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PubMed:21676868 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin.
T2 113-240 Sentence denotes Up-regulation of the dolichol pathway, a "hallmark" of asparagine-linked protein glycosylation, enhances angiogenesis in vitro.
T3 241-328 Sentence denotes The dynamic relationship between these two processes is now evaluated with tunicamycin.
T4 329-455 Sentence denotes Capillary endothelial cells treated with tunicamycin were growth inhibited and could not be reversed with exogenous VEGF(165).
T5 456-670 Sentence denotes Inhibition of angiogenesis is supported by down-regulation of (i) phosphorylated VEGFR1 and VEGFR2 receptors; (ii) VEGF(165)-specific phosphotyrosine kinase activity; and (iii) Matrigel(TM) invasion and chemotaxis.
T6 671-781 Sentence denotes In vivo, tunicamycin prevented the vessel development in Matrigel(TM) implants in athymic Balb/c (nu/nu) mice.
T7 782-887 Sentence denotes Immunohistochemical analysis of CD34 (p < 0.001) and CD144 (p < 0.001) exhibited reduced vascularization.
T8 888-1071 Sentence denotes A 3.8-fold increased expression of TSP-1, an endogenous angiogenesis inhibitor in Matrigel(TM) implants correlated with that in tunicamycin (32 h)-treated capillary endothelial cells.
T9 1072-1247 Sentence denotes Intravenous injection of tunicamycin (0.5 mg/kg to 1.0 mg/kg) per week slowed down a double negative (MDA-MB-435) grade III breast adenocarcinoma growth by ∼50-60% in 3 weeks.
T10 1248-1398 Sentence denotes Histopathological analysis of the paraffin sections indicated significant reduction in vessel size, the microvascular density and tumor mitotic index.
T11 1399-1459 Sentence denotes Ki-67 and VEGF expression in tumor tissue were also reduced.
T12 1460-1546 Sentence denotes A significant reduction of N-glycan expression in tumor microvessel was also observed.
T13 1547-1969 Sentence denotes High expression of GRP-78 in CD144-positive cells supported unfolded protein response-mediated ER stress in tumor microvasculature. ∼65% reduction of a triple negative (MDA-MB-231) breast tumor xenograft in 1 week with tunicamycin (0.25 mg/kg) given orally and the absence of systemic and/or organ failure strongly supported tunicamycin's potential for a powerful glycotherapeutic treatment of breast cancer in the clinic.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 706-712 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T2 1335-1341 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1378-1383 HP_0002664 denotes tumor
T2 1428-1433 HP_0002664 denotes tumor
T3 1510-1515 HP_0002664 denotes tumor
T4 1655-1660 HP_0002664 denotes tumor
T5 1728-1740 HP_0003002 denotes breast tumor
T6 1728-1740 HP_0100013 denotes breast tumor
T7 1735-1740 HP_0002664 denotes tumor
T8 1941-1954 HP_0003002 denotes breast cancer
T9 1941-1954 HP_0100013 denotes breast cancer
T10 1948-1954 HP_0002664 denotes cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 82-94 Disease denotes breast tumor http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100
T3 923-926 Disease denotes TSP http://purl.obolibrary.org/obo/MONDO_0008039
T4 1196-1217 Disease denotes breast adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004988
T5 1378-1383 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1428-1433 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 1510-1515 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 1655-1660 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 1728-1740 Disease denotes breast tumor http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100
T11 1941-1954 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 706-712 Body_part denotes vessel http://purl.obolibrary.org/obo/MAT_0000393
T2 1335-1341 Body_part denotes vessel http://purl.obolibrary.org/obo/MAT_0000393

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 82-94 Phenotype denotes breast tumor HP:0100013
T2 1378-1383 Phenotype denotes tumor HP:0002664
T3 1428-1433 Phenotype denotes tumor HP:0002664
T4 1510-1515 Phenotype denotes tumor HP:0002664
T5 1655-1660 Phenotype denotes tumor HP:0002664
T6 1728-1740 Phenotype denotes breast tumor HP:0100013
T7 1941-1954 Phenotype denotes breast cancer HP:0003002

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 47-51 OrganismTaxon denotes mice 10088
T2 776-780 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 52-68 Body_part denotes microvasculature http://purl.obolibrary.org/obo/UBERON_8410081
T2 82-88 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 329-356 Body_part denotes Capillary endothelial cells http://purl.obolibrary.org/obo/CL_0002144
T4 706-712 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T5 1043-1070 Body_part denotes capillary endothelial cells http://purl.obolibrary.org/obo/CL_0002144
T6 1196-1202 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 1335-1341 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T8 1434-1440 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 1516-1527 Body_part denotes microvessel http://purl.obolibrary.org/obo/UBERON_8410081
T10 1661-1677 Body_part denotes microvasculature http://purl.obolibrary.org/obo/UBERON_8410081
T11 1728-1734 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T12 1839-1844 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T14 1941-1947 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 329-356 Cell denotes Capillary endothelial cells http://purl.obolibrary.org/obo/CL:0002144
T2 1043-1070 Cell denotes capillary endothelial cells http://purl.obolibrary.org/obo/CL:0002144