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PubMed:21949119 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 160-163 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 349-352 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 419-422 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 616-619 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 701-717 Glycan_Motif denotes glucosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71142DF
T10 917-920 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T12 1255-1258 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T14 1325-1328 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T16 1748-1751 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes A glycosphingolipid/caveolin-1 signaling complex inhibits motility of human ovarian carcinoma cells.
T2 101-401 Sentence denotes The genetic (stable overexpression of sialyltransferase I, GM3 synthase) or pharmacological (selective pressure by N-(4-hydroxyphenyl)retinamide)) manipulation of A2780 human ovarian cancer cells allowed us to obtain clones characterized by higher GM3 synthase activity compared with wild-type cells.
T3 402-607 Sentence denotes Clones with high GM3 synthase expression had elevated ganglioside levels, reduced in vitro cell motility, and enhanced expression of the membrane adaptor protein caveolin-1 with respect to wild-type cells.
T4 608-885 Sentence denotes In high GM3 synthase-expressing clones, both depletion of gangliosides by treatment with the glucosylceramide synthase inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and silencing of caveolin-1 by siRNA were able to strongly increase in vitro cell motility.
T5 886-1118 Sentence denotes The motility of wild-type, low GM3 synthase-expressing cells was reduced in the presence of a Src inhibitor, and treatment of these cells with exogenous gangliosides, able to reduce their in vitro motility, inactivated c-Src kinase.
T6 1119-1316 Sentence denotes Conversely, ganglioside depletion by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol treatment or caveolin-1 silencing in high GM3 synthase-expressing cells led to c-Src kinase activation.
T7 1317-1514 Sentence denotes In high GM3 synthase-expressing cells, caveolin-1 was associated with sphingolipids, integrin receptor subunits, p130(CAS), and c-Src forming a Triton X-100-insoluble noncaveolar signaling complex.
T8 1515-1840 Sentence denotes These data suggest a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, responsible for Src inactivation downstream to integrin receptors, and imply that GM3 synthase is a key target for the regulation of cell motility in human ovarian carcinoma.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 160-163 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 160-163 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 349-352 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 349-352 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 419-422 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 419-422 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 616-619 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 616-619 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 701-717 https://glytoucan.org/Structures/Glycans/G71142DF denotes glucosylceramide
T10 917-920 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T11 917-920 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T12 1255-1258 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T13 1255-1258 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T14 1325-1328 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T15 1325-1328 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T16 1748-1751 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T17 1748-1751 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

DisGeNET

Id Subject Object Predicate Lexical cue
T0 160-172 gene:8869 denotes GM3 synthase
T1 276-290 disease:C0029925 denotes ovarian cancer
T2 160-172 gene:8869 denotes GM3 synthase
T3 276-290 disease:C1140680 denotes ovarian cancer
T4 349-361 gene:8869 denotes GM3 synthase
T5 276-290 disease:C0029925 denotes ovarian cancer
T6 349-361 gene:8869 denotes GM3 synthase
T7 276-290 disease:C1140680 denotes ovarian cancer
T8 1654-1664 gene:857 denotes caveolin-1
T9 1822-1839 disease:C0029925 denotes ovarian carcinoma
T10 1654-1664 gene:857 denotes caveolin-1
T11 1822-1839 disease:C0677886 denotes ovarian carcinoma
T12 1748-1760 gene:8869 denotes GM3 synthase
T13 1822-1839 disease:C0029925 denotes ovarian carcinoma
T14 1748-1760 gene:8869 denotes GM3 synthase
T15 1822-1839 disease:C0677886 denotes ovarian carcinoma
R1 T0 T1 associated_with GM3 synthase,ovarian cancer
R2 T2 T3 associated_with GM3 synthase,ovarian cancer
R3 T4 T5 associated_with GM3 synthase,ovarian cancer
R4 T6 T7 associated_with GM3 synthase,ovarian cancer
R5 T8 T9 associated_with caveolin-1,ovarian carcinoma
R6 T10 T11 associated_with caveolin-1,ovarian carcinoma
R7 T12 T13 associated_with GM3 synthase,ovarian carcinoma
R8 T14 T15 associated_with GM3 synthase,ovarian carcinoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 276-290 HP_0100615 denotes ovarian cancer
T2 284-290 HP_0002664 denotes cancer
T3 1572-1577 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21949119_6_0 1356-1434 expanded denotes caveolin-1 was associated with sphingolipids, integrin receptor subunits, p130
SS2_21949119_6_0 1435-1438 abbr denotes CAS
AE1_21949119_6_0 SS1_21949119_6_0 SS2_21949119_6_0 abbreviatedTo "caveolin-1 was associated with sphingolipids, integrin receptor subunits, p130",CAS

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21949119-1#59#71#gene8869 160-172 gene8869 denotes GM3 synthase
21949119-1#248#260#gene8869 349-361 gene8869 denotes GM3 synthase
21949119-1#175#189#diseaseC1140680 276-290 diseaseC1140680 denotes ovarian cancer
21949119-7#139#149#gene857 1654-1664 gene857 denotes caveolin-1
21949119-7#233#245#gene8869 1748-1760 gene8869 denotes GM3 synthase
21949119-7#307#324#diseaseC0029925 1822-1839 diseaseC0029925 denotes ovarian carcinoma
21949119-7#307#324#diseaseC0677886 1822-1839 diseaseC0677886 denotes ovarian carcinoma
21949119-7#307#324#diseaseC0029925 1822-1839 diseaseC0029925 denotes ovarian carcinoma
21949119-7#307#324#diseaseC0677886 1822-1839 diseaseC0677886 denotes ovarian carcinoma
59#71#gene8869175#189#diseaseC1140680 21949119-1#59#71#gene8869 21949119-1#175#189#diseaseC1140680 associated_with GM3 synthase,ovarian cancer
248#260#gene8869175#189#diseaseC1140680 21949119-1#248#260#gene8869 21949119-1#175#189#diseaseC1140680 associated_with GM3 synthase,ovarian cancer
139#149#gene857307#324#diseaseC0029925 21949119-7#139#149#gene857 21949119-7#307#324#diseaseC0029925 associated_with caveolin-1,ovarian carcinoma
139#149#gene857307#324#diseaseC0677886 21949119-7#139#149#gene857 21949119-7#307#324#diseaseC0677886 associated_with caveolin-1,ovarian carcinoma
139#149#gene857307#324#diseaseC0029925 21949119-7#139#149#gene857 21949119-7#307#324#diseaseC0029925 associated_with caveolin-1,ovarian carcinoma
139#149#gene857307#324#diseaseC0677886 21949119-7#139#149#gene857 21949119-7#307#324#diseaseC0677886 associated_with caveolin-1,ovarian carcinoma
233#245#gene8869307#324#diseaseC0029925 21949119-7#233#245#gene8869 21949119-7#307#324#diseaseC0029925 associated_with GM3 synthase,ovarian carcinoma
233#245#gene8869307#324#diseaseC0677886 21949119-7#233#245#gene8869 21949119-7#307#324#diseaseC0677886 associated_with GM3 synthase,ovarian carcinoma
233#245#gene8869307#324#diseaseC0029925 21949119-7#233#245#gene8869 21949119-7#307#324#diseaseC0029925 associated_with GM3 synthase,ovarian carcinoma
233#245#gene8869307#324#diseaseC0677886 21949119-7#233#245#gene8869 21949119-7#307#324#diseaseC0677886 associated_with GM3 synthase,ovarian carcinoma

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 160-163 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 349-352 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 419-422 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 616-619 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 917-920 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1255-1258 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1325-1328 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1748-1751 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 76-93 Disease denotes ovarian carcinoma http://purl.obolibrary.org/obo/MONDO_0005140
T2 276-290 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170
T3 1572-1577 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 1822-1839 Disease denotes ovarian carcinoma http://purl.obolibrary.org/obo/MONDO_0005140

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 160-163 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 349-352 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 419-422 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 616-619 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 917-920 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1255-1258 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1325-1328 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1748-1751 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 76-93 Phenotype denotes ovarian carcinoma HP:0025318
T2 276-290 Phenotype denotes ovarian cancer HP:0100615
T3 1572-1577 Phenotype denotes tumor HP:0002664
T4 1822-1839 Phenotype denotes ovarian carcinoma HP:0025318

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 284-296 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 1572-1582 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 539-547 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 76-93 Disease denotes ovarian carcinoma MONDO:0005140
T2 276-290 Disease denotes ovarian cancer MONDO:0005140|MONDO:0008170
T4 1572-1577 Disease denotes tumor MONDO:0005070
T5 1822-1839 Disease denotes ovarian carcinoma MONDO:0005140

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 70-75 Organism denotes human 9606
T2 270-275 Organism denotes human 9606
T3 1816-1821 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes A glycosphingolipid/caveolin-1 signaling complex inhibits motility of human ovarian carcinoma cells.
T2 101-401 Sentence denotes The genetic (stable overexpression of sialyltransferase I, GM3 synthase) or pharmacological (selective pressure by N-(4-hydroxyphenyl)retinamide)) manipulation of A2780 human ovarian cancer cells allowed us to obtain clones characterized by higher GM3 synthase activity compared with wild-type cells.
T3 402-607 Sentence denotes Clones with high GM3 synthase expression had elevated ganglioside levels, reduced in vitro cell motility, and enhanced expression of the membrane adaptor protein caveolin-1 with respect to wild-type cells.
T4 608-885 Sentence denotes In high GM3 synthase-expressing clones, both depletion of gangliosides by treatment with the glucosylceramide synthase inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and silencing of caveolin-1 by siRNA were able to strongly increase in vitro cell motility.
T5 886-1118 Sentence denotes The motility of wild-type, low GM3 synthase-expressing cells was reduced in the presence of a Src inhibitor, and treatment of these cells with exogenous gangliosides, able to reduce their in vitro motility, inactivated c-Src kinase.
T6 1119-1316 Sentence denotes Conversely, ganglioside depletion by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol treatment or caveolin-1 silencing in high GM3 synthase-expressing cells led to c-Src kinase activation.
T7 1317-1514 Sentence denotes In high GM3 synthase-expressing cells, caveolin-1 was associated with sphingolipids, integrin receptor subunits, p130(CAS), and c-Src forming a Triton X-100-insoluble noncaveolar signaling complex.
T8 1515-1840 Sentence denotes These data suggest a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, responsible for Src inactivation downstream to integrin receptors, and imply that GM3 synthase is a key target for the regulation of cell motility in human ovarian carcinoma.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 70-75 OrganismTaxon denotes human 9606
T2 270-275 OrganismTaxon denotes human 9606
T3 1816-1821 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 539-547 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 76-93 Phenotype denotes ovarian carcinoma HP:0025318
T2 276-290 Phenotype denotes ovarian cancer HP:0100615
T3 1572-1577 Phenotype denotes tumor HP:0002664
T4 1822-1839 Phenotype denotes ovarian carcinoma HP:0025318

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 284-296 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 1572-1582 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063