> top > docs > PubMed:21760535 > annotations

PubMed:21760535 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 127-256 DRI_Challenge denotes Better understanding of the pathogenesis of spinal cord injury (SCI) is needed for the development of new therapeutic strategies.
T2 257-428 DRI_Background denotes Spinal cord injury has been investigated in various rodent models, but extrapolation to humans requires the use of a large animal model that more closely mimics human SCI.
T3 429-541 DRI_Background denotes Dogs frequently develop spontaneous SCI with features that bear a striking resemblance to the human counterpart.
T4 542-735 DRI_Approach denotes We investigated the temporal course of the immune response during naturally occurring canine SCI and in organotypic canine spinal cord slice cultures that are devoid of peripheral immune cells.
T5 736-929 DRI_Background denotes By immunohistochemistry, the inflammatory response in subacute canine SCI was largely restricted to resident immune cells as demonstrated by activation of major histocompatibility complex class
T6 965-966 DRI_Background denotes .
T7 967-1091 DRI_Background denotes By quantitative polymerase chain reaction, there was parallel upregulation of proinflammatory cytokine gene expression (i.e.
T8 1092-1204 DRI_Outcome denotes of interleukin 6 [IL-6] and IL-8 with a trend toward upregulation of tumor necrosis factor) in acute canine SCI.
T9 1337-1626 DRI_Outcome denotes In organotypic spinal cord slices, there was similar activation of major histocompatibility complex class II-positive microglia and prolonged upregulation of inflammatory cytokines, indicating that resident rather than infiltrating cells play major roles in the postinjury immune response.
T10 1627-1768 DRI_Approach denotes Thus, canine SCI represents a bridge between rodent models and human SCI that may be relevant for clinical and preclinical treatment studies.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 21-31 CVCL_C410|Hybridoma|Mus musculus denotes activation
T2 276-279 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T3 276-279 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T4 372-373 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 411-417 CVCL_Z366|Spontaneously_immortalized_cell_line|Spodoptera frugiperda denotes mimics
T6 488-492 CVCL_0D14|Cancer_cell_line|Canis lupus familiaris denotes bear
T7 493-494 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 542-544 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T9 877-887 CVCL_C410|Hybridoma|Mus musculus denotes activation
T10 1130-1131 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 1390-1400 CVCL_C410|Hybridoma|Mus musculus denotes activation
T12 1655-1656 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1705-1708 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T1 61-76 GO:0006955 denotes immune response
T2 100-106 UBERON:0003674 denotes canine
T3 107-118 UBERON:0002240 denotes spinal cord
T6 107-125 D013119 denotes spinal cord injury
T7 107-125 D013119 denotes spinal cord injury
T9 155-167 GO:0009405 denotes pathogenesis
T10 171-182 UBERON:0002240 denotes spinal cord
T13 171-189 D013119 denotes spinal cord injury
T14 171-189 D013119 denotes spinal cord injury
T16 257-268 UBERON:0002240 denotes Spinal cord
T19 257-275 D013119 denotes Spinal cord injury
T20 257-275 D013119 denotes Spinal cord injury
T22 309-315 D012377 denotes rodent
T23 380-386 UBERON:3010325 denotes animal
T24 380-386 UBERON:0000468 denotes animal
T25 418-423 D006801 denotes human
T26 429-433 D004285 denotes Dogs
T27 488-492 9641 denotes bear
T28 523-528 D006801 denotes human
T29 585-600 GO:0006955 denotes immune response
T30 628-634 UBERON:0003674 denotes canine
T31 658-664 UBERON:0003674 denotes canine
T32 665-676 UBERON:0002240 denotes spinal cord
T33 665-676 D013118 denotes spinal cord
T34 665-676 D013118 denotes spinal cord
T36 765-786 GO:0006954 denotes inflammatory response
T37 799-805 UBERON:0003674 denotes canine
T38 891-923 GO:0046776 denotes major histocompatibility complex
T39 924-932 SO:0000182 denotes class II
T40 944-953 CL:0000129 denotes microglia
T41 994-999 SO:0000419 denotes chain
T42 994-1008 MOP:0000635 denotes chain reaction
T43 1070-1074 SO:0000704 denotes gene
T44 1070-1085 GO:0010467 denotes gene expression
T47 1095-1108 P05231 denotes interleukin 6
T48 1095-1108 B6CKP4 denotes interleukin 6
T49 1095-1108 Q95181 denotes interleukin 6
T50 1095-1108 Q28319 denotes interleukin 6
T52 1095-1108 P41323 denotes interleukin 6
T53 1095-1108 Q6V919 denotes interleukin 6
T54 1095-1108 A3FBE9 denotes interleukin 6
T55 1095-1108 P46650 denotes interleukin 6
T56 1095-1108 Q28747 denotes interleukin 6
T57 1095-1108 Q25BC2 denotes interleukin 6
T58 1095-1108 Q5I6E3 denotes interleukin 6
T59 1095-1108 Q6L6X6 denotes interleukin 6
T60 1095-1108 P08505 denotes interleukin 6
T61 1095-1108 Q9XT80 denotes interleukin 6
T62 1095-1108 A0S0B0 denotes interleukin 6
T63 1095-1108 Q865W7 denotes interleukin 6
T64 1095-1108 Q9MZR1 denotes interleukin 6
T65 1095-1108 Q865X6 denotes interleukin 6
T66 1095-1108 P20607 denotes interleukin 6
T67 1095-1108 P41693 denotes interleukin 6
T68 1095-1108 PR:000001393 denotes interleukin 6
T69 1095-1108 Q0GGL7 denotes interleukin 6
T70 1095-1108 P51494 denotes interleukin 6
T71 1095-1108 P26893 denotes interleukin 6
T72 1095-1108 Q2MH06 denotes interleukin 6
T73 1095-1108 O35736 denotes interleukin 6
T74 1095-1108 P79341 denotes interleukin 6
T76 1095-1108 P29455 denotes interleukin 6
T77 1095-1108 Q28819 denotes interleukin 6
T78 1095-1108 P41683 denotes interleukin 6
T79 1095-1108 Q90YI0 denotes interleukin 6
T80 1095-1108 Q8MKH0 denotes interleukin 6
T81 1095-1108 P26892 denotes interleukin 6
T51 1095-1108 D015850 denotes interleukin 6
T75 1095-1108 D015850 denotes interleukin 6
T82 1110-1114 P05231 denotes IL-6
T83 1110-1114 B6CKP4 denotes IL-6
T84 1110-1114 Q95181 denotes IL-6
T85 1110-1114 Q28319 denotes IL-6
T87 1110-1114 P41323 denotes IL-6
T88 1110-1114 Q6V919 denotes IL-6
T89 1110-1114 A3FBE9 denotes IL-6
T90 1110-1114 PR:Q90YI0 denotes IL-6
T91 1110-1114 P46650 denotes IL-6
T92 1110-1114 Q28747 denotes IL-6
T93 1110-1114 Q25BC2 denotes IL-6
T94 1110-1114 Q5I6E3 denotes IL-6
T95 1110-1114 Q6L6X6 denotes IL-6
T96 1110-1114 P08505 denotes IL-6
T97 1110-1114 Q9XT80 denotes IL-6
T98 1110-1114 A0S0B0 denotes IL-6
T99 1110-1114 Q865W7 denotes IL-6
T100 1110-1114 Q9MZR1 denotes IL-6
T101 1110-1114 PR:P20607 denotes IL-6
T102 1110-1114 Q865X6 denotes IL-6
T103 1110-1114 PR:P08505 denotes IL-6
T104 1110-1114 P20607 denotes IL-6
T105 1110-1114 P41693 denotes IL-6
T106 1110-1114 PR:000001393 denotes IL-6
T107 1110-1114 Q0GGL7 denotes IL-6
T108 1110-1114 P51494 denotes IL-6
T109 1110-1114 PR:P05231 denotes IL-6
T110 1110-1114 P26893 denotes IL-6
T111 1110-1114 Q2MH06 denotes IL-6
T112 1110-1114 O35736 denotes IL-6
T113 1110-1114 P79341 denotes IL-6
T115 1110-1114 P29455 denotes IL-6
T116 1110-1114 Q28819 denotes IL-6
T117 1110-1114 Q90YI0 denotes IL-6
T118 1110-1114 P41683 denotes IL-6
T120 1110-1114 Q8MKH0 denotes IL-6
T121 1110-1114 P26892 denotes IL-6
T86 1110-1114 D015850 denotes IL-6
T119 1110-1114 D015850 denotes IL-6
T114 1110-1114 GO:0005138 denotes IL-6
T122 1120-1124 P19874 denotes IL-8
T123 1120-1124 PR:000001395 denotes IL-8
T124 1120-1124 P10145 denotes IL-8
T125 1120-1124 Q102R3 denotes IL-8
T126 1120-1124 P67813 denotes IL-8
T127 1120-1124 P67814 denotes IL-8
T128 1120-1124 P08317 denotes IL-8
T129 1120-1124 P79255 denotes IL-8
T130 1120-1124 P49113 denotes IL-8
T131 1120-1124 P41324 denotes IL-8
T132 1120-1124 P26894 denotes IL-8
T134 1120-1124 PR:P10145 denotes IL-8
T135 1120-1124 P46653 denotes IL-8
T136 1120-1124 Q7YRB5 denotes IL-8
T137 1120-1124 P36925 denotes IL-8
T139 1120-1124 PR:P08317 denotes IL-8
T142 1120-1124 Q9XSX5 denotes IL-8
T143 1120-1124 O62812 denotes IL-8
T133 1120-1124 D016209 denotes IL-8
T138 1120-1124 D016209 denotes IL-8
T141 1120-1124 CHEBI:138181 denotes IL-8
T140 1120-1124 GO:0005153 denotes IL-8
T144 1161-1166 D009369 denotes tumor
T145 1161-1166 D009369 denotes tumor
T146 1161-1182 P19101 denotes tumor necrosis factor
T147 1161-1182 Q06599 denotes tumor necrosis factor
T148 1161-1182 O35734 denotes tumor necrosis factor
T149 1161-1182 Q8JFG3 denotes tumor necrosis factor
T152 1161-1182 PR:000000134 denotes tumor necrosis factor
T153 1161-1182 Q8MKG8 denotes tumor necrosis factor
T154 1161-1182 P29553 denotes tumor necrosis factor
T155 1161-1182 P23563 denotes tumor necrosis factor
T156 1161-1182 P33620 denotes tumor necrosis factor
T157 1161-1182 P06804 denotes tumor necrosis factor
T158 1161-1182 Q1WM27 denotes tumor necrosis factor
T159 1161-1182 Q539C2 denotes tumor necrosis factor
T160 1161-1182 P59695 denotes tumor necrosis factor
T161 1161-1182 Q8WNR1 denotes tumor necrosis factor
T162 1161-1182 Q8HZD9 denotes tumor necrosis factor
T163 1161-1182 Q75N23 denotes tumor necrosis factor
T164 1161-1182 O77764 denotes tumor necrosis factor
T165 1161-1182 P48094 denotes tumor necrosis factor
T166 1161-1182 P59694 denotes tumor necrosis factor
T167 1161-1182 P79374 denotes tumor necrosis factor
T168 1161-1182 Q9BEA1 denotes tumor necrosis factor
T169 1161-1182 Q2MH05 denotes tumor necrosis factor
T170 1161-1182 P23383 denotes tumor necrosis factor
T171 1161-1182 O77510 denotes tumor necrosis factor
T172 1161-1182 P59693 denotes tumor necrosis factor
T173 1161-1182 P51742 denotes tumor necrosis factor
T174 1161-1182 P59684 denotes tumor necrosis factor
T175 1161-1182 P04924 denotes tumor necrosis factor
T176 1161-1182 P51435 denotes tumor necrosis factor
T178 1161-1182 Q1G1A2 denotes tumor necrosis factor
T179 1161-1182 P01375 denotes tumor necrosis factor
T180 1161-1182 P13296 denotes tumor necrosis factor
T181 1161-1182 Q19LH4 denotes tumor necrosis factor
T182 1161-1182 P16599 denotes tumor necrosis factor
T183 1161-1182 P79337 denotes tumor necrosis factor
T184 1161-1182 P36939 denotes tumor necrosis factor
T185 1161-1182 P51743 denotes tumor necrosis factor
T150 1161-1182 D014409 denotes tumor necrosis factor
T151 1161-1182 D014409 denotes tumor necrosis factor
T177 1161-1182 GO:0005164 denotes tumor necrosis factor
T186 1167-1175 GO:0019835 denotes necrosis
T187 1167-1175 GO:0008219 denotes necrosis
T190 1167-1175 GO:0008220 denotes necrosis
T191 1167-1175 GO:0001906 denotes necrosis
T192 1167-1175 GO:0070265 denotes necrosis
T188 1167-1175 D009336 denotes necrosis
T189 1167-1175 D009336 denotes necrosis
T193 1193-1199 UBERON:0003674 denotes canine
T194 1235-1244 D016207 denotes cytokines
T195 1235-1244 D016207 denotes cytokines
T196 1251-1256 PR:000001471 denotes IL-10
T197 1251-1256 Q29408 denotes IL-10
T198 1251-1256 P18893 denotes IL-10
T199 1251-1256 PR:Q6A2H4 denotes IL-10
T200 1251-1256 Q25BC1 denotes IL-10
T201 1251-1256 Q9TSJ4 denotes IL-10
T202 1251-1256 O97798 denotes IL-10
T203 1251-1256 P46651 denotes IL-10
T204 1251-1256 P51497 denotes IL-10
T205 1251-1256 O46673 denotes IL-10
T206 1251-1256 P29456 denotes IL-10
T207 1251-1256 Q8MKG9 denotes IL-10
T208 1251-1256 Q6A2H4 denotes IL-10
T209 1251-1256 P79338 denotes IL-10
T211 1251-1256 Q29055 denotes IL-10
T212 1251-1256 P48411 denotes IL-10
T213 1251-1256 PR:P29456 denotes IL-10
T214 1251-1256 Q2PE73 denotes IL-10
T215 1251-1256 A2T6Z6 denotes IL-10
T216 1251-1256 PR:P22301 denotes IL-10
T217 1251-1256 Q865X4 denotes IL-10
T218 1251-1256 Q5Q0V6 denotes IL-10
T219 1251-1256 Q9Z1Y5 denotes IL-10
T220 1251-1256 PR:P18893 denotes IL-10
T221 1251-1256 P55029 denotes IL-10
T222 1251-1256 P43480 denotes IL-10
T223 1251-1256 P47965 denotes IL-10
T224 1251-1256 P22301 denotes IL-10
T226 1251-1256 Q9JHK7 denotes IL-10
T227 1251-1256 Q0Z972 denotes IL-10
T229 1251-1256 P51746 denotes IL-10
T230 1251-1256 Q28374 denotes IL-10
T231 1251-1256 P51496 denotes IL-10
T210 1251-1256 D016753 denotes IL-10
T225 1251-1256 D016753 denotes IL-10
T228 1251-1256 GO:0005141 denotes IL-10
T232 1282-1308 D015291 denotes transforming growth factor
T233 1282-1308 D015291 denotes transforming growth factor
T234 1295-1308 P08441 denotes growth factor
T235 1295-1308 P08072 denotes growth factor
T236 1295-1308 Q776B5 denotes growth factor
T237 1295-1308 Q6RZT5 denotes growth factor
T238 1295-1308 Q8V307 denotes growth factor
T239 1352-1363 UBERON:0002240 denotes spinal cord
T240 1352-1363 D013118 denotes spinal cord
T241 1352-1363 D013118 denotes spinal cord
T243 1404-1436 GO:0046776 denotes major histocompatibility complex
T244 1437-1445 SO:0000182 denotes class II
T245 1455-1464 CL:0000129 denotes microglia
T246 1508-1517 D016207 denotes cytokines
T247 1508-1517 D016207 denotes cytokines
T248 1610-1625 GO:0006955 denotes immune response
T249 1633-1639 UBERON:0003674 denotes canine
T250 1672-1678 D012377 denotes rodent
T251 1690-1695 D006801 denotes human

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury.
T2 127-256 Sentence denotes Better understanding of the pathogenesis of spinal cord injury (SCI) is needed for the development of new therapeutic strategies.
T3 257-428 Sentence denotes Spinal cord injury has been investigated in various rodent models, but extrapolation to humans requires the use of a large animal model that more closely mimics human SCI.
T4 429-541 Sentence denotes Dogs frequently develop spontaneous SCI with features that bear a striking resemblance to the human counterpart.
T5 542-735 Sentence denotes We investigated the temporal course of the immune response during naturally occurring canine SCI and in organotypic canine spinal cord slice cultures that are devoid of peripheral immune cells.
T6 736-966 Sentence denotes By immunohistochemistry, the inflammatory response in subacute canine SCI was largely restricted to resident immune cells as demonstrated by activation of major histocompatibility complex class II-expressing microglia/macrophages.
T7 967-1204 Sentence denotes By quantitative polymerase chain reaction, there was parallel upregulation of proinflammatory cytokine gene expression (i.e. of interleukin 6 [IL-6] and IL-8 with a trend toward upregulation of tumor necrosis factor) in acute canine SCI.
T8 1205-1336 Sentence denotes Expression of neuroprotective cytokines (e.g. IL-10) remained unchanged, and transforming growth factor β upregulation was delayed.
T9 1337-1626 Sentence denotes In organotypic spinal cord slices, there was similar activation of major histocompatibility complex class II-positive microglia and prolonged upregulation of inflammatory cytokines, indicating that resident rather than infiltrating cells play major roles in the postinjury immune response.
T10 1627-1768 Sentence denotes Thus, canine SCI represents a bridge between rodent models and human SCI that may be relevant for clinical and preclinical treatment studies.
T1 0-126 Sentence denotes Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury.
T2 127-256 Sentence denotes Better understanding of the pathogenesis of spinal cord injury (SCI) is needed for the development of new therapeutic strategies.
T3 257-428 Sentence denotes Spinal cord injury has been investigated in various rodent models, but extrapolation to humans requires the use of a large animal model that more closely mimics human SCI.
T4 429-541 Sentence denotes Dogs frequently develop spontaneous SCI with features that bear a striking resemblance to the human counterpart.
T5 542-735 Sentence denotes We investigated the temporal course of the immune response during naturally occurring canine SCI and in organotypic canine spinal cord slice cultures that are devoid of peripheral immune cells.
T6 736-966 Sentence denotes By immunohistochemistry, the inflammatory response in subacute canine SCI was largely restricted to resident immune cells as demonstrated by activation of major histocompatibility complex class II-expressing microglia/macrophages.
T7 967-1204 Sentence denotes By quantitative polymerase chain reaction, there was parallel upregulation of proinflammatory cytokine gene expression (i.e. of interleukin 6 [IL-6] and IL-8 with a trend toward upregulation of tumor necrosis factor) in acute canine SCI.
T8 1205-1336 Sentence denotes Expression of neuroprotective cytokines (e.g. IL-10) remained unchanged, and transforming growth factor β upregulation was delayed.
T9 1337-1626 Sentence denotes In organotypic spinal cord slices, there was similar activation of major histocompatibility complex class II-positive microglia and prolonged upregulation of inflammatory cytokines, indicating that resident rather than infiltrating cells play major roles in the postinjury immune response.
T10 1627-1768 Sentence denotes Thus, canine SCI represents a bridge between rodent models and human SCI that may be relevant for clinical and preclinical treatment studies.

Allie

Id Subject Object Predicate Lexical cue
SS1_21760535_1_0 171-189 expanded denotes spinal cord injury
SS2_21760535_1_0 191-194 abbr denotes SCI
SS1_21760535_6_0 1095-1108 expanded denotes interleukin 6
SS2_21760535_6_0 1110-1114 abbr denotes IL-6
AE1_21760535_1_0 SS1_21760535_1_0 SS2_21760535_1_0 abbreviatedTo spinal cord injury,SCI
AE1_21760535_6_0 SS1_21760535_6_0 SS2_21760535_6_0 abbreviatedTo interleukin 6,IL-6

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1161-1166 HP_0002664 denotes tumor