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PubMed:21768350 JSONTXT

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LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
2 38-55 OrganismTaxon denotes Shigella flexneri Tax:623
3 71-87 OrganismTaxon denotes Escherichia coli Tax:562
22 458-478 OrganismTaxon denotes Shigella flexneri 2a Tax:42897
23 516-532 OrganismTaxon denotes Escherichia coli Tax:562
24 567-572 OrganismTaxon denotes human Tax:9606
25 664-680 ChemicalEntity denotes O-linked glycans
26 870-882 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
27 1010-1013 ChemicalEntity denotes Thr MESH:D013912
28 1017-1020 ChemicalEntity denotes Ser MESH:D012694
29 1077-1089 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
30 1094-1104 DiseaseOrPhenotypicFeature denotes malignancy MESH:D009369
31 1154-1159 OrganismTaxon denotes human Tax:9606
32 1183-1186 ChemicalEntity denotes Pic
33 1278-1281 ChemicalEntity denotes Pic
34 1374-1377 GeneOrGeneProduct denotes Tsh Gene:5962120
35 1413-1423 DiseaseOrPhenotypicFeature denotes infections MESH:D007239
36 1500-1510 OrganismTaxon denotes guinea pig Tax:10141
37 1511-1531 DiseaseOrPhenotypicFeature denotes keratoconjunctivitis MESH:D007637
38 1541-1549 OrganismTaxon denotes Shigella Tax:42897
39 1577-1589 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 350-359 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T2 533-540 DiseaseOrPhenotypicFeature denotes strains D013180
T3 870-882 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T5 1077-1089 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T7 1094-1104 DiseaseOrPhenotypicFeature denotes malignancy D009369
T8 1324-1329 DiseaseOrPhenotypicFeature denotes death D003643
T9 1413-1423 DiseaseOrPhenotypicFeature denotes infections D007239
T10 1511-1531 DiseaseOrPhenotypicFeature denotes keratoconjunctivitis D007637
T11 1577-1589 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T13 1606-1612 DiseaseOrPhenotypicFeature denotes strain D013180

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 350-359 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T2 870-882 DiseaseOrPhenotypicFeature denotes inflammation D007249
T3 1077-1089 DiseaseOrPhenotypicFeature denotes inflammation D007249
T4 1094-1104 DiseaseOrPhenotypicFeature denotes malignancy D009369
T5 1511-1531 DiseaseOrPhenotypicFeature denotes keratoconjunctivitis D007637
T6 1577-1589 DiseaseOrPhenotypicFeature denotes inflammation D007249

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
T2 137-291 Sentence denotes The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway.
T3 292-397 Sentence denotes We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2).
T4 398-601 Sentence denotes Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a broad range of human leukocyte adhesion proteins.
T5 602-883 Sentence denotes Substrate specificity was restricted to glycoproteins rich in O-linked glycans, including CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, migration, and inflammation.
T6 884-1030 Sentence denotes N-terminal sequencing of proteolytic products revealed Pic (protease involved in colonization) cleavage sites to occur before Thr or Ser residues.
T7 1031-1141 Sentence denotes The purified carbohydrate sLewis-X implied in inflammation and malignancy inhibited cleavage of PSGL-1 by Pic.
T8 1142-1330 Sentence denotes Exposure of human leukocytes to purified Pic resulted in polymorphonuclear cell activation, but impaired chemotaxis and transmigration; Pic-treated T cells underwent programmed cell death.
T9 1331-1492 Sentence denotes We also show that the Pic-related protease Tsh/Hbp, implicated in extraintestinal infections, exhibited a spectrum of substrates similar to those cleaved by Pic.
T10 1493-1613 Sentence denotes In the guinea pig keratoconjunctivitis model, a Shigella pic mutant induced greater inflammation than its parent strain.
T11 1614-1712 Sentence denotes We suggest that the class-2 SPATEs represent unique immune-modulating bacterial virulence factors.
T1 0-136 Sentence denotes Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
T2 137-291 Sentence denotes The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway.
T3 292-397 Sentence denotes We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2).
T4 398-601 Sentence denotes Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a broad range of human leukocyte adhesion proteins.
T5 602-883 Sentence denotes Substrate specificity was restricted to glycoproteins rich in O-linked glycans, including CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, migration, and inflammation.
T6 884-1030 Sentence denotes N-terminal sequencing of proteolytic products revealed Pic (protease involved in colonization) cleavage sites to occur before Thr or Ser residues.
T7 1031-1141 Sentence denotes The purified carbohydrate sLewis-X implied in inflammation and malignancy inhibited cleavage of PSGL-1 by Pic.
T8 1142-1330 Sentence denotes Exposure of human leukocytes to purified Pic resulted in polymorphonuclear cell activation, but impaired chemotaxis and transmigration; Pic-treated T cells underwent programmed cell death.
T9 1331-1492 Sentence denotes We also show that the Pic-related protease Tsh/Hbp, implicated in extraintestinal infections, exhibited a spectrum of substrates similar to those cleaved by Pic.
T10 1493-1613 Sentence denotes In the guinea pig keratoconjunctivitis model, a Shigella pic mutant induced greater inflammation than its parent strain.
T11 1614-1712 Sentence denotes We suggest that the class-2 SPATEs represent unique immune-modulating bacterial virulence factors.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1127-1133 gene:6404 denotes PSGL-1
T1 1094-1104 disease:C0006826 denotes malignancy
T2 1127-1133 gene:6404 denotes PSGL-1
T3 1094-1104 disease:C1306459 denotes malignancy
R1 T0 T1 associated_with PSGL-1,malignancy
R2 T2 T3 associated_with PSGL-1,malignancy

Allie

Id Subject Object Predicate Lexical cue
SS1_21768350_1_0 141-195 expanded denotes serine protease autotransporters of Enterobacteriaceae
SS2_21768350_1_0 197-203 abbr denotes SPATEs
AE1_21768350_1_0 SS1_21768350_1_0 SS2_21768350_1_0 abbreviatedTo serine protease autotransporters of Enterobacteriaceae,SPATEs