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PubMed:2160380 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 218-225 HP_0002748 denotes rickets
T2 2603-2610 HP_0002748 denotes rickets

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-21 cell_line denotes Lymphocyte cell lines
T2 94-133 protein denotes 1 alpha,25-dihydroxyvitamin D3 receptor
T3 135-156 cell_line denotes Lymphocyte cell lines
T4 474-496 cell_line denotes T-lymphocyte cell line
T5 498-503 cell_line denotes S-LB1
T6 559-564 cell_line denotes S-LB1
T7 606-643 protein denotes chick intestinal 1,25(OH)2D3 receptor
T8 810-820 cell_line denotes cell lines
T9 864-867 protein denotes VDR
T10 872-875 protein denotes VDR
T11 884-887 protein denotes VDR
T12 936-944 protein denotes receptor
T13 966-980 cell_line denotes cultured cells
T14 1125-1156 protein denotes functional 1,25(OH)2D3 receptor
T15 1170-1179 cell_line denotes cell line
T16 1181-1187 cell_line denotes A1-VDR
T17 1249-1272 protein denotes 25(OH)D3-24-hydroxylase
T18 1380-1389 cell_line denotes cell line
T19 1402-1408 cell_line denotes Ro-VDR
T20 1478-1495 cell_line denotes control cell line
T21 1537-1545 protein denotes receptor
T22 1573-1579 cell_line denotes Ro-VDR
T23 1588-1598 cell_line denotes cell lines
T24 1630-1638 protein denotes receptor
T25 1659-1667 protein denotes receptor
T26 1844-1850 cell_line denotes Ro-VDR
T27 1855-1867 cell_line denotes A1-VDR cells
T28 1963-1983 protein denotes 1,25(OH)2D3 receptor
T29 1991-2003 cell_line denotes Ro-VDR cells
T30 2047-2078 protein denotes unoccupied 1,25(OH)2D3 receptor
T31 2120-2128 protein denotes receptor
T32 2134-2146 cell_line denotes A1-VDR cells
T33 2267-2272 RNA denotes mRNAs
T34 2293-2307 DNA denotes c-myc oncogene
T35 2423-2443 protein denotes 1,25(OH)2D3 receptor
T36 2480-2490 cell_line denotes cell lines
T37 2555-2563 protein denotes receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-134 Sentence denotes Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor.
S2 135-245 Sentence denotes Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II).
S3 246-337 Sentence denotes These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I).
S4 338-530 Sentence denotes Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to binding studies using a T-lymphocyte cell line (S-LB1) from a normal individual.
S5 531-803 Sentence denotes The 1,25(OH)2D3 receptor of S-LB1 was comparable to the well-characterized chick intestinal 1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose.
S6 804-1157 Sentence denotes Three cell lines established from patients with VDDR-II (Rh-VDR, Sh-VDR, and Ab-VDR) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 (24,25(OH)2D3), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor.
S7 1158-1301 Sentence denotes In a fourth cell line, A1-VDR, the receptor for 1,25(OH)2D3 had a low binding capacity and 25(OH)D3-24-hydroxylase activity was not detectable.
S8 1302-1516 Sentence denotes Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the fifth cell line, designated Ro-VDR, although the sensitivity to hormone treatment was lower than in the control cell line from a normal donor.
S9 1517-1580 Sentence denotes The capacity of the receptor for 1,25(OH)2D3 was low in Ro-VDR.
S10 1581-1756 Sentence denotes In all cell lines where 1,25(OH)2D3 binding to a receptor was detectable, the receptor had the typical sedimentation coefficient of 3.7 S on sucrose density gradient analysis.
S11 1757-1984 Sentence denotes Binding and elution properties to DNA-cellulose, however, differed from normal in both Ro-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor.
S12 1985-2187 Sentence denotes While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor, neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus.
S13 2188-2466 Sentence denotes In a series of functional studies we found that modulation of the level of the mRNAs coding for both the c-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 receptor status of these cells.
S14 2467-2686 Sentence denotes Use of these cell lines will facilitate further study of the molecular defect(s) in the receptor for 1,25(OH)2D3 in vitamin D-dependent rickets type II and will allow a correlation with impairment of cellular functions.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-21 NP denotes Lymphocyte cell lines
C2 27-62 NP denotes vitamin D-dependent rickets type II
C3 135-156 NP denotes Lymphocyte cell lines
C4 198-244 NP denotes vitamin D-dependent rickets, type II (VDDR-II)
C5 246-257 NP denotes These lines
C6 349-397 NP denotes [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3)
C7 401-404 NP denotes its
C8 417-433 NP denotes these cell lines
C9 583-643 NP denotes the well-characterized chick intestinal 1,25(OH)2D3 receptor
C10 656-659 NP denotes its
C11 698-701 NP denotes its
C12 743-746 NP denotes its
C13 852-888 NP denotes VDDR-II (Rh-VDR, Sh-VDR, and Ab-VDR)
C14 919-930 NP denotes 1,25(OH)2D3
C15 986-997 NP denotes 1,25(OH)2D3
C16 1030-1071 NP denotes 24,25-dihydroxy-vitamin D3 (24,25(OH)2D3)
C18 1073-1083 NP denotes a response
C19 1084-1089 NP denotes which
C17 1073-1156 NP denotes a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor
C20 1181-1187 NP denotes A1-VDR
C22 1206-1217 NP denotes 1,25(OH)2D3
C21 1189-1217 NP denotes the receptor for 1,25(OH)2D3
C23 1342-1353 NP denotes 1,25(OH)2D3
C24 1402-1408 NP denotes Ro-VDR
C26 1550-1561 NP denotes 1,25(OH)2D3
C25 1533-1561 NP denotes the receptor for 1,25(OH)2D3
C27 1573-1579 NP denotes Ro-VDR
C28 1584-1598 NP denotes all cell lines
C29 1599-1604 NP denotes where
C30 1628-1638 NP denotes a receptor
C31 1655-1667 NP denotes the receptor
C32 1791-1804 NP denotes DNA-cellulose
C33 1839-1867 NP denotes both Ro-VDR and A1-VDR cells
C34 1868-1873 NP denotes where
C35 1887-1900 NP denotes DNA-cellulose
C36 1959-1983 NP denotes the 1,25(OH)2D3 receptor
C37 1991-2003 NP denotes Ro-VDR cells
C38 2391-2402 NP denotes 1,25(OH)2D3
C40 2568-2579 NP denotes 1,25(OH)2D3
C39 2551-2579 NP denotes the receptor for 1,25(OH)2D3
C41 2583-2618 NP denotes vitamin D-dependent rickets type II
R1 C3 C1 coref-ident Lymphocyte cell lines,Lymphocyte cell lines
R2 C4 C2 coref-ident "vitamin D-dependent rickets, type II (VDDR-II)",vitamin D-dependent rickets type II
R3 C5 C3 coref-ident These lines,Lymphocyte cell lines
R4 C7 C6 coref-pron its,"[3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3)"
R5 C8 C5 coref-ident these cell lines,These lines
R6 C10 C9 coref-pron its,"the well-characterized chick intestinal 1,25(OH)2D3 receptor"
R7 C11 C9 coref-pron its,"the well-characterized chick intestinal 1,25(OH)2D3 receptor"
R8 C12 C9 coref-pron its,"the well-characterized chick intestinal 1,25(OH)2D3 receptor"
R9 C13 C4 coref-ident "VDDR-II (Rh-VDR, Sh-VDR, and Ab-VDR)","vitamin D-dependent rickets, type II (VDDR-II)"
R10 C14 C6 coref-ident "1,25(OH)2D3","[3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3)"
R11 C15 C14 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R12 C19 C18 coref-relat which,a response
R13 C17 C16 coref-appos "a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor","24,25-dihydroxy-vitamin D3 (24,25(OH)2D3)"
R14 C22 C15 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R15 C21 C20 coref-appos "the receptor for 1,25(OH)2D3",A1-VDR
R16 C23 C22 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R17 C26 C23 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R18 C25 C21 coref-ident "the receptor for 1,25(OH)2D3","the receptor for 1,25(OH)2D3"
R19 C27 C24 coref-ident Ro-VDR,Ro-VDR
R20 C29 C28 coref-relat where,all cell lines
R21 C31 C30 coref-ident the receptor,a receptor
R22 C34 C33 coref-relat where,both Ro-VDR and A1-VDR cells
R23 C35 C32 coref-ident DNA-cellulose,DNA-cellulose
R24 C36 C25 coref-ident "the 1,25(OH)2D3 receptor","the receptor for 1,25(OH)2D3"
R25 C37 C27 coref-ident Ro-VDR cells,Ro-VDR
R26 C38 C26 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R27 C40 C38 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R28 C39 C36 coref-ident "the receptor for 1,25(OH)2D3","the 1,25(OH)2D3 receptor"
R29 C41 C13 coref-ident vitamin D-dependent rickets type II,"VDDR-II (Rh-VDR, Sh-VDR, and Ab-VDR)"

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 cell_line denotes Lymphocyte cell lines
T2 27-62 other_name denotes vitamin D-dependent rickets type II
T3 94-133 protein_family_or_group denotes 1 alpha,25-dihydroxyvitamin D3 receptor
T4 135-156 cell_line denotes Lymphocyte cell lines
T5 184-192 multi_cell denotes patients
T6 198-225 other_name denotes vitamin D-dependent rickets
T7 236-243 other_name denotes VDDR-II
T8 293-327 virus denotes human T-lymphotrophic virus type I
T9 329-335 virus denotes HTLV-I
T10 349-383 lipid denotes [3H]1 alpha,25-dihydroxyvitamin D3
T11 385-396 lipid denotes 1,25(OH)2D3
T12 474-496 cell_line denotes T-lymphocyte cell line
T13 498-503 cell_line denotes S-LB1
T14 535-546 lipid denotes 1,25(OH)2D3
T15 559-564 cell_line denotes S-LB1
T16 606-622 protein_family_or_group denotes chick intestinal
T17 623-634 lipid denotes 1,25(OH)2D3
T18 789-802 other_name denotes DNA-cellulose
T19 810-820 cell_line denotes cell lines
T20 838-846 multi_cell denotes patients
T21 852-859 other_name denotes VDDR-II
T22 861-864 other_name denotes Rh-
T23 864-867 protein_family_or_group denotes VDR
T24 869-872 other_name denotes Sh-
T25 872-875 protein_family_or_group denotes VDR
T26 881-884 other_name denotes Ab-
T27 884-887 protein_family_or_group denotes VDR
T28 919-930 lipid denotes 1,25(OH)2D3
T29 936-944 protein_family_or_group denotes receptor
T30 966-980 cell_line denotes cultured cells
T31 986-997 lipid denotes 1,25(OH)2D3
T32 1030-1056 lipid denotes 24,25-dihydroxy-vitamin D3
T33 1058-1070 lipid denotes 24,25(OH)2D3
T34 1125-1135 protein_family_or_group denotes functional
T35 1136-1147 lipid denotes 1,25(OH)2D3
T36 1170-1179 cell_line denotes cell line
T37 1181-1187 cell_line denotes A1-VDR
T38 1206-1217 lipid denotes 1,25(OH)2D3
T39 1249-1272 protein_molecule denotes 25(OH)D3-24-hydroxylase
T40 1315-1338 other_name denotes 24,25-(OH)2D3 synthesis
T41 1342-1353 lipid denotes 1,25(OH)2D3
T42 1380-1389 cell_line denotes cell line
T43 1402-1408 cell_line denotes Ro-VDR
T44 1478-1495 cell_line denotes control cell line
T45 1503-1515 multi_cell denotes normal donor
T46 1537-1545 protein_family_or_group denotes receptor
T47 1550-1561 lipid denotes 1,25(OH)2D3
T48 1573-1579 cell_line denotes Ro-VDR
T49 1588-1598 cell_line denotes cell lines
T50 1605-1616 lipid denotes 1,25(OH)2D3
T51 1630-1638 protein_family_or_group denotes receptor
T52 1659-1667 protein_family_or_group denotes receptor
T53 1684-1709 other_name denotes sedimentation coefficient
T54 1722-1755 other_name denotes sucrose density gradient analysis
T55 1757-1764 other_name denotes Binding
T56 1769-1787 other_name denotes elution properties
T57 1791-1804 other_name denotes DNA-cellulose
T58 1844-1850 cell_line denotes Ro-VDR
T59 1855-1861 cell_line denotes A1-VDR
T60 1887-1900 other_name denotes DNA-cellulose
T61 1921-1939 other_name denotes salt concentration
T62 1963-1974 lipid denotes 1,25(OH)2D3
T63 1975-1983 protein_family_or_group denotes receptor
T64 1991-1997 cell_line denotes Ro-VDR
T65 2047-2057 protein_family_or_group denotes unoccupied
T66 2058-2069 lipid denotes 1,25(OH)2D3
T67 2070-2078 protein_family_or_group denotes receptor
T68 2120-2128 protein_family_or_group denotes receptor
T69 2134-2140 cell_line denotes A1-VDR
T70 2179-2186 cell_component denotes nucleus
T71 2203-2221 other_name denotes functional studies
T72 2267-2272 RNA_family_or_group denotes mRNAs
T73 2293-2307 DNA_domain_or_region denotes c-myc oncogene
T74 2316-2329 other_name denotes growth factor
T75 2339-2387 other_name denotes granulocyte-monocyte colony stimulating activity
T76 2391-2402 lipid denotes 1,25(OH)2D3
T77 2423-2434 lipid denotes 1,25(OH)2D3
T78 2435-2443 protein_family_or_group denotes receptor
T79 2480-2490 cell_line denotes cell lines
T80 2555-2563 protein_family_or_group denotes receptor
T81 2568-2579 lipid denotes 1,25(OH)2D3
T82 2583-2618 other_name denotes vitamin D-dependent rickets type II
T83 2667-2685 other_name denotes cellular functions