PubMed:21697764 JSONTXT

{"project":"Allie","denotations":[{"id":"SS1_21697764_2_0","span":{"begin":115,"end":138},"obj":"expanded"},{"id":"SS2_21697764_2_0","span":{"begin":140,"end":143},"obj":"abbr"}],"relations":[{"id":"AE1_21697764_2_0","pred":"abbreviatedTo","subj":"SS1_21697764_2_0","obj":"SS2_21697764_2_0"}],"text":"Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.\nOBJECTIVES: Four genome-wide association (GWA) studies have found that variation in a region of strong linkage disequilibrium on the long arm of chromosome 15 (15q24-25.1) containing nicotinic acetylcholine receptor genes contributes to lung cancer risk. Because cigarette smoking is a major risk factor for developing both lung cancer and pancreatic cancer, we hypothesized that variation in this region may also modify individual susceptibility to pancreatic cancer.\nMETHODS: We conducted a case-control study of 523 patients with pathologically confirmed pancreatic adenocarcinoma and 1046 age-, sex-, ethnicity-, and smoking behavior-matched cancer-free controls.\nRESULTS: We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A\u003eG and rs1051730: G\u003eA, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.\nCONCLUSIONS: The results of our study suggest that the 2 single nucleotide polymorphisms at 15q25.1 do not modify pancreatic cancer risk."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":335,"end":346},"obj":"HP_0100526"},{"id":"T2","span":{"begin":340,"end":346},"obj":"HP_0002664"},{"id":"T3","span":{"begin":422,"end":433},"obj":"HP_0100526"},{"id":"T4","span":{"begin":427,"end":433},"obj":"HP_0002664"},{"id":"T5","span":{"begin":438,"end":455},"obj":"HP_0002894"},{"id":"T6","span":{"begin":449,"end":455},"obj":"HP_0002664"},{"id":"T7","span":{"begin":548,"end":565},"obj":"HP_0002894"},{"id":"T8","span":{"begin":559,"end":565},"obj":"HP_0002664"}],"text":"Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.\nOBJECTIVES: Four genome-wide association (GWA) studies have found that variation in a region of strong linkage disequilibrium on the long arm of chromosome 15 (15q24-25.1) containing nicotinic acetylcholine receptor genes contributes to lung cancer risk. Because cigarette smoking is a major risk factor for developing both lung cancer and pancreatic cancer, we hypothesized that variation in this region may also modify individual susceptibility to pancreatic cancer.\nMETHODS: We conducted a case-control study of 523 patients with pathologically confirmed pancreatic adenocarcinoma and 1046 age-, sex-, ethnicity-, and smoking behavior-matched cancer-free controls.\nRESULTS: We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A\u003eG and rs1051730: G\u003eA, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.\nCONCLUSIONS: The results of our study suggest that the 2 single nucleotide polymorphisms at 15q25.1 do not modify pancreatic cancer risk."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"21697764-4#93#102#geners8034191","span":{"begin":868,"end":877},"obj":"geners8034191"},{"id":"21697764-4#112#121#geners1051730","span":{"begin":887,"end":896},"obj":"geners1051730"},{"id":"21697764-4#69#80#diseaseC0242379","span":{"begin":844,"end":855},"obj":"diseaseC0242379"},{"id":"21697764-4#69#80#diseaseC0684249","span":{"begin":844,"end":855},"obj":"diseaseC0684249"},{"id":"21697764-4#69#80#diseaseC1306460","span":{"begin":844,"end":855},"obj":"diseaseC1306460"},{"id":"21697764-4#195#212#diseaseC0235974","span":{"begin":970,"end":987},"obj":"diseaseC0235974"},{"id":"21697764-4#195#212#diseaseC0346647","span":{"begin":970,"end":987},"obj":"diseaseC0346647"},{"id":"21697764-4#69#80#diseaseC0242379","span":{"begin":844,"end":855},"obj":"diseaseC0242379"},{"id":"21697764-4#69#80#diseaseC0684249","span":{"begin":844,"end":855},"obj":"diseaseC0684249"},{"id":"21697764-4#69#80#diseaseC1306460","span":{"begin":844,"end":855},"obj":"diseaseC1306460"},{"id":"21697764-4#195#212#diseaseC0235974","span":{"begin":970,"end":987},"obj":"diseaseC0235974"},{"id":"21697764-4#195#212#diseaseC0346647","span":{"begin":970,"end":987},"obj":"diseaseC0346647"}],"relations":[{"id":"93#102#geners803419169#80#diseaseC0242379","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC0242379"},{"id":"93#102#geners803419169#80#diseaseC0684249","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC0684249"},{"id":"93#102#geners803419169#80#diseaseC1306460","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC1306460"},{"id":"93#102#geners8034191195#212#diseaseC0235974","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#195#212#diseaseC0235974"},{"id":"93#102#geners8034191195#212#diseaseC0346647","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#195#212#diseaseC0346647"},{"id":"93#102#geners803419169#80#diseaseC0242379","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC0242379"},{"id":"93#102#geners803419169#80#diseaseC0684249","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC0684249"},{"id":"93#102#geners803419169#80#diseaseC1306460","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#69#80#diseaseC1306460"},{"id":"93#102#geners8034191195#212#diseaseC0235974","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#195#212#diseaseC0235974"},{"id":"93#102#geners8034191195#212#diseaseC0346647","pred":"associated_with","subj":"21697764-4#93#102#geners8034191","obj":"21697764-4#195#212#diseaseC0346647"},{"id":"112#121#geners105173069#80#diseaseC0242379","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC0242379"},{"id":"112#121#geners105173069#80#diseaseC0684249","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC0684249"},{"id":"112#121#geners105173069#80#diseaseC1306460","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC1306460"},{"id":"112#121#geners1051730195#212#diseaseC0235974","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#195#212#diseaseC0235974"},{"id":"112#121#geners1051730195#212#diseaseC0346647","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#195#212#diseaseC0346647"},{"id":"112#121#geners105173069#80#diseaseC0242379","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC0242379"},{"id":"112#121#geners105173069#80#diseaseC0684249","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC0684249"},{"id":"112#121#geners105173069#80#diseaseC1306460","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#69#80#diseaseC1306460"},{"id":"112#121#geners1051730195#212#diseaseC0235974","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#195#212#diseaseC0235974"},{"id":"112#121#geners1051730195#212#diseaseC0346647","pred":"associated_with","subj":"21697764-4#112#121#geners1051730","obj":"21697764-4#195#212#diseaseC0346647"}],"text":"Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.\nOBJECTIVES: Four genome-wide association (GWA) studies have found that variation in a region of strong linkage disequilibrium on the long arm of chromosome 15 (15q24-25.1) containing nicotinic acetylcholine receptor genes contributes to lung cancer risk. Because cigarette smoking is a major risk factor for developing both lung cancer and pancreatic cancer, we hypothesized that variation in this region may also modify individual susceptibility to pancreatic cancer.\nMETHODS: We conducted a case-control study of 523 patients with pathologically confirmed pancreatic adenocarcinoma and 1046 age-, sex-, ethnicity-, and smoking behavior-matched cancer-free controls.\nRESULTS: We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A\u003eG and rs1051730: G\u003eA, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.\nCONCLUSIONS: The results of our study suggest that the 2 single nucleotide polymorphisms at 15q25.1 do not modify pancreatic cancer risk."}