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PubMed:21969818 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1.
TextSentencer_T2 128-206 Sentence denotes Increasing evidence suggests that FOXO1 possesses a tumor suppressor function.
TextSentencer_T3 207-351 Sentence denotes Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment.
TextSentencer_T4 352-558 Sentence denotes In this study, we identified a FOXO1-derived peptide termed FO1-6nls that inhibits cyclin-dependent kinases 1 and 2 (CDK1/2)-mediated phosphorylation of FOXO1 at the serine 249 residue in vitro and in vivo.
TextSentencer_T5 559-733 Sentence denotes Overexpression of FO1-6nls in prostate cancer (PCa) cells not only blocked CDK1-induced cytoplasmic localization of FOXO1 but also augmented FOXO1's transcriptional activity.
TextSentencer_T6 734-796 Sentence denotes This effect of FO1-6nls requires its binding to CDK1 and CDK2.
TextSentencer_T7 797-896 Sentence denotes Moreover, the ectopic expression of FO1-6nls inhibited the growth of PTEN-positive DU145 PCa cells.
TextSentencer_T8 897-975 Sentence denotes Importantly, the growth-inhibitory function of FO1-6nls is dependent on FOXO1.
TextSentencer_T9 976-1094 Sentence denotes Finally, the ectopic expression of FO1-6nls overcame CDK1-mediated inhibition of FOXO1-induced apoptosis of PCa cells.
TextSentencer_T10 1095-1353 Sentence denotes These results indicate that the FOXO1-derived peptide FO1-6nls can restore FOXO1's tumor suppressor function by specifically opposing CDK1/2-mediated phosphorylation and inhibition of FOXO1 and hence may have a therapeutic potential for the treatment of PCa.
T1 0-127 Sentence denotes Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1.
T2 128-206 Sentence denotes Increasing evidence suggests that FOXO1 possesses a tumor suppressor function.
T3 207-351 Sentence denotes Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment.
T4 352-558 Sentence denotes In this study, we identified a FOXO1-derived peptide termed FO1-6nls that inhibits cyclin-dependent kinases 1 and 2 (CDK1/2)-mediated phosphorylation of FOXO1 at the serine 249 residue in vitro and in vivo.
T5 559-733 Sentence denotes Overexpression of FO1-6nls in prostate cancer (PCa) cells not only blocked CDK1-induced cytoplasmic localization of FOXO1 but also augmented FOXO1's transcriptional activity.
T6 734-796 Sentence denotes This effect of FO1-6nls requires its binding to CDK1 and CDK2.
T7 797-896 Sentence denotes Moreover, the ectopic expression of FO1-6nls inhibited the growth of PTEN-positive DU145 PCa cells.
T8 897-975 Sentence denotes Importantly, the growth-inhibitory function of FO1-6nls is dependent on FOXO1.
T9 976-1094 Sentence denotes Finally, the ectopic expression of FO1-6nls overcame CDK1-mediated inhibition of FOXO1-induced apoptosis of PCa cells.
T10 1095-1353 Sentence denotes These results indicate that the FOXO1-derived peptide FO1-6nls can restore FOXO1's tumor suppressor function by specifically opposing CDK1/2-mediated phosphorylation and inhibition of FOXO1 and hence may have a therapeutic potential for the treatment of PCa.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 57-62 gene:2308 denotes FOXO1
T1 67-82 disease:C0600139 denotes prostate cancer
T2 121-126 gene:2308 denotes FOXO1
T3 67-82 disease:C0600139 denotes prostate cancer
T4 121-126 gene:2308 denotes FOXO1
T5 67-82 disease:C0376358 denotes prostate cancer
T6 57-62 gene:2308 denotes FOXO1
T7 67-82 disease:C0376358 denotes prostate cancer
T8 14-20 gene:5111 denotes cyclin
T9 67-82 disease:C0600139 denotes prostate cancer
T10 14-20 gene:5111 denotes cyclin
T11 67-82 disease:C0376358 denotes prostate cancer
T12 223-228 gene:2308 denotes FOXO1
T13 272-278 disease:C0006826 denotes cancer
T14 310-315 gene:2308 denotes FOXO1
T15 334-340 disease:C0006826 denotes cancer
T16 223-228 gene:2308 denotes FOXO1
T17 334-340 disease:C1306459 denotes cancer
T18 310-315 gene:2308 denotes FOXO1
T19 334-340 disease:C1306459 denotes cancer
T20 223-228 gene:2308 denotes FOXO1
T21 334-340 disease:C0006826 denotes cancer
T22 223-228 gene:2308 denotes FOXO1
T23 272-278 disease:C1306459 denotes cancer
T24 634-638 gene:983 denotes CDK1
T25 589-604 disease:C0376358 denotes prostate cancer
T26 634-638 gene:983 denotes CDK1
T27 589-604 disease:C0600139 denotes prostate cancer
T28 675-680 gene:2308 denotes FOXO1
T29 589-604 disease:C0376358 denotes prostate cancer
T30 675-680 gene:2308 denotes FOXO1
T31 589-604 disease:C0600139 denotes prostate cancer
T32 700-705 gene:2308 denotes FOXO1
T33 589-604 disease:C0376358 denotes prostate cancer
T34 700-705 gene:2308 denotes FOXO1
T35 589-604 disease:C0600139 denotes prostate cancer
R1 T0 T1 associated_with FOXO1,prostate cancer
R2 T2 T3 associated_with FOXO1,prostate cancer
R3 T4 T5 associated_with FOXO1,prostate cancer
R4 T6 T7 associated_with FOXO1,prostate cancer
R5 T8 T9 associated_with cyclin,prostate cancer
R6 T10 T11 associated_with cyclin,prostate cancer
R7 T12 T13 associated_with FOXO1,cancer
R8 T14 T15 associated_with FOXO1,cancer
R9 T16 T17 associated_with FOXO1,cancer
R10 T18 T19 associated_with FOXO1,cancer
R11 T20 T21 associated_with FOXO1,cancer
R12 T22 T23 associated_with FOXO1,cancer
R13 T24 T25 associated_with CDK1,prostate cancer
R14 T26 T27 associated_with CDK1,prostate cancer
R15 T28 T29 associated_with FOXO1,prostate cancer
R16 T30 T31 associated_with FOXO1,prostate cancer
R17 T32 T33 associated_with FOXO1,prostate cancer
R18 T34 T35 associated_with FOXO1,prostate cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 180-185 HP_0002664 denotes tumor
T2 272-278 HP_0002664 denotes cancer
T3 334-340 HP_0002664 denotes cancer
T4 589-604 HP_0012125 denotes prostate cancer
T5 598-604 HP_0002664 denotes cancer
T6 1178-1183 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21969818_4_0 589-604 expanded denotes prostate cancer
SS2_21969818_4_0 606-609 abbr denotes PCa
AE1_21969818_4_0 SS1_21969818_4_0 SS2_21969818_4_0 abbreviatedTo prostate cancer,PCa

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21969818-0#14#20#gene5111 14-20 gene5111 denotes cyclin
21969818-0#57#62#gene2308 57-62 gene2308 denotes FOXO1
21969818-0#121#126#gene2308 121-126 gene2308 denotes FOXO1
21969818-0#67#82#diseaseC0376358 67-82 diseaseC0376358 denotes prostate cancer
21969818-0#67#82#diseaseC0600139 67-82 diseaseC0600139 denotes prostate cancer
21969818-0#67#82#diseaseC0376358 67-82 diseaseC0376358 denotes prostate cancer
21969818-0#67#82#diseaseC0600139 67-82 diseaseC0600139 denotes prostate cancer
21969818-0#67#82#diseaseC0376358 67-82 diseaseC0376358 denotes prostate cancer
21969818-0#67#82#diseaseC0600139 67-82 diseaseC0600139 denotes prostate cancer
21969818-6#69#73#gene5728 866-870 gene5728 denotes PTEN
21969818-6#89#92#diseaseC0376358 886-889 diseaseC0376358 denotes PCa
21969818-6#89#92#diseaseC0600139 886-889 diseaseC0600139 denotes PCa
21969818-9#134#138#gene983 1229-1233 gene983 denotes CDK1
21969818-9#254#257#diseaseC0376358 1349-1352 diseaseC0376358 denotes PCa
21969818-9#254#257#diseaseC0600139 1349-1352 diseaseC0600139 denotes PCa
14#20#gene511167#82#diseaseC0376358 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0376358 associated_with cyclin,prostate cancer
14#20#gene511167#82#diseaseC0600139 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0600139 associated_with cyclin,prostate cancer
14#20#gene511167#82#diseaseC0376358 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0376358 associated_with cyclin,prostate cancer
14#20#gene511167#82#diseaseC0600139 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0600139 associated_with cyclin,prostate cancer
14#20#gene511167#82#diseaseC0376358 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0376358 associated_with cyclin,prostate cancer
14#20#gene511167#82#diseaseC0600139 21969818-0#14#20#gene5111 21969818-0#67#82#diseaseC0600139 associated_with cyclin,prostate cancer
57#62#gene230867#82#diseaseC0376358 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
57#62#gene230867#82#diseaseC0600139 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
57#62#gene230867#82#diseaseC0376358 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
57#62#gene230867#82#diseaseC0600139 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
57#62#gene230867#82#diseaseC0376358 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
57#62#gene230867#82#diseaseC0600139 21969818-0#57#62#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0376358 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0600139 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0376358 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0600139 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0376358 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0376358 associated_with FOXO1,prostate cancer
121#126#gene230867#82#diseaseC0600139 21969818-0#121#126#gene2308 21969818-0#67#82#diseaseC0600139 associated_with FOXO1,prostate cancer
69#73#gene572889#92#diseaseC0376358 21969818-6#69#73#gene5728 21969818-6#89#92#diseaseC0376358 associated_with PTEN,PCa
69#73#gene572889#92#diseaseC0600139 21969818-6#69#73#gene5728 21969818-6#89#92#diseaseC0600139 associated_with PTEN,PCa
134#138#gene983254#257#diseaseC0376358 21969818-9#134#138#gene983 21969818-9#254#257#diseaseC0376358 associated_with CDK1,PCa
134#138#gene983254#257#diseaseC0600139 21969818-9#134#138#gene983 21969818-9#254#257#diseaseC0600139 associated_with CDK1,PCa

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T433 1229-1233 gene:983 denotes CDK1
T434 1349-1352 disease:C0376358 denotes PCa
R1 T433 T434 associated_with CDK1,PCa
R2 T433 T434 associated_with CDK1,PCa