> top > docs > PubMed:21698001 > annotations

PubMed:21698001 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 30-35 PR:Q5S006 denotes LRRK2
T2 30-35 PR:000003033 denotes LRRK2
T3 30-35 PR:Q5S007 denotes LRRK2
T4 39-44 UBERON:0007023 denotes adult
T5 45-49 10118 denotes rats
T6 45-49 10116 denotes rats
T7 45-49 D051381 denotes rats
T12 58-66 3628 denotes dopamine
T8 58-66 CHEBI:59905 denotes dopamine
T9 58-66 CHEBI:18243 denotes dopamine
T10 58-66 D004298 denotes dopamine
T11 58-66 D004298 denotes dopamine
T13 89-96 D004194 denotes disease
T14 89-96 D004194 denotes disease
T15 218-226 SO:0000109 denotes mutation
T16 252-260 SO:0000109 denotes Mutation
T18 268-275 6308 denotes leucine
T17 268-275 CHEBI:15603 denotes leucine
T20 268-275 D007930 denotes leucine
T21 268-275 CHEBI:25017 denotes leucine
T22 268-275 D007930 denotes leucine
T19 268-275 SO:0001437 denotes leucine
T23 281-287 SO:0001068 denotes repeat
T24 298-303 PR:Q5S006 denotes LRRK2
T25 298-303 PR:000003033 denotes LRRK2
T26 298-303 PR:Q5S007 denotes LRRK2
T27 305-309 SO:0000704 denotes gene
T28 378-392 MOP:0000795 denotes S substitution
T29 380-392 SO:1000002 denotes substitution
T30 434-439 PR:Q5S006 denotes LRRK2
T31 434-439 PR:000003033 denotes LRRK2
T32 434-439 PR:Q5S007 denotes LRRK2
T33 443-453 SO:0000781 denotes transgenic
T34 443-458 10090 denotes transgenic mice
T35 443-458 D008822 denotes transgenic mice
T36 454-458 PR:000005054 denotes mice
T38 454-458 O89094 denotes mice
T40 475-481 CL:0000540 denotes neuron
T41 475-487 GO:0070997 denotes neuron death
T42 517-524 D004194 denotes disease
T43 517-524 D004194 denotes disease
T44 525-529 SO:0000704 denotes gene
T45 601-605 PR:000005054 denotes mice
T47 601-605 O89094 denotes mice
T46 601-605 D051379 denotes mice
T48 601-605 10095 denotes mice
T49 625-630 PR:Q5S006 denotes LRRK2
T50 625-630 PR:000003033 denotes LRRK2
T51 625-630 PR:Q5S007 denotes LRRK2
T52 631-643 GO:0009405 denotes pathogenesis
T53 666-676 SO:0000781 denotes transgenic
T54 666-681 D055647 denotes transgenic rats
T58 693-698 D006801 denotes human
T59 699-704 PR:Q5S006 denotes LRRK2
T60 699-704 PR:000003033 denotes LRRK2
T61 699-704 PR:Q5S007 denotes LRRK2
T62 715-729 MOP:0000795 denotes S substitution
T63 717-729 SO:1000002 denotes substitution
T64 758-763 PR:Q5S006 denotes LRRK2
T65 758-763 PR:000003033 denotes LRRK2
T66 758-763 PR:Q5S007 denotes LRRK2
T67 775-780 UBERON:0007023 denotes adult
T68 781-785 10118 denotes rats
T69 781-785 10116 denotes rats
T70 781-785 D051381 denotes rats
T75 795-803 3628 denotes dopamine
T71 795-803 CHEBI:59905 denotes dopamine
T72 795-803 CHEBI:18243 denotes dopamine
T73 795-803 D004298 denotes dopamine
T74 795-803 D004298 denotes dopamine
T80 816-824 3628 denotes dopamine
T82 816-841 D050483 denotes dopamine transporter (DAT
T83 838-841 PR:Q61327 denotes DAT
T84 838-841 Q03614 denotes DAT
T86 838-841 PR:P13483 denotes DAT
T87 838-841 P27922 denotes DAT
T88 838-841 Q61327 denotes DAT
T89 838-841 P23977 denotes DAT
T90 838-841 Q9GJT6 denotes DAT
T91 838-841 PR:000015188 denotes DAT
T92 838-841 PR:Q94521 denotes DAT
T93 838-841 Q01959 denotes DAT
T94 838-841 PR:Q7K4Y6 denotes DAT
T95 922-932 SO:0000781 denotes transgenic
T96 922-937 D055647 denotes transgenic rats
T100 968-972 SO:0000704 denotes gene
T101 1003-1006 PR:Q61327 denotes DAT
T102 1003-1006 Q03614 denotes DAT
T104 1003-1006 PR:P13483 denotes DAT
T105 1003-1006 P27922 denotes DAT
T106 1003-1006 Q61327 denotes DAT
T107 1003-1006 P23977 denotes DAT
T108 1003-1006 Q9GJT6 denotes DAT
T109 1003-1006 PR:000015188 denotes DAT
T110 1003-1006 PR:Q94521 denotes DAT
T111 1003-1006 Q01959 denotes DAT
T112 1003-1006 PR:Q7K4Y6 denotes DAT
T103 1003-1006 CHEBI:137433 denotes DAT
T113 1007-1014 SO:0100018 denotes binding
T114 1007-1014 SO:0001091 denotes binding
T115 1007-1014 GO:0005488 denotes binding
T116 1114-1122 SO:0000109 denotes mutation
T117 1126-1131 PR:Q5S006 denotes LRRK2
T118 1126-1131 PR:000003033 denotes LRRK2
T119 1126-1131 PR:Q5S007 denotes LRRK2
T120 1137-1147 SO:0000781 denotes transgenic
T121 1137-1152 D055647 denotes transgenic rats
T125 1239-1247 SO:0000109 denotes mutation
T126 1251-1256 PR:Q5S006 denotes LRRK2
T127 1251-1256 PR:000003033 denotes LRRK2
T128 1251-1256 PR:Q5S007 denotes LRRK2
T129 1268-1278 SO:0000781 denotes transgenic
T130 1376-1386 SO:0000781 denotes transgenic
T131 1376-1391 D055647 denotes transgenic rats
T135 1414-1419 PR:Q5S006 denotes LRRK2
T136 1414-1419 PR:000003033 denotes LRRK2
T137 1414-1419 PR:Q5S007 denotes LRRK2
T138 1420-1430 SO:0000781 denotes transgenic
T139 1420-1435 D055647 denotes transgenic rats
T143 1481-1491 SO:0000781 denotes transgenic
T144 1525-1534 SO:0000902 denotes transgene
T145 1583-1587 SO:0000704 denotes gene
T146 1583-1598 GO:0010467 denotes gene expression
T147 1616-1623 D012377 denotes rodents

Allie

Id Subject Object Predicate Lexical cue
SS1_21698001_1_0 77-96 expanded denotes Parkinson's disease
SS2_21698001_1_0 98-100 abbr denotes PD
SS1_21698001_3_0 268-296 expanded denotes leucine-rich repeat kinase-2
SS2_21698001_3_0 298-303 abbr denotes LRRK2
SS1_21698001_6_0 816-836 expanded denotes dopamine transporter
SS2_21698001_6_0 838-841 abbr denotes DAT
AE1_21698001_1_0 SS1_21698001_1_0 SS2_21698001_1_0 abbreviatedTo Parkinson's disease,PD
AE1_21698001_3_0 SS1_21698001_3_0 SS2_21698001_3_0 abbreviatedTo leucine-rich repeat kinase-2,LRRK2
AE1_21698001_6_0 SS1_21698001_6_0 SS2_21698001_6_0 abbreviatedTo dopamine transporter,DAT

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-76 DRI_Background denotes Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.
T2 77-164 DRI_Background denotes Parkinson's disease (PD) results from progressive degeneration of dopaminergic neurons.
T3 165-251 DRI_Outcome denotes Most PD cases are sporadic, but some have pathogenic mutation in the individual genes.
T4 252-393 DRI_Approach denotes Mutation of the leucine-rich repeat kinase-2 (LRRK2) gene is associated with familial and sporadic PD, as exemplified by G2019S substitution.
T5 394-606 DRI_Challenge denotes While constitutive expression of mutant LRRK2 in transgenic mice fails to induce neuron death, transient expression of the disease gene by viral delivery causes a substantial loss of dopaminergic neurons in mice.
T6 607-730 DRI_Outcome denotes To further assess LRRK2 pathogenesis, we created inducible transgenic rats expressing human LRRK2 with G2019S substitution.
T7 731-994 DRI_Background denotes Temporal overexpression of LRRK2(G2019S) in adult rats impaired dopamine reuptake by dopamine transporter (DAT) and thus enhanced locomotor activity, the phenotypes that were not observed in transgenic rats constitutively expressing the gene throughout life time.
T8 995-1132 DRI_Background denotes Reduced DAT binding activity is an early sign of dopaminergic dysfunction in asymptomatic subjects carrying pathogenic mutation in LRRK2.
T9 1133-1257 DRI_Outcome denotes Our transgenic rats recapitulated the initiation process of dopaminergic dysfunction caused by pathogenic mutation in LRRK2.
T10 1258-1392 DRI_Background denotes Inducible transgenic approach uncovered phenotypes that may be obscured by developmental compensation in constitutive transgenic rats.
T11 1393-1645 DRI_Background denotes Finding in inducible LRRK2 transgenic rats would guide developing effective strategy in transgenic studies: Inducible expression of transgene may induce greater phenotypes than constitutive gene expression, particularly in rodents with short life time.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 77-164 DRI_Background denotes Parkinson's disease (PD) results from progressive degeneration of dopaminergic neurons.
T2 165-251 DRI_Outcome denotes Most PD cases are sporadic, but some have pathogenic mutation in the individual genes.
T3 252-393 DRI_Approach denotes Mutation of the leucine-rich repeat kinase-2 (LRRK2) gene is associated with familial and sporadic PD, as exemplified by G2019S substitution.
T4 394-606 DRI_Challenge denotes While constitutive expression of mutant LRRK2 in transgenic mice fails to induce neuron death, transient expression of the disease gene by viral delivery causes a substantial loss of dopaminergic neurons in mice.
T5 607-730 DRI_Outcome denotes To further assess LRRK2 pathogenesis, we created inducible transgenic rats expressing human LRRK2 with G2019S substitution.
T6 731-994 DRI_Background denotes Temporal overexpression of LRRK2(G2019S) in adult rats impaired dopamine reuptake by dopamine transporter (DAT) and thus enhanced locomotor activity, the phenotypes that were not observed in transgenic rats constitutively expressing the gene throughout life time.
T7 995-1132 DRI_Background denotes Reduced DAT binding activity is an early sign of dopaminergic dysfunction in asymptomatic subjects carrying pathogenic mutation in LRRK2.
T8 1133-1257 DRI_Outcome denotes Our transgenic rats recapitulated the initiation process of dopaminergic dysfunction caused by pathogenic mutation in LRRK2.
T9 1258-1392 DRI_Background denotes Inducible transgenic approach uncovered phenotypes that may be obscured by developmental compensation in constitutive transgenic rats.
T10 1393-1645 DRI_Background denotes Finding in inducible LRRK2 transgenic rats would guide developing effective strategy in transgenic studies: Inducible expression of transgene may induce greater phenotypes than constitutive gene expression, particularly in rodents with short life time.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 77-86 HP_0001300 denotes Parkinson

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21698001-3#16#44#gene120892 268-296 gene120892 denotes leucine-rich repeat kinase-2
21698001-3#46#51#gene120892 298-303 gene120892 denotes LRRK2
21698001-3#99#101#diseaseC0030567 351-353 diseaseC0030567 denotes PD
21698001-7#8#11#gene6531 1003-1006 gene6531 denotes DAT
21698001-7#131#136#gene120892 1126-1131 gene120892 denotes LRRK2
21698001-7#62#73#diseaseC3887505 1057-1068 diseaseC3887505 denotes dysfunction
16#44#gene12089299#101#diseaseC0030567 21698001-3#16#44#gene120892 21698001-3#99#101#diseaseC0030567 associated_with leucine-rich repeat kinase-2,PD
46#51#gene12089299#101#diseaseC0030567 21698001-3#46#51#gene120892 21698001-3#99#101#diseaseC0030567 associated_with LRRK2,PD
8#11#gene653162#73#diseaseC3887505 21698001-7#8#11#gene6531 21698001-7#62#73#diseaseC3887505 associated_with DAT,dysfunction
131#136#gene12089262#73#diseaseC3887505 21698001-7#131#136#gene120892 21698001-7#62#73#diseaseC3887505 associated_with LRRK2,dysfunction