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PubMed:21835783 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 367-374 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 376-382 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T3 387-406 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 367-374 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 376-382 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T3 387-406 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 367-374 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 376-382 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T3 387-406 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-151 Sentence denotes Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
TextSentencer_T2 152-224 Sentence denotes Ischemia/reperfusion (I/R) is an important cause of acute renal failure.
TextSentencer_T3 225-491 Sentence denotes Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role in the pathogenesis of ischemic acute renal failure.
TextSentencer_T4 492-699 Sentence denotes MBP causes complement activation through the MBP lectin pathway and a resulting complement component, C3b, is accumulated on the brush borders of kidney proximal tubules in a renal I/R-operated mouse kidney.
TextSentencer_T5 700-788 Sentence denotes However, the initial step of the complement activation has not been studied extensively.
TextSentencer_T6 789-942 Sentence denotes We previously identified both meprins α and β, highly glycosylated zinc metalloproteases, localized on kidney proximal tubules as endogenous MBP ligands.
TextSentencer_T7 943-1122 Sentence denotes In the present study, we demonstrated that serum-type MBP (S-MBP) and C3b were co-localized with meprins on both the cortex and the medulla in the renal I/R-operated mouse kidney.
TextSentencer_T8 1123-1307 Sentence denotes S-MBP was indicated to interact with meprins in vivo in the I/R-operated mouse kidney and was shown to initiate the complement activation through the interaction with meprins in vitro.
TextSentencer_T9 1308-1557 Sentence denotes Taken together, the present study strongly suggested that the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to I/R on kidney transplantation and hemorrhagic shock.
T1 0-151 Sentence denotes Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
T2 152-224 Sentence denotes Ischemia/reperfusion (I/R) is an important cause of acute renal failure.
T3 225-491 Sentence denotes Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role in the pathogenesis of ischemic acute renal failure.
T4 492-699 Sentence denotes MBP causes complement activation through the MBP lectin pathway and a resulting complement component, C3b, is accumulated on the brush borders of kidney proximal tubules in a renal I/R-operated mouse kidney.
T5 700-788 Sentence denotes However, the initial step of the complement activation has not been studied extensively.
T6 789-942 Sentence denotes We previously identified both meprins α and β, highly glycosylated zinc metalloproteases, localized on kidney proximal tubules as endogenous MBP ligands.
T7 943-1122 Sentence denotes In the present study, we demonstrated that serum-type MBP (S-MBP) and C3b were co-localized with meprins on both the cortex and the medulla in the renal I/R-operated mouse kidney.
T8 1123-1307 Sentence denotes S-MBP was indicated to interact with meprins in vivo in the I/R-operated mouse kidney and was shown to initiate the complement activation through the interaction with meprins in vitro.
T9 1308-1557 Sentence denotes Taken together, the present study strongly suggested that the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to I/R on kidney transplantation and hemorrhagic shock.
T1 0-151 Sentence denotes Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
T2 152-224 Sentence denotes Ischemia/reperfusion (I/R) is an important cause of acute renal failure.
T3 225-491 Sentence denotes Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role in the pathogenesis of ischemic acute renal failure.
T4 492-699 Sentence denotes MBP causes complement activation through the MBP lectin pathway and a resulting complement component, C3b, is accumulated on the brush borders of kidney proximal tubules in a renal I/R-operated mouse kidney.
T5 700-788 Sentence denotes However, the initial step of the complement activation has not been studied extensively.
T6 789-942 Sentence denotes We previously identified both meprins α and β, highly glycosylated zinc metalloproteases, localized on kidney proximal tubules as endogenous MBP ligands.
T7 943-1122 Sentence denotes In the present study, we demonstrated that serum-type MBP (S-MBP) and C3b were co-localized with meprins on both the cortex and the medulla in the renal I/R-operated mouse kidney.
T8 1123-1307 Sentence denotes S-MBP was indicated to interact with meprins in vivo in the I/R-operated mouse kidney and was shown to initiate the complement activation through the interaction with meprins in vitro.
T9 1308-1557 Sentence denotes Taken together, the present study strongly suggested that the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to I/R on kidney transplantation and hemorrhagic shock.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 144-150 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 638-644 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T3 645-653 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T4 692-698 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T5 892-898 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T6 899-907 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T7 1115-1121 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T8 1202-1208 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T9 1512-1518 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

DisGeNET

Id Subject Object Predicate Lexical cue
T0 23-45 gene:4153 denotes mannan-binding protein
T1 107-115 disease:C0022116 denotes ischemia
T2 318-321 gene:4153 denotes MBP
T3 471-490 disease:C0022660 denotes acute renal failure
T4 294-316 gene:4153 denotes mannan-binding protein
T5 471-490 disease:C0022660 denotes acute renal failure
R1 T0 T1 associated_with mannan-binding protein,ischemia
R2 T2 T3 associated_with MBP,acute renal failure
R3 T4 T5 associated_with mannan-binding protein,acute renal failure

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 204-223 HP_0001919 denotes acute renal failure
T2 210-223 HP_0000083 denotes renal failure
T3 471-490 HP_0001919 denotes acute renal failure
T4 477-490 HP_0000083 denotes renal failure
T5 1478-1497 HP_0001919 denotes acute renal failure
T6 1484-1497 HP_0000083 denotes renal failure

ICD10

Id Subject Object Predicate Lexical cue
T1 128-134 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T2 204-223 http://purl.bioontology.org/ontology/ICD10/O90.4 denotes acute renal failure
T3 471-490 http://purl.bioontology.org/ontology/ICD10/O90.4 denotes acute renal failure
T4 1478-1497 http://purl.bioontology.org/ontology/ICD10/O90.4 denotes acute renal failure
T5 204-223 http://purl.bioontology.org/ontology/ICD10/N17.8 denotes acute renal failure
T6 471-490 http://purl.bioontology.org/ontology/ICD10/N17.8 denotes acute renal failure
T7 1478-1497 http://purl.bioontology.org/ontology/ICD10/N17.8 denotes acute renal failure
T8 204-223 http://purl.bioontology.org/ontology/ICD10/N17.9 denotes acute renal failure
T9 471-490 http://purl.bioontology.org/ontology/ICD10/N17.9 denotes acute renal failure
T10 1478-1497 http://purl.bioontology.org/ontology/ICD10/N17.9 denotes acute renal failure
T11 204-223 http://purl.bioontology.org/ontology/ICD10/N17 denotes acute renal failure
T12 471-490 http://purl.bioontology.org/ontology/ICD10/N17 denotes acute renal failure
T13 1478-1497 http://purl.bioontology.org/ontology/ICD10/N17 denotes acute renal failure
T14 210-223 http://purl.bioontology.org/ontology/ICD10/N17-N19.9 denotes renal failure
T15 477-490 http://purl.bioontology.org/ontology/ICD10/N17-N19.9 denotes renal failure
T16 1484-1497 http://purl.bioontology.org/ontology/ICD10/N17-N19.9 denotes renal failure
T17 210-223 http://purl.bioontology.org/ontology/ICD10/N19 denotes renal failure
T18 477-490 http://purl.bioontology.org/ontology/ICD10/N19 denotes renal failure
T19 1484-1497 http://purl.bioontology.org/ontology/ICD10/N19 denotes renal failure
T20 1551-1556 http://purl.bioontology.org/ontology/ICD10/R57.9 denotes shock

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 38-45 FMAID:165447 denotes protein
_T2 38-45 FMAID:67257 denotes protein
_T3 144-150 FMAID:7203 denotes kidney
_T4 144-150 FMAID:93681 denotes kidney
_T5 309-316 FMAID:165447 denotes protein
_T6 309-316 FMAID:67257 denotes protein
_T7 318-321 FMAID:242152 denotes MBP
_T8 342-347 FMAID:167330 denotes serum
_T9 367-374 FMAID:82801 denotes mannose
_T10 367-374 FMAID:196796 denotes mannose
_T11 376-382 FMAID:196784 denotes fucose
_T12 376-382 FMAID:82790 denotes fucose
_T13 387-406 FMAID:82787 denotes N-acetylglucosamine
_T14 387-406 FMAID:196781 denotes N-acetylglucosamine
_T15 492-495 FMAID:242152 denotes MBP
_T16 537-540 FMAID:242152 denotes MBP
_T17 627-644 FMAID:108803 denotes borders of kidney
_T18 627-644 FMAID:105755 denotes borders of kidney
_T19 627-644 FMAID:108801 denotes borders of kidney
_T20 638-644 FMAID:7203 denotes kidney
_T21 638-644 FMAID:93681 denotes kidney
_T22 645-653 FMAID:171415 denotes proximal
_T23 645-653 FMAID:30326 denotes proximal
_T24 654-661 FMAID:199223 denotes tubules
_T25 654-661 FMAID:199224 denotes tubules
_T26 692-698 FMAID:93681 denotes kidney
_T27 692-698 FMAID:7203 denotes kidney
_T28 892-898 FMAID:7203 denotes kidney
_T29 892-898 FMAID:93681 denotes kidney
_T30 899-907 FMAID:30326 denotes proximal
_T31 899-907 FMAID:171415 denotes proximal
_T32 908-915 FMAID:199224 denotes tubules
_T33 908-915 FMAID:199223 denotes tubules
_T34 930-933 FMAID:242152 denotes MBP
_T35 986-991 FMAID:167330 denotes serum
_T36 997-1000 FMAID:242152 denotes MBP
_T37 1004-1007 FMAID:242152 denotes MBP
_T38 1060-1066 FMAID:161599 denotes cortex
_T39 1060-1066 FMAID:61109 denotes cortex
_T40 1075-1082 FMAID:161598 denotes medulla
_T41 1075-1082 FMAID:61108 denotes medulla
_T42 1115-1121 FMAID:93681 denotes kidney
_T43 1115-1121 FMAID:7203 denotes kidney
_T44 1125-1128 FMAID:242152 denotes MBP
_T45 1202-1208 FMAID:93681 denotes kidney
_T46 1202-1208 FMAID:7203 denotes kidney
_T47 1383-1386 FMAID:242152 denotes MBP
_T48 1512-1518 FMAID:7203 denotes kidney
_T49 1512-1518 FMAID:93681 denotes kidney

uniprot-human

Id Subject Object Predicate Lexical cue
T1 23-45 http://www.uniprot.org/uniprot/Q96TF8 denotes mannan-binding protein
T2 294-316 http://www.uniprot.org/uniprot/Q96TF8 denotes mannan-binding protein
T3 318-321 http://www.uniprot.org/uniprot/P13727 denotes MBP
T4 492-495 http://www.uniprot.org/uniprot/P13727 denotes MBP
T5 537-540 http://www.uniprot.org/uniprot/P13727 denotes MBP
T6 930-933 http://www.uniprot.org/uniprot/P13727 denotes MBP
T7 997-1000 http://www.uniprot.org/uniprot/P13727 denotes MBP
T8 1004-1007 http://www.uniprot.org/uniprot/P13727 denotes MBP
T9 1125-1128 http://www.uniprot.org/uniprot/P13727 denotes MBP
T10 1383-1386 http://www.uniprot.org/uniprot/P13727 denotes MBP
T11 318-321 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T12 492-495 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T13 537-540 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T14 930-933 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T15 997-1000 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T16 1004-1007 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T17 1125-1128 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP
T18 1383-1386 http://www.uniprot.org/uniprot/Q6FI04 denotes MBP

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 23-45 http://www.uniprot.org/uniprot/P39039 denotes mannan-binding protein
T2 294-316 http://www.uniprot.org/uniprot/P39039 denotes mannan-binding protein
T3 23-45 http://www.uniprot.org/uniprot/P41317 denotes mannan-binding protein
T4 294-316 http://www.uniprot.org/uniprot/P41317 denotes mannan-binding protein
T5 318-321 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T6 492-495 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T7 537-540 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T8 930-933 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T9 997-1000 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T10 1004-1007 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T11 1125-1128 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T12 1383-1386 http://www.uniprot.org/uniprot/Q61878 denotes MBP
T13 318-321 http://www.uniprot.org/uniprot/P04370 denotes MBP
T14 492-495 http://www.uniprot.org/uniprot/P04370 denotes MBP
T15 537-540 http://www.uniprot.org/uniprot/P04370 denotes MBP
T16 930-933 http://www.uniprot.org/uniprot/P04370 denotes MBP
T17 997-1000 http://www.uniprot.org/uniprot/P04370 denotes MBP
T18 1004-1007 http://www.uniprot.org/uniprot/P04370 denotes MBP
T19 1125-1128 http://www.uniprot.org/uniprot/P04370 denotes MBP
T20 1383-1386 http://www.uniprot.org/uniprot/P04370 denotes MBP

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1022-1024 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co

GO-BP

Id Subject Object Predicate Lexical cue
T1 82-103 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T2 503-524 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T3 733-754 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T4 1239-1260 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T5 1411-1432 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T6 446-458 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T7 744-758 http://purl.obolibrary.org/obo/GO_0050501 denotes activation has
T8 843-855 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T9 879-888 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T10 1025-1034 http://purl.obolibrary.org/obo/GO_0051179 denotes localized

GO-MF

Id Subject Object Predicate Lexical cue
T1 23-37 http://purl.obolibrary.org/obo/GO_2001065 denotes mannan-binding
T2 294-308 http://purl.obolibrary.org/obo/GO_2001065 denotes mannan-binding
T3 30-37 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 301-308 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1370-1377 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 30-37 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 301-308 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 1370-1377 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 30-37 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 301-308 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T11 1370-1377 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 30-37 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 301-308 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14 1370-1377 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15 30-45 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T16 301-316 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T17 934-941 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands

GO-CC

Id Subject Object Predicate Lexical cue
T1 621-634 http://purl.obolibrary.org/obo/GO_0005903 denotes brush borders
T2 654-661 http://purl.obolibrary.org/obo/GO_0097649 denotes tubules
T3 908-915 http://purl.obolibrary.org/obo/GO_0097649 denotes tubules

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 144-150 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T2 638-644 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T3 692-698 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T4 892-898 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T5 1115-1121 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T6 1202-1208 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T7 1512-1518 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T8 342-347 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T9 986-991 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T10 645-661 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
T11 899-915 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
T12 776-787 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively
T13 1060-1066 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex

Allie

Id Subject Object Predicate Lexical cue
SS1_21835783_1_0 152-172 expanded denotes Ischemia/reperfusion
SS2_21835783_1_0 174-177 abbr denotes I/R
SS1_21835783_2_0 294-316 expanded denotes mannan-binding protein
SS2_21835783_2_0 318-321 abbr denotes MBP
SS1_21835783_6_0 986-1000 expanded denotes serum-type MBP
SS2_21835783_6_0 1002-1007 abbr denotes S-MBP
AE1_21835783_1_0 SS1_21835783_1_0 SS2_21835783_1_0 abbreviatedTo Ischemia/reperfusion,I/R
AE1_21835783_2_0 SS1_21835783_2_0 SS2_21835783_2_0 abbreviatedTo mannan-binding protein,MBP
AE1_21835783_6_0 SS1_21835783_6_0 SS2_21835783_6_0 abbreviatedTo serum-type MBP,S-MBP

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 8-19 http://edamontology.org/topic_0602 denotes interaction
T2 38-45 http://edamontology.org/topic_0078 denotes protein
T3 232-239 http://edamontology.org/topic_3678 denotes studies
T4 309-316 http://edamontology.org/topic_0078 denotes protein
T5 548-555 http://edamontology.org/topic_0602 denotes pathway
T6 768-775 http://edamontology.org/topic_3678 denotes studied
T7 958-963 http://edamontology.org/topic_3678 denotes study
T8 1146-1154 http://edamontology.org/topic_0602 denotes interact
T9 1273-1284 http://edamontology.org/topic_0602 denotes interaction
T10 1336-1341 http://edamontology.org/topic_3678 denotes study
T11 1452-1459 http://edamontology.org/topic_0602 denotes pathway
T12 1519-1534 http://edamontology.org/topic_3421 denotes transplantation

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 38-45 http://edamontology.org/format_1208 denotes protein
T2 38-45 http://edamontology.org/data_1467 denotes protein
T3 309-316 http://edamontology.org/data_1467 denotes protein
T4 309-316 http://edamontology.org/format_1208 denotes protein
T5 407-415 http://edamontology.org/data_1756 denotes residues
T6 548-555 http://edamontology.org/data_2600 denotes pathway
T7 803-813 http://edamontology.org/data_0842 denotes identified
T8 803-813 http://edamontology.org/data_2611 denotes identified
T9 968-980 http://edamontology.org/operation_2246 denotes demonstrated
T10 1452-1459 http://edamontology.org/data_2600 denotes pathway

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21835783-2#69#91#gene4153 294-316 gene4153 denotes mannan-binding protein
21835783-2#93#96#gene4153 318-321 gene4153 denotes MBP
21835783-2#246#265#diseaseC0022660 471-490 diseaseC0022660 denotes acute renal failure
21835783-2#246#265#diseaseC3854173 471-490 diseaseC3854173 denotes acute renal failure
21835783-2#246#265#diseaseC0022660 471-490 diseaseC0022660 denotes acute renal failure
21835783-2#246#265#diseaseC3854173 471-490 diseaseC3854173 denotes acute renal failure
69#91#gene4153246#265#diseaseC0022660 21835783-2#69#91#gene4153 21835783-2#246#265#diseaseC0022660 associated_with mannan-binding protein,acute renal failure
69#91#gene4153246#265#diseaseC3854173 21835783-2#69#91#gene4153 21835783-2#246#265#diseaseC3854173 associated_with mannan-binding protein,acute renal failure
69#91#gene4153246#265#diseaseC0022660 21835783-2#69#91#gene4153 21835783-2#246#265#diseaseC0022660 associated_with mannan-binding protein,acute renal failure
69#91#gene4153246#265#diseaseC3854173 21835783-2#69#91#gene4153 21835783-2#246#265#diseaseC3854173 associated_with mannan-binding protein,acute renal failure
93#96#gene4153246#265#diseaseC0022660 21835783-2#93#96#gene4153 21835783-2#246#265#diseaseC0022660 associated_with MBP,acute renal failure
93#96#gene4153246#265#diseaseC3854173 21835783-2#93#96#gene4153 21835783-2#246#265#diseaseC3854173 associated_with MBP,acute renal failure
93#96#gene4153246#265#diseaseC0022660 21835783-2#93#96#gene4153 21835783-2#246#265#diseaseC0022660 associated_with MBP,acute renal failure
93#96#gene4153246#265#diseaseC3854173 21835783-2#93#96#gene4153 21835783-2#246#265#diseaseC3854173 associated_with MBP,acute renal failure

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 144-150 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 638-644 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T3 645-653 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T4 692-698 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T5 892-898 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T6 899-907 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T7 1115-1121 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T8 1202-1208 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T9 1512-1518 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 23-45 https://acgg.asia/db/lfdb/LfDB0016 denotes mannan-binding protein
Lectin_T2 294-316 https://acgg.asia/db/lfdb/LfDB0016 denotes mannan-binding protein
Lectin_T3 23-45 https://acgg.asia/db/lfdb/LfDB0042 denotes mannan-binding protein
Lectin_T4 294-316 https://acgg.asia/db/lfdb/LfDB0042 denotes mannan-binding protein
Lectin_T5 318-321 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T6 492-495 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T7 537-540 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T8 930-933 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T9 997-1000 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T10 1004-1007 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T11 1125-1128 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T12 1383-1386 https://acgg.asia/db/lfdb/LfDB0015 denotes MBP
Lectin_T13 318-321 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T14 492-495 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T15 537-540 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T16 930-933 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T17 997-1000 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T18 1004-1007 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T19 1125-1128 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP
Lectin_T20 1383-1386 https://acgg.asia/db/lfdb/LfDB0041 denotes MBP

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 342-347 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 986-991 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 144-150 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T4 638-644 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T5 692-698 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T6 892-898 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T7 1115-1121 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T8 1202-1208 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T9 1512-1518 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T10 776-787 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively
PD-UBERON-AE-B_T11 645-661 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
PD-UBERON-AE-B_T12 899-915 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
PD-UBERON-AE-B_T13 1060-1066 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 204-223 Phenotype denotes acute renal failure HP:0001919
T2 471-490 Phenotype denotes acute renal failure HP:0001919
T3 1478-1497 Phenotype denotes acute renal failure HP:0001919
T4 1551-1556 Phenotype denotes shock HP:0031273

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 107-134 Disease denotes ischemia/reperfusion injury http://purl.obolibrary.org/obo/MONDO_0005203
T2 152-160 Disease denotes Ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T3 204-223 Disease denotes acute renal failure http://purl.obolibrary.org/obo/MONDO_0002492
T4 471-490 Disease denotes acute renal failure http://purl.obolibrary.org/obo/MONDO_0002492
T5 1478-1497 Disease denotes acute renal failure http://purl.obolibrary.org/obo/MONDO_0002492

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
T2 152-224 Sentence denotes Ischemia/reperfusion (I/R) is an important cause of acute renal failure.
T3 225-491 Sentence denotes Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role in the pathogenesis of ischemic acute renal failure.
T4 492-699 Sentence denotes MBP causes complement activation through the MBP lectin pathway and a resulting complement component, C3b, is accumulated on the brush borders of kidney proximal tubules in a renal I/R-operated mouse kidney.
T5 700-788 Sentence denotes However, the initial step of the complement activation has not been studied extensively.
T6 789-942 Sentence denotes We previously identified both meprins α and β, highly glycosylated zinc metalloproteases, localized on kidney proximal tubules as endogenous MBP ligands.
T7 943-1122 Sentence denotes In the present study, we demonstrated that serum-type MBP (S-MBP) and C3b were co-localized with meprins on both the cortex and the medulla in the renal I/R-operated mouse kidney.
T8 1123-1307 Sentence denotes S-MBP was indicated to interact with meprins in vivo in the I/R-operated mouse kidney and was shown to initiate the complement activation through the interaction with meprins in vitro.
T9 1308-1557 Sentence denotes Taken together, the present study strongly suggested that the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to I/R on kidney transplantation and hemorrhagic shock.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 138-143 OrganismTaxon denotes mouse 10088|10090
T3 686-691 OrganismTaxon denotes mouse 10088|10090
T5 1109-1114 OrganismTaxon denotes mouse 10088|10090
T7 1196-1201 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 144-150 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 621-634 Body_part denotes brush borders http://purl.obolibrary.org/obo/UBERON_0012424
T3 638-661 Body_part denotes kidney proximal tubules http://purl.obolibrary.org/obo/UBERON_0004134
T4 692-698 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 892-915 Body_part denotes kidney proximal tubules http://purl.obolibrary.org/obo/UBERON_0004134
T6 1060-1066 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T7 1075-1082 Body_part denotes medulla http://purl.obolibrary.org/obo/UBERON_0000958|http://purl.obolibrary.org/obo/UBERON_0001896
T9 1115-1121 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T10 1202-1208 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T11 1512-1518 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 144-150 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T2 638-644 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T3 645-653 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T4 692-698 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T5 892-898 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T6 899-907 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T7 1115-1121 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T8 1202-1208 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T9 1512-1518 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119