are restricted to Old World monkeys, apes, and humans and have previously been shown to impair inflammasome assembly and/or NF-κB p65 transcriptional activity in transfected epithelial cells.
T4 496-608 Sentence denotes However, the biological role of POP2 and the molecular basis for its observed functions are not well understood.
T5 609-772 Sentence denotes In this report we demonstrate that POP2 regulates TNFα and IL-1β responses in human monocytic THP-1 cells and in stable transfectants of mouse J774A.1 macrophages.
T6 773-928 Sentence denotes Deletion analysis of POP2 revealed that the first α-helix (residues 1-19) is necessary and sufficient for both inflammasome and NF-κB inhibitory functions.
T7 929-1083 Sentence denotes Further, key acidic residues Glu(6), Asp(8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome inhibition.
T8 1084-1262 Sentence denotes Moreover, these mutations did not reduce the effect of POP2 upon NF-κB, indicating that the inflammasome and NF-κB inhibitory properties of POP2 can be uncoupled mechanistically.
T9 1263-1447 Sentence denotes Collectively, these data demonstrate that POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first α-helix.
T1 0-97 Sentence denotes Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
T2 98-276 Sentence denotes Activation of transcription factor NF-κB and inflammasome-directed caspase-1 cleavage of IL-1β are key processes in the inflammatory response to pathogen or host-derived signals.
T3 277-495 Sentence denotes Pyrin-only proteins (POPs) are restricted to Old World monkeys, apes, and humans and have previously been shown to impair inflammasome assembly and/or NF-κB p65 transcriptional activity in transfected epithelial cells.
T4 496-608 Sentence denotes However, the biological role of POP2 and the molecular basis for its observed functions are not well understood.
T5 609-772 Sentence denotes In this report we demonstrate that POP2 regulates TNFα and IL-1β responses in human monocytic THP-1 cells and in stable transfectants of mouse J774A.1 macrophages.
T6 773-928 Sentence denotes Deletion analysis of POP2 revealed that the first α-helix (residues 1-19) is necessary and sufficient for both inflammasome and NF-κB inhibitory functions.
T7 929-1083 Sentence denotes Further, key acidic residues Glu(6), Asp(8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome inhibition.
T8 1084-1262 Sentence denotes Moreover, these mutations did not reduce the effect of POP2 upon NF-κB, indicating that the inflammasome and NF-κB inhibitory properties of POP2 can be uncoupled mechanistically.
T9 1263-1447 Sentence denotes Collectively, these data demonstrate that POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first α-helix.

sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
T2 98-276 Sentence denotes Activation of transcription factor NF-κB and inflammasome-directed caspase-1 cleavage of IL-1β are key processes in the inflammatory response to pathogen or host-derived signals.
T3 277-495 Sentence denotes Pyrin-only proteins (POPs) are restricted to Old World monkeys, apes, and humans and have previously been shown to impair inflammasome assembly and/or NF-κB p65 transcriptional activity in transfected epithelial cells.
T4 496-608 Sentence denotes However, the biological role of POP2 and the molecular basis for its observed functions are not well understood.
T5 609-772 Sentence denotes In this report we demonstrate that POP2 regulates TNFα and IL-1β responses in human monocytic THP-1 cells and in stable transfectants of mouse J774A.1 macrophages.
T6 773-928 Sentence denotes Deletion analysis of POP2 revealed that the first α-helix (residues 1-19) is necessary and sufficient for both inflammasome and NF-κB inhibitory functions.
T7 929-1083 Sentence denotes Further, key acidic residues Glu(6), Asp(8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome inhibition.
T8 1084-1262 Sentence denotes Moreover, these mutations did not reduce the effect of POP2 upon NF-κB, indicating that the inflammasome and NF-κB inhibitory properties of POP2 can be uncoupled mechanistically.
T9 1263-1447 Sentence denotes Collectively, these data demonstrate that POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first α-helix.

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 14-34 Gene_or_gene_product denotes Pyrin-only protein 2
T2 36-40 Gene_or_gene_product denotes POP2
T3 70-75 Complex denotes NF-κB
T4 133-138 Complex denotes NF-κB
T5 165-174 Gene_or_gene_product denotes caspase-1
T6 187-192 Gene_or_gene_product denotes IL-1β
T7 277-296 Gene_or_gene_product denotes Pyrin-only proteins
T8 298-302 Gene_or_gene_product denotes POPs
T9 428-433 Complex denotes NF-κB
T10 434-437 Gene_or_gene_product denotes p65
T11 528-532 Gene_or_gene_product denotes POP2
T12 644-648 Gene_or_gene_product denotes POP2
T13 659-663 Gene_or_gene_product denotes TNFα
T14 668-673 Gene_or_gene_product denotes IL-1β
T15 794-798 Gene_or_gene_product denotes POP2
T16 901-906 Complex denotes NF-κB
T17 958-964 Simple_chemical denotes Glu(6)
T18 966-972 Simple_chemical denotes Asp(8)
T19 978-985 Simple_chemical denotes Glu(16)
T20 1009-1014 Gene_or_gene_product denotes Pyrin
T21 1015-1020 Gene_or_gene_product denotes Pyrin
T22 1139-1143 Gene_or_gene_product denotes POP2
T23 1149-1154 Complex denotes NF-κB
T24 1193-1198 Complex denotes NF-κB
T25 1224-1228 Gene_or_gene_product denotes POP2
T26 1305-1309 Gene_or_gene_product denotes POP2

Allie

Id Subject Object Predicate Lexical cue
SS1_21976665_0_0 14-34 expanded denotes Pyrin-only protein 2
SS2_21976665_0_0 36-40 abbr denotes POP2
SS1_21976665_2_0 277-296 expanded denotes Pyrin-only proteins
SS2_21976665_2_0 298-302 abbr denotes POPs
AE1_21976665_0_0 SS1_21976665_0_0 SS2_21976665_0_0 abbreviatedTo Pyrin-only protein 2,POP2
AE1_21976665_2_0 SS1_21976665_2_0 SS2_21976665_2_0 abbreviatedTo Pyrin-only proteins,POPs

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 332-339 OrganismTaxon denotes monkeys 9479|9527
T3 687-692 OrganismTaxon denotes human 9606
T4 746-751 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 478-494 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T2 760-771 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T3 825-830 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T4 1441-1446 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 478-494 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 693-702 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 760-771 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394