
PubMed:21676935
Annnotations
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 137-337 | DRI_Challenge | denotes | Temporal lobe seizures in humans correlate with stereotyped electrophysiological patterns that can be reproduced in animal models to study the cellular and network changes responsible for ictogenesis. |
T2 | 338-558 | DRI_Challenge | denotes | Seizure-like discharges that mimic seizure patterns in humans were induced in the entorhinal cortex of the in vitro isolated guinea pig brain by 3-min arterial applications of the GABA(A) receptor antagonist bicuculline. |
T3 | 559-782 | DRI_Background | denotes | The onset of seizure is characterized by a paradoxical interruption of firing for several seconds in principal neurons coupled with both enhanced interneuronal firing and increased extracellular potassium (Gnatkovsky et al. |
T4 | 790-956 | DRI_Outcome | denotes | The evolution of action potential features from firing break to excessive and synchronous activity associated with the progression of seizure itself is analyzed here. |
T5 | 957-1093 | DRI_Approach | denotes | We utilized phase plot analysis to characterize action potential features of entorhinal cortex neurons in different phases of a seizure. |
T6 | 1094-1402 | DRI_Outcome | denotes | Compared with preictal action potentials, resumed spikes in layer II-III neurons (n = 17) during the early phase of the seizure-like discharge displayed 1) depolarized threshold, 2) lower peak amplitude, 3) depolarized voltage of repolarization and 4) decelerated depolarizing phase, and 5) spike doublettes. |
T7 | 1403-1552 | DRI_Approach | denotes | Action potentials in deep-layer principal cells (n = 8) during seizure did not show the marked feature changes observed in superficial layer neurons. |
T8 | 1553-1638 | DRI_Outcome | denotes | Action potential reappearance correlated with an increase in extracellular potassium. |
T9 | 1639-1873 | DRI_Background | denotes | High-threshold, slow-action potentials similar to those observed in the irregular firing phase of a seizure were reproduced in layer II-III neurons by direct cortical application of a highly concentrated potassium solution (12-24 mM). |
T10 | 1874-2107 | DRI_Challenge | denotes | We propose that the generation of possibly nonsomatic action potentials by increased extracellular potassium represents a crucial step toward reestablish firing after an initial depression in an acute model of temporal lobe seizures. |
T11 | 2108-2286 | DRI_Approach | denotes | Resumed firing reengages principal neurons into seizure discharge and promotes the transition toward the synchronized burst firing that characterizes the late phase of a seizure. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-7 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | Changes |
T2 | 301-308 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
T3 | 367-372 | CVCL_Z366|Spontaneously_immortalized_cell_line|Spodoptera frugiperda | denotes | mimic |
T4 | 485-488 | CVCL_E777|Transformed_cell_line|Homo sapiens | denotes | min |
T5 | 523-524 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | A |
T6 | 600-601 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T7 | 779-781 | CVCL_CX61|Hybrid_cell_line|Cricetulus griseus,Homo sapiens | denotes | al |
T8 | 783-787 | CVCL_0473|Cancer_cell_line|Homo sapiens | denotes | 2008 |
T9 | 880-888 | CVCL_C410|Hybridoma|Mus musculus | denotes | activity |
T10 | 957-959 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
T11 | 1083-1084 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T12 | 1282-1286 | CVCL_3772|Transformed_cell_line|Homo sapiens | denotes | peak |
T13 | 1339-1344 | CVCL_K225|Induced_pluripotent_stem_cell|Homo sapiens | denotes | and 4 |
T14 | 1452-1457 | CVCL_D463|Transformed_cell_line|Mus musculus | denotes | n = 8 |
T15 | 1452-1457 | CVCL_IZ69|Spontaneously_immortalized_cell_line|Homo sapiens | denotes | n = 8 |
T16 | 1506-1513 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
T17 | 1599-1601 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T18 | 1599-1601 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T19 | 1737-1738 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T20 | 1821-1822 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T21 | 1874-1876 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
T22 | 1994-1995 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T23 | 2041-2043 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T24 | 2041-2043 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T25 | 2066-2068 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T26 | 2066-2068 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T27 | 2276-2277 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 11-27 | GO:0001508 | denotes | action potential |
T2 | 44-57 | D012640 | denotes | focal seizure |
T3 | 44-57 | D012640 | denotes | focal seizure |
T6 | 76-93 | UBERON:0002728 | denotes | entorhinal cortex |
T7 | 76-93 | UBERON:0002895 | denotes | entorhinal cortex |
T9 | 119-129 | D006168 | denotes | guinea pig |
T10 | 119-129 | 10141 | denotes | guinea pig |
T12 | 126-129 | P30941 | denotes | pig |
T13 | 130-135 | UBERON:6110636 | denotes | brain |
T14 | 130-135 | UBERON:0000955 | denotes | brain |
T15 | 151-159 | D012640 | denotes | seizures |
T16 | 151-159 | D012640 | denotes | seizures |
T17 | 253-259 | UBERON:3010325 | denotes | animal |
T18 | 253-259 | UBERON:0000468 | denotes | animal |
T19 | 338-345 | D012640 | denotes | Seizure |
T20 | 338-345 | D012640 | denotes | Seizure |
T21 | 367-372 | CVCL_Z366 | denotes | mimic |
T22 | 373-380 | D012640 | denotes | seizure |
T23 | 373-380 | D012640 | denotes | seizure |
T24 | 420-437 | UBERON:0002728 | denotes | entorhinal cortex |
T25 | 420-437 | UBERON:0002895 | denotes | entorhinal cortex |
T27 | 463-473 | D006168 | denotes | guinea pig |
T28 | 463-473 | 10141 | denotes | guinea pig |
T30 | 470-473 | P30941 | denotes | pig |
T31 | 474-479 | UBERON:6110636 | denotes | brain |
T32 | 474-479 | UBERON:0000955 | denotes | brain |
T33 | 485-488 | CVCL_E777 | denotes | min |
T37 | 518-534 | G5ECJ0 | denotes | GABA(A) receptor |
T39 | 518-534 | Q9BLY8 | denotes | GABA(A) receptor |
T40 | 518-534 | P26714 | denotes | GABA(A) receptor |
T41 | 518-534 | Q08832 | denotes | GABA(A) receptor |
T42 | 518-545 | D058787 | denotes | GABA(A) receptor antagonist |
T43 | 518-545 | D058787 | denotes | GABA(A) receptor antagonist |
T45 | 546-557 | D001640 | denotes | bicuculline |
T46 | 546-557 | D001640 | denotes | bicuculline |
T47 | 546-557 | CHEBI:3092 | denotes | bicuculline |
T48 | 572-579 | D012640 | denotes | seizure |
T49 | 572-579 | D012640 | denotes | seizure |
T50 | 740-753 | GO:0005576 | denotes | extracellular |
T54 | 754-763 | 8588 | denotes | potassium |
T51 | 754-763 | D011188 | denotes | potassium |
T52 | 754-763 | D011188 | denotes | potassium |
T53 | 754-763 | CHEBI:26216 | denotes | potassium |
T55 | 807-823 | GO:0001508 | denotes | action potential |
T56 | 924-931 | D012640 | denotes | seizure |
T57 | 924-931 | D012640 | denotes | seizure |
T58 | 1005-1021 | GO:0001508 | denotes | action potential |
T59 | 1034-1051 | UBERON:0002728 | denotes | entorhinal cortex |
T60 | 1034-1051 | UBERON:0002895 | denotes | entorhinal cortex |
T62 | 1085-1092 | D012640 | denotes | seizure |
T63 | 1085-1092 | D012640 | denotes | seizure |
T64 | 1154-1159 | UBERON:0000119 | denotes | layer |
T65 | 1154-1159 | UBERON:0022303 | denotes | layer |
T66 | 1214-1221 | D012640 | denotes | seizure |
T67 | 1214-1221 | D012640 | denotes | seizure |
T69 | 1385-1390 | Q65914 | denotes | spike |
T70 | 1385-1390 | P35774 | denotes | spike |
T71 | 1385-1390 | P35773 | denotes | spike |
T72 | 1385-1390 | P68983 | denotes | spike |
T73 | 1385-1390 | P04501 | denotes | spike |
T74 | 1385-1390 | P36711 | denotes | spike |
T75 | 1385-1390 | P19721 | denotes | spike |
T76 | 1385-1390 | P36844 | denotes | spike |
T77 | 1385-1390 | Q03553 | denotes | spike |
T78 | 1385-1390 | P68982 | denotes | spike |
T79 | 1385-1390 | P11818 | denotes | spike |
T80 | 1385-1390 | P15141 | denotes | spike |
T81 | 1385-1390 | P22230 | denotes | spike |
T82 | 1385-1390 | P18047 | denotes | spike |
T83 | 1385-1390 | P36848 | denotes | spike |
T84 | 1385-1390 | A9CB96 | denotes | spike |
T85 | 1385-1390 | Q65961 | denotes | spike |
T86 | 1385-1390 | P03275 | denotes | spike |
T87 | 1385-1390 | P36847 | denotes | spike |
T88 | 1385-1390 | Q83457 | denotes | spike |
T89 | 1385-1390 | P36845 | denotes | spike |
T90 | 1385-1390 | Q96689 | denotes | spike |
T91 | 1403-1409 | CHEBI:5133 | denotes | Action |
T92 | 1429-1434 | UBERON:0000119 | denotes | layer |
T93 | 1429-1434 | UBERON:0022303 | denotes | layer |
T94 | 1466-1473 | D012640 | denotes | seizure |
T95 | 1466-1473 | D012640 | denotes | seizure |
T96 | 1538-1543 | UBERON:0000119 | denotes | layer |
T97 | 1538-1543 | UBERON:0022303 | denotes | layer |
T98 | 1553-1559 | CHEBI:5133 | denotes | Action |
T99 | 1553-1569 | GO:0001508 | denotes | Action potential |
T100 | 1614-1627 | GO:0005576 | denotes | extracellular |
T104 | 1628-1637 | 8588 | denotes | potassium |
T101 | 1628-1637 | D011188 | denotes | potassium |
T102 | 1628-1637 | D011188 | denotes | potassium |
T103 | 1628-1637 | CHEBI:26216 | denotes | potassium |
T105 | 1739-1746 | D012640 | denotes | seizure |
T106 | 1739-1746 | D012640 | denotes | seizure |
T107 | 1766-1771 | UBERON:0000119 | denotes | layer |
T108 | 1766-1771 | UBERON:0022303 | denotes | layer |
T112 | 1843-1852 | 8588 | denotes | potassium |
T109 | 1843-1852 | D011188 | denotes | potassium |
T110 | 1843-1852 | D011188 | denotes | potassium |
T111 | 1843-1852 | CHEBI:26216 | denotes | potassium |
T113 | 1853-1861 | CHEBI:75958 | denotes | solution |
T114 | 1959-1972 | GO:0005576 | denotes | extracellular |
T118 | 1973-1982 | 8588 | denotes | potassium |
T115 | 1973-1982 | D011188 | denotes | potassium |
T116 | 1973-1982 | D011188 | denotes | potassium |
T117 | 1973-1982 | CHEBI:26216 | denotes | potassium |
T119 | 2052-2062 | UBERON:0004704 | denotes | depression |
T120 | 2084-2097 | UBERON:0001871 | denotes | temporal lobe |
T121 | 2098-2106 | D012640 | denotes | seizures |
T122 | 2098-2106 | D012640 | denotes | seizures |
T123 | 2156-2163 | D012640 | denotes | seizure |
T124 | 2156-2163 | D012640 | denotes | seizure |
T125 | 2191-2201 | SO:1000009 | denotes | transition |
T126 | 2278-2285 | D012640 | denotes | seizure |
T127 | 2278-2285 | D012640 | denotes | seizure |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 151-159 | HP_0001250 | denotes | seizures |
T2 | 338-345 | HP_0001250 | denotes | Seizure |
T3 | 373-380 | HP_0001250 | denotes | seizure |
T4 | 572-579 | HP_0001250 | denotes | seizure |
T5 | 924-931 | HP_0001250 | denotes | seizure |
T6 | 1085-1092 | HP_0001250 | denotes | seizure |
T7 | 1214-1221 | HP_0001250 | denotes | seizure |
T8 | 1466-1473 | HP_0001250 | denotes | seizure |
T9 | 1739-1746 | HP_0001250 | denotes | seizure |
T10 | 2052-2062 | HP_0000716 | denotes | depression |
T11 | 2098-2106 | HP_0001250 | denotes | seizures |
T12 | 2156-2163 | HP_0001250 | denotes | seizure |
T13 | 2278-2285 | HP_0001250 | denotes | seizure |