PubMed:21803834 / 714-1151 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T5","span":{"begin":167,"end":201},"obj":"Cell"}],"attributes":[{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000842"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:2000001"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"Glycan-Motif","denotations":[{"id":"T5","span":{"begin":311,"end":315},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T5","span":{"begin":311,"end":315},"obj":"Glycan_Motif"}],"attributes":[{"id":"A5","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T5","span":{"begin":0,"end":284},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":285,"end":437},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":437},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":284},"obj":"Sentence"},{"id":"T6","span":{"begin":285,"end":437},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":129,"end":140},"obj":"http://purl.obolibrary.org/obo/MAT_0000084"},{"id":"T2","span":{"begin":129,"end":133},"obj":"http://purl.obolibrary.org/obo/MAT_0000299"},{"id":"T3","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/MAT_0000083"},{"id":"T4","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/MAT_0000315"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"DisGeNET","denotations":[{"id":"T4","span":{"begin":32,"end":36},"obj":"gene:54414"},{"id":"T5","span":{"begin":91,"end":94},"obj":"disease:C0023452"}],"relations":[{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T29","span":{"begin":54,"end":63},"obj":"FMAID:162299"},{"id":"_T30","span":{"begin":54,"end":63},"obj":"FMAID:63836"},{"id":"_T31","span":{"begin":118,"end":123},"obj":"FMAID:169002"},{"id":"_T32","span":{"begin":118,"end":123},"obj":"FMAID:68646"},{"id":"_T33","span":{"begin":129,"end":133},"obj":"FMAID:30317"},{"id":"_T34","span":{"begin":129,"end":133},"obj":"FMAID:172618"},{"id":"_T35","span":{"begin":129,"end":133},"obj":"FMAID:123537"},{"id":"_T36","span":{"begin":129,"end":140},"obj":"FMAID:97498"},{"id":"_T37","span":{"begin":129,"end":140},"obj":"FMAID:9608"},{"id":"_T38","span":{"begin":167,"end":177},"obj":"FMAID:222825"},{"id":"_T39","span":{"begin":167,"end":177},"obj":"FMAID:179289"},{"id":"_T40","span":{"begin":167,"end":177},"obj":"FMAID:74552"},{"id":"_T41","span":{"begin":167,"end":183},"obj":"FMAID:201651"},{"id":"_T42","span":{"begin":167,"end":183},"obj":"FMAID:86697"},{"id":"_T43","span":{"begin":167,"end":201},"obj":"FMAID:201667"},{"id":"_T44","span":{"begin":167,"end":201},"obj":"FMAID:86713"},{"id":"_T45","span":{"begin":178,"end":183},"obj":"FMAID:256053"},{"id":"_T46","span":{"begin":196,"end":201},"obj":"FMAID:68646"},{"id":"_T47","span":{"begin":196,"end":201},"obj":"FMAID:169002"},{"id":"_T48","span":{"begin":341,"end":350},"obj":"FMAID:63836"},{"id":"_T49","span":{"begin":341,"end":350},"obj":"FMAID:162299"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"uniprot-human","denotations":[{"id":"T4","span":{"begin":32,"end":36},"obj":"http://www.uniprot.org/uniprot/Q9HAT2"},{"id":"T5","span":{"begin":392,"end":396},"obj":"http://www.uniprot.org/uniprot/Q9HAT2"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T8","span":{"begin":118,"end":123},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T9","span":{"begin":196,"end":201},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T10","span":{"begin":263,"end":269},"obj":"http://purl.bioontology.org/ontology/STY/T096"},{"id":"T11","span":{"begin":280,"end":283},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/208766"},{"id":"T12","span":{"begin":280,"end":283},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/172412"},{"id":"T13","span":{"begin":311,"end":315},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/208766"},{"id":"T14","span":{"begin":311,"end":315},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/172412"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":54,"end":63},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T2","span":{"begin":341,"end":350},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T4","span":{"begin":68,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0005829"},{"id":"T5","span":{"begin":323,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0005829"},{"id":"T7","span":{"begin":95,"end":99},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8","span":{"begin":118,"end":123},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":196,"end":201},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":129,"end":140},"obj":"http://purl.obolibrary.org/obo/UBERON_0002371"},{"id":"T2","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":54,"end":63},"obj":"http://edamontology.org/topic_0616"},{"id":"T2","span":{"begin":341,"end":350},"obj":"http://edamontology.org/topic_0616"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":95,"end":109},"obj":"http://edamontology.org/data_0963"},{"id":"T2","span":{"begin":375,"end":386},"obj":"http://edamontology.org/operation_3465"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":129,"end":133},"obj":"http://purl.obolibrary.org/obo/MAT_0000299"},{"id":"T2","span":{"begin":129,"end":140},"obj":"http://purl.obolibrary.org/obo/MAT_0000084"},{"id":"T3","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/MAT_0000083"},{"id":"T4","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/MAT_0000315"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T2","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G41652MJ\""},{"id":"GlycanIUPAC_T6","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G20761YC\""},{"id":"GlycanIUPAC_T10","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G19807HM\""},{"id":"GlycanIUPAC_T14","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G20351TE\""},{"id":"GlycanIUPAC_T18","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G71957MR\""},{"id":"GlycanIUPAC_T22","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G59040AE\""},{"id":"GlycanIUPAC_T26","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G14987PW\""},{"id":"GlycanIUPAC_T30","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G95064PC\""},{"id":"GlycanIUPAC_T34","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G39143AQ\""},{"id":"GlycanIUPAC_T38","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G65149OO\""},{"id":"GlycanIUPAC_T42","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G02766SY\""},{"id":"GlycanIUPAC_T46","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G26019KJ\""},{"id":"GlycanIUPAC_T50","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G36429CZ\""},{"id":"GlycanIUPAC_T54","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G89633TP\""},{"id":"GlycanIUPAC_T58","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G28494FO\""},{"id":"GlycanIUPAC_T62","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G06219CP\""},{"id":"GlycanIUPAC_T66","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G44237SM\""},{"id":"GlycanIUPAC_T70","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G57948RL\""},{"id":"GlycanIUPAC_T74","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G64016DN\""},{"id":"GlycanIUPAC_T78","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G14536PC\""},{"id":"GlycanIUPAC_T82","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G14356FW\""},{"id":"GlycanIUPAC_T86","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G34565UO\""},{"id":"GlycanIUPAC_T90","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G67124MW\""},{"id":"GlycanIUPAC_T94","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G71457ZU\""},{"id":"GlycanIUPAC_T98","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G55228VZ\""},{"id":"GlycanIUPAC_T102","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G31034MJ\""},{"id":"GlycanIUPAC_T106","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G25776IP\""},{"id":"GlycanIUPAC_T110","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G64442BV\""},{"id":"GlycanIUPAC_T114","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G57018LE\""},{"id":"GlycanIUPAC_T118","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G61761GX\""},{"id":"GlycanIUPAC_T122","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G76318UX\""},{"id":"GlycanIUPAC_T126","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G61906ER\""},{"id":"GlycanIUPAC_T130","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G68723GR\""},{"id":"GlycanIUPAC_T134","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G19540LE\""},{"id":"GlycanIUPAC_T138","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G74944PO\""},{"id":"GlycanIUPAC_T142","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G89489ZJ\""},{"id":"GlycanIUPAC_T146","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G04434YU\""},{"id":"GlycanIUPAC_T150","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G21450PB\""},{"id":"GlycanIUPAC_T154","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G93629QY\""},{"id":"GlycanIUPAC_T158","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G02603TR\""},{"id":"GlycanIUPAC_T162","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G40280JP\""},{"id":"GlycanIUPAC_T166","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G95259IC\""},{"id":"GlycanIUPAC_T170","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G26900FE\""},{"id":"GlycanIUPAC_T174","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G21346KK\""},{"id":"GlycanIUPAC_T178","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G62509FF\""},{"id":"GlycanIUPAC_T182","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G83932AK\""},{"id":"GlycanIUPAC_T186","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G96978IB\""},{"id":"GlycanIUPAC_T190","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G34275DN\""},{"id":"GlycanIUPAC_T194","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G07071JF\""},{"id":"GlycanIUPAC_T198","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G80639QD\""},{"id":"GlycanIUPAC_T202","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G99460PJ\""},{"id":"GlycanIUPAC_T206","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G22024BZ\""},{"id":"GlycanIUPAC_T210","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G74097ZY\""},{"id":"GlycanIUPAC_T214","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G84439YP\""},{"id":"GlycanIUPAC_T218","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G52207WQ\""},{"id":"GlycanIUPAC_T222","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G90695MS\""},{"id":"GlycanIUPAC_T226","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G50398QX\""},{"id":"GlycanIUPAC_T230","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G12166ZT\""},{"id":"GlycanIUPAC_T234","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G48368BR\""},{"id":"GlycanIUPAC_T238","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G57407RW\""},{"id":"GlycanIUPAC_T242","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G00386TY\""},{"id":"GlycanIUPAC_T246","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G18723JK\""},{"id":"GlycanIUPAC_T250","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G93757OR\""},{"id":"GlycanIUPAC_T254","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G29006SI\""},{"id":"GlycanIUPAC_T258","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G03099OQ\""},{"id":"GlycanIUPAC_T262","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G53739OW\""},{"id":"GlycanIUPAC_T266","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G70440ZO\""},{"id":"GlycanIUPAC_T270","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G29951RR\""},{"id":"GlycanIUPAC_T274","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G58402TI\""},{"id":"GlycanIUPAC_T278","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G39875TP\""},{"id":"GlycanIUPAC_T282","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G83439QV\""},{"id":"GlycanIUPAC_T286","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G41762RC\""},{"id":"GlycanIUPAC_T290","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G91604UI\""},{"id":"GlycanIUPAC_T294","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G88447WE\""},{"id":"GlycanIUPAC_T298","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G93634BS\""},{"id":"GlycanIUPAC_T302","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G02587BH\""},{"id":"GlycanIUPAC_T306","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G43511MX\""},{"id":"GlycanIUPAC_T310","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G64958DH\""},{"id":"GlycanIUPAC_T314","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G30384TR\""},{"id":"GlycanIUPAC_T318","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G15624EX\""},{"id":"GlycanIUPAC_T322","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G22706ST\""},{"id":"GlycanIUPAC_T326","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G57408PI\""},{"id":"GlycanIUPAC_T330","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G86403XX\""},{"id":"GlycanIUPAC_T334","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G78043YB\""},{"id":"GlycanIUPAC_T338","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G18952JK\""},{"id":"GlycanIUPAC_T342","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G49020ND\""},{"id":"GlycanIUPAC_T346","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G63590YW\""},{"id":"GlycanIUPAC_T350","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G22793KS\""},{"id":"GlycanIUPAC_T354","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G64134SS\""},{"id":"GlycanIUPAC_T358","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G17338HY\""},{"id":"GlycanIUPAC_T362","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G99745XF\""},{"id":"GlycanIUPAC_T366","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G27782HN\""},{"id":"GlycanIUPAC_T370","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G57496DC\""},{"id":"GlycanIUPAC_T374","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G93169WB\""},{"id":"GlycanIUPAC_T378","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G05518TD\""},{"id":"GlycanIUPAC_T382","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G62603DN\""},{"id":"GlycanIUPAC_T386","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G59574FS\""},{"id":"GlycanIUPAC_T390","span":{"begin":91,"end":94},"obj":"\"http://rdf.glycoinfo.org/glycan/G47567WC\""}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":178,"end":183},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":129,"end":140},"obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":129,"end":140},"obj":"Body_part"},{"id":"T2","span":{"begin":178,"end":183},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000084"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000083"},{"id":"A3","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000315"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"HP-phenotype","denotations":[{"id":"T4","span":{"begin":91,"end":94},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0006721"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"mondo_disease","denotations":[{"id":"T4","span":{"begin":91,"end":94},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0004967"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":129,"end":140},"obj":"Body_part"},{"id":"T2","span":{"begin":167,"end":201},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000842"},{"id":"A3","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_2000001"}],"text":"We further observed a decreased SIAE activity in both lysosomal and cytosolic fractions of ALL cell lines and primary cells from bone marrow of patients compared with peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyze O-acetyl groups at C-9 of Sia. The level of O-acetylated Sias in the cytosolic and the lysosomal fractions showed a good correlation with SIAE activity in the corresponding fractions."}