Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-66 |
Sentence |
denotes |
The roles of adenosine and adenosine receptors in bone remodeling. |
T2 |
67-249 |
Sentence |
denotes |
Adenosine regulates a wide variety of physiological processes including heart rate, vasodilation and inflammation through the activation of specific cell surface adenosine receptors. |
T3 |
250-422 |
Sentence |
denotes |
In addition to these well-established roles of adenosine, recent genetic and pharmacological research has implicated adenosine as an important regulator in bone remodeling. |
T4 |
423-529 |
Sentence |
denotes |
The secretion of adenosine and the presence of its four receptors in bone cells have been well documented. |
T5 |
530-797 |
Sentence |
denotes |
More recently, we provided the first evidence that adenosine regulates osteoclast formation and function through A1 receptor (A1R), and showed that A1R-knockout mice have significantly increased bone volume as a result of impaired osteoclast-mediated bone resorption. |
T6 |
798-973 |
Sentence |
denotes |
Moreover, adenosine A1R-knockout mice are protective from boss loss following ovariectomy further supporting the involvement of adenosine in osteoclast formation and function. |
T7 |
974-1112 |
Sentence |
denotes |
This short review summarizes current knowledge related to the roles of adenosine and adenosine receptors in bone formation and remodeling. |
T8 |
1113-1251 |
Sentence |
denotes |
A deeper insight into the regulation of bone metabolism by adenosine receptors should assist in developing new therapies for osteoporosis. |
T1 |
0-66 |
Sentence |
denotes |
The roles of adenosine and adenosine receptors in bone remodeling. |
T2 |
67-249 |
Sentence |
denotes |
Adenosine regulates a wide variety of physiological processes including heart rate, vasodilation and inflammation through the activation of specific cell surface adenosine receptors. |
T3 |
250-422 |
Sentence |
denotes |
In addition to these well-established roles of adenosine, recent genetic and pharmacological research has implicated adenosine as an important regulator in bone remodeling. |
T4 |
423-529 |
Sentence |
denotes |
The secretion of adenosine and the presence of its four receptors in bone cells have been well documented. |
T5 |
530-797 |
Sentence |
denotes |
More recently, we provided the first evidence that adenosine regulates osteoclast formation and function through A1 receptor (A1R), and showed that A1R-knockout mice have significantly increased bone volume as a result of impaired osteoclast-mediated bone resorption. |
T6 |
798-973 |
Sentence |
denotes |
Moreover, adenosine A1R-knockout mice are protective from boss loss following ovariectomy further supporting the involvement of adenosine in osteoclast formation and function. |
T7 |
974-1112 |
Sentence |
denotes |
This short review summarizes current knowledge related to the roles of adenosine and adenosine receptors in bone formation and remodeling. |
T8 |
1113-1251 |
Sentence |
denotes |
A deeper insight into the regulation of bone metabolism by adenosine receptors should assist in developing new therapies for osteoporosis. |