> top > docs > PubMed:21699507 > annotations

PubMed:21699507 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 131-595 OBJECTIVE denotes Spreading depression (SD) is a local, temporary disruption of cellular ionic homeostasis that propagates slowly across the cerebral cortex and other neural tissues such as the retina. Spreading depolarization associated with SD occurs in different types of stroke, and this phenomenon correlates also with the initiation of classical migraine aura. The aim of this study was to investigate how NMDA receptor antagonists with different subtype selectivity alter SD.
T2 619-808 METHODS denotes Immunoblotting was applied to the chick retina for NMDA receptor subunit protein analysis, and an efficient in vitro chick retinal model used with SD imaging for NMDA receptor pharmacology.
T3 822-1355 RESULTS denotes The prominent NMDA receptor subtypes GluN1, GluN2A and GluN2B were found highly expressed in the chick retina. Nanomolar concentrations of NVP-AAM077 (GluN2A-preferring receptor antagonist) markedly suppressed high K(+) -induced SD; that is, ∼30 times more effectively than MK801. At sub-micromolar concentrations, Ro 25-6981 (GluN2B-preferring receptor antagonist) produced a moderate SD inhibition, whereas CP-101,606 (also GluN2B-preferring receptor antagonist) and UBP141 (GluN2C/2D-preferring receptor antagonist) had no effect.
T4 1386-1807 CONCLUSIONS denotes The expression of major NMDA receptor subtypes, GluN1, GluN2A and GluN2B in the chick retina makes them pertinent targets for pharmacological inhibition of SD. The high efficacy of NVP-AAM077 on SD inhibition suggests a critical role of GluN2A-containing receptors in SD genesis. Such high anti-SD potency suggests that NVP-AAM077, and other GluN2A-selective drug-like candidates, could be potential anti-migraine agents.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 153-155 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T2 160-161 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 356-358 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T4 592-594 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T5 714-716 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T6 714-716 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T7 766-768 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T8 1051-1053 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T9 1065-1067 CVCL_J925|Hybridoma|Mus musculus denotes 30
T10 1068-1073 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes times
T11 1137-1139 CVCL_1886|Transformed_cell_line|Homo sapiens denotes Ro
T12 1137-1139 CVCL_U878|Cancer_cell_line|Homo sapiens denotes Ro
T13 1197-1198 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1208-1210 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T15 1231-1233 CVCL_6F78|Spontaneously_immortalized_cell_line|Anabas testudineus denotes CP
T16 1542-1544 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T17 1581-1583 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T18 1604-1605 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T19 1654-1656 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD
T20 1681-1683 CVCL_W902|Cancer_cell_line|Homo sapiens denotes SD

GoldHamster

Id Subject Object Predicate Lexical cue
T5 11-24 GO:0004972 denotes NMDA receptor
T6 11-36 CHEBI:60643 denotes NMDA receptor antagonists
T8 77-84 D012172 denotes retinal
T9 77-84 CHEBI:17898 denotes retinal
T10 77-84 D012172 denotes retinal
T11 77-84 CHEBI:15035 denotes retinal
T12 77-84 CHEBI:45487 denotes retinal
T13 95-105 UBERON:0004704 denotes depression
T14 118-121 1481724 denotes AND
T15 141-151 UBERON:0004704 denotes depression
T16 208-219 GO:0042592 denotes homeostasis
T17 254-269 UBERON:0000956 denotes cerebral cortex
T19 307-313 UBERON:0000966 denotes retina
T20 455-473 D020325 denotes classical migraine
T21 455-473 D020325 denotes classical migraine
T27 474-478 PR:P59241 denotes aura
T28 474-478 PR:000004515 denotes aura
T30 474-478 PR:P97477 denotes aura
T31 474-478 PR:O14965 denotes aura
T26 474-478 CHEBI:144786 denotes aura
T25 474-478 D004827 denotes aura
T29 474-478 D004827 denotes aura
T36 525-538 GO:0004972 denotes NMDA receptor
T37 525-550 CHEBI:60643 denotes NMDA receptor antagonists
T39 659-665 UBERON:0000966 denotes retina
T40 670-674 D016202 denotes NMDA
T41 670-674 CHEBI:6121 denotes NMDA
T42 670-674 D016202 denotes NMDA
T43 670-674 CHEBI:31882 denotes NMDA
T44 670-683 GO:0004972 denotes NMDA receptor
T45 684-699 D021122 denotes subunit protein
T50 692-699 SO:0000104 denotes protein
T49 692-699 PR:000000001 denotes protein
T46 692-699 GO:0003675 denotes protein
T51 742-749 D012172 denotes retinal
T52 742-749 CHEBI:17898 denotes retinal
T53 742-749 D012172 denotes retinal
T54 742-749 CHEBI:15035 denotes retinal
T55 742-749 CHEBI:45487 denotes retinal
T56 781-785 D016202 denotes NMDA
T57 781-785 CHEBI:6121 denotes NMDA
T58 781-785 D016202 denotes NMDA
T59 781-785 CHEBI:31882 denotes NMDA
T60 781-794 GO:0004972 denotes NMDA receptor
T61 836-840 D016202 denotes NMDA
T62 836-840 CHEBI:6121 denotes NMDA
T63 836-840 D016202 denotes NMDA
T64 836-840 CHEBI:31882 denotes NMDA
T65 836-849 GO:0004972 denotes NMDA receptor
T66 859-864 Q5R1P0 denotes GluN1
T67 859-864 PR:000008245 denotes GluN1
T68 859-864 P35438 denotes GluN1
T69 859-864 A0A1L8F5J9 denotes GluN1
T70 859-864 P35439 denotes GluN1
T71 859-864 Q05586 denotes GluN1
T72 866-872 P35436 denotes GluN2A
T73 866-872 B7ZSK1 denotes GluN2A
T74 866-872 PR:000008246 denotes GluN2A
T75 866-872 Q00959 denotes GluN2A
T76 866-872 Q5IS45 denotes GluN2A
T77 866-872 Q12879 denotes GluN2A
T78 877-883 Q13224 denotes GluN2B
T79 877-883 Q00960 denotes GluN2B
T80 877-883 Q01097 denotes GluN2B
T81 877-883 Q5R1P3 denotes GluN2B
T82 877-883 PR:000008247 denotes GluN2B
T83 877-883 A7XY94 denotes GluN2B
T84 925-931 UBERON:0000966 denotes retina
T86 961-971 C498554 denotes NVP-AAM077
T87 961-971 C498554 denotes NVP-AAM077
T88 973-979 P35436 denotes GluN2A
T89 973-979 B7ZSK1 denotes GluN2A
T90 973-979 PR:000008246 denotes GluN2A
T91 973-979 Q00959 denotes GluN2A
T92 973-979 Q5IS45 denotes GluN2A
T93 973-979 Q12879 denotes GluN2A
T94 1000-1010 CHEBI:48706 denotes antagonist
T96 1096-1101 D016291 denotes MK801
T97 1096-1101 CHEBI:34725 denotes MK801
T98 1096-1101 D016291 denotes MK801
T99 1103-1109 PR:Q8RWZ1 denotes At sub
T102 1137-1147 C109643 denotes Ro 25-6981
T103 1137-1147 C109643 denotes Ro 25-6981
T104 1137-1147 C109643 denotes Ro 25-6981
T105 1137-1147 C109643 denotes Ro 25-6981
T106 1149-1155 Q13224 denotes GluN2B
T107 1149-1155 Q00960 denotes GluN2B
T108 1149-1155 Q01097 denotes GluN2B
T109 1149-1155 Q5R1P3 denotes GluN2B
T110 1149-1155 PR:000008247 denotes GluN2B
T111 1149-1155 A7XY94 denotes GluN2B
T112 1176-1186 CHEBI:48706 denotes antagonist
T113 1231-1241 C095106 denotes CP-101,606
T114 1231-1241 C095106 denotes CP-101,606
T115 1248-1254 Q13224 denotes GluN2B
T116 1248-1254 Q00960 denotes GluN2B
T117 1248-1254 Q01097 denotes GluN2B
T118 1248-1254 Q5R1P3 denotes GluN2B
T119 1248-1254 PR:000008247 denotes GluN2B
T120 1248-1254 A7XY94 denotes GluN2B
T121 1275-1285 CHEBI:48706 denotes antagonist
T122 1291-1294 O43765 denotes UBP
T123 1291-1294 PR:000017145 denotes UBP
T124 1291-1294 PR:000014807 denotes UBP
T125 1291-1294 GO:0004843 denotes UBP
T126 1299-1305 Q00961 denotes GluN2C
T127 1299-1305 Q01098 denotes GluN2C
T128 1299-1305 PR:000008248 denotes GluN2C
T129 1299-1305 Q14957 denotes GluN2C
T130 1303-1307 CVCL_VM41 denotes 2C/2
T131 1304-1308 CVCL_H596 denotes C/2D
T132 1304-1308 217000 denotes C/2D
T133 1329-1339 CHEBI:48706 denotes antagonist
T134 1368-1371 1481724 denotes AND
T135 1410-1414 D016202 denotes NMDA
T136 1410-1414 CHEBI:6121 denotes NMDA
T137 1410-1414 D016202 denotes NMDA
T138 1410-1414 CHEBI:31882 denotes NMDA
T139 1410-1423 GO:0004972 denotes NMDA receptor
T140 1434-1439 Q5R1P0 denotes GluN1
T141 1434-1439 PR:000008245 denotes GluN1
T142 1434-1439 P35438 denotes GluN1
T143 1434-1439 A0A1L8F5J9 denotes GluN1
T144 1434-1439 P35439 denotes GluN1
T145 1434-1439 Q05586 denotes GluN1
T146 1441-1447 P35436 denotes GluN2A
T147 1441-1447 B7ZSK1 denotes GluN2A
T148 1441-1447 PR:000008246 denotes GluN2A
T149 1441-1447 Q00959 denotes GluN2A
T150 1441-1447 Q5IS45 denotes GluN2A
T151 1441-1447 Q12879 denotes GluN2A
T152 1452-1458 Q13224 denotes GluN2B
T153 1452-1458 Q00960 denotes GluN2B
T154 1452-1458 Q01097 denotes GluN2B
T155 1452-1458 Q5R1P3 denotes GluN2B
T156 1452-1458 PR:000008247 denotes GluN2B
T157 1452-1458 A7XY94 denotes GluN2B
T158 1472-1478 UBERON:0000966 denotes retina
T160 1567-1577 C498554 denotes NVP-AAM077
T161 1567-1577 C498554 denotes NVP-AAM077
T162 1623-1629 P35436 denotes GluN2A
T163 1623-1629 B7ZSK1 denotes GluN2A
T164 1623-1629 PR:000008246 denotes GluN2A
T165 1623-1629 Q00959 denotes GluN2A
T166 1623-1629 Q5IS45 denotes GluN2A
T167 1623-1629 Q12879 denotes GluN2A
T169 1706-1716 C498554 denotes NVP-AAM077
T170 1706-1716 C498554 denotes NVP-AAM077
T171 1728-1734 P35436 denotes GluN2A
T172 1728-1734 B7ZSK1 denotes GluN2A
T173 1728-1734 PR:000008246 denotes GluN2A
T174 1728-1734 Q00959 denotes GluN2A
T175 1728-1734 Q5IS45 denotes GluN2A
T176 1728-1734 Q12879 denotes GluN2A
T177 1745-1749 CHEBI:23888 denotes drug
T178 1791-1799 157300 denotes migraine
T179 1791-1799 D008881 denotes migraine
T180 1791-1799 D008881 denotes migraine

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 141-151 HP_0000716 denotes depression
T2 388-394 HP_0001297 denotes stroke
T3 465-478 HP_0002083 denotes migraine aura
T4 465-478 HP_0002077 denotes migraine aura
T5 465-473 HP_0002076 denotes migraine
T6 474-478 HP_0011157 denotes aura

Allie

Id Subject Object Predicate Lexical cue
SS1_21699507_2_0 131-151 expanded denotes Spreading depression
SS2_21699507_2_0 153-155 abbr denotes SD
AE1_21699507_2_0 SS1_21699507_2_0 SS2_21699507_2_0 abbreviatedTo Spreading depression,SD