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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 111-287 DRI_Approach denotes We previously reported that isolated endothelium-removed bovine pulmonary arteries (BPAs) contract to hypoxia associated with removal of peroxide- and cGMP-mediated relaxation.
T2 288-434 DRI_Challenge denotes In contrast, bovine coronary arteries (BCAs) relax to hypoxia associated with cytosolic NADPH oxidation coordinating multiple relaxing mechanisms.
T3 435-731 DRI_Approach denotes Since we recently found that H(2)O(2) relaxes BPAs through PKG activation by both soluble guanylate cyclase (sGC)/cGMP-dependent and cGMP-independent thiol oxidation/subunit dimerization mechanisms, we investigated if these mechanisms participate in BPA contraction and BCA relaxation to hypoxia.
T4 732-847 DRI_Outcome denotes The contraction of BPA (precontracted with 20 mM KCl) to hypoxia was associated with decreased PKG dimerization and
T5 884-922 DRI_Outcome denotes phosphoprotein (VASP) phosphorylation.
T6 923-953 DRI_Background denotes In contrast, exposure of 20 mM
T7 997-1078 DRI_Background denotes to hypoxia caused relaxation and increased dimerization and VASP phosphorylation.
T8 1079-1357 DRI_Background denotes Depletion of sGC by organoid culture of BPAs with an oxidant of the sGC heme (10 μM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) increased aerobic force generation, decreased VASP phosphorylation, and inhibited further contraction to hypoxia and changes in VASP phosphorylation.
T9 1358-1511 DRI_Background denotes Thiol reduction with dithiothreitol increased aerobic force in BPAs and decreased PKG dimerization, VASP phosphorylation, and the contraction to hypoxia.
T10 1512-1570 DRI_Outcome denotes Furthermore, PKG-1α and sGC β(1)-subunit small interfering
T11 1592-1772 DRI_Outcome denotes demonstrated increased aerobic K(+) force and inhibition of further contraction to hypoxia, associated with an attenuation of H(2)O(2)-elicited relaxation and VASP phosphorylation.
T12 1773-1945 DRI_Approach denotes Thus, decreases in both a sGC/cGMP-dependent and a dimerization-dependent activation of PKG by H(2)O(2) appear to contribute to the contraction of BPAs elicited by hypoxia.
T13 1946-2072 DRI_Challenge denotes In addition, stimulation of PKG activation by dimerization may be important in the relaxation of coronary arteries to hypoxia.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 111-113 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T2 441-443 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T3 464-468 CVCL_HA54|Induced_pluripotent_stem_cell|Homo sapiens denotes H(2)
T4 464-468 CVCL_JF96|Induced_pluripotent_stem_cell|Macaca fascicularis denotes H(2)
T5 464-468 CVCL_N542|Embryonic_stem_cell|Mus musculus denotes H(2)
T6 498-508 CVCL_C410|Hybridoma|Mus musculus denotes activation
T7 634-636 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T8 775-777 CVCL_J923|Hybridoma|Mus musculus denotes 20
T9 948-950 CVCL_J923|Hybridoma|Mus musculus denotes 20
T10 1129-1131 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T11 1129-1131 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T12 1163-1165 CVCL_J416|Transformed_cell_line|Mus musculus denotes 1H
T13 1188-1189 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1203-1206 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T15 1325-1332 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T16 1700-1702 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T17 1700-1702 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T18 1718-1722 CVCL_HA54|Induced_pluripotent_stem_cell|Homo sapiens denotes H(2)
T19 1718-1722 CVCL_JF96|Induced_pluripotent_stem_cell|Macaca fascicularis denotes H(2)
T20 1718-1722 CVCL_N542|Embryonic_stem_cell|Mus musculus denotes H(2)
T21 1797-1798 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T22 1822-1823 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T23 1847-1857 CVCL_C410|Hybridoma|Mus musculus denotes activation
T24 1868-1872 CVCL_HA54|Induced_pluripotent_stem_cell|Homo sapiens denotes H(2)
T25 1868-1872 CVCL_JF96|Induced_pluripotent_stem_cell|Macaca fascicularis denotes H(2)
T26 1868-1872 CVCL_N542|Embryonic_stem_cell|Mus musculus denotes H(2)
T27 1978-1988 CVCL_C410|Hybridoma|Mus musculus denotes activation
T28 2005-2008 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T5 39-46 SO:0000104 denotes protein
T4 39-46 PR:000000001 denotes protein
T1 39-46 GO:0003675 denotes protein
T7 39-55 D017869 denotes protein kinase G
T8 73-88 UBERON:0001621 denotes coronary artery
T9 73-88 D003324 denotes coronary artery
T10 73-88 D003324 denotes coronary artery
T12 102-109 D000860 denotes hypoxia
T13 102-109 D000860 denotes hypoxia
T14 148-159 UBERON:0001986 denotes endothelium
T15 168-174 9913 denotes bovine
T16 185-193 UBERON:0001637 denotes arteries
T17 213-220 D000860 denotes hypoxia
T18 213-220 D000860 denotes hypoxia
T19 248-256 CHEBI:44785 denotes peroxide
T20 262-266 CHEBI:16356 denotes cGMP
T21 301-307 9913 denotes bovine
T22 317-325 UBERON:0001637 denotes arteries
T23 342-349 D000860 denotes hypoxia
T24 342-349 D000860 denotes hypoxia
T25 376-381 CHEBI:57783 denotes NADPH
T26 376-381 CHEBI:16474 denotes NADPH
T27 376-381 D009249 denotes NADPH
T28 376-381 D009249 denotes NADPH
T29 376-391 GO:0070995 denotes NADPH oxidation
T30 382-391 MOP:0000568 denotes oxidation
T33 464-471 CHEBI:16240 denotes H(2)O(2
T34 494-497 GO:0004692 denotes PKG
T35 517-524 GO:0005625 denotes soluble
T36 517-542 D000071756 denotes soluble guanylate cyclase
T37 525-542 P16065 denotes guanylate cyclase
T39 525-542 Q9ZVR7 denotes guanylate cyclase
T40 525-542 P11528 denotes guanylate cyclase
T41 544-547 PR:Q9M345 denotes sGC
T42 549-553 CHEBI:16356 denotes cGMP
T43 568-572 CHEBI:16356 denotes cGMP
T44 585-590 CHEBI:29256 denotes thiol
T45 585-590 CHEBI:29917 denotes thiol
T46 591-600 MOP:0000568 denotes oxidation
T47 685-688 Q9PTU8 denotes BPA
T48 685-688 Q91ZU6 denotes BPA
T49 685-688 Q03001 denotes BPA
T50 685-688 PR:000031275 denotes BPA
T51 685-688 CHEBI:33216 denotes BPA
T52 705-708 UBERON:2005000 denotes BCA
T53 723-730 D000860 denotes hypoxia
T54 723-730 D000860 denotes hypoxia
T55 751-754 Q9PTU8 denotes BPA
T56 751-754 Q91ZU6 denotes BPA
T57 751-754 Q03001 denotes BPA
T58 751-754 PR:000031275 denotes BPA
T59 751-754 CHEBI:33216 denotes BPA
T60 781-784 CHEBI:32588 denotes KCl
T61 789-796 D000860 denotes hypoxia
T62 789-796 D000860 denotes hypoxia
T63 827-830 GO:0004692 denotes PKG
T64 848-851 GO:0004692 denotes PKG
T67 861-898 P50552 denotes vasodilator-stimulated phosphoprotein
T68 861-898 P50551 denotes vasodilator-stimulated phosphoprotein
T70 861-898 PR:000017263 denotes vasodilator-stimulated phosphoprotein
T71 861-898 Q2TA49 denotes vasodilator-stimulated phosphoprotein
T73 861-898 P70460 denotes vasodilator-stimulated phosphoprotein
T66 861-898 C087636 denotes vasodilator-stimulated phosphoprotein
T69 861-898 C087636 denotes vasodilator-stimulated phosphoprotein
T72 861-898 C087636 denotes vasodilator-stimulated phosphoprotein
T74 861-898 C087636 denotes vasodilator-stimulated phosphoprotein
T176 900-904 PR:P50552 denotes VASP
T177 900-904 P50552 denotes VASP
T178 900-904 PR:P70460 denotes VASP
T179 900-904 P50551 denotes VASP
T180 900-904 PR:000017263 denotes VASP
T181 900-904 Q2TA49 denotes VASP
T182 900-904 P70460 denotes VASP
T183 900-904 PR:Q5TJ65 denotes VASP
T184 906-921 GO:0016310 denotes phosphorylation
T185 954-957 CHEBI:32588 denotes KCl
T186 972-983 UBERON:0001986 denotes endothelium
T187 1000-1007 D000860 denotes hypoxia
T188 1000-1007 D000860 denotes hypoxia
T189 1057-1061 PR:P50552 denotes VASP
T190 1057-1061 P50552 denotes VASP
T191 1057-1061 PR:P70460 denotes VASP
T192 1057-1061 P50551 denotes VASP
T193 1057-1061 PR:000017263 denotes VASP
T194 1057-1061 Q2TA49 denotes VASP
T195 1057-1061 P70460 denotes VASP
T196 1057-1061 PR:Q5TJ65 denotes VASP
T197 1062-1077 GO:0016310 denotes phosphorylation
T198 1092-1095 PR:Q9M345 denotes sGC
T199 1132-1139 CHEBI:63248 denotes oxidant
T200 1147-1150 PR:Q9M345 denotes sGC
T202 1151-1155 PR:Q54DF9 denotes heme
T206 1151-1155 PR:Q2FXA3 denotes heme
T207 1151-1155 PR:P29680 denotes heme
T201 1151-1155 CHEBI:17627 denotes heme
T203 1151-1155 CHEBI:30413 denotes heme
T204 1151-1155 D006418 denotes heme
T205 1151-1155 CHEBI:26355 denotes heme
T208 1151-1155 D006418 denotes heme
T218 1163-1206 C095284 denotes 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
T219 1163-1206 C095284 denotes 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
T220 1163-1206 CHEBI:91215 denotes 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
T221 1254-1258 PR:P50552 denotes VASP
T222 1254-1258 P50552 denotes VASP
T223 1254-1258 PR:P70460 denotes VASP
T224 1254-1258 P50551 denotes VASP
T225 1254-1258 PR:000017263 denotes VASP
T226 1254-1258 Q2TA49 denotes VASP
T227 1254-1258 P70460 denotes VASP
T228 1254-1258 PR:Q5TJ65 denotes VASP
T229 1259-1274 GO:0016310 denotes phosphorylation
T230 1313-1320 D000860 denotes hypoxia
T231 1313-1320 D000860 denotes hypoxia
T232 1336-1340 PR:P50552 denotes VASP
T233 1336-1340 P50552 denotes VASP
T234 1336-1340 PR:P70460 denotes VASP
T235 1336-1340 P50551 denotes VASP
T236 1336-1340 PR:000017263 denotes VASP
T237 1336-1340 Q2TA49 denotes VASP
T238 1336-1340 P70460 denotes VASP
T239 1336-1340 PR:Q5TJ65 denotes VASP
T240 1341-1356 GO:0016310 denotes phosphorylation
T241 1358-1363 CHEBI:29256 denotes Thiol
T242 1358-1363 CHEBI:29917 denotes Thiol
T243 1364-1373 MOP:0000569 denotes reduction
T244 1379-1393 D004229 denotes dithiothreitol
T245 1379-1393 CHEBI:18320 denotes dithiothreitol
T246 1379-1393 D004229 denotes dithiothreitol
T247 1440-1443 GO:0004692 denotes PKG
T248 1458-1462 PR:P50552 denotes VASP
T249 1458-1462 P50552 denotes VASP
T250 1458-1462 PR:P70460 denotes VASP
T251 1458-1462 P50551 denotes VASP
T252 1458-1462 PR:000017263 denotes VASP
T253 1458-1462 Q2TA49 denotes VASP
T254 1458-1462 P70460 denotes VASP
T255 1458-1462 PR:Q5TJ65 denotes VASP
T256 1463-1478 GO:0016310 denotes phosphorylation
T257 1503-1510 D000860 denotes hypoxia
T258 1503-1510 D000860 denotes hypoxia
T259 1525-1528 GO:0004692 denotes PKG
T260 6-9 PR:Q9M345 denotes for
T263 1553-1574 SO:0000646 denotes small interfering RNA
T262 1553-1574 D034741 denotes small interfering RNA
T266 1571-1574 GO:0005562 denotes RNA
T268 1675-1682 D000860 denotes hypoxia
T269 1675-1682 D000860 denotes hypoxia
T272 1718-1725 CHEBI:16240 denotes H(2)O(2
T273 1751-1755 PR:P50552 denotes VASP
T274 1751-1755 P50552 denotes VASP
T275 1751-1755 PR:P70460 denotes VASP
T276 1751-1755 P50551 denotes VASP
T277 1751-1755 PR:000017263 denotes VASP
T278 1751-1755 Q2TA49 denotes VASP
T279 1751-1755 P70460 denotes VASP
T280 1751-1755 PR:Q5TJ65 denotes VASP
T281 1756-1771 GO:0016310 denotes phosphorylation
T282 1799-1802 PR:Q9M345 denotes sGC
T283 1803-1807 CHEBI:16356 denotes cGMP
T284 1861-1864 GO:0004692 denotes PKG
T287 1868-1875 CHEBI:16240 denotes H(2)O(2
T288 1937-1944 D000860 denotes hypoxia
T289 1937-1944 D000860 denotes hypoxia
T290 1974-1977 GO:0004692 denotes PKG
T291 2052-2060 UBERON:0001637 denotes arteries
T292 2064-2071 D000860 denotes hypoxia
T293 2064-2071 D000860 denotes hypoxia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 201-209 HP_0001371 denotes contract
T2 689-700 HP_0001371 denotes contraction
T3 736-747 HP_0001371 denotes contraction
T4 1298-1309 HP_0001371 denotes contraction
T5 1488-1499 HP_0001371 denotes contraction
T6 1660-1671 HP_0001371 denotes contraction
T7 1905-1916 HP_0001371 denotes contraction

Allie

Id Subject Object Predicate Lexical cue
SS1_21926339_1_0 168-193 expanded denotes bovine pulmonary arteries
SS2_21926339_1_0 195-199 abbr denotes BPAs
SS1_21926339_2_0 301-325 expanded denotes bovine coronary arteries
SS2_21926339_2_0 327-331 abbr denotes BCAs
SS1_21926339_3_0 517-542 expanded denotes soluble guanylate cyclase
SS2_21926339_3_0 544-547 abbr denotes sGC
SS1_21926339_4_0 861-898 expanded denotes vasodilator-stimulated phosphoprotein
SS2_21926339_4_0 900-904 abbr denotes VASP
AE1_21926339_1_0 SS1_21926339_1_0 SS2_21926339_1_0 abbreviatedTo bovine pulmonary arteries,BPAs
AE1_21926339_2_0 SS1_21926339_2_0 SS2_21926339_2_0 abbreviatedTo bovine coronary arteries,BCAs
AE1_21926339_3_0 SS1_21926339_3_0 SS2_21926339_3_0 abbreviatedTo soluble guanylate cyclase,sGC
AE1_21926339_4_0 SS1_21926339_4_0 SS2_21926339_4_0 abbreviatedTo vasodilator-stimulated phosphoprotein,VASP