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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Peripheral vascular decoupling in porcine endotoxic shock.
T2 59-237 Sentence denotes Cardiac output measurement from arterial pressure waveforms presumes a defined relationship between the arterial pulse pressure (PP), vascular compliance (C), and resistance (R).
T3 238-306 Sentence denotes Cardiac output estimates degrade if these assumptions are incorrect.
T4 307-481 Sentence denotes We hypothesized that sepsis would differentially alter central and peripheral vasomotor tone, decoupling the usual pressure wave propagation from central to peripheral sites.
T5 482-842 Sentence denotes We assessed arterial input impedance (Z), C, and R from central and peripheral arterial pressures, and aortic blood flow in an anesthetized porcine model (n = 19) of fluid resuscitated endotoxic shock induced by endotoxin infusion (7 μg·kg⁻¹·h⁻¹ increased to 14 and 20 μg·kg⁻¹·h⁻¹ every 10 min and stopped when mean arterial pressure <40 mmHg or Sv(O₂) < 45%).
T6 843-937 Sentence denotes Aortic, femoral, and radial artery pressures and aortic and radial artery flows were measured.
T7 938-988 Sentence denotes Z was calculated by FFT of flow and pressure data.
T8 989-1047 Sentence denotes R and C were derived using a two-element Windkessel model.
T9 1048-1110 Sentence denotes Arterial PP increased from aortic to femoral and radial sites.
T10 1111-1303 Sentence denotes During stable endotoxemia with fluid resuscitation, aortic and radial blood flows returned to or exceeded baseline while mean arterial pressure remained similarly decreased at all three sites.
T11 1304-1368 Sentence denotes However, aortic PP exceeded both femoral and radial arterial PP.
T12 1369-1664 Sentence denotes Although Z, R, and C derived from aortic and radial pressure and aortic flow were similar during baseline, Z increases and C decreases when derived from aortic pressure whereas Z decreases and C increases when derived from radial pressure, while R decreased similarly with both pressure signals.
T13 1665-2108 Sentence denotes This central-to-peripheral vascular tone decoupling, as quantified by the difference in calculated Z and C from aortic and radial artery pressure, may explain the decreasing precision of peripheral arterial pressure profile algorithms in assessing cardiac output in septic shock patients and suggests that different algorithms taking this vascular decoupling into account may be necessary to improve their precision in this patient population.
T1 0-58 Sentence denotes Peripheral vascular decoupling in porcine endotoxic shock.
T2 59-237 Sentence denotes Cardiac output measurement from arterial pressure waveforms presumes a defined relationship between the arterial pulse pressure (PP), vascular compliance (C), and resistance (R).
T3 238-306 Sentence denotes Cardiac output estimates degrade if these assumptions are incorrect.
T4 307-481 Sentence denotes We hypothesized that sepsis would differentially alter central and peripheral vasomotor tone, decoupling the usual pressure wave propagation from central to peripheral sites.
T5 482-842 Sentence denotes We assessed arterial input impedance (Z), C, and R from central and peripheral arterial pressures, and aortic blood flow in an anesthetized porcine model (n = 19) of fluid resuscitated endotoxic shock induced by endotoxin infusion (7 μg·kg⁻¹·h⁻¹ increased to 14 and 20 μg·kg⁻¹·h⁻¹ every 10 min and stopped when mean arterial pressure <40 mmHg or Sv(O₂) < 45%).
T6 843-937 Sentence denotes Aortic, femoral, and radial artery pressures and aortic and radial artery flows were measured.
T7 938-988 Sentence denotes Z was calculated by FFT of flow and pressure data.
T8 989-1047 Sentence denotes R and C were derived using a two-element Windkessel model.
T9 1048-1110 Sentence denotes Arterial PP increased from aortic to femoral and radial sites.
T10 1111-1303 Sentence denotes During stable endotoxemia with fluid resuscitation, aortic and radial blood flows returned to or exceeded baseline while mean arterial pressure remained similarly decreased at all three sites.
T11 1304-1368 Sentence denotes However, aortic PP exceeded both femoral and radial arterial PP.
T12 1369-1664 Sentence denotes Although Z, R, and C derived from aortic and radial pressure and aortic flow were similar during baseline, Z increases and C decreases when derived from aortic pressure whereas Z decreases and C increases when derived from radial pressure, while R decreased similarly with both pressure signals.
T13 1665-2108 Sentence denotes This central-to-peripheral vascular tone decoupling, as quantified by the difference in calculated Z and C from aortic and radial artery pressure, may explain the decreasing precision of peripheral arterial pressure profile algorithms in assessing cardiac output in septic shock patients and suggests that different algorithms taking this vascular decoupling into account may be necessary to improve their precision in this patient population.

LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
1 42-57 DiseaseOrPhenotypicFeature denotes endotoxic shock MESH:D012772
8 328-334 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
9 667-682 DiseaseOrPhenotypicFeature denotes endotoxic shock MESH:D012772
10 1125-1136 DiseaseOrPhenotypicFeature denotes endotoxemia MESH:D019446
11 1931-1943 DiseaseOrPhenotypicFeature denotes septic shock MESH:D012772
12 1944-1952 OrganismTaxon denotes patients Tax:9606
13 2089-2096 OrganismTaxon denotes patient Tax:9606

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 42-57 DiseaseOrPhenotypicFeature denotes endotoxic shock D012772
T2 328-334 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3 667-682 DiseaseOrPhenotypicFeature denotes endotoxic shock D012772
T4 1125-1136 DiseaseOrPhenotypicFeature denotes endotoxemia D019446
T5 1931-1943 DiseaseOrPhenotypicFeature denotes septic shock D012772

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 42-57 DiseaseOrPhenotypicFeature denotes endotoxic shock D012772
T2 328-334 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3 667-682 DiseaseOrPhenotypicFeature denotes endotoxic shock D012772
T4 1125-1136 DiseaseOrPhenotypicFeature denotes endotoxemia D019446
T5 1931-1943 DiseaseOrPhenotypicFeature denotes septic shock D012772

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 328-334 HP_0100806 denotes sepsis

Allie

Id Subject Object Predicate Lexical cue
SS1_21700890_1_0 172-186 expanded denotes pulse pressure
SS2_21700890_1_0 188-190 abbr denotes PP
AE1_21700890_1_0 SS1_21700890_1_0 SS2_21700890_1_0 abbreviatedTo pulse pressure,PP