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PubMed:21913717 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 250-255 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

Allie

Id Subject Object Predicate Lexical cue
SS1_21913717_1_0 93-117 expanded denotes Hepatocellular carcinoma
SS2_21913717_1_0 119-122 abbr denotes HCC
SS1_21913717_4_0 656-684 expanded denotes Power Law Global Error Model
SS2_21913717_4_0 686-691 abbr denotes PLGEM
AE1_21913717_1_0 SS1_21913717_1_0 SS2_21913717_1_0 abbreviatedTo Hepatocellular carcinoma,HCC
AE1_21913717_4_0 SS1_21913717_4_0 SS2_21913717_4_0 abbreviatedTo Power Law Global Error Model,PLGEM

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 93-117 HP_0001402 denotes Hepatocellular carcinoma

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 93-117 HP:0001402 denotes Hepatocellular carcinoma
TI1 33-57 HP:0001402 denotes hepatocellular carcinoma

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 93-117 ORDO:88673 denotes Hepatocellular carcinoma
AB2 119-122 ORDO:88673 denotes HCC
TI1 33-57 ORDO:88673 denotes hepatocellular carcinoma
AB3 315-318 ORDO:88673 denotes HCC
AB4 459-462 ORDO:88673 denotes HCC
AB5 847-850 ORDO:88673 denotes HCC
AB6 1047-1050 ORDO:88673 denotes HCC
AB7 1203-1206 ORDO:88673 denotes HCC
AB8 1290-1293 ORDO:88673 denotes HCC
AB9 1557-1560 ORDO:88673 denotes HCC

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery.
TextSentencer_T2 93-204 Sentence denotes Hepatocellular carcinoma (HCC) is one of the leading causes of mortality from solid organ malignancy worldwide.
TextSentencer_T3 205-338 Sentence denotes Because of the complexity of proteins within liver cells and tissues, the discovery of therapeutic targets of HCC has been difficult.
TextSentencer_T4 339-599 Sentence denotes To investigate strategies for decreasing the complexity of tissue samples for detecting meaningful protein mediators of HCC, we employed subcellular fractionation combined with 1D-gel electrophoresis and liquid chromatography-tandem mass spectrometry analysis.
TextSentencer_T5 600-777 Sentence denotes Moreover, we utilized a statistical method, namely, the Power Law Global Error Model (PLGEM), to distinguish differentially expressed proteins in a duplicate proteomic data set.
TextSentencer_T6 778-913 Sentence denotes Mass spectrometric analysis identified 3045 proteins in nontumor and HCC from cytosolic, membrane, nuclear, and cytoskeletal fractions.
TextSentencer_T7 914-1121 Sentence denotes The final lists of highly differentiated proteins from the targeted fractions were searched for potentially translocated proteins in HCC from soluble compartments to the nuclear or cytoskeletal compartments.
TextSentencer_T8 1122-1228 Sentence denotes This analysis refined our targets of interest to include 21 potential targets of HCC from these fractions.
TextSentencer_T9 1229-1401 Sentence denotes Furthermore, we validated the potential molecular targets of HCC, MATR3, LETM1, ILF2, and IQGAP2 by Western blotting, immunohistochemisty, and immunofluorescent microscopy.
TextSentencer_T10 1402-1561 Sentence denotes Here we demonstrate an efficient strategy of subcellular tissue proteomics toward molecular target discovery of one of the most complicated human disease, HCC.
T1 0-92 Sentence denotes Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery.
T2 93-204 Sentence denotes Hepatocellular carcinoma (HCC) is one of the leading causes of mortality from solid organ malignancy worldwide.
T3 205-338 Sentence denotes Because of the complexity of proteins within liver cells and tissues, the discovery of therapeutic targets of HCC has been difficult.
T4 339-599 Sentence denotes To investigate strategies for decreasing the complexity of tissue samples for detecting meaningful protein mediators of HCC, we employed subcellular fractionation combined with 1D-gel electrophoresis and liquid chromatography-tandem mass spectrometry analysis.
T5 600-777 Sentence denotes Moreover, we utilized a statistical method, namely, the Power Law Global Error Model (PLGEM), to distinguish differentially expressed proteins in a duplicate proteomic data set.
T6 778-913 Sentence denotes Mass spectrometric analysis identified 3045 proteins in nontumor and HCC from cytosolic, membrane, nuclear, and cytoskeletal fractions.
T7 914-1121 Sentence denotes The final lists of highly differentiated proteins from the targeted fractions were searched for potentially translocated proteins in HCC from soluble compartments to the nuclear or cytoskeletal compartments.
T8 1122-1228 Sentence denotes This analysis refined our targets of interest to include 21 potential targets of HCC from these fractions.
T9 1229-1401 Sentence denotes Furthermore, we validated the potential molecular targets of HCC, MATR3, LETM1, ILF2, and IQGAP2 by Western blotting, immunohistochemisty, and immunofluorescent microscopy.
T10 1402-1561 Sentence denotes Here we demonstrate an efficient strategy of subcellular tissue proteomics toward molecular target discovery of one of the most complicated human disease, HCC.

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 250-255 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 12-18 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 266-273 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T4 398-404 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 1459-1465 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T6 177-182 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 33-57 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T2 93-117 Disease denotes Hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T3 119-122 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T4 315-318 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T5 459-462 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T6 847-850 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T7 1047-1050 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T8 1203-1206 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T9 1290-1293 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T10 1557-1560 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 250-255 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 33-57 Phenotype denotes hepatocellular carcinoma HP:0001402
T2 93-117 Phenotype denotes Hepatocellular carcinoma HP:0001402
T3 119-122 Phenotype denotes HCC HP:0001402
T4 315-318 Phenotype denotes HCC HP:0001402
T5 459-462 Phenotype denotes HCC HP:0001402
T6 847-850 Phenotype denotes HCC HP:0001402
T7 1047-1050 Phenotype denotes HCC HP:0001402
T8 1203-1206 Phenotype denotes HCC HP:0001402
T9 1290-1293 Phenotype denotes HCC HP:0001402
T10 1557-1560 Phenotype denotes HCC HP:0001402

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1542-1547 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 12-18 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 171-182 Body_part denotes solid organ http://purl.obolibrary.org/obo/UBERON_0000491
T3 250-255 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 398-404 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 867-875 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 1459-1465 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479