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PubMed:21708247 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-131 Sentence denotes NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells.
TextSentencer_T2 132-343 Sentence denotes Cross talk between unrelated cell surface receptors, such as G-protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTK), is a crucial signaling mechanism to expand the cellular communication network.
TextSentencer_T3 344-504 Sentence denotes We investigated the ability of the GPCR formyl peptide receptor-like 1 (FPRL1) to transactivate the RTK epidermal growth factor receptor (EGFR) in CaLu-6 cells.
TextSentencer_T4 505-754 Sentence denotes We observed that stimulation with WKYMVm, an FPRL1 agonist isolated by screening synthetic peptide libraries, induces EGFR tyrosine phosphorylation, p47(phox) phosphorylation, NADPH-oxidase-dependent superoxide generation, and c-Src kinase activity.
TextSentencer_T5 755-891 Sentence denotes As a result of EGFR transactivation, phosphotyrosine residues provide docking sites for recruitment and triggering of the STAT3 pathway.
TextSentencer_T6 892-1040 Sentence denotes WKYMVm-induced EGFR transactivation is prevented by the FPRL1-selective antagonist WRWWWW, by pertussis toxin (PTX), and by the c-Src inhibitor PP2.
TextSentencer_T7 1041-1267 Sentence denotes The critical role of NADPH-oxidase-dependent superoxide generation in this cross-talk mechanism is corroborated by the finding that apocynin or a siRNA against p22(phox) prevents EGFR transactivation and c-Src kinase activity.
TextSentencer_T8 1268-1357 Sentence denotes In addition, WKYMVm promotes CaLu-6 cell growth, which is prevented by PTX and by WRWWWW.
TextSentencer_T9 1358-1572 Sentence denotes These results highlight the role of FPRL1 as a potential target of new drugs and suggest that targeting both FPRL1 and EGFR may yield superior therapeutic effects compared with targeting either receptor separately.
T1 0-131 Sentence denotes NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells.
T2 132-343 Sentence denotes Cross talk between unrelated cell surface receptors, such as G-protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTK), is a crucial signaling mechanism to expand the cellular communication network.
T3 344-504 Sentence denotes We investigated the ability of the GPCR formyl peptide receptor-like 1 (FPRL1) to transactivate the RTK epidermal growth factor receptor (EGFR) in CaLu-6 cells.
T4 505-754 Sentence denotes We observed that stimulation with WKYMVm, an FPRL1 agonist isolated by screening synthetic peptide libraries, induces EGFR tyrosine phosphorylation, p47(phox) phosphorylation, NADPH-oxidase-dependent superoxide generation, and c-Src kinase activity.
T5 755-891 Sentence denotes As a result of EGFR transactivation, phosphotyrosine residues provide docking sites for recruitment and triggering of the STAT3 pathway.
T6 892-1040 Sentence denotes WKYMVm-induced EGFR transactivation is prevented by the FPRL1-selective antagonist WRWWWW, by pertussis toxin (PTX), and by the c-Src inhibitor PP2.
T7 1041-1267 Sentence denotes The critical role of NADPH-oxidase-dependent superoxide generation in this cross-talk mechanism is corroborated by the finding that apocynin or a siRNA against p22(phox) prevents EGFR transactivation and c-Src kinase activity.
T8 1268-1357 Sentence denotes In addition, WKYMVm promotes CaLu-6 cell growth, which is prevented by PTX and by WRWWWW.
T9 1358-1572 Sentence denotes These results highlight the role of FPRL1 as a potential target of new drugs and suggest that targeting both FPRL1 and EGFR may yield superior therapeutic effects compared with targeting either receptor separately.

Allie

Id Subject Object Predicate Lexical cue
SS1_21708247_1_0 193-220 expanded denotes G-protein-coupled receptors
SS2_21708247_1_0 222-226 abbr denotes GPCR
SS1_21708247_1_1 232-257 expanded denotes receptor tyrosine kinases
SS2_21708247_1_1 259-262 abbr denotes RTK
SS1_21708247_2_0 384-414 expanded denotes formyl peptide receptor-like 1
SS2_21708247_2_0 416-421 abbr denotes FPRL1
SS1_21708247_2_1 448-480 expanded denotes epidermal growth factor receptor
SS2_21708247_2_1 482-486 abbr denotes EGFR
SS1_21708247_5_0 986-1001 expanded denotes pertussis toxin
SS2_21708247_5_0 1003-1006 abbr denotes PTX
AE1_21708247_1_0 SS1_21708247_1_0 SS2_21708247_1_0 abbreviatedTo G-protein-coupled receptors,GPCR
AE1_21708247_1_1 SS1_21708247_1_1 SS2_21708247_1_1 abbreviatedTo receptor tyrosine kinases,RTK
AE1_21708247_2_0 SS1_21708247_2_0 SS2_21708247_2_0 abbreviatedTo formyl peptide receptor-like 1,FPRL1
AE1_21708247_2_1 SS1_21708247_2_1 SS2_21708247_2_1 abbreviatedTo epidermal growth factor receptor,EGFR
AE1_21708247_5_0 SS1_21708247_5_0 SS2_21708247_5_0 abbreviatedTo pertussis toxin,PTX

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21708247-0#80#85#gene2358 80-85 gene2358 denotes FPRL1
21708247-0#113#124#diseaseC0242379 113-124 diseaseC0242379 denotes lung cancer
21708247-0#113#124#diseaseC0684249 113-124 diseaseC0684249 denotes lung cancer
21708247-0#113#124#diseaseC1306460 113-124 diseaseC1306460 denotes lung cancer
80#85#gene2358113#124#diseaseC0242379 21708247-0#80#85#gene2358 21708247-0#113#124#diseaseC0242379 associated_with FPRL1,lung cancer
80#85#gene2358113#124#diseaseC0684249 21708247-0#80#85#gene2358 21708247-0#113#124#diseaseC0684249 associated_with FPRL1,lung cancer
80#85#gene2358113#124#diseaseC1306460 21708247-0#80#85#gene2358 21708247-0#113#124#diseaseC1306460 associated_with FPRL1,lung cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2047 80-85 gene:2358 denotes FPRL1
T2048 113-124 disease:C0242379 denotes lung cancer
R1 T2047 T2048 associated_with FPRL1,lung cancer
R2 T2047 T2048 associated_with FPRL1,lung cancer
R3 T2047 T2048 associated_with FPRL1,lung cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 113-117 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 113-117 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung