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sentences

Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
T2 92-199 Sentence denotes Steroid hormones play essential roles in a wide variety of biological processes in multicellular organisms.
T3 200-390 Sentence denotes The principal steroid hormones in nematodes and arthropods are dafachronic acids and ecdysteroids, respectively, both of which are synthesized from cholesterol as an indispensable precursor.
T4 391-531 Sentence denotes The first critical catalytic step in the biosynthesis of these ecdysozoan steroids is the conversion of cholesterol to 7-dehydrocholesterol.
T5 532-639 Sentence denotes However, the enzymes responsible for cholesterol 7,8-dehydrogenation remain unclear at the molecular level.
T6 640-739 Sentence denotes Here we report that the Rieske oxygenase DAF-36/Neverland (Nvd) is a cholesterol 7,8-dehydrogenase.
T7 740-1051 Sentence denotes The daf-36/nvd genes are evolutionarily conserved, not only in nematodes and insects but also in deuterostome species that do not produce dafachronic acids or ecdysteroids, including the sea urchin Hemicentrotus pulcherrimus, the sea squirt Ciona intestinalis, the fish Danio rerio, and the frog Xenopus laevis.
T8 1052-1202 Sentence denotes An in vitro enzymatic assay system reveals that all DAF-36/Nvd proteins cloned so far have the ability to convert cholesterol to 7-dehydrocholesterol.
T9 1203-1449 Sentence denotes Moreover, the lethality of loss of nvd function in the fruit fly Drosophila melanogaster is rescued by the expression of daf-36/nvd genes from the nematode Caenorhabditis elegans, the insect Bombyx mori, or the vertebrates D. rerio and X. laevis.
T10 1450-1552 Sentence denotes These data suggest that daf-36/nvd genes are functionally orthologous across the bilaterian phylogeny.
T11 1553-1681 Sentence denotes We propose that the daf-36/nvd family of proteins is a novel conserved player in cholesterol metabolism across the animal phyla.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1414-1425 http://purl.obolibrary.org/obo/MAT_0000373 denotes vertebrates

silkworm

Id Subject Object Predicate Lexical cue
T1 31-47 Gene:5740633 denotes DAF-36/Neverland
T2 59-70 Chemical:MESH:D002784 denotes cholesterol
T3 92-108 Chemical:MESH:D013256 denotes Steroid hormones
T4 214-230 Chemical:MESH:D013256 denotes steroid hormones
T5 263-280 Chemical:MESH:C533800 denotes dafachronic acids
T6 285-297 Chemical:MESH:D026461 denotes ecdysteroids
T7 348-359 Chemical:MESH:D002784 denotes cholesterol
T8 454-473 Chemical:- denotes ecdysozoan steroids
T9 495-506 Chemical:MESH:D002784 denotes cholesterol
T10 510-530 Chemical:MESH:C016705 denotes 7-dehydrocholesterol
T11 569-580 Chemical:MESH:D002784 denotes cholesterol
T12 681-697 Gene:5740633 denotes DAF-36/Neverland
T13 699-702 Gene:5740633 denotes Nvd
T14 751-754 Gene:5740633 denotes nvd
T15 878-895 Chemical:MESH:C533800 denotes dafachronic acids
T16 927-964 Disease:MESH:D009041 denotes sea urchin Hemicentrotus pulcherrimus
T17 981-999 Species:7719 denotes Ciona intestinalis
T18 1010-1021 Species:7955 denotes Danio rerio
T19 1036-1050 Species:8355 denotes Xenopus laevis
T20 1111-1114 Gene:5740633 denotes Nvd
T21 1166-1177 Chemical:MESH:D002784 denotes cholesterol
T22 1181-1201 Chemical:MESH:C016705 denotes 7-dehydrocholesterol
T23 1238-1241 Gene:5740633 denotes nvd
T24 1258-1267 Species:7227 denotes fruit fly
T25 1268-1291 Species:7227 denotes Drosophila melanogaster
T26 1331-1334 Gene:5740633 denotes nvd
T27 1359-1381 Species:6239 denotes Caenorhabditis elegans
T28 1394-1405 Species:7091 denotes Bombyx mori
T29 1426-1434 Species:7955 denotes D. rerio
T30 1439-1448 Species:8355 denotes X. laevis
T31 1481-1484 Gene:5740633 denotes nvd
T32 1580-1583 Gene:5740633 denotes nvd
T33 1634-1645 Chemical:MESH:D002784 denotes cholesterol

silkwormbase

Id Subject Object Predicate Lexical cue
T1 31-47 Gene:5740633 denotes DAF-36/Neverland
T10 510-530 Chemical:MESH:C016705 denotes 7-dehydrocholesterol
T11 569-580 Chemical:MESH:D002784 denotes cholesterol
T12 681-697 Gene:5740633 denotes DAF-36/Neverland
T13 699-702 Gene:5740633 denotes Nvd
T14 751-754 Gene:5740633 denotes nvd
T15 878-895 Chemical:MESH:C533800 denotes dafachronic acids
T16 927-964 Disease:MESH:D009041 denotes sea urchin Hemicentrotus pulcherrimus
T17 981-999 Species:7719 denotes Ciona intestinalis
T18 1010-1021 Species:7955 denotes Danio rerio
T19 1036-1050 Species:8355 denotes Xenopus laevis
T2 59-70 Chemical:MESH:D002784 denotes cholesterol
T20 1111-1114 Gene:5740633 denotes Nvd
T21 1166-1177 Chemical:MESH:D002784 denotes cholesterol
T22 1181-1201 Chemical:MESH:C016705 denotes 7-dehydrocholesterol
T23 1238-1241 Gene:5740633 denotes nvd
T24 1258-1267 Species:7227 denotes fruit fly
T25 1268-1291 Species:7227 denotes Drosophila melanogaster
T26 1331-1334 Gene:5740633 denotes nvd
T27 1359-1381 Species:6239 denotes Caenorhabditis elegans
T28 1394-1405 Species:7091 denotes Bombyx mori
T29 1426-1434 Species:7955 denotes D. rerio
T3 92-108 Chemical:MESH:D013256 denotes Steroid hormones
T30 1439-1448 Species:8355 denotes X. laevis
T31 1481-1484 Gene:5740633 denotes nvd
T32 1580-1583 Gene:5740633 denotes nvd
T33 1634-1645 Chemical:MESH:D002784 denotes cholesterol
T4 214-230 Chemical:MESH:D013256 denotes steroid hormones
T5 263-280 Chemical:MESH:C533800 denotes dafachronic acids
T6 285-297 Chemical:MESH:D026461 denotes ecdysteroids
T7 348-359 Chemical:MESH:D002784 denotes cholesterol
T8 454-473 Chemical:- denotes ecdysozoan steroids
T9 495-506 Chemical:MESH:D002784 denotes cholesterol

Allie

Id Subject Object Predicate Lexical cue
SS1_21632547_5_0 688-697 expanded denotes Neverland
SS2_21632547_5_0 699-702 abbr denotes Nvd
AE1_21632547_5_0 SS1_21632547_5_0 SS2_21632547_5_0 abbreviatedTo Neverland,Nvd

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1414-1425 Body_part denotes vertebrates http://purl.obolibrary.org/obo/MAT_0000373

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 234-243 OrganismTaxon denotes nematodes 6231
T2 803-812 OrganismTaxon denotes nematodes 6231
T3 837-849 OrganismTaxon denotes deuterostome 33511
T4 927-937 OrganismTaxon denotes sea urchin 7625
T5 938-964 OrganismTaxon denotes Hemicentrotus pulcherrimus 7650
T6 981-999 OrganismTaxon denotes Ciona intestinalis 7719
T7 1005-1009 OrganismTaxon denotes fish 117565|117569|118072|7777|7878|7898
T13 1010-1021 OrganismTaxon denotes Danio rerio 7955
T14 1036-1050 OrganismTaxon denotes Xenopus laevis 8355
T15 1258-1267 OrganismTaxon denotes fruit fly 7211|7215
T17 1268-1291 OrganismTaxon denotes Drosophila melanogaster 7227
T18 1350-1358 OrganismTaxon denotes nematode 6231
T19 1359-1381 OrganismTaxon denotes Caenorhabditis elegans 6239
T20 1394-1405 OrganismTaxon denotes Bombyx mori 7091
T21 1675-1680 OrganismTaxon denotes phyla 443529|86858

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 175-198 Body_part denotes multicellular organisms http://purl.obolibrary.org/obo/UBERON_0000468