PubMed:2157089 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	423-435	HP_0000822	denotes	hypertension
T2	1219-1231	HP_0000822	denotes	hypertension

Id	Subject	Object	Predicate	Lexical cue
T1	140-167	protein	denotes	mineralocorticoid receptors
T2	171-199	cell_type	denotes	human mononuclear leukocytes
T3	201-204	cell_type	denotes	HML
T4	282-285	cell_type	denotes	HML
T5	469-472	cell_type	denotes	HML
T6	772-784	protein	denotes	Plasma renin
T7	909-936	protein	denotes	mineralocorticoid receptors
T8	1083-1110	protein	denotes	mineralocorticoid receptors
T9	1188-1191	cell_type	denotes	HML

Id	Subject	Object	Predicate	Lexical cue
S1	0-104	Sentence	denotes	Effects of aldosterone on intralymphocytic sodium and potassium in patients with essential hypertension.
S2	105-314	Sentence	denotes	In vitro binding of aldosterone to mineralocorticoid receptors on human mononuclear leukocytes (HML) and its effects on the intracellular sodium and potassium concentrations of HML have already been described.
S3	315-436	Sentence	denotes	In the present paper this easily accessible human cell model was investigated in 13 patients with essential hypertension.
S4	437-548	Sentence	denotes	In only four patients sodium in HML without incubation was elevated compared with the range for normal persons.
S5	549-663	Sentence	denotes	A decrease of intracellular sodium or potassium occurred during incubation without aldosterone (P less than 0.02).
S6	664-771	Sentence	denotes	The addition of 1.4 nM aldosterone did not prevent this loss of electrolytes as observed in normal persons.
S7	772-894	Sentence	denotes	Plasma renin activity and aldosterone were not correlated with the electrolyte response and were within the normal limits.
S8	895-991	Sentence	denotes	The number of mineralocorticoid receptors/cell were within or close to the normal range (n = 9).
S9	992-1232	Sentence	denotes	The independence of intracellular electrolytes from aldosterone despite a normal number of mineralocorticoid receptors may reflect an impairment of the mineralocorticoid effector mechanism in the HML of patients with essential hypertension.

Id	Subject	Object	Predicate	Lexical cue
C1	11-22	NP	denotes	aldosterone
C2	67-103	NP	denotes	patients with essential hypertension
C3	396-435	NP	denotes	13 patients with essential hypertension
C4	533-547	NP	denotes	normal persons
C5	632-643	NP	denotes	aldosterone
C6	756-770	NP	denotes	normal persons
C7	798-809	NP	denotes	aldosterone
C8	1044-1055	NP	denotes	aldosterone
C9	1195-1231	NP	denotes	patients with essential hypertension
R1	C3	C2	coref-ident	13 patients with essential hypertension,patients with essential hypertension
R2	C5	C1	coref-ident	aldosterone,aldosterone
R3	C6	C4	coref-ident	normal persons,normal persons
R4	C7	C5	coref-ident	aldosterone,aldosterone
R5	C8	C7	coref-ident	aldosterone,aldosterone
R6	C9	C2	coref-ident	patients with essential hypertension,patients with essential hypertension

Id	Subject	Object	Predicate	Lexical cue
T1	26-49	atom	denotes	intralymphocytic sodium
T2	67-75	multi_cell	denotes	patients
T3	81-103	other_name	denotes	essential hypertension
T4	125-136	lipid	denotes	aldosterone
T5	140-157	lipid	denotes	mineralocorticoid
T6	171-199	cell_type	denotes	human mononuclear leukocytes
T7	201-204	cell_type	denotes	HML
T8	282-285	cell_type	denotes	HML
T9	359-375	other_name	denotes	human cell model
T10	399-407	multi_cell	denotes	patients
T11	413-435	other_name	denotes	essential hypertension
T12	450-458	multi_cell	denotes	patients
T13	469-472	cell_type	denotes	HML
T14	533-547	multi_cell	denotes	normal persons
T15	563-583	atom	denotes	intracellular sodium
T16	587-596	atom	denotes	potassium
T17	632-643	lipid	denotes	aldosterone
T18	687-698	lipid	denotes	aldosterone
T19	756-770	multi_cell	denotes	normal persons
T20	772-784	protein_molecule	denotes	Plasma renin
T21	798-809	lipid	denotes	aldosterone
T22	839-850	atom	denotes	electrolyte
T23	909-926	lipid	denotes	mineralocorticoid
T24	1012-1038	atom	denotes	intracellular electrolytes
T25	1044-1055	lipid	denotes	aldosterone
T26	1083-1100	lipid	denotes	mineralocorticoid
T27	1144-1161	lipid	denotes	mineralocorticoid
T28	1188-1191	cell_type	denotes	HML
T29	1195-1203	multi_cell	denotes	patients
T30	1209-1231	other_name	denotes	essential hypertension