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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Roles of G1359A polymorphism of the cannabinoid receptor gene (CNR1) on weight loss and adipocytokines after a hypocaloric diet.
T2 129-140 Sentence denotes BACKGROUND:
T3 141-359 Sentence denotes A intragenic biallelic polymorphism (1359 G/A) of the CB1 gene resulting in the substitution of the G to A at nucleotide position 1359 in codon 435 (Thr), was reported as a common polymorphism in Caucasian populations.
T4 360-427 Sentence denotes Intervention studies with this polymorphism have not been realized.
T5 428-438 Sentence denotes OBJECTIVE:
T6 439-669 Sentence denotes We decided to investigate the role of the polymorphism (G1359A) of CB1 receptor gene on adipocytokines response and weight loss secondary to a lifestyle modification (Mediterranean hypocaloric diet and exercise) in obese patients.
T7 670-677 Sentence denotes DESIGN:
T8 678-732 Sentence denotes A population of 94 patients with obesity was analyzed.
T9 733-890 Sentence denotes Before and after 3 months on a hypocaloric diet, an anthropometric evaluation, an assessment of nutritional intake and a biochemical analysis were performed.
T10 891-1036 Sentence denotes The statistical analysis was performed for the combined G1359A and A1359A as a group and wild type G1359G as second group, with a dominant model.
T11 1037-1045 Sentence denotes RESULTS:
T12 1046-1231 Sentence denotes Forty seven patients (50%) had the genotype G1359G (wild type group) and 47 (50%) patients G1359A (41 patients, 43.6%) or A1359A (6 patients, 6.4%) (mutant type group) had the genotype.
T13 1232-1357 Sentence denotes In wild and mutant type groups, weight, body mass index, fat mass, waist circumference and systolic blood pressure decreased.
T14 1358-1428 Sentence denotes In mutant type group, resistin (4.15 ± 1.7 ng/ml vs. 3.90 ± 2.1 ng/ml:
T15 1429-1483 Sentence denotes P < 0.05), leptin (78.4 ± 69 ng/ml vs 66.2 ± 32 ng/ml:
T16 1484-1541 Sentence denotes P < 0.05) and IL-6 (1.40 ± 1.9 pg/ml vs 0.81 ± 1.5 pg/ml:
T17 1542-1593 Sentence denotes P < 0.05) levels decreased after dietary treatment.
T18 1594-1605 Sentence denotes CONCLUSION:
T19 1606-1765 Sentence denotes The novel finding of this study is the association of the mutant allele (A1359) with a decrease of resistin, leptin and interleukin-6 secondary to weight loss.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 279-284 OrganismTaxon denotes codon NCBItxid:79338

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8633 9-15 SequenceVariant denotes G1359A DBSNP:rs1049353
8634 36-56 GeneOrGeneProduct denotes cannabinoid receptor NCBIGene:1268
8635 63-67 GeneOrGeneProduct denotes CNR1 NCBIGene:1268
8636 72-83 DiseaseOrPhenotypicFeature denotes weight loss MESH:D015431
8637 178-186 SequenceVariant denotes 1359 G/A DBSNP:rs1049353
8638 195-198 GeneOrGeneProduct denotes CB1 NCBIGene:1268
8639 241-275 SequenceVariant denotes G to A at nucleotide position 1359 DBSNP:rs1049353
8640 279-294 SequenceVariant denotes codon 435 (Thr) DBSNP:rs1049353
8641 495-501 SequenceVariant denotes G1359A DBSNP:rs1049353
8642 506-518 GeneOrGeneProduct denotes CB1 receptor NCBIGene:1268
8643 555-566 DiseaseOrPhenotypicFeature denotes weight loss MESH:D015431
8644 654-659 DiseaseOrPhenotypicFeature denotes obese MESH:D009765
8645 660-668 OrganismTaxon denotes patients NCBITaxon:9606
8646 697-705 OrganismTaxon denotes patients NCBITaxon:9606
8647 711-718 DiseaseOrPhenotypicFeature denotes obesity MESH:D009765
8648 947-953 SequenceVariant denotes G1359A DBSNP:rs1049353
8649 958-964 SequenceVariant denotes A1359A DBSNP:rs1049353
8650 990-996 SequenceVariant denotes G1359G DBSNP:rs1049353
8651 1058-1066 OrganismTaxon denotes patients NCBITaxon:9606
8652 1090-1096 SequenceVariant denotes G1359G DBSNP:rs1049353
8653 1128-1136 OrganismTaxon denotes patients NCBITaxon:9606
8654 1137-1143 SequenceVariant denotes G1359A DBSNP:rs1049353
8655 1148-1156 OrganismTaxon denotes patients NCBITaxon:9606
8656 1168-1174 SequenceVariant denotes A1359A DBSNP:rs1049353
8657 1178-1186 OrganismTaxon denotes patients NCBITaxon:9606
8658 1380-1388 GeneOrGeneProduct denotes resistin NCBIGene:56729
8659 1440-1446 GeneOrGeneProduct denotes leptin NCBIGene:3952
8660 1498-1502 GeneOrGeneProduct denotes IL-6 NCBIGene:3569
8661 1679-1684 SequenceVariant denotes A1359 DBSNP:rs1049353
8662 1705-1713 GeneOrGeneProduct denotes resistin NCBIGene:56729
8663 1715-1721 GeneOrGeneProduct denotes leptin NCBIGene:3952
8664 1726-1739 GeneOrGeneProduct denotes interleukin-6 NCBIGene:3569
8665 1753-1764 DiseaseOrPhenotypicFeature denotes weight loss MESH:D015431

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 9-15 SequenceVariant denotes G1359A
T2 495-501 SequenceVariant denotes G1359A
T3 947-953 SequenceVariant denotes G1359A
T4 958-964 SequenceVariant denotes A1359A
T5 990-996 SequenceVariant denotes G1359G
T6 1090-1096 SequenceVariant denotes G1359G
T7 1137-1143 SequenceVariant denotes G1359A
T8 1168-1174 SequenceVariant denotes A1359A

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 36-56 GeneOrGeneProduct denotes cannabinoid receptor
T2 63-67 GeneOrGeneProduct denotes CNR1
T3 195-198 GeneOrGeneProduct denotes CB1
T4 506-509 GeneOrGeneProduct denotes CB1
T5 510-518 GeneOrGeneProduct denotes receptor
T6 654-659 GeneOrGeneProduct denotes obese
T7 711-718 GeneOrGeneProduct denotes obesity
T8 1195-1201 GeneOrGeneProduct denotes mutant
T9 1244-1250 GeneOrGeneProduct denotes mutant
T10 1272-1287 GeneOrGeneProduct denotes body mass index
T11 1293-1297 GeneOrGeneProduct denotes mass
T12 1299-1304 GeneOrGeneProduct denotes waist
T13 1361-1367 GeneOrGeneProduct denotes mutant
T14 1380-1388 GeneOrGeneProduct denotes resistin
T15 1404-1406 GeneOrGeneProduct denotes ml
T16 1418-1421 GeneOrGeneProduct denotes 2.1
T17 1425-1430 GeneOrGeneProduct denotes ml: P
T18 1440-1446 GeneOrGeneProduct denotes leptin
T19 1461-1463 GeneOrGeneProduct denotes ml
T20 1480-1485 GeneOrGeneProduct denotes ml: P
T21 1498-1502 GeneOrGeneProduct denotes IL-6
T26 1664-1670 GeneOrGeneProduct denotes mutant
T22 1518-1520 GeneOrGeneProduct denotes ml
T23 1538-1543 GeneOrGeneProduct denotes ml: P
T24 1610-1615 GeneOrGeneProduct denotes novel
T25 1616-1623 GeneOrGeneProduct denotes finding
T27 1705-1713 GeneOrGeneProduct denotes resistin
T28 1715-1721 GeneOrGeneProduct denotes leptin
T29 1726-1739 GeneOrGeneProduct denotes interleukin-6

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 36-56 GeneOrGeneProduct denotes cannabinoid receptor
T2 63-67 GeneOrGeneProduct denotes CNR1
T3 195-198 GeneOrGeneProduct denotes CB1
T4 506-509 GeneOrGeneProduct denotes CB1
T5 510-518 GeneOrGeneProduct denotes receptor
T6 654-659 GeneOrGeneProduct denotes obese
T7 1195-1201 GeneOrGeneProduct denotes mutant
T8 1244-1250 GeneOrGeneProduct denotes mutant
T9 1272-1287 GeneOrGeneProduct denotes body mass index
T10 1361-1367 GeneOrGeneProduct denotes mutant
T11 1380-1388 GeneOrGeneProduct denotes resistin
T12 1440-1446 GeneOrGeneProduct denotes leptin
T13 1498-1502 GeneOrGeneProduct denotes IL-6
T14 1610-1615 GeneOrGeneProduct denotes novel
T15 1664-1670 GeneOrGeneProduct denotes mutant
T16 1705-1713 GeneOrGeneProduct denotes resistin
T17 1715-1721 GeneOrGeneProduct denotes leptin
T18 1726-1739 GeneOrGeneProduct denotes interleukin-6

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 72-83 DiseaseOrPhenotypicFeature denotes weight loss D015431
T2 555-566 DiseaseOrPhenotypicFeature denotes weight loss D015431
T3 654-659 DiseaseOrPhenotypicFeature denotes obese DISEASE
T4 711-718 DiseaseOrPhenotypicFeature denotes obesity D009765
T5 1264-1276 DiseaseOrPhenotypicFeature denotes weight, body D001835
T6 1753-1764 DiseaseOrPhenotypicFeature denotes weight loss D015431

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 36-56 GeneOrGeneProduct denotes cannabinoid receptor
T2 63-67 GeneOrGeneProduct denotes CNR1
T3 195-198 GeneOrGeneProduct denotes CB1
T4 506-509 GeneOrGeneProduct denotes CB1
T5 1380-1388 GeneOrGeneProduct denotes resistin
T6 1440-1446 GeneOrGeneProduct denotes leptin
T7 1498-1502 GeneOrGeneProduct denotes IL-6
T8 1705-1713 GeneOrGeneProduct denotes resistin
T9 1715-1721 GeneOrGeneProduct denotes leptin
T10 1726-1739 GeneOrGeneProduct denotes interleukin-6

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 711-718 DiseaseOrPhenotypicFeature denotes obesity 0011122

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 72-83 DiseaseOrPhenotypicFeature denotes weight loss D015431
T2 555-566 DiseaseOrPhenotypicFeature denotes weight loss D015431
T3 654-659 DiseaseOrPhenotypicFeature denotes obese DISEASE
T4 711-718 DiseaseOrPhenotypicFeature denotes obesity D009765
T5 1264-1276 DiseaseOrPhenotypicFeature denotes weight, body D001835
T6 1753-1764 DiseaseOrPhenotypicFeature denotes weight loss D015431

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 660-668 OrganismTaxon denotes patients
T2 697-705 OrganismTaxon denotes patients
T3 1058-1066 OrganismTaxon denotes patients
T4 1128-1136 OrganismTaxon denotes patients
T5 1148-1156 OrganismTaxon denotes patients
T6 1178-1186 OrganismTaxon denotes patients

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 72-83 DiseaseOrPhenotypicFeature denotes weight loss D015431
T2 555-566 DiseaseOrPhenotypicFeature denotes weight loss D015431
T3 654-659 DiseaseOrPhenotypicFeature denotes obese DISEASE
T4 711-718 DiseaseOrPhenotypicFeature denotes obesity D009765
T5 1264-1276 DiseaseOrPhenotypicFeature denotes weight, body D001835
T6 1753-1764 DiseaseOrPhenotypicFeature denotes weight loss D015431

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 36-47 ChemicalEntity denotes cannabinoid D002186|http://purl.obolibrary.org/obo/CHEBI_67194
T3 290-293 ChemicalEntity denotes Thr http://purl.obolibrary.org/obo/CHEBI_30013|http://purl.obolibrary.org/obo/CHEBI_16857
T5 1380-1388 ChemicalEntity denotes resistin http://purl.obolibrary.org/obo/CHEBI_81573
T6 1705-1713 ChemicalEntity denotes resistin http://purl.obolibrary.org/obo/CHEBI_81573

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T6 1705-1713 ChemicalEntity denotes resistin http://purl.obolibrary.org/obo/CHEBI_81573
T5 1380-1388 ChemicalEntity denotes resistin http://purl.obolibrary.org/obo/CHEBI_81573
T3 290-293 ChemicalEntity denotes Thr http://purl.obolibrary.org/obo/CHEBI_16857|http://purl.obolibrary.org/obo/CHEBI_30013
T1 36-47 ChemicalEntity denotes cannabinoid http://purl.obolibrary.org/obo/CHEBI_67194|D002186
T10 1726-1739 GeneOrGeneProduct denotes interleukin-6
T9 1715-1721 GeneOrGeneProduct denotes leptin
T8 1705-1713 GeneOrGeneProduct denotes resistin
T7 1498-1502 GeneOrGeneProduct denotes IL-6
T22845 1440-1446 GeneOrGeneProduct denotes leptin
T77154 1380-1388 GeneOrGeneProduct denotes resistin
T4 506-509 GeneOrGeneProduct denotes CB1
T24234 195-198 GeneOrGeneProduct denotes CB1
T2 63-67 GeneOrGeneProduct denotes CNR1
T57950 36-56 GeneOrGeneProduct denotes cannabinoid receptor
T59348 1753-1764 DiseaseOrPhenotypicFeature denotes weight loss D015431
T15418 1264-1276 DiseaseOrPhenotypicFeature denotes weight, body D001835
T45745 711-718 DiseaseOrPhenotypicFeature denotes obesity D009765
T54072 654-659 DiseaseOrPhenotypicFeature denotes obese DISEASE
T12253 555-566 DiseaseOrPhenotypicFeature denotes weight loss D015431
T86509 72-83 DiseaseOrPhenotypicFeature denotes weight loss D015431
T68213 1178-1186 OrganismTaxon denotes patients
T20333 1148-1156 OrganismTaxon denotes patients
T37247 1128-1136 OrganismTaxon denotes patients
T50653 1058-1066 OrganismTaxon denotes patients
T74154 697-705 OrganismTaxon denotes patients
T71283 660-668 OrganismTaxon denotes patients
T25361 1168-1174 SequenceVariant denotes A1359A
T73854 1137-1143 SequenceVariant denotes G1359A
T80887 1090-1096 SequenceVariant denotes G1359G
T4534 990-996 SequenceVariant denotes G1359G
T5668 958-964 SequenceVariant denotes A1359A
T24184 947-953 SequenceVariant denotes G1359A
T99700 495-501 SequenceVariant denotes G1359A
T85717 9-15 SequenceVariant denotes G1359A

DisGeNET

Id Subject Object Predicate Lexical cue
T0 506-509 gene:1268 denotes CB1
T1 654-659 disease:C0028754 denotes obese
R1 T0 T1 associated_with CB1,obese

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21666969-3#67#70#gene1268 506-509 gene1268 denotes CB1
21666969-3#215#220#diseaseC0028754 654-659 diseaseC0028754 denotes obese
67#70#gene1268215#220#diseaseC0028754 21666969-3#67#70#gene1268 21666969-3#215#220#diseaseC0028754 associated_with CB1,obese

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 178-186 DNAMutation:g|SUB|G|1359|A denotes 1359 G/A