PubMed:21823662
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1472-1492 | Disease | denotes | bacterial infections | http://purl.obolibrary.org/obo/MONDO_0005113 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 68-71 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 437-440 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 674-677 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 899-902 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1472-1492 | Disease | denotes | bacterial infections | http://purl.obolibrary.org/obo/MONDO_0005113 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 148-156 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T3 | 175-183 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T5 | 297-305 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T7 | 736-744 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T9 | 1100-1108 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T11 | 1301-1309 | OrganismTaxon | denotes | bacteria | 2|629395 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 371-375 | Body_part | denotes | wall | http://purl.obolibrary.org/obo/UBERON_0000060 |
| T2 | 1272-1276 | Body_part | denotes | wall | http://purl.obolibrary.org/obo/UBERON_0000060 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-157 | Sentence | denotes | A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria. |
| T2 | 158-275 | Sentence | denotes | The emergence of bacteria resistant to vancomycin, often the antibiotic of last resort, poses a major health problem. |
| T3 | 276-555 | Sentence | denotes | Vancomycin-resistant bacteria sense a glycopeptide antibiotic challenge and remodel their cell wall precursor peptidoglycan terminus from d-Ala-d-Ala to d-Ala-d-Lac, reducing the binding of vancomycin to its target 1000-fold and accounting for the loss in antimicrobial activity. |
| T4 | 556-745 | Sentence | denotes | Here, we report [Ψ[C(═NH)NH]Tpg(4)]vancomycin aglycon designed to exhibit the dual binding to d-Ala-d-Ala and d-Ala-d-Lac needed to reinstate activity against vancomycin-resistant bacteria. |
| T5 | 746-975 | Sentence | denotes | Its binding to a model d-Ala-d-Ala ligand was found to be only 2-fold less than vancomycin aglycon and this affinity was maintained with a model d-Ala-d-Lac ligand, representing a 600-fold increase relative to vancomycin aglycon. |
| T6 | 976-1138 | Sentence | denotes | Accurately reflecting these binding characteristics, it exhibits potent antimicrobial activity against vancomycin-resistant bacteria (MIC = 0.31 μg/mL, VanA VRE). |
| T7 | 1139-1493 | Sentence | denotes | Thus, a complementary single atom exchange in the vancomycin core structure (O → NH) to counter the single atom exchange in the cell wall precursors of resistant bacteria (NH → O) reinstates potent antimicrobial activity and charts a rational path forward for the development of antibiotics for the treatment of vancomycin-resistant bacterial infections. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 68-71 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 437-440 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 674-677 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 899-902 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 148-156 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T3 | 175-183 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T5 | 297-305 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T7 | 736-744 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T9 | 1100-1108 | OrganismTaxon | denotes | bacteria | 2|629395 |
| T11 | 1301-1309 | OrganismTaxon | denotes | bacteria | 2|629395 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 371-375 | Body_part | denotes | wall | http://purl.obolibrary.org/obo/UBERON_0000060 |
| T2 | 1272-1276 | Body_part | denotes | wall | http://purl.obolibrary.org/obo/UBERON_0000060 |