> top > docs > PubMed:21931845 > annotations

PubMed:21931845 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 117-191 DRI_Background denotes The intestinal resident Candida glabrata opportunistically infects humans.
T2 192-282 DRI_Challenge denotes However few genetic factors for adaptation in the intestine are identified in this fungus.
T3 283-411 DRI_Challenge denotes Here we describe the C. glabrata CYB2 gene encoding lactate dehydrogenase as an adaptation factor for survival in the intestine.
T4 412-484 DRI_Background denotes CYB2 was identified as a virulence factor by a silkworm infection study.
T5 485-572 DRI_Approach denotes To determine the function of CYB2, we analysed in vitro phenotypes of the mutant Δcyb2.
T6 573-833 DRI_Background denotes The Δcyb2 mutant grew well in glucose medium under aerobic and anaerobic conditions, was not supersensitive to nitric oxide which has fungicidal-effect in phagocytes, and had normal levels of general virulence factors protease, lipase and adherence activities.
T7 834-913 DRI_Background denotes A previous report suggested that Cyb2p is responsible for lactate assimilation.
T8 914-1120 DRI_Challenge denotes Additionally, it was speculated that lactate assimilation was required for Candida virulence because Candida must synthesize glucose via gluconeogenesis under glucose-limited conditions such as in the host.
T9 1121-1308 DRI_Challenge denotes Indeed, the Δcyb2 mutant could not grow on lactate medium in which lactate is the sole carbon source in the absence of glucose, indicating that Cyb2p plays a role in lactate assimilation.
T10 1309-1502 DRI_Challenge denotes We hypothesized that Cyb2p-mediated lactate assimilation is necessary for proliferation in the intestinal tract, as the intestine is rich in lactate produced by bacteria flora, but not glucose.
T11 1503-1623 DRI_Outcome denotes The Δcyb2 mutant showed 100-fold decreased adaptation and few cells of Saccharomyces cerevisiae can adapt in mouse ceca.
T12 1624-1749 DRI_Background denotes Interestingly, C. glabrata could assimilate lactate under hypoxic conditions, dependent on CYB2, but not yeast S. cerevisiae.
T13 1750-1912 DRI_Challenge denotes Because accessible oxygen is limited in the intestine, the ability for lactate assimilation in hypoxic conditions may provide an advantage for a pathogenic yeast.
T14 1913-2036 DRI_Challenge denotes From those results, we conclude that Cyb2p-mediated lactate assimilation is an intestinal adaptation factor of C. glabrata.

silkworm

Id Subject Object Predicate Lexical cue
T1 20-25 Species:4932 denotes yeast
T2 26-42 Species:5478 denotes Candida glabrata
T3 67-74 Chemical:MESH:D019344 denotes lactate
T4 100-105 Species:10090 denotes mouse
T5 141-157 Species:5478 denotes Candida glabrata
T6 184-190 Species:9606 denotes humans
T7 304-315 Species:5478 denotes C. glabrata
T8 459-467 Species:7091 denotes silkworm
T9 603-610 Chemical:MESH:D005947 denotes glucose
T10 684-696 Chemical:MESH:D009569 denotes nitric oxide
T11 892-899 Chemical:MESH:D019344 denotes lactate
T12 951-958 Chemical:MESH:D019344 denotes lactate
T13 989-996 Species:5478 denotes Candida
T14 1015-1022 Species:5478 denotes Candida
T15 1039-1046 Chemical:MESH:D005947 denotes glucose
T16 1073-1080 Chemical:MESH:D005947 denotes glucose
T17 1164-1171 Chemical:MESH:D019344 denotes lactate
T18 1188-1195 Chemical:MESH:D019344 denotes lactate
T19 1208-1214 Chemical:MESH:D002244 denotes carbon
T20 1240-1247 Chemical:MESH:D005947 denotes glucose
T21 1287-1294 Chemical:MESH:D019344 denotes lactate
T22 1345-1352 Chemical:MESH:D019344 denotes lactate
T23 1450-1457 Chemical:MESH:D019344 denotes lactate
T24 1494-1501 Chemical:MESH:D005947 denotes glucose
T25 1574-1598 Species:4932 denotes Saccharomyces cerevisiae
T26 1612-1617 Species:10090 denotes mouse
T27 1639-1650 Species:5478 denotes C. glabrata
T28 1668-1675 Chemical:MESH:D019344 denotes lactate
T29 1682-1700 Disease:MESH:D009135 denotes hypoxic conditions
T30 1729-1734 Species:4932 denotes yeast
T31 1735-1748 Species:4932 denotes S. cerevisiae
T32 1769-1775 Chemical:MESH:D010100 denotes oxygen
T33 1821-1828 Chemical:MESH:D019344 denotes lactate
T34 1845-1863 Disease:MESH:D009135 denotes hypoxic conditions
T35 1906-1911 Species:4932 denotes yeast
T36 1965-1972 Chemical:MESH:D019344 denotes lactate
T37 2024-2035 Species:5478 denotes C. glabrata

silkwormbase

Id Subject Object Predicate Lexical cue
T1 20-25 Species:4932 denotes yeast
T10 684-696 Chemical:MESH:D009569 denotes nitric oxide
T11 892-899 Chemical:MESH:D019344 denotes lactate
T12 951-958 Chemical:MESH:D019344 denotes lactate
T13 989-996 Species:5478 denotes Candida
T14 1015-1022 Species:5478 denotes Candida
T15 1039-1046 Chemical:MESH:D005947 denotes glucose
T16 1073-1080 Chemical:MESH:D005947 denotes glucose
T17 1164-1171 Chemical:MESH:D019344 denotes lactate
T18 1188-1195 Chemical:MESH:D019344 denotes lactate
T19 1208-1214 Chemical:MESH:D002244 denotes carbon
T2 26-42 Species:5478 denotes Candida glabrata
T20 1240-1247 Chemical:MESH:D005947 denotes glucose
T21 1287-1294 Chemical:MESH:D019344 denotes lactate
T22 1345-1352 Chemical:MESH:D019344 denotes lactate
T23 1450-1457 Chemical:MESH:D019344 denotes lactate
T24 1494-1501 Chemical:MESH:D005947 denotes glucose
T25 1574-1598 Species:4932 denotes Saccharomyces cerevisiae
T26 1612-1617 Species:10090 denotes mouse
T27 1639-1650 Species:5478 denotes C. glabrata
T29 1682-1700 Disease:MESH:D009135 denotes hypoxic conditions
T3 67-74 Chemical:MESH:D019344 denotes lactate
T30 1729-1734 Species:4932 denotes yeast
T31 1735-1748 Species:4932 denotes S. cerevisiae
T32 1769-1775 Chemical:MESH:D010100 denotes oxygen
T33 1821-1828 Chemical:MESH:D019344 denotes lactate
T34 1845-1863 Disease:MESH:D009135 denotes hypoxic conditions
T35 1906-1911 Species:4932 denotes yeast
T36 1965-1972 Chemical:MESH:D019344 denotes lactate
T37 2024-2035 Species:5478 denotes C. glabrata
T4 100-105 Species:10090 denotes mouse
T5 141-157 Species:5478 denotes Candida glabrata
T6 184-190 Species:9606 denotes humans
T7 304-315 Species:5478 denotes C. glabrata
T8 459-467 Species:7091 denotes silkworm
T9 603-610 Chemical:MESH:D005947 denotes glucose