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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.
T2 145-284 Sentence denotes Interleukin-10 (IL-10) modulates inflammatory responses elicited in vitro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete.
T3 285-356 Sentence denotes How IL-10 modulates these inflammatory responses still remains elusive.
T4 357-517 Sentence denotes We hypothesize that IL-10 inhibits effector functions of multiple genes induced by B. burgdorferi in macrophages to control concomitantly elicited inflammation.
T5 518-707 Sentence denotes Because macrophages are essential in the initiation of inflammation, we used mouse J774 macrophages and live B. burgdorferi spirochetes as the model target cell and stimulant, respectively.
T6 708-901 Sentence denotes First, we employed transcriptome profiling to identify genes that were induced by stimulation of cells with live spirochetes and that were perturbed by addition of IL-10 to spirochete cultures.
T7 902-999 Sentence denotes Spirochetes significantly induced upregulation of 347 genes at both the 4-h and 24-h time points.
T8 1000-1157 Sentence denotes IL-10 inhibited the expression levels, respectively, of 53 and 65 of the 4-h and 24-h genes, and potentiated, respectively, at 4 h and 24 h, 65 and 50 genes.
T9 1158-1368 Sentence denotes Prominent among the novel identified IL-10-inhibited genes also validated by quantitative real-time PCR (qRT-PCR) were Toll-like receptor 1 (TLR1), TLR2, IRAK3, TRAF1, IRG1, PTGS2, MMP9, IFI44, IFIT1, and CD40.
T10 1369-1759 Sentence denotes Proteome analysis using a multiplex enzyme-linked immunosorbent assay (ELISA) revealed the IL-10 modulation/and or potentiation of RANTES/CCL5, macrophage inflammatory protein 2 (MIP-2)/CXCL2, IP-10/CXCL10, MIP-1α/CCL3, granulocyte colony-stimulating factor (G-CSF)/CSF3, CXCL1, CXCL5, CCL2, CCL4, IL-6, tumor necrosis factor alpha (TNF-α), IL-1α, IL-1β, gamma interferon (IFN-γ), and IL-9.
T11 1760-1847 Sentence denotes Similar results were obtained using sonicated spirochetes or lipoprotein as stimulants.
T12 1848-1988 Sentence denotes Our data show that IL-10 alters effectors induced by B. burgdorferi in macrophages to control concomitantly elicited inflammatory responses.
T13 1989-2131 Sentence denotes Moreover, for the first time, this study provides global insight into potential mechanisms used by IL-10 to control Lyme disease inflammation.
T1 0-144 Sentence denotes Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.
T2 145-284 Sentence denotes Interleukin-10 (IL-10) modulates inflammatory responses elicited in vitro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete.
T3 285-356 Sentence denotes How IL-10 modulates these inflammatory responses still remains elusive.
T4 357-517 Sentence denotes We hypothesize that IL-10 inhibits effector functions of multiple genes induced by B. burgdorferi in macrophages to control concomitantly elicited inflammation.
T5 518-707 Sentence denotes Because macrophages are essential in the initiation of inflammation, we used mouse J774 macrophages and live B. burgdorferi spirochetes as the model target cell and stimulant, respectively.
T6 708-901 Sentence denotes First, we employed transcriptome profiling to identify genes that were induced by stimulation of cells with live spirochetes and that were perturbed by addition of IL-10 to spirochete cultures.
T7 902-999 Sentence denotes Spirochetes significantly induced upregulation of 347 genes at both the 4-h and 24-h time points.
T8 1000-1157 Sentence denotes IL-10 inhibited the expression levels, respectively, of 53 and 65 of the 4-h and 24-h genes, and potentiated, respectively, at 4 h and 24 h, 65 and 50 genes.
T9 1158-1368 Sentence denotes Prominent among the novel identified IL-10-inhibited genes also validated by quantitative real-time PCR (qRT-PCR) were Toll-like receptor 1 (TLR1), TLR2, IRAK3, TRAF1, IRG1, PTGS2, MMP9, IFI44, IFIT1, and CD40.
T10 1369-1759 Sentence denotes Proteome analysis using a multiplex enzyme-linked immunosorbent assay (ELISA) revealed the IL-10 modulation/and or potentiation of RANTES/CCL5, macrophage inflammatory protein 2 (MIP-2)/CXCL2, IP-10/CXCL10, MIP-1α/CCL3, granulocyte colony-stimulating factor (G-CSF)/CSF3, CXCL1, CXCL5, CCL2, CCL4, IL-6, tumor necrosis factor alpha (TNF-α), IL-1α, IL-1β, gamma interferon (IFN-γ), and IL-9.
T11 1760-1847 Sentence denotes Similar results were obtained using sonicated spirochetes or lipoprotein as stimulants.
T12 1848-1988 Sentence denotes Our data show that IL-10 alters effectors induced by B. burgdorferi in macrophages to control concomitantly elicited inflammatory responses.
T13 1989-2131 Sentence denotes Moreover, for the first time, this study provides global insight into potential mechanisms used by IL-10 to control Lyme disease inflammation.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1673-1678 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21947773_1_0 145-159 expanded denotes Interleukin-10
SS2_21947773_1_0 161-166 abbr denotes IL-10
SS1_21947773_8_0 1235-1261 expanded denotes quantitative real-time PCR
SS2_21947773_8_0 1263-1270 abbr denotes qRT-PCR
SS1_21947773_8_1 1277-1297 expanded denotes Toll-like receptor 1
SS2_21947773_8_1 1299-1303 abbr denotes TLR1
SS1_21947773_9_0 1405-1438 expanded denotes enzyme-linked immunosorbent assay
SS2_21947773_9_0 1440-1445 abbr denotes ELISA
SS1_21947773_9_1 1513-1546 expanded denotes macrophage inflammatory protein 2
SS2_21947773_9_1 1548-1553 abbr denotes MIP-2
SS1_21947773_9_2 1589-1626 expanded denotes granulocyte colony-stimulating factor
SS2_21947773_9_2 1628-1633 abbr denotes G-CSF
SS1_21947773_9_3 1673-1700 expanded denotes tumor necrosis factor alpha
SS2_21947773_9_3 1702-1707 abbr denotes TNF-α
AE1_21947773_1_0 SS1_21947773_1_0 SS2_21947773_1_0 abbreviatedTo Interleukin-10,IL-10
AE1_21947773_8_0 SS1_21947773_8_0 SS2_21947773_8_0 abbreviatedTo quantitative real-time PCR,qRT-PCR
AE1_21947773_8_1 SS1_21947773_8_1 SS2_21947773_8_1 abbreviatedTo Toll-like receptor 1,TLR1
AE1_21947773_9_0 SS1_21947773_9_0 SS2_21947773_9_0 abbreviatedTo enzyme-linked immunosorbent assay,ELISA
AE1_21947773_9_1 SS1_21947773_9_1 SS2_21947773_9_1 abbreviatedTo macrophage inflammatory protein 2,MIP-2
AE1_21947773_9_2 SS1_21947773_9_2 SS2_21947773_9_2 abbreviatedTo granulocyte colony-stimulating factor,G-CSF
AE1_21947773_9_3 SS1_21947773_9_3 SS2_21947773_9_3 abbreviatedTo tumor necrosis factor alpha,TNF-α